Alphabetical Listing of Research Labs
Scientists in the Aderem Lab are studying innate responses to HIV, tuberculosis, influenza, and other pathogens that significantly impact global health. Our goal is to define the mechanisms that result in a successful immune response to infection or vaccination and identify targets for therapeutic intervention to correct inadequate or dysregulated responses.
Related topics: Systems biology, tuberculosis, big data, computational biology, genomics, proteomics, host-pathogen interaction, infectious disease, OMICS, predictive analytics, immunology
In the Aitchison Lab, we have spent several years using yeast as a tractable model system to develop technologies and systems biology approaches and to gain fundamental insights into cell biology. Building on these developments, advances in systems biology are being applied, through collaborative research programs, to dengue, HIV, trypanosomiasis, malaria and immune responses to infection
Related topics: Malaria, HIV/AIDS, biotechnology, genetic engineering, global health, big data, computational biology, genomics, proteomics, OMICS, predictive analytics, data analysis, immunology, influenza
The Beier Lab uses genetic and genomic analysis in model systems to understand human biology and disease and identifies genes that contribute to human disease and developmental abnormalities.
Related topics: Congenital developmental defects, genetic kidney disease
The Bennett Lab investigates the contribution of post-zygotic mutations on human development and birth defects, with a focus on vascular malformations. We also study the impact of rapid diagnostic genomic sequencing in management of children in intensive care units.
Related topics: Precision medicine
The Cherry Lab investigates how the visual system develops, and how genetic variations contribute to blindness and other visual disorders. The lab utilizes high-throughput DNA and RNA sequencing technologies to identify and characterize human and mouse retinal enhancers to elucidate the transcriptional regulation of retinal development and function.
Related topics: Retinal disease, vision, eyes
The Christakis Lab studies how the early environment impacts childhood behavior and development and develops strategies that help parents optimize their children's social, cognitive, and emotional development.
Related topics: Facebook, early TV exposure, television, internet-based models
The Crane Lab is unraveling exactly how cancer cells disarm immune cells, with the goal of finding ways to reprogram those immune cells so they can elude cancer's defenses and destroy brain tumors, neuroblastoma and other cancers.
Related topics: T cells, immunotherapy, oncology
Craniofacial Outcomes Research and Epidemiology (CORE) Group
The Craniofacial Outcomes Research and Epidemiology (CORE) Group conducts clinical research that aims to understand the epidemiology of craniofacial conditions and to identify treatments that lead to improved outcomes for those conditions.
Related topics: Integrative research, resource team
The Cunningham Lab investigates the mechanisms behind craniosynostosis and other malformations. Our goal is to make discoveries that lead to better care for patients with craniofacial conditions.
Related topics: Genetics, next-generation sequencing
The Debley Lab is engaged in an array of basic and translational work investigating the role of the airway epithelium in childhood asthma. Active studies include assessment of airway remodeling responses by asthmatic airway epithelial cells as well as investigation of innate immune responses of the airway epithelium to respiratory viruses in asthmatic and healthy children. In addition, Dr. Debley pioneered the measurement of exhaled nitric oxide in infants and toddlers with recurrent wheezing and his research has assessed the utility of this and other biomarkers for predicting asthma and decline in lung function among preschool children at risk for asthma.
Related topics: Pulmonary
The Evans Lab investigates sleep and breathing in children born with craniofacial conditions. Evans's current research focuses on children born with micrognathia, glossoptosis and cleft palate, also known as Robin sequence (RS). Her goals include improving the understanding of RS's phenotype, or physical characteristics, and identifying risk factors that may play a role in causing children to be born with the condition.
The goal of the Ferguson Lab is to use a multi-level approach, combining molecular biology, circuit-mapping and behavioral neuroscience, to understand the role of cortico-basal ganglia-thalamic circuitry in the development of behaviors that are associated with drug reward and addiction, as well as in the processes that underlie decision-making, motivation and impulsivity.
The Frenkel Lab focuses on key questions related to HIV. The lab aims to: understand the mechanisms that allow HIV to persist during antiretroviral therapy; develop practical, affordable tests to detect drug-resistant HIV; make insights into reservoirs of drug-resistant HIV and illuminate the pathogenesis of HIV-related diseases.
The Garrison Lab studies the interactions between sleep, media use and physical activity, and how these affect child and adolescent health, behavior and development.
Related topics: Television, TV, digital media
The Grundner Lab seeks to map the signaling pathways that underlie Mycobacterium tuberculosis’ (Mtb) adaptability and pathogenesis. Our studies provide fundamental insight into Mtb biology and identify new targets for therapeutic interference. We use chemical proteomics approaches towards high-throughput identification of functions for these unknown proteins. These new tools allow probing of even the most divergent enzyme space.
Related topics: Infectious disease, systems biology, biotechnology, genetic engineering, drug resistance, global health, host-pathogen interaction, genetics, immunology
The Gumbiner Lab studies how tissues and organs are built from collections of individual cells. This leads to discoveries about how animals and humans develop, and how their tissues are maintained, repaired and regenerated throughout life. Understanding how these biological processes malfunction provides insights into the causes of birth defects and many diseases, including cancer metastasis and inflammatory diseases of the bowel and lungs; they may also provide approaches for potential new therapies.
Related topics: Cell adhesion, catenins, cadherins
The Hahn Lab is pioneering the use of targeted proteomics for applications in newborn screening from dried blood spots (DBS). This powerful approach enables the direct detection of extremely-low-abundance peptides that would have been previously unusable as diagnostic biomarkers. Currently, the Hahn lab is developing a newborn screening platform for primary immunodeficiencies, Wilson disease and Cystinosis as a single multiplex analysis.
Related topics: Tandem mass spectrometry, PIDDs
The Harrington Lab focuses on intergenerational immune interactions and their effect on susceptibility to infection during pregnancy and infection. In particular, we investigate the role of maternal microchimerism (maternal cells acquired by the fetus in utero) in fetal and infant immune development, early vaccine responses, and susceptibility to infection.
Related topics: Malaria
The Heike Lab conducts innovative research on questions related to craniofacial microsomia, 22q11.2-related disorders and other craniofacial conditions. The lab aims to unravel the causes of these conditions, develop new evaluation tools and assess treatment outcomes. Ultimately, we aim to improve care for children with conditions that affect the head and neck.
The Hernandez Lab uses a combination of genetics, molecular biology, cell culture models and animal models to probe the interactions between mycobacterial pathogens and host immune cells. The lab’s goal is to make insights that lead to new strategies to improve the efficacy and shorten the duration of antibiotic regimens for mycobacterial infections.
Related topics: Immunology
Hing Studies investigates the genetic causes of craniofacial disorders to improve the diagnosis and management of infants, children and adolescents with these conditions. Hing contributes to many other studies of a variety of disorders including craniofacial microsomia, microtia and oculo-otofacial dysplasia. Identifying the genes behind these conditions could dramatically improve our understanding of their causes and could potentially lead to tests that tell parents if they carry these genes.
Innovation in Child Healthcare Delivery Lab
Led by Dr. Tumaini Coker, the Innovation in Child Healthcare Delivery Lab uses a community-engaged approach to develop innovative ways to deliver healthcare. The lab’s current research includes investigating, designing and implementing new methods of delivering primary care services to children in low-income communities. Our goal is to reduce socioeconomic and racial/ethnic disparities in child health and healthcare.
Related topics: Integrative research, resource
The James Lab is interested in uncovering biochemical mechanisms that contribute to drug resistance and to immunological disease. To do so, we investigate many features of protein behavior, including their impact on differentiation, their interactions with other molecules and whether mutation regulates these processes.
Related topics: Immunology, B cells, genetic variation
The Jensen Lab investigates ways to reprogram immune cells by inserting new genetic instructions that tell them to find cancer cells and destroy them. The lab carries its innovations into clinical trials and uses the information learned there to make immunotherapies safer and more powerful.
Related topics: T cells, oncology, immunotherapy
The Kalia Lab is enabling progress toward immunotherapies that can be applied to any type of cancer. Their goal is to gain an in-depth understanding of how the immune system fends off disease. By comparing disease models that are effectively controlled by the immune system with models that escape immune control, we seek to delineate unique signals that drive the development of a potent immune response.
Related topics: T cells, oncology, immunotherapy
The Kalume Lab investigates the mechanisms that drive epilepsy and related conditions, with the goal of making discoveries that lead to improved treatments for affected children and adults. The lab focuses on severe, debilitating, and life-threatening forms of epilepsy caused by genetic mutations. These types of epilepsy often present at an early age and are difficult to treat with current anti-epileptic drugs. The current work of the lab focuses on the following epileptic disorders: Dravet syndrome, focal cortical dysplasia, and Leigh syndrome.
Related topics: Genetics, sudden unexpected death, brain malformation, mitochondrial disorder
The Kappe Lab is focused on understanding the complex biology of the malaria parasite and the immune responses to infection, using this information to design transformational interventions that will help win the fight against malaria.
Related topics: Cell and molecular biology, biotechnology, genetic engineering, drug resistance, systems biology, global health, host-pathogen interaction, immunology, infectious disease, vaccine development, genetically attenuated parasite (GAP) strains for vaccination
The Kaushansky Lab works with the pathogens of infectious diseases like malaria that infect hundreds of millions of people every year. Our lab aims to identify what these pathogens need from their host and use this knowledge to prevent and eliminate infectious diseases.
Related topics: Malaria host-parasite interaction, host-based drug discovery, cross-pathogen studies and co-infections, global health, immunology, infectious disease
The Luquetti Lab studies the genetics and epidemiology of to identify their causes and develop research methods that can be used to study a wide variety of birth defects. Our goals are to identify genetic variations that contribute to craniofacial microsomia (CFM) and to pinpoint how these variations affect a child’s physical characteristics or phenotype.
The Maga Lab investigates the contributions of genetic and environmental factors responsible for human malformations, specifically craniofacial disorders and normal phenotypic variation. The lab is currently unraveling the epigenetic changes - alternations in the genome due to environmental factors as opposed to mutations - that contribute to fetal alcohol spectrum disorders (FASD).
The Majesky Lab uses molecular, biological and developmental genetic approaches to address fundamental questions in the development and differentiation of blood vessels. The goal is to understand the molecular mechanisms involved in the embryonic development of the heart and vascular system to discover and develop applications for stem and progenitor cell-based therapies.
Related topics: Congenital heart defects
The Mangione-Smith Lab develops innovative ways to pinpoint which medical treatments, procedures and practices improve health outcomes for children.
Research Focus Areas/Topics: quality and appropriateness of care in pediatrics, children with medical complexity, mental health care, hospital-to-home care transitions, respiratory illness, provider-patient communication
The Maves Lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new treatments for muscular dystrophy and heart disorders. We use the zebrafish as an animal model because of advantages for genetic manipulations, in vivo imaging, and drug screening.
The Mendoza Lab focuses on interventions to promote physical activity and improve nutrition among at-risk populations including racial/ethnic minorities, low-income families, cancer survivors, and those with chronic diseases such as diabetes.
Related topics: Health equity, physical activity, food security, obesity, television, digital media, safe routes to school, community outreach and engagement, mHealth
The Miao Lab pursues safer, more effective treatments for hemophilia. The lab focuses on developing innovative gene therapy and immunotherapy approaches.
The Millen Lab uses molecular genetic approaches to define causes of structural birth defects in the brain and neurodevelopmental disorders such as hydrocephalus, epilepsy, autism and intellectual disability. Our aim is to develop therapies that target root causes rather than simply treat symptoms. We are also working to harness the brain’s own ability to heal itself.
Related topics: Model organisms, translational research, preclinical drug trials
Dr. Ghayda Mirzaa’s research team is focused on advancing our knowledge regarding the genetic causes, natural history and mechanisms of neurodevelopmental disorders that affect children worldwide. Work performed by Dr. Mirzaa and her colleagues in the past has led to the discovery of a number of genes that cause focal cortical dysplasia, malformations of cortical development and brain growth abnormalities (megalencephaly and microcephaly). Dr. Mirzaa’s lab is now focused on developing ways to efficiently translate the wealth of human genomic data to mechanistic studies, as well as pre-clinical and clinical therapeutic trials.
Related topics: Genetics, brain disorders, human stem cells
The Morgan Lab is investigating molecules that can reverse the shortened life spans and neurological defects of animals with mitochondrial dysfunction. Morgan's team is also working to understand anesthesia's possible long-term effects on newborns and infants and how volatile anesthetics function.
The Myers Lab is focused on providing evidence-based mental healthcare services through telemental health to rectify current disparities in access to mental healthcare.
The Myler Lab uses cutting-edge genomic, bioinformatic and molecular approaches to study gene function and protein structure in a variety of infectious disease organisms.
Related topics: Leishmania, systems biology, global health, structural genomics, infectious disease, trypanosomiasis
Neonatal Respiratory Support Technologies (NeoRest)
The NeoRest team is working to reduce infant mortality and morbidity by developing affordable, easy-to-use and easy-to-maintain respiratory support solutions. The team's innovative approach to respiratory care, including the development of respiratory support devices may revolutionize the way premature infants are treated in resource-limited countries.
Dr. Aaron Olson is unraveling the basic mechanisms for preventing heart failure; a devastating problem often caused by congenital heart defects and genetic conditions. Specifically, Olson's team is investigating how glucose regulates the overall function of cardiac cells.
Related topics: Genetics, cardiac metabolism
Palliative Care and Resilience Research Program (PCAR)
Led by Drs. Abby Rosenberg and Joyce Yi-Frazier, the mission of the Palliative Care and Resilience (PCAR) Research Program is to create evidence-based interventions to build resilience, alleviate suffering, and improve quality of life among patients and families facing serious illness.
Related topics: Health care intervention, coping skills, psychology, stress management
The Parsons Lab works to identify drug targets and drug candidates for such diseases including human African trypanosomiasis (also known as African sleeping sickness), leishmaniasis, and toxoplasmosis. We are seeking to discover new ways to kill the parasites specifically without harming the human host.
Related topics: HIV/AIDS, Ebola, Zika, systems biology, global health, genomics, virology, genetics, infectious disease, OMICS
Pediatric Pain and Sleep Innovations Lab
The Pediatric Pain and Sleep Innovations Lab's research focus is on pediatric chronic and recurrent pain – in particular, the psychosocial, behavioral and family factors that influence pain and adjustment and behavioral approaches to prevent and reduce pain and disability.
Related topics: Pain management, digital health interventions, sleep disturbances
The Piliponsky Lab studies inflammatory responses involving mast cells and myeloid cells. Its goal is to understand how the body controls the immune system’s response to bacterial infections – and how this process becomes dysregulated.
Related topics: Immunology, infection, inflammation
Portman Research Group
The Portman Research Group is developing innovative ways to protect children's hearts from damage related to heart surgery and is improving how the medical community understands and treats Kawasaki disease.
Related topics: Myocardial protection program, heart disease
The Rabbitts Lab focuses on long-term pain and health outcomes in children and adolescents undergoing surgery. Her current research studies examine the role of biopsychosocial factors including child psychosocial factors, parental/family factors, and psychophysical processes in acute to chronic pain transition, and the efficacy of treatments for secondary prevention.
Related topics: Longitudinal studies, multi-method research, daily monitoring, quantitative sensory testing, clinical trials
The Rajagopal Lab utilizes genetic, molecular, biochemical and proteomic approaches as well as infection models to study infectious diseases caused by bacteria and certain viruses. The lab studies human pathogens including B Streptococcus, Staphylococcus aureus and zika virus.
Related topics: Immunology, infection, genetics, preterm birth
The Ramirez Lab investigates brain functions to develop new ways to treat – and potentially cure – neurological disorders. Interests include how neurons form into networks, and how those networks turn on and off to create rhythms that direct the brain – and the body – to perform different functions.
Related topics: Rett syndrome, breathing, SIDS, epilepsy
The Rose Lab focuses on the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 and its transmission and pathogenic role in AIDS-related malignancies.
Related topics: Lymphoma, HIV, Kaposi’s Sarcoma
The Saelens Lab conducts research in environmental influences on physical activity and eating behaviors and on the psychosocial factors that influence individual choice for weight-related behaviors. This work includes examining how the neighborhood environment impacts weight status, physical activity and dietary behaviors across the lifespan, and evaluating new approaches to the treatment of childhood obesity.
The Sarkar Lab is finding ways to help the immune system remember cancer and attack it if it relapses – whether that’s months or decades after a child goes into remission.
Related topics: Immunotherapy, T cells, vitamin D
The Sather Lab utilizes state-of-the-art technology to develop novel vaccine immunogens and strategies. In addition, the lab is interested in deciphering the mechanisms of antibody mediated protective immunity by HIV or malaria vaccination.
Related topics: Systems biology, genetic engineering, global health, genetics, host-pathogen interaction, infectious disease, immunology
The Sathyanarayana Lab investigates how chemicals in our environment impact children, and develops ways to reduce chemical exposures and help families lead healthier lives. The lab’s current research looks at how phthalates – endocrine-disrupting chemicals that are in our general environment and everyday products – affect how children develop, starting with babies in the womb.
Related topics: Neurodevelopment, genetics
Seattle Children’s Innovative Technologies Lab (SCITL)
SCITL is dedicated to using, advancing and developing everyday technologies for improving the lives of children with autism spectrum disorder and other developmental conditions. Our work focuses on both theoretical and applied advances that help to develop practical tools for understanding individual change, optimizing treatment, and decoding fundamental mechanisms.
Related topics: Social attention, development, big data approaches, eye tracking, near infrared spectroscopy, mobile applications, social robotics, gamification
Seattle Pediatric Concussion Research Collaborative
At the Seattle Pediatric Concussion Research Collaborative, we are pursuing research to help reduce the incidence and consequences of concussion among children and adolescents.
Building on work in C. elegans, Dr. Margaret Sedensky's team has found that disrupting mitochondrial function in mice causes them to be hypersensitive to gas anesthetics. The Sedensky Lab has characterized a particular mutant and is actively investigating it.
Related topics: Mitochondria
Led by Dr. Stephen E.P. Smith, the SEPS Lab is working to uncover what the gene variations that contribute to autism have in common.
Related topics: Genetics, synapse, protein interactions, immunoprecipitation
The Sherman Lab is internationally recognized, both for integrating approaches of systems biology into tuberculosis (TB) research and for its TB drug discovery work. The lab is focused on developing novel drugs, diagnostics and vaccines to combat this devastating disease.
Related topics: Systems biology, drug discovery, pathogenesis, gene expression, drug resistance, global health, big data, computational biology, genomics, host-pathogen interaction, immunology
The Shih Lab uses advanced optical imaging to study neurovascular function in the living brain. Our goal is to better understand how blood flows through the brain by watching and learning from model organisms. This can provide clues on the development and repair of key vascular functions, such as the blood-brain barrier, which may one day help protect blood vessels in the aging and diseased brain.
Related topics: Neurovascular development, function and disease
The Smith Lab studies the biology of the Plasmodium malaria parasite during the blood stage. The main research interests of the lab are to characterize parasite-host binding interactions and to better understand malaria disease mechanisms. We use this knowledge to design vaccine or disease interventions.
Related topics: Systems biology, global health, infectious disease, immunology
Work in the Sodora Lab primarily focuses on two principal areas of HIV research: HIV transmission and HIV-induced disease and immune factors that impact progression to AIDS. Collectively, these research strategies are designed to produce novel vaccine approaches and immune therapies that will decrease the spread of HIV and/or prevent disease progression in HIV-infected people.
Related topics: Tuberculosis, Ebola, system biology, global health, virology, infectious disease, immunology
The Stevens Lab is working to understand what causes autoimmune diseases, and is pursuing innovative treatments for scleroderma, lupus and juvenile idiopathic arthritis. The lab currently investigates how T cells are regulated, how that process goes awry in patients with autoimmune disease, and how it can be corrected through potential new treatments.
Related topics: PDL1, oral health
Research in the Stuart Lab is focused on protozoan pathogens and the diseases that they cause. These include malaria which is caused by Plasmodium parasites and Human African Trypanosomiasis (sleeping sickness), Chagas disease and Leishmaniasis that are caused by three Trypanosomatid parasites. The lab investigates molecular and cellular processes of the parasites and immune responses to infection and vaccines in order to develop drugs, vaccines and diagnostics that are needed.
Related topics: Immunology, infectious disease, global health, genetic engineering, systems biology, biotechnology, host-pathogen interaction
The Turner Lab is defining brain pathways underlying motivation, emotion and addiction, and using genetic and optogenetic strategies to map brain circuits in mice.
Related topics: Habenula, nicotine, mood regulation
The primary goal of the Urdahl Lab is to perform fundamental research into the immune response to TB that will help inform the rational design of a new and effective vaccine.
Related topics: Infectious disease, tuberculosis, systems biology, drug resistance, global health, host-pathogen interaction, immunology, T cells
The Webb Lab is dedicated to furthering research efforts into the etiology, course and treatment of developmental disabilities, such as autism spectrum disorders (ASD). Through research into early development, neural processes, brain-behavior relations, and clinical applications, the lab focuses on social and cognitive development. Our goal is to make a positive difference in the lives of individuals with autism and other neurodevelopmental disabilities.
Related topics: Neuroscience, EEG, social abilities, cognitive abilities, neural circuits, development
The Welsh Lab focuses on the role of brain rhythms in cognitive and motor function. The goal of this research is to better understand the reasons why children with autism are unable to generate high-frequency brain rhythms in the cerebral cortex, leading to an inability to rapidly process sound sequences and learn language during a critical period of brain development.
Dr. Kai Yu uses mouse models and human embryonic tissues to study how craniofacial malformations occur, opening the door to new ways to diagnose, prevent and treat them.
Related topics: Cleft palate, genetics, hyaluronic acid, growth factors
The mission of the Vaughan Lab ultimately is to alleviate the suffering of those affected by the disease malaria, which kills upwards of 400,000 people, mostly young children, every year. We study both the human malaria parasites Plasmodium falciparum and Plasmodium vivax as well as the rodent malaria models Plasmodium yoelii and Plasmodium berghei.
Related topics: Systems biology, biotechnology, genetic engineering, drug resistance, global health, genetics, host-pathogen interaction, infectious disease, immunology