The Jaspan Lab seeks to better understand the interplay between host microbial and immunological factors that impacts susceptibility to infectious diseases in infant and adolescents from sub-Saharan Africa. Our overarching goal is to pinpoint mechanisms by which dynamic community structures of commensal bacteria regulate immunology at mucosal surfaces and how that ultimately mitigates or promotes susceptibility to infectious disease. We additionally seek to elucidate the role that maternal HIV infection has on these commensal communities, and the resultant effects of HIV exposure on infant immunity immunology and vaccine responses. We utilize clinical, preclinical and computational approaches to address these topics.
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