Russell P Saneto, DO, PhD

Russell P Saneto, DO, PhD

Neurosciences Center, Neurology, Epilepsy Program, Mitochondrial Medicine and Metabolism Clinic

On staff since November 2001

Children's Title: Attending Physician, Neurology

Academic Title: Professor, Neurology; Adjunct Professor, Pediatrics

Research Center: Center for Integrative Brain Research

  • Patient Testimonials
  • Awards and Honors
    Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    Seattle Top Doctor - 2019 Seattle Magazine 2019
    SEATTLE'S TOP DOCTOR - 2018 Seattle Magazine 2018
    SEATTLE'S TOP DOCTOR - 2015 Seattle Met Magazine 2015
    Seattle's Top Doc Seattle Met Magazine 2013
    Best Doctors' Best Doctors is a nomination and electoral process that selects 5% of the physicians nationwide for inclusion on the Best Doctors list. Best Doctors 2009 - 2014
  • Publications

    Other Publications

    • Buckley RT, Morgan T, Saneto RP, Barber J, Ellenbogen RG, Ojemann JG
      Dysphagia after pediatric functional hemispherectomy.
      24206342 Journal of neurosurgery. Pediatrics, 2013 Nov 8
    • Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R, Mitochondrial Medicine Society Clinical Directors Working Group, Clinical Director's Work Group
      Practice patterns of mitochondrial disease physicians in North America. Part 2: treatment, care and management.
      24063850 Mitochondrion, 2013 Nov. : 13(6)681-7
    • Wirrell EC, Laux L, Franz DN, Sullivan J, Saneto RP, Morse RP, Devinsky O, Chugani H, Hernandez A, Hamiwka L, Mikati MA, Valencia I, Le Guern ME, Chancharme L, de Menezes MS
      Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
      23848835 Epilepsia, 2013 Sept. : 54(9)1595-604
    • Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R, for the Mitochondrial Medicine Society Clinical Directors Working Group, Clinical Director's Work Group
      Practice patterns of mitochondrial disease physicians in North America. Part 1: Diagnostic and clinical challenges.
      23891656 Mitochondrion, 2013 Jul 26
    • Poliachik SL, Poliakov AV, Jansen LA, McDaniel SS, Wray CD, Kuratani J, Saneto RP, Ojemann JG, Novotny EJ Jr
      Tissue localization during resective epilepsy surgery.
      23724842 Neurosurgical focus, 2013 June : 34(6)E8
    • Saneto RP, Sedensky MM
      Mitochondrial disease in childhood: mtDNA encoded.
      23224691 Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013 April : 10(2)199-211 PMCID:PMC3625387
    • Stumpf JD, Saneto RP, Copeland WC
      Clinical and molecular features of POLG-related mitochondrial disease.
      23545419 Cold Spring Harbor perspectives in biology, 2013 Apr 1 : 5(4)a011395
    • Saneto RP, Cohen BH, Copeland WC, Naviaux RK
      Alpers-Huttenlocher syndrome.
      23419467 Pediatric neurology, 2013 March : 48(3)167-78 PMCID:PMC3578656
    • Lew SM, Matthews AE, Hartman AL, Haranhalli N, Post-Hemispherectomy Hydrocephalus Workgroup
      Posthemispherectomy hydrocephalus: results of a comprehensive, multiinstitutional review.
      23106378 Epilepsia, 2013 Feb. : 54(2)383-9 PMCID:PMC3566367
    • Vasta V, Merritt JL 2nd, Saneto RP, Hahn SH
      Next-generation sequencing for mitochondrial diseases: a wide diagnostic spectrum.
      22494076 Pediatrics international : official journal of the Japan Pediatric Society, 2012 Oct. : 54(5)585-601
    • Ojemann JG, Hersonskey TY, Abeshaus S, Geyer JR, Saneto RP, Novotny EJ, Kollros P, Leary S, Holmes MD
      Epilepsy surgery after treatment of pediatric malignant brain tumors.
      22835666 Seizure : the journal of the British Epilepsy Association, 2012 Oct. : 21(8)624-30
    • Cohen BH, Saneto RP
      Mitochondrial translational inhibitors in the pharmacopeia.
      22421540 Biochimica et biophysica acta, 2012 Sept. : 1819(9-10)1067-74
    • Carr RB, Khanna PC, Saneto RP
      Childhood subdural hemorrhage, macrocephaly, and coagulopathy associated with Prader-Willi syndrome: case report and review of the literature.
      22704020 Pediatric neurology, 2012 July : 47(1)59-61
    • Anderson GD, Saneto RP
      Current oral and non-oral routes of antiepileptic drug delivery.
      22326840 Advanced drug delivery reviews, 2012 July : 64(10)911-8
    • Golden AS, Law YM, Shurtleff H, Warner M, Saneto RP
      Mitochondrial electron transport chain deficiency, cardiomyopathy, and long-term cardiac transplant outcome.
      22248292 Pediatric transplantation, 2012 May : 16(3)265-8
    • Wray CD, McDaniel SS, Saneto RP, Novotny EJ Jr, Ojemann JG
      Is postresective intraoperative electrocorticography predictive of seizure outcomes in children?
      22546034 Journal of neurosurgery. Pediatrics, 2012 May : 9(5)546-51
    • Russell P. Saneto, DO, PhD, Dravet syndrome: patients with co-morbid SCN1A gene mutatins and mitochondrial electron transport chain defects.
      Craig AK, Sotero de Menezes M, Saneto RP
      Seizure, 2012 : 17-21
    • Russell P. Saneto, DO, PhD, Tao, H, Manak JR, Sowers L, Mei X, Kiyonari H, Abe T, Dalhdaleh NS, Yang T, Wu S, Chen S, Fox MH, Cunnett C, Montine T, Bird T, Shaffer LG, Rosenfeld JA, McConnell J, Madan-Khetarpal S, Beny-Kravis E, Criesback H, Saneto RP, Scott MP, Antic D, Reed J, Boland R, Ehaldeb SN, El-Shanti H, Mahagan VB, Ferguson PJ, Axelrod JD, Lehesjoki A-E, Fritzsch B, Slusaraski DC, Wemmie J, Ueno N, Bussuk AG.
      Mutations in Pickle orthologs cause seizures in flies, mice, and humans.
      Am J Med Genetics, 2011 : 138-146
    • Russell P. Saneto, DO, PhD, Khanna P, Poliakov AV, Ishak GE, Poliachik SL, Friedman SD, Saneto RP, Novotny EJ, Ojemann JG, Shaw DWW.
      Preserved interhemispheric functional connectivity in a case of corpus callosum agenesis.
      Neuroradiology, 2011 : (Epub ahead of print)
    • Saneto RP, Singh KK
      Illness-induced exacerbation of Leigh syndrome in a patient with the MTATP6 mutation, m. 9185 T>C.
      20546952 Mitochondrion, 2010 Aug. : 567-72
    • Saneto RP, Naviaux RK
      Polymerase gamma disease through the ages.
      20818731 Developmental disabilities research reviews, 2010 June : 163-74
    • Weiss MD, Saneto RP
      Sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) in late life due to compound heterozygous POLG mutations.
      20513108 Muscle & nerve, 2010 June : 882-5
    • Friedman SD, Shaw DW, Ishak G, Gropman AL, Saneto RP
      The use of neuroimaging in the diagnosis of mitochondrial disease.
      20818727 Developmental disabilities research reviews, 2010 June : 129-35
    • Saneto RP, Lee IC, Koenig MK, Bao X, Weng SW, Naviaux RK, Wong LJ
      POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
      20138553 Seizure : the journal of the British Epilepsy Association, 2010 April : 140-6
    • Saneto RP, Anderson GD
      Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide.
      19536315 Therapeutics and clinical risk management, 2009 April : 271-80
    • Pearl PL, Vezina LG, Saneto RP, McCarter R, Molloy-Wells E, Heffron A, Trzcinski S, McClintock WM, Conry JA, Elling NJ, Goodkin HP, de Menezes MS, Ferri R, Gilles E, Kadom N, Gaillard WD
      Cerebral MRI abnormalities associated with vigabatrin therapy.
      18783433 Epilepsia, 2009 Feb. : 184-94
    • Saneto RP, Friedman SD, Shaw DW
      Neuroimaging of mitochondrial disease.
      18590986 Mitochondrion, 2008 Dec. : 396-413
    • Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh J, Basinger AA, Burton BK, Swoboda K, Gilbert DL, Vanderver A, Saneto RP, Maranda B, Arnold G, Abdenur JE, Waters PJ, Copeland WC
      Molecular and clinical genetics of mitochondrial diseases due to POLG mutations.
      18546365 Human mutation, 2008 Sept. : E150-72
    • Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, Wong LJ, Cohen BH, Naviaux RK
      The in-depth evaluation of suspected mitochondrial disease.
      18243024 Molecular genetics and metabolism, 2008 May : 16-37
    • Holmes MD, Brown M, Tucker DM, Saneto RP, Miller KJ, Wig GS, Ojemann JG
      Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordings.
      19066438 Pediatric neurosurgery, 2008 : 474-9
    • Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, Cohen BH
      Mitochondrial disease: a practical approach for primary care physicians.
      18055683 Pediatrics, 2007 Dec. : 1326-33
    • Miyagawa T, Sotero M, Avellino AM, Kuratani J, Saneto RP, Ellenbogen RG, Ojemann JG
      Apnea caused by mesial temporal lobe mass lesions in infants: report of 3 cases.
      17890404 Journal of child neurology, 2007 Sept. : 1079-83
    • Arthur TM, Saneto RP, de Menezes MS, Devinsky O, Lajoie J, Murphy PJ, Cook WB, Ojemann JG
      Vagus nerve stimulation in children with mitochondrial electron transport chain deficiencies.
      17513178 Mitochondrion, 2007 July : 279-83
    • Saneto RP, Sotero de Menezes M
      Persistence of suppression-bursts in a patient with Ohtahara syndrome.
      17690073 Journal of child neurology, 2007 May : 631-4
    • Smyth MD, Limbrick DD Jr, Ojemann JG, Zempel J, Robinson S, O'Brien DF, Saneto RP, Goyal M, Appleton RE, Mangano FT, Park TS
      Outcome following surgery for temporal lobe epilepsy with hippocampal involvement in preadolescent children: emphasis on mesial temporal sclerosis.
      17465386 Journal of neurosurgery, 2007 March : 205-10
    • Saneto RP, Sotero de Menezes MA, Ojemann JG, Bournival BD, Murphy PJ, Cook WB, Avellino AM, Ellenbogen RG
      Vagus nerve stimulation for intractable seizures in children.
      17074602 Pediatric neurology, 2006 Nov. : 323-6
    • Everett LL, van Rooyen IF, Warner MH, Shurtleff HA, Saneto RP, Ojemann JG
      Use of dexmedetomidine in awake craniotomy in adolescents: report of two cases.
      16490103 Paediatric anaesthesia, 2006 March : 338-42
    • Saneto RP, Bouldin A
      A boy with muscle weakness, hypercarbia, and the mitochondrial DNA A3243G mutation.
      16551459 Journal of child neurology, 2006 Jan. : 77-9
    • Parikh S, goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto RP.
      Clinical Director's Work Group: Practice patterns of mitochondrial disease physicians in North America. Part 2: Treatment, care, and management.
      Mitochondrion, 13(6)681-687 PMCID:24063850


Board Certification(s)

Neurology with Special Qualification in Child Neurology

Medical/Professional School

Des Moines University College of Osteopathic Medicine, Des Moines, IA


Cleveland Clinic Childrens, Cleveland, OH


Cleveland Clinic, Cleveland, OH

Clinical Interests

Diagnosis and treatment of mitochondrial disease, intractable seizures, epilepsy surgery candidates, neurometabolic and neurogenetic disorders

Research Focus Area

Translational Research, Mitochondrial disease