Research in the Powell Lab uses molecular and physiologic measures of circadian rhythms to define the roles of the circadian clock and time in human airways and lung diseases. We conduct mechanistic research using primary airway epithelial cells with linked patient characterization in order to link the molecular clock to clinically-oriented outcomes and measures. We focus on how circadian machinery intersects with mechanisms driving viral responses linked to asthma exacerbations, airway remodeling and disease outcomes.
We also explore how the clock in the airway epithelium functions in multiple airway diseases, such as pediatric obstructive sleep apnea (OSA), pediatric asthma, and viral infections e.g. croup. Leveraging an understanding of chronobiology in human disease, we aim to answer not only “what and why” of disease pathogenesis and treatment, but also “when.”
Join Our Lab
The lab is growing and seeking new members! Interested individuals should e-mail a CV and cover letter with career goals and interests to Dr. Powell.
Support Our Lab
If you would like to contribute to our ongoing work, please go the Seattle Children's donation page, choose “Other” and type in “Powell Lab” when asked where to donate.
Center for Respiratory Biology and Therapeutics
1900 Ninth Ave.
Seattle, WA 98101