Research Areas and Labs
Welcome to the Harrington Lab
The Harrington Lab focuses on intergenerational immune interactions and their effect on susceptibility to infection during pregnancy and infection. In particular, we investigate the role of maternal microchimerism (maternal cells acquired by the fetus in utero) in fetal and infant immune development, early vaccine responses, and susceptibility to infection. We have ongoing collaborations with Drs. Lisa Frenkel and Heather Jaspan from Seattle Children’s, Drs. Marion Pepper and Hilary Gammill from the University of Washington (UW) and Dr. Lee Nelson from the Fred Hutchinson Cancer Research Center.
Current Research Projects
We have previously demonstrated that malaria infection and inflammation of the placenta results in infants acquiring more maternal cells. In addition, we found that infants with detectable maternal cells were more susceptible to malaria infection but, interestingly, less likely to be sick from their infections. Current projects in the lab include isolating and phenotyping the maternal cells, determining whether infants acquire a maternal graft with immunologic memory, and whether the maternal cells affect the development of immune responses against malaria and HIV.
About Dr. Harrington
Whitney Harrington, MD, PhD, is a member of the Center for Global Infectious Disease Research at Seattle Children’s Research Institute, an assistant professor in the Department of Pediatrics, Division of Infectious Diseases, University of Washington, and an affiliate investigator at Fred Hutch. Her research is supported by grants from NIH’s National Institute of Allergy and Infectious Diseases and Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Burroughs Wellcome Fund and the UW Center for AIDS Research (CFAR).
- Shree R, Harrington WE, Kanaan SB, Forsyth A, Cousin E, Lopez A, Nelson JL and Gammill HS. Fetal microchimerism by mode of delivery in healthy pregnancies. BJOG 2018, in press.
- Harrington WE, Kakuru A and Jagannathan P. Consequences of malaria in pregnancy on the development of fetal and infant immunity. Parasite Immunol 2018, in press. Review.
- Gammill HS and Harrington WE. Microchimerism: Defining and redefining the prepregnancy context – A review.Placenta 2017 Dec;60:130-133. Review. PMID28911790. PMC5718967.
- Harrington WE, Kanaan SB, Muehlenbachs A, Morrison R, Stevenson P, Fried M, Duffy PE and Lee Nelson J. Maternal microchimerism predicts increased infection but decreased disease due to Plasmodium falciparum during early childhood. J Infect Dis 2017 May 1;215(9):1445-1451. PMID28329160. PMC5790147.
- Kanaan SB, Gammill HS, Harrington WE, De Rosa SC, Stevenson PA, Forsyth AM, Allen J, Cousin E, van Besien K, Delaney CS and Nelson JL. Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant. Oncoimmunology 2017 6(5):e1311436. PMID28638735. PMC5467984.