Research Areas and Labs
The Center for Global Infectious Disease Research's members have expertise in a wide spectrum of specialties including adolescent medicine, virology and bacteriology. Their projects aim to make discoveries and implement new solutions to help children and their parents avoid and recover from infections.
The CGIDR's research areas include:
- Viral transmission and dissemination (Drs. Frenkel, Rose)
- Viral diagnostics (Drs. Rose, Frenkel)
- Viral persistence and reservoirs (Drs. Bull, Frenkel, Wagner, Rose, Harrington)
- Viral immunology (Drs. Jaspan, Harrington)
- Viral infection-related cancers (Drs. Rose)
- Viral treatment (Drs. Wagner, Frenkel)
- Viral drug resistance (Drs. Frenkel, Bull)
- Animal models of human disease (Dr. Rose)
- Mucosal virome (Dr. Jaspan)
- Bacterial pathogenesis (Dr. Rajagopal)
- Bacterial virulence (Dr. Rajagopal)
- Animal models of human disease (Dr. Rajagopal)
- Mucosal microbiota (Dr. Jaspan)
Scientists in the Aderem Lab are studying innate responses to HIV, tuberculosis, influenza, and other pathogens that significantly impact global health.
The Aitchison Lab focuses on the development and application of systems biology approaches to infectious diseases.
The Frenkel Lab focuses on key questions related to HIV. The lab aims to: understand the mechanisms that allow HIV to persist during antiretroviral therapy; develop practical, affordable tests to detect drug-resistant HIV; make insights into reservoirs of drug-resistant HIV and illuminate the pathogenesis of HIV-related diseases.
The Grundner Lab seeks to map the signaling pathways that underlie Mycobacterium tuberculosis’ (Mtb) adaptability and pathogenesis.
The Harrington Lab focuses on intergenerational immune interactions and their effect on susceptibility to infection during pregnancy and infection.
The Hernandez Lab uses a combination of genetics, molecular biology, cell culture models and animal models to probe the interactions between mycobacterial pathogens and host immune cells. The lab’s goal is to make insights that lead to new strategies to improve the efficacy and shorten the duration of antibiotic regimens for mycobacterial infections.
The Kappe Lab is focused on understanding the complex biology of the malaria parasite and the immune responses to infection, using this information to design transformational interventions that will help win the fight against malaria.
The Kaushansky Lab works with the pathogens of infectious diseases like malaria that infect hundreds of millions of people every year.
The Myler Lab uses cutting-edge genomic, bioinformatic and molecular approaches to study gene function and protein structure in a variety of infectious disease organisms.
The Parsons Lab works on two infectious diseases that are especially prevalent in low-income populations of the world: human African trypanosomiasis (also known as African sleeping sickness) and toxoplasmosis.
The Rajagopal Lab utilizes genetic, molecular, biochemical and proteomic approaches to study infectious diseases caused by bacteria. The lab focuses on the human pathogens B Streptococcus and Staphylococcus aureus.
The Rose Lab focuses on the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 and its transmission and pathogenic role in AIDS-related malignancies.
The Sather Lab studies the interactions between invading pathogens and the host immune system, with the goal of leveraging these discoveries toward the development of novel vaccines and vaccination regimens.
The Sherman Lab is focused on developing novel drugs, diagnostics and vaccines to combat tuberculosis.
The Smith Lab studies the biology of the Plasmodium malaria parasite during the blood stage. The main research interests of the lab are to characterize parasite-host binding interactions and to better understand malaria disease mechanisms.
Work in the Sodora Lab primarily focuses on two principal areas of HIV research: 1) HIV transmission and 2) HIV-induced disease and immune factors that impact progression to AIDS.
Research in the Stuart Lab is focused on protozoan pathogens and the diseases that they cause. These include malaria which is caused by Plasmodium parasites and Human African Trypanosomiasis (sleeping sickness), Chagas disease and Leishmaniasis that are caused by three Trypanosomatid parasites.
The primary goal of the Urdahl Lab is to perform fundamental research into the immune response to tuberculosis that will help inform the rational design of a new and effective vaccine.
The Vaughan Lab focuses our studies on the human malaria parasite Plasmodium falciparum and the rodent malaria models Plasmodium yoelii and Plasmodium berghei.