Center for Global Infectious Disease Research
Accelerating Progress Toward Cures
Dr. Rachel Katzenellenbogen investigates high-risk human papillomavirus infections and how they lead to cancer.
Reseachers show how a toxin made by GBS causes fetal injury and how that same toxin stimulates host immune cells to fight the bacteria.
Developing groundbreaking treatments takes more than just the right ideas. It also takes the right people – and the CGIDR is recruiting new members.
Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby JC, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DWW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M Jr., Rajagopal L. Fetal brain lesions after subcutaneous inoculation of Zika Virus in a pregnant nonhuman primate. Nat Med 2016; available online 9/12/2016, in press. PMID27618651. PMC Journal – In Progress.
Bruce AG, Horst JA, Rose TM (2016). Conservation of the glycoprotein B homologs of the Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV8) and old world primate rhadinoviruses of chimpanzees and macaques. Virology 494:29-46. PMCID Journal – In Process.
Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JA, Sodora DL, Gray CM, Jaspan HB. Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants. Vaccine 2015;33(38):4782-4789. PMID26259542. PMCID: PMC4562895.
Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway DP, Adams Waldorf K, Piliponsky AM, Rajagopal L. Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 2015;1:e1400225. PMCID: PMC4584422.
Ticona E, Bull ME, Soria J, Tapia K, Legard J, Styrchak SM, Williams C, Mitchell C, La Rosa A, Coombs RW, Frenkel LM. Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive anti-retroviral therapy (ART). AIDS 2015;29(13):1617-1622. PMC Journal – In Process.
Bruce AG, Thouless ME, Haines AS, Pallen MJ, Grundhoff A, Rose TM. Complete genome sequence of MneRV2, the pigtailed macaque RV2 rhadinovirus, and evolutionary relationship with rhesus macaque RRV and human herpesvirus 8/KSHV. J Virol 2015;89:3888-3909. PMID25609822, PMCID: PMC4403432.
Waghmare A, Wagner T, Andrews R, Smith S, Kuypers J, Moss R, Englund J. Successful treatment of parainfluenza virus (PIV) respiratory infection with DAS181 in 3 immunocompromised children. J Pediatr Infect Dis 2015;4(2):114-118. PMCID: PMC4501511.
Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA. Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest. Virology 2015;478:50-60. PMID25723053. PMCID: PMC4383269.
- Study shows how group B strep establishes in utero infection, posing risk to baby – Newswise
Despite the substantial impact on pregnancy outcomes, scientists know little about how group B strep (GBS), a common bacteria present in the vagina of about 1 in 4 women, establishes an in utero infection. In a paper published in the Journal of Clinical Investigation, Dr. Lakshmi Rajagopal, a principal investigator in Seattle Children’s Research Institute’s Center for Global Infectious Disease Research describes a newly uncovered mechanism by which GBS gains access to a woman’s uterus.
- AAAS names 8 UW researchers as fellows in 2017 – University of Washington
Dr. Lisa Frenkel, professor of both pediatrics and laboratory medicine, was selected for her distinguished research on HIV infections in newborns, children and adults. She practices at the Pediatric Infectious Diseases Virology Clinic at Seattle Children’s and co-directs the Seattle Children’s Center for Global Infectious Diseases.
- Seattle scientists first to show monkey model of Zika damage
Seattle researchers infected a pregnant, 9-year-old macaque monkey with Zika virus, becoming the first to demonstrate the terrible effects of the disease in the fetus of a nonhuman primate. The work is meant to put researchers on the path to testing possible therapies.
- Research on Common Bacteria Could Prevent Stillbirths, Premature Births
A study led by Seattle Children’s Research Institute and published today in EMBO Molecular Medicine, titled “A Streptococcal Lipid Toxin Induces Membrane Permeabilization and Pyroptosis Leading to Fetal Injury,” reveals new information on the common bacteria Group B Streptococcus (GBS). Researchers hope these discoveries could one day be used to prevent premature births and stillbirths.
Collaborations and partnerships are integral to the CGIDR’s approach. Our investigators work closely with colleagues at the University of Washington, Fred Hutchinson Cancer Research Center and other institutions.
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