Our Labs and Programs


Ferguson Lab

Ferguson LabThe Ferguson Lab investigates the development of behaviors associated with drug reward and addiction.

Hahn Lab

HahnThe Hahn Laboratory develops and validates tests that help screen for, diagnose and monitor childhood disorders including mitochondrial diseases, Wilson disease and primary immunodeficiencies.

Kalume Laboratory

Kalume LabThe Kalume Laboratory investigates the mechanisms that drive epilepsy and related conditions, with the goal of making discoveries that lead to improved treatments for affected children and adults.

Millen Lab

Kathleen MillenThe Millen Lab uses molecular genetic approaches to explore the pathogenesis of congenital brain defects in humans and mice.

Mirzaa Laboratory

Mirzaa 70x70The Mirzaa Laboratory pinpoints the genes that contribute to many neurodevelopmental disorders, opening the door to new treatments.

Morgan Laboratory

MorganThe Morgan Laboratory pioneered the use of C. elegans – a simple invertebrate – to understand the relationship between mitochondrial dysfunction and anesthetics. By investigating how volatile anesthetics trigger a range of behaviors in mutant animals, the Morgan laboratory identified key molecules that control how C. elegans responds to anesthetics. His laboratory is actively investigating molecules that can reverse shortened life spans and neurological defects in animals with mitochondrial dysfunction.

Olson Lab

OlsonThe Olson Lab is unraveling how changes in cardiac energy production affect heart function, leading to innovative treatments for heart disease.

Portman Research Group

Michael PortmanThe Portman Research Group is developing innovative ways to protect children's hearts from damage related to heart surgery, and is improving how the medical community understands and treats Kawasaki disease.

Ramirez Lab

The Ramirez Lab investigates brain functions in order to develop new ways to treat – and potentially cure – neurological disorders.

Saneto Laboratory

Russell SanetoDr. Russell Saneto's research focuses on improving detection and treatment of pediatric epilepsies caused by mitochondrial dysfunction. He is also interested in using non-invasive neuroimaging modalities, such as proton magnetic resonance imaging (1H-MRS) and diffusion tensor imaging (DTI) to understand how mitochondrial disease can alter brain development due to alteration of neuronal metabolism and myelination.

Sedensky Laboratory

SedenskyBuilding on work in C. elegans, Dr. Margaret Sedensky's team has found that disrupting mitochondrial function in mice causes them to be hypersensitive to gas anesthetics. The Sedensky Laboratory has characterized a particular mutant and is actively investigating it. This mutant has unusual behaviors when exposed to several commonly-used anesthetics. The Sedensky Laboratory is working closely with the Morgan Laboratory to study this exciting animal model.


Stephen SmithLed by Dr. Stephen E.P. Smith, the SEPS Lab is working to uncover what the gene variations that contribute to autism have in common.

Turner Lab

Turner Eric 70x70The Turner Lab is defining brain pathways underlying motivation, emotion and addiction, and using genetic and optogenetic strategies to map brain circuits in mice.

Welsh Lab

Welsh LabThe Welsh Lab is dedicated to researching why children with autism struggle with language development.


Program in Mitochondrial Biology

PMBThe Program in Mitochondrial Biology conducts research that pursues cures for mitochondrial diseases, while providing the best possible care for patients and their families.

Neonatal Respiratory Support Technologies Team

Intubated BabyThe Neonatal Respiratory Support Technologies (NeoRest) team is working to reduce infant mortality and morbidity by developing affordable, easy-to-use and easy-to-maintain respiratory support solutions. The team's goal is to revolutionize the way premature infants are treated in resource-limited countries.