Our Vision

CIIT researchers study rare and common disorders that yield powerful insights into the immune system. We use these insights to pursue innovative therapies for pediatric diseases and conditions.

Harnessing the Power of the Immune System

  • New Lupus Therapy Targets T Cells

    A drug derived from sea anemone venom demonstrates the potential to suppress inflammation without the severe side effects of existing therapies.

  • The Power of Partnerships

    We’re partnering with companies to turn our discoveries into real-life advances that could transform pediatric health and well-being.

Publications

Engineering and Flow-Cytometric Analysis of Chimeric LAGLIDADG Homing Endonucleases from Homologous I-OnuI-Family Enzymes. Baxter SK, Scharenberg AM,Lambert AR. Methods Mol Biol. 2014;1123:191-221. doi: 10.1007/978-1-62703-968-0_14.

The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation. Lebrec H, Molinier B, Boverhof D, Collinge M, Freebern W, Henson K, Mytych DT, Ochs HD, Wange R, Yang Y, Zhou L, Arrington J, Christin-Piché MS, Shenton J. Regul Toxicol Pharmacol. 2014 Feb 22. pii: S0273-2300 (14)00032-4. doi: 10.1016/j.yrtph.2014.02.008.

Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps. Hulse KE, Chaung K, Seshadri S, Suh L, Norton JE, Carter RG, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Torgerson TR, Kato A, Schleimer RP. J Allergy Clin Immunol. 2014 Jan;133 (1):275-7.e1. doi: 10.1016/j.jaci.2013.08.015.

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ. J Clin Invest. 2013 May 1;123 (5):2024-36. doi: 10.1172/JCI66963.

See more publications from the Center for Immunity and Immunotherapies

Latest News

Read more news about the Center for Immunity and Immunotherapies