Our Labs

The Acharya lab studies how immune cells integrate signals from pathogens and their environment to produce effective immunity against pathogens while maintaining tolerance to self-derived antigens.

The Allenspach Lab focuses on translational work to understand immune dysregulation disorders - those with overlapping immunodeficiency and autoimmune features.

The Carbone Lab investigates the master role of dendritic cells (DCs) in orchestrating immune responses, with a focus on their impact in cancer immunotherapy. By studying how DCs recruit and activate other immune cells within the tumor microenvironment, we aim to uncover novel mechanisms that can enhance anti-tumor immunity.

The Jackson Lab studies the immune mechanisms underlying the development of systemic autoimmune diseases, focusing in particular on the role of B cells in systemic lupus erythematosus (SLE). The lab uses various chimeric and genetic knock-in murine strains to model the biology of human autoimmune diseases.

The James Lab is interested in uncovering biochemical mechanisms that contribute to drug resistance and to immunological disease. To do so, we investigate many features of protein behavior, including their impact on differentiation, their interactions with other molecules and whether mutation regulates these processes.

Related topics: Immunology, B cells, genetic variation

We are interested in the design of probabilistic machine learning methods and statistical models that incorporate known biochemical principles to facilitate decision-making from limited data and to allow for asking smarter questions. We have a major focus on quantitative analysis of regulatory variation inthe human genome from large scale functional genomics data and its application to rare diseases and precision medicine.

The Pavel-Dinu Lab is interested in studying the complex networks that support hematopoietic regeneration; understanding how it goes awry in the rare monogenetic immune diseases known as inborn errors of immunity; and turning our scientific insights into innovative and long-lasting gene and cell therapies.

The Piliponsky Lab studies inflammatory responses involving mast cells and myeloid cells. Our goal is to understand how the body controls the immune system’s response to bacterial infections – and how this process becomes dysregulated.

The Torbett Lab studies HIV entry, evolution, and assembly at the genomic, biochemical and structural levels, as well as human hematopoietic stem cell resistance of HIV lentiviral vector entry.