Heather B. Jaspan, MD, PhD

Infectious Disease

On staff since June 2013

Academic Title: Assistant Professor

  • Award Name Award Description Awarded By Award Date
    Octave Workshop for Young and Emerging Investigators New York 2011
    Clinical Research Loan Repayment Program NIH 2011
    Young Investigator Award Conference on Retroviruses and Opportunistic Infections 2009
    AztraZeneca Highly Commended Clinical Research Young Investigator Award Medical Research Day 2008, Cape Town 2008
    International Scholarship Award Conference on Retroviruses and Opportunistic Infections 2008
    Clinical Research Loan Repayment Program NIH 2004 - 2007
    Outstanding Medical Student in Pediatrics New Orleans Pediatric Society 1999
    Patrick Hanley Scholarship Tulane Medical School 1997
    National Research Service Award NIMH 1995 - 1999
    Phi Beta Kappa 1993
  • Manuscripts in Refereed Journals

    • Gray CM, O'Hagan KL, Lorenzo-Redondo R, Olivier AJ, Amu S, Chigorimbo-Murefu N, Harryparsad R, Sebaa S, Maziya L, Dietrich J, Otwombe K, Martinson N, Ferrian S, Mkhize NN, Lewis DA, Lang D, Carias AM, Jaspan HB, Wilson DPK, McGilvray M, Cianci GC, Anderson MR, Dinh MH, Williamson AL, Passmore JS, Chiodi F, Hope TJ
      Impact of chemokine C-C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males.
      31619762 Mucosal immunology, 2020 Jan. : 13(1)118-127
    • Gudza-Mugabe M, Havyarimana E, Jaumdally S, Garson KL, Lennard K, Tarupiwa A, Mugabe F, Marere T, Mavenyengwa RT, Masson L, Jaspan HB
      HIV infection is associated with preterm delivery independent of vaginal microbiota in pregnant African women.
      31722395 The Journal of infectious diseases, 2019 Nov. 13
    • Konstantinus IN, Balle C, Jaumdally SZ, Galmieldien H, Pidwell T, Masson L, Tanko RF, Happel AU, Sinkala M, Myer L, Bosinger SE, Gill K, Bekker LG, Jaspan HB, Passmore JS
      Impact of hormonal contraceptives on cervical Th17 phenotype and function in adolescents: Results from a randomized cross-over study comparing long-acting injectable norethisterone oenanthate (NET-EN), combined oral contraceptive pills, and combined contraceptive vaginal rings.
      31675420 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Nov. 2
    • Scheepers IM, Cryan JF, Bastiaanssen TFS, Rea K, Clarke G, Jaspan HB, Harvey BH, Hemmings SMJ, Santana L, van der Sluis R, Malan-Müller S, Wolmarans W
      Natural compulsive-like behaviour in the deer mouse (Peromyscus maniculatus bairdii) is associated with altered gut microbiota composition.
      31663195 The European journal of neuroscience, 2019 Oct. 29
    • Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL
      Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.
      31605528 The Journal of infectious diseases, 2019 Oct. 12
    • Jaumdally SZ, Liebenberg LJP, Gumbi PP, Little F, Jaspan HB, Gamieldien H, Tiemessen CT, Coetzee D, Martin DP, Williamson C, Williamson AL, Passmore JS
      Partner HIV Serostatus Impacts Viral Load, Genital HIV Shedding, and Immune Activation in HIV-Infected Individuals.
      31169767 Journal of acquired immune deficiency syndromes (1999), 2019 Sept. 1 : 82(1)51-60
    • Brown BP, Jaspan HB
      Compositional analyses reveal correlations between taxon-level gut bacterial abundance and peripheral T cell marker expression in African infants.
      31347944 Gut microbes, 2019 July 26 : 1-8
    • Darby MG, Chetty A, Mrjden D, Rolot M, Smith K, Mackowiak C, Sedda D, Nyangahu D, Jaspan H, Toellner KM, Waisman A, Quesniaux V, Ryffel B, Cunningham AF, Dewals BG, Brombacher F, Horsnell WGC
      Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.
      31236458 Science advances, 2019 May : 5(5)eaav3058 PMCID:PMC6587632
    • McKinnon LR, Achilles SL, Bradshaw CS, Burgener A, Crucitti T, Fredricks DN, Jaspan HB, Kaul R, Kaushic C, Klatt N, Kwon DS, Marrazzo JM, Masson L, McClelland RS, Ravel J, van de Wijgert JHHM, Vodstrcil LA, Tachedjian G
      The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.
      30638028 AIDS research and human retroviruses, 2019 March : 35(3)219-228 PMCID:PMC6434601
    • Chetwin E, Manhanzva MT, Abrahams AG, Froissart R, Gamieldien H, Jaspan H, Jaumdally SZ, Barnabas SL, Dabee S, Happel AU, Bowers D, Davids L, Passmore JS, Masson L
      Antimicrobial and inflammatory properties of South African clinical Lactobacillus isolates and vaginal probiotics.
      30760770 Scientific reports, 2019 Feb. 13 : 9(1)1917 PMCID:PMC6374385
    • Dzanibe S, Jaspan HB, Zulu MZ, Kiravu A, Gray CM
      Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity.
      30577072 Journal of leukocyte biology, 2019 Feb. : 105(2)281-289
    • Masson L, Barnabas S, Deese J, Lennard K, Dabee S, Gamieldien H, Jaumdally SZ, Williamson AL, Little F, Van Damme L, Ahmed K, Crucitti T, Abdellati S, Bekker LG, Gray G, Dietrich J, Jaspan H, Passmore JS
      Inflammatory cytokine biomarkers of asymptomatic sexually transmitted infections and vaginal dysbiosis: a multicentre validation study.
      30018088 Sexually transmitted infections, 2019 Feb. : 95(1)5-12
    • Dabee S, Barnabas SL, Lennard KS, Jaumdally SZ, Gamieldien H, Balle C, Happel AU, Murugan BD, Williamson AL, Mkhize N, Dietrich J, Lewis DA, Chiodi F, Hope TJ, Shattock R, Gray G, Bekker LG, Jaspan HB, Passmore JS
      Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.
      30947260 PloS one, 2019 : 14(4)e0213975 PMCID:PMC6448899
    • Dabee S, Barnabas SL, Lennard KS, Jaumdally SZ, Gamieldien H, Balle C, Happel AU, Murugan BD, Williamson AL, Mkhize N, Dietrich J, Lewis DA, Chiodi F, Hope TJ, Shattock R, Gray G, Bekker LG, Jaspan HB, Passmore JS
      Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.
      30947260 PloS one, 2019 : 14(4)e0213975 PMCID:PMC6448899
    • Kiravu A, Osawe S, Happel AU, Nundalall T, Wendoh J, Beer S, Dontsa N, Alinde OB, Mohammed S, Datong P, Cameron DW, Rosenthal K, Abimiku A, Jaspan HB, Gray CM
      Bacille Calmette-Guérin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants.
      31649662 Frontiers in immunology, 2019 : 102307 PMCID:PMC6793433
    • Tchakoute CT, Sainani KL, Osawe S, Datong P, Kiravu A, Rosenthal KL, Gray CM, Cameron DW, Abimiku A, Jaspan HB, INFANT study team.
      Breastfeeding mitigates the effects of maternal HIV on infant infectious morbidity in the Option B+ era.
      30134300 AIDS (London, England), 2018 Oct. 23 : 32(16)2383-2391
    • Ho NT, Li F, Lee-Sarwar KA, Tun HM, Brown BP, Pannaraj PS, Bender JM, Azad MB, Thompson AL, Weiss ST, Azcarate-Peril MA, Litonjua AA, Kozyrskyj AL, Jaspan HB, Aldrovandi GM, Kuhn L
      Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations.
      30301893 Nature communications, 2018 Oct. 9 : 9(1)4169 PMCID:PMC6177445
    • Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB
      Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.
      29659737 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018 Sept. 28 : 67(8)1237-1246 PMCID:PMC6455922
    • Balle C, Lennard K, Dabee S, Barnabas SL, Jaumdally SZ, Gasper MA, Maseko V, Mbulawa ZZA, Williamson AL, Bekker LG, Lewis DA, Passmore JS, Jaspan HB
      Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection.
      30038262 Scientific reports, 2018 July 23 : 8(1)11109 PMCID:PMC6056523
    • Nyangahu DD, Lennard KS, Brown BP, Darby MG, Wendoh JM, Havyarimana E, Smith P, Butcher J, Stintzi A, Mulder N, Horsnell W, Jaspan HB
      Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity.
      29981583 Microbiome, 2018 July 7 : 6(1)124 PMCID:PMC6035804
    • Barnabas SL, Dabee S, Passmore JS, Jaspan HB, Lewis DA, Jaumdally SZ, Gamieldien H, Masson L, Muller E, Maseko VD, Mkhize N, Mbulawa Z, Williamson AL, Gray CM, Hope TJ, Chiodi F, Dietrich J, Gray G, Bekker LG, Women’s Initiative in Sexual Health (WISH) study team.
      Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV.
      29198180 International journal of STD & AIDS, 2018 May : 29(6)531-539
    • Mbulawa ZZA, van Schalkwyk C, Hu NC, Meiring TL, Barnabas S, Dabee S, Jaspan H, Kriek JM, Jaumdally SZ, Muller E, Bekker LG, Lewis DA, Dietrich J, Gray G, Passmore JS, Williamson AL
      High human papillomavirus (HPV) prevalence in South African adolescents and young women encourages expanded HPV vaccination campaigns.
      29293566 PloS one, 2018 : 13(1)e0190166 PMCID:PMC5749739
    • Lennard K, Dabee S, Barnabas SL, Havyarimana E, Blakney A, Jaumdally SZ, Botha G, Mkhize NN, Bekker LG, Lewis DA, Gray G, Mulder N, Passmore JS, Jaspan HB
      Microbial composition predicts genital tract inflammation and persistent bacterial vaginosis in adolescent South African women.
      29038128 Infection and immunity, 2017 Oct. 16
    • Jaumdally SZ, Picton A, Tiemessen CT, Paximadis M, Jaspan HB, Gamieldien H, Masson L, Coetzee D, Williamson AL, Little F, Gumbi PP, Passmore JS
      CCR5 expression, haplotype and immune activation in protection from infection in HIV-exposed uninfected individuals in HIV-serodiscordant relationships.
      28398593 Immunology, 2017 Aug. : 151(4)464-473 PMCID:PMC5506425
    • Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, Jaspan HB
      BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.
      28405623 JCI insight, 2017 April 6 : 2(7)e91963 PMCID:PMC5374072
    • Happel AU, Jaumdally SZ, Pidwell T, Cornelius T, Jaspan HB, Froissart R, Barnabas SL, Passmore JS
      Probiotics for vaginal health in South Africa: what is on retailers' shelves?
      28103868 BMC women's health, 2017 Jan. 19 : 17(1)7 PMCID:PMC5248517
    • Wood LF, Wood MP, Fisher BS, Jaspan HB, Sodora DL
      T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure.
      29312338 Frontiers in immunology, 2017 : 81857 PMCID:PMC5743911
    • Hesseling AC, Blakney AK, Jones CE, Esser MM, de Beer C, Kuhn L, Cotton MF, Jaspan HB
      Delayed BCG immunization does not alter antibody responses to EPI vaccines in HIV-exposed and -unexposed South African infants.
      27055019 Vaccine, 2016 July 12 : 34(32)3702-9
    • Passmore JA, Jaspan HB, Masson L
      Genital inflammation, immune activation and risk of sexual HIV acquisition.
      26628324 Current opinion in HIV and AIDS, 2016 March : 11(2)156-62
    • Esra RT, Olivier AJ, Passmore JA, Jaspan HB, Harryparsad R, Gray CM
      Does HIV Exploit the Inflammatory Milieu of the Male Genital Tract for Successful Infection?
      27446076 Frontiers in immunology, 2016 : 7245 PMCID:PMC4919362
    • Masson L, Salkinder AL, Olivier AJ, McKinnon LR, Gamieldien H, Mlisana K, Scriba TJ, Lewis DA, Little F, Jaspan HB, Ronacher K, Denny L, Abdool Karim SS, Passmore JA
      Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells.
      26302175 Immunology, 2015 Dec. : 146(4)557-67 PMCID:PMC4693890
    • Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JA, Sodora DL, Gray CM, Jaspan HB
      Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants.
      26259542 Vaccine, 2015 Sept. 11 : 33(38)4782-9 PMCID:PMC4562895
    • Hesseling AC, Jaspan HB, Black GF, Nene N, Walzl G
      Immunogenicity of BCG in HIV-exposed and non-exposed infants following routine birth or delayed vaccination.
      25860002 The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015 April : 19(4)454-62 PMCID:PMC4530999
    • Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB
      Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants.
      25108027 The Journal of infectious diseases, 2015 Feb. 1 : 211(3)338-46 PMCID:PMC4318913
    • Kidzeru EB, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB
      In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.
      24785950 AIDS (London, England), 2014 June 19 : 28(10)1421-30 PMCID:PMC4333196
    • Rametse CL, Olivier AJ, Masson L, Barnabas S, McKinnon LR, Ngcapu S, Liebenberg LJ, Jaumdally SZ, Gray CM, Jaspan HB, Passmore JA
      Role of semen in altering the balance between inflammation and tolerance in the female genital tract: does it contribute to HIV risk?
      24821528 Viral immunology, 2014 June : 27(5)200-6
    • Gantt S, Gervassi A, Jaspan H, Horton H
      The role of myeloid-derived suppressor cells in immune ontogeny.
      25165466 Frontiers in immunology, 2014 : 5387 PMCID:PMC4131407
    • Gervassi A, Lejarcegui N, Dross S, Jacobson A, Itaya G, Kidzeru E, Gantt S, Jaspan H, Horton H
      Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses.
      25248150 PloS one, 2014 : 9(9)e107816 PMCID:PMC4172591
    • Wood LF, Chahroudi A, Chen HL, Jaspan HB, Sodora DL
      The oral mucosa immune environment and oral transmission of HIV/SIV.
      23772613 Immunological reviews, 2013 July : 254(1)34-53 PMCID:PMC3821196
    • Adler D, Laher F, Wallace M, Grzesik K, Jaspan H, Bekker LG, Gray G, Valley-Omar Z, Allan B, Williamson AL
      High Rate of Multiple Concurrent Human Papillomavirus Infections among HIV-Uninfected South African Adolescents.
      25333073 Journal of immunological techniques in infectious diseases, 2013 : 2(1)1000106 PMCID:PMC4201846
    • Nglazi MD, Kranzer K, Holele P, Kaplan R, Mark D, Jaspan H, Lawn SD, Wood R, Bekker LG
      Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa.
      22273267 BMC infectious diseases, 2012 Jan. 25 : 1221 PMCID:PMC3295677
    • Jaspan HB, Myer L, Madhi SA, Violari A, Gibb DM, Stevens WS, Dobbels E, Cotton MF
      Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study.
      22103994 BMC pediatrics, 2011 Nov. 21 : 11104 PMCID:PMC3258191
    • Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA
      Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.
      21940422 The Journal of infectious diseases, 2011 Nov. 15 : 204(10)1550-6 PMCID:PMC3192190
    • Jaspan HB, Mueller AD, Myer L, Bekker LG, Orrell C
      Effect of caregivers' depression and alcohol use on child antiretroviral adherence in South Africa.
      21470047 AIDS patient care and STDs, 2011 Oct. : 25(10)595-600 PMCID:PMC3183652
    • Jaspan HB, Flisher AJ, Myer L, Mathews C, Middelkoop K, Mark D, Bekker LG
      Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort.
      21700155 The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2011 July : 49(1)42-6 PMCID:PMC3124666
    • Müller AD, Jaspan HB, Myer L, Hunter AL, Harling G, Bekker LG, Orrell C
      Standard measures are inadequate to monitor pediatric adherence in a resource-limited setting.
      20953692 AIDS and behavior, 2011 Feb. : 15(2)422-31 PMCID:PMC3032912
    • Zembe L, Burgers WA, Jaspan HB, Bekker LG, Bredell H, Stevens G, Gilmour J, Cox JH, Fast P, Hayes P, Vardas E, Williamson C, Gray CM
      Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials.
      22022524 PloS one, 2011 : 6(10)e26096 PMCID:PMC3192159
    • Jaspan HB, Brothers AW, Campbell AJ, McGuire JK, Browd SR, Manley TJ, Pak D, Weissman SJ
      Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
      20010311 The Pediatric infectious disease journal, 2010 April : 29(4)379-81
    • Müller AD, Myer L, Jaspan H
      Virological suppression achieved with suboptimal adherence levels among South African children receiving boosted protease inhibitor-based antiretroviral therapy.
      19025495 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009 Jan. 1 : 48(1)e3-5
    • Jaspan HB, Berrisford AE, Boulle AM
      Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program.
      18818556 The Pediatric infectious disease journal, 2008 Nov. : 27(11)993-8
    • Jaspan HB, Soka NF, Strode AE, Mathews C, Mark D, Flisher AJ, Wood R, Bekker LG
      Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa.
      18782594 Vaccine, 2008 Oct. 23 : 26(45)5679-83 PMCID:PMC2590661
    • Huang LC, Myer L, Jaspan HB
      The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: a retrospective cohort study.
      18811982 BMC infectious diseases, 2008 Sept. 24 : 8127 PMCID:PMC2570677
    • Jaspan HB, Huang LC, Cotton MF, Whitelaw A, Myer L
      Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study.
      18813340 PloS one, 2008 Sept. 24 : 3(9)e3260 PMCID:PMC2533121
    • Jaspan HB, Cunningham CK, Tucker TJ, Wright PF, Self SG, Sheets RL, Rogers AS, Bekker LG, Wilson CM, Duerr A, Wasserheit JN, HIV Vaccine Adolescent Trials Working Group
      Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads.
      17984759 Journal of acquired immune deficiency syndromes (1999), 2008 Jan. 1 : 47(1)86-92
    • Jaspan HB, Hanekom WA
      Immunology of infants through adolescents: responses to emulate for HIV vaccines.
      19372917 Current opinion in HIV and AIDS, 2007 Sept. : 2(5)391-8
    • Jaspan HB, Flisher AJ, Myer L, Mathews C, Seebregts C, Berwick JR, Wood R, Bekker LG
      Brief report: methods for collecting sexual behaviour information from South African adolescents--a comparison of paper versus personal digital assistant questionnaires.
      17187853 Journal of adolescence, 2007 April : 30(2)353-9
    • Jaspan HB, Berwick JR, Myer L, Mathews C, Flisher AJ, Wood R, Bekker LG
      Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials.
      17046499 The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2006 Nov. : 39(5)642-8
    • Jaspan HB, Lawn SD, Safrit JT, Bekker LG
      The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents.
      16470112 AIDS (London, England), 2006 Feb. 28 : 20(4)483-94
    • Bekker LG, Jaspan H, McIntyre J, Wood R, Gray G
      Adolescents and HIV vaccine trials: what are the clinical trial site issues?
      16533798 Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), 2005 Dec. : 4(4)93-7
    • Jaspan HB, Gray GE, Robinson AK, Coovadia HM, Bekker LG
      Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South Africa.
      16327928 South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2005 Sept. : 95(9)685-7
    • Jaspan HB, Robinson JE, Amedee AM, Van Dyke RB, Garry RF
      Amniotic fluid has higher relative levels of lentivirus-specific antibodies than plasma and can contain neutralizing antibodies.
      15465411 Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004 Nov. : 31(3)190-7
    • Jaspan HB, Garry RF
      Preventing neonatal HIV: a review.
      15046256 Current HIV research, 2003 July : 1(3)321-7
    • Jaspan HB, Richard Gaumer H, Garry RF
      Quantitative competitive reverse transcription polymerase chain reaction is not a useful method for quantification of CD4 and CD8 cell status during HIV infection.
      12702212 Journal of negative results in biomedicine, 2003 March 12 : 22 PMCID:PMC153544
    • Jaspan HB, Gaumer HR, Garry RF
      Expression of granzyme B mRNA is altered in human immunodeficiency virus infected patients.
      12645627 Experimental and molecular pathology, 2003 Feb. : 74(1)13-6

    Book Chapters

    • Contributor to Paediatric Antiretroviral Therapy. In Handbook of HIV Medicine, 2nd Edition, Oxford University Press, Oxford, UK
      2009
    • Meyers T, Jaspan H, Rabie H, and Cotton M
      Principles of Paediatric Antiretroviral Therapy. In From the ground up: A guide to Comprehensive HIV/AIDS Care in Resource–Limited Settings. Eds R Marlink and S Teitelman, Washington DC, Elizabeth Glaser Pediatric AIDS Foundation
      2008
    • Owor M, Fowler MG, Jaspan H, Rabie H, Cotton M, and Musoke P
      Treatment and Prevention of Opportunistic Infections in Children Living with HIV. In From the Ground Up: Building Comprehensive HIV/AIDS Care Programs in Resource-Limited Settings. Eds R Marlink and S Teitelman, Washington DC, Elizabeth Glaser Pediatric AIDS Foundation
      2008

  • Presentations Title Event Location Date
    Gut microbiome, HIV-exposure, and vaccine immunogenicity in HIV-exposed African infants (Lecture) 9th World Congress of the International Society of Developmental Origins of Health and Disease, 11/2015 Cape Town, South Africa
    Can we eliminate Pediatric HIV? (Lecture) ARV Master Class, University of Cape Town, 2008 Cape Town, South Africa
    Adolescents in HIV Vaccine Trials (Lecture) At Immunobiology: From Infection to Immune Control, 3/2009 Keystone, Colorado
    Prevention and the microbiome (Lecture) 3rd HIV Research for Prevention Conference, 10/2018 Madrid, Spain
    South African HIV Clinicians Society Skills Development Program (Lecture) Durban AIDS Conference, 6/2005 Durban, South Africa
    Interplay between vaginal microbiome and genital immunity in South African adolescents at high risk for HIV (Lecture) CFAR New Faces Seminar, 4/2016 Seattle, WA
    HIV risk in young women: vaginal microbiome, inflammation, structural and behavioural determinants (Lecture) 12th INTEREST Conference, 5/2018 Kigali, Rwanda
    Effects of hormonal contraception on female genital microbiota and immunity in South African adolescents: A randomized trial (Lecture) Center for Global Infectious Disease Research Seminar, 10/2018 Seattle, WA
    Infant Feeding and HIV (Lecture) Durban AIDS Conference, 6/2011 Durban, South Africa
    Mucosal microbiome and immunity in South African adolescents (Lecture) CFAR Microbiome Workshop, 5/2016 Seattle, WA
    Vaccine responses in HIV-exposed infants (Lecture) Infectious Diseases in Africa Symposium, 10/2014 Cape Town, South Africa
    Mucosal microbiome and immunity (Lecture) 1st IUIS-FAIS Southern African Regional Immunology Workshop, 6th ID in Africa Symposium & 6th African Flow Cytometry Workshop, 10/2015 Cape Town, South Africa
    Maternal infections influence infant gut microbiota and immunity (Lecture) 7th FIDSSA Congress, 11/2017 Johannesburg, South Africa
    Maternal-neonatal microbiome; an international perspective (Lecture) ASM Microbe, 6/2019 San Francisco, CA
    Mucosal Microbiome (Lecture) South African Immunological Society Meeting, 3/2016 Johannesburg, South Africa
    HIV vaccine trials and adolescents (Lecture) IRENSA Training, University of Cape Town, 2006 & 2007 Cape Town, South Africa
  • Grant Title Grantor Amount Award Date
    Immune correlates of tuberculosis and non-tuberculosis infectious morbidity in Southern African HIV-exposed, uninfected infants. R01 AI142670 (PI: Powis) Oct. 1, 2018 - Sept. 30, 2023
    Impact of vaginal microbiome on Chlamydia trachomatis infection. R01AI13214401 (PI: Balkus) Sept. 1, 2018 - Aug. 31, 2023
    Impact of HIV exposure, feeding status, and microbiome on immune ontogeny and vaccine responses in infants. U01 AI131302 (MPI: Blish, Jaspan and Gray) Stanford University/NIH March 1, 2017 - Feb. 28, 2022
    Mucosal injury from sexual practices: Behaviour and biology of South African adolescents. R01 AI128792 (MPI: Jaspan, Passmore) NIH/NIAID Dec. 1, 2016 - Nov. 30, 2020
    Barrier Integrity, Microbiome and HIV target cell interaction in the human foreskin. R01 DK108434-01A1 (PI: Hope) NW University/NIH Dec. 1, 2016 - Nov. 30, 2021
    Effects of hormonal contraceptives on genital immunity and HIV susceptibility. R01 HD089831 (MPI: Heffron and Jaspan) UW/NIH Sept. 1, 2016 - Aug. 31, 2021
    Mucosal microbiome and vaccine responses in HIV-exposed African infants. R01 AI120714 (PI: Jaspan) NIH July 11, 2016 - June 30, 2021
    Vaginal virome of South African adolescents at high risk for HIV. R01 HD083040 (MPI: Jaspan and Passmore) NIH April 3, 2015 - Feb. 29, 2020
    Intestinal microbiota, immune activation and vaccine responsiveness of the HIV-exposed infant (Co-PI with Cameron) Canadian Institutes of Health Research 2014 - 2015
    Innate, Adaptive and Mucosal Immune Responses in HIV-1 Exposed Uninfected Infants: A Human Model to Understand Correlates of Immune Protection Canadian HIV Vaccine Initiative/Canadian Institutes for Health Research 2012 - 2017
    Myeloid-derived Suppressor cells (MDSC) suppress infant immune responses (PI: Horton) (Jaspan: South African PI) NICHHD/NIH 2012 - 2017
    K08 - Assessing feeding practices, immune activation, and HIV risk in South African infants NIH/NIAID 2011 - 2016

Overview

Board Certification(s)

Pediatrics
Pediatric Infectious Diseases

Medical/Professional School

Tulane University School of Medicine, New Orleans
Tulane University School of Medicine, New Orleans

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Pediatric Infectious Disease, Seattle Children's Hospital, Seattle

Clinical Interests

Infant immunology, vaccines, HIV

Research Description

Heather Jaspan, MD, PhD is an investigator in the Center for Global Infectious Disease Research and an assistant professor of pediatric infectious diseases at the University of Washington. At this time, most of Dr. Jaspan's research is conducted in South Africa: In sub-Saharan Africa, there are 200,000 new infant HIV infections annually and adolescents are the fastest growing group of infected individuals. Our lab seeks to: identify correlates of HIV risk at mucosal surfaces, namely the infant gut and the adolescent genital tract; study the role of the commensal bacteria at these mucosal surfaces in modulating immunity; understand immunity of infants born to HIV-infected mothers, who are uninfected yet have high morbidity and mortality; identify vaccination strategies that reduce HIV infection and improve infectious morbidities in these vulnerable HIV-exposed infants. Our clinical site is primarily located in Cape Town, South Africa, where recruitment and sample processing occur.