Lisa M Frenkel, MD

Lisa M Frenkel, MD

Infectious Disease and Virology

On staff since March 1995

Academic Title: Professor, Pediatrics and Laboratory Medicine and Pathology

Research Center: Center for Global Infectious Disease Research

  • Biography

    Dr. Lisa Frenkel is an internationally recognized expert on HIV and infectious disease. She is Co-Director of the Center for Global Infectious Disease Research at Seattle Children's Research Institute; Professor of Pediatric Infectious Diseases, Laboratory Medicine and Pathology at the University of Washington; and co-director of Seattle Children's Pediatric Infectious Diseases and Virology Clinics.

    Professor of Pediatrics and Laboratory Medicine and Pathology; Member, Division of Infectious Diseases and Co-Director of Seattle Children’s Research Institute’s Center for Global Infectious Disease Research (CGIDR).

    EDUCATION

    1976 Universidad de Costa Rica, San Jose
    1977 B.A., Kansas University, Lawrence, Kansas
    1981 M.D., Kansas University Medical School, Kansas City, Kansas

    POSTGRADUATE TRAINING

    1981-1984 Pediatric Residency, University of California, Los Angeles, California
    1984-1987 Infectious Disease Fellowship, University of California, Los Angeles, California

    FACULTY POSITIONS HELD (since 1999)

    1999-present Director, HIV-1 Drug Resistance Testing for University of Washington Clinical Laboratory
    2003-present Professor of Pediatrics, University of Washington, Seattle Children’s Hospital, Seattle, Washington
    2003-present Professor of Laboratory Medicine, University of Washington, Seattle, Washington
    2010-present Affiliate Investigator, Vaccine and Infectious Disease Division of the Fred Hutchinson Cancer Research Center, Seattle, Washington

    • Related Pages

    • Frenkel Lab

      The Frenkel Lab aims to: understand the mechanisms that allow HIV to persist during antiretroviral therapy; develop practical, affordable tests to detect drug-resistant HIV; make insights into reservoirs of drug-resistant HIV and illuminate the pathogenesis of HIV-related diseases.

    • My Bibliography - NCBI

      For a list of my publications, please access MyBibliography.

  • Patient Testimonials
  • Awards and Honors
    Award Name Award Description Awarded By Award Date
    Chair, NIH, Special Emphasis Panel 2018
    Top Meeting Participant, XXXVII International Workshop on HIV & Hepatitis Virus Drug Resistance 2018
    Awarded "AAAS Fellow" distinction, American Association for Advancement of Science (AAAS) 2017
    IDWeek 2016 Diagnostics Abstract Award, given to best abstracts submitted in diagnostics 2016
    Reviewer of application scoring across Integrated Review Groups for NIH Center for Scientific Review 2015 - 2016
    Best Poster of Meeting, International Workshop on HIV and Hepatitis Virus Drug Resistance 2013
    Best Poster of Meeting, International Workshop on HIV & Hepatitis Virus Drug Resistance 2013
    Outstanding Mentor Award of 2011, University of WA, Dept Pediatrics 2011
    Member, (extended 4y + 2yr) NIH-NIAID AIDS Research Review Committee (AIDSRRC) 2011 - 2013
    Extraordinary Professor in the Department of Immunology, Faculty of Health Sciences, University of Pretoria 2010 - 2012
    Member, NIH-NIAID AIDS Research Review Committee (AIDSRRC) 2007 - 2011
    Member, 4-year term, NIH AARR-3/ADDT Study Section 2002 - 2006
    1st William F. Friedman Lectureship, UCLA 1994
    Russel Haden Medal for medical student research Kansas University 1978
  • Presentations
    Presentations Title Event Location Date
    Invited Speaker, UW Department of Global Health, Pathobiology Interdisciplinary Program, "Reconsidering HIV drug resistance: When is it a problem and can it be avoided?" Seattle, WA 2017
    Invited Speaker, Seattle Childrens Hospital, UW Pediatrics, ID Adult Fellows, "Neonatal HSV," Seattle, WA 2017
    Invited Speaker, NIH Consultation on Global Trends of HIV Drug Resistance Meeting, Rockville, Maryland 2016
    Invited Speaker, Vaccine and Infectious Disease Division of the Fred Hutchinson Cancer Research Center, "How are HIV reservoirs sustained during antiretroviral treatment (ART)?" Seattle, Washington 2015
    Invited Speaker, NIAID-NICHD, IMPAACT Leadership Meeting, on "HIV Virology: Laboratory priorities for future," Washington, DC 2015
    Invited Speaker, Antiretroviral Treatment in Children International Course HIV: Pathogenesis, Prevention and Treatment2015: Toward to HIV Cure Lima, Peru 2015
    Invited Speaker, International Course HIV: Pathogenesis, Prevention and Treatment2015: Toward to HIV Cure, "Antiretroviral Treatment in Children," Lima, Peru 2015
    Invited Speaker, Cape Town HVTN Immunology Laboratorys Next Generation Sequencing in Clinical Vaccine Trials Workshop, Cape Town, South Africa 2015
    Seattle Childrens Hospital, Pediatric Departmental Grand Rounds Speaker 2014
    Invited Speaker, Conference on Cell and Gene Therapy for HIV Cure 2014 FHCRC Seattle, WA 2014
    Use of point mutation assays for resistance testing in Kenya - challenges and benefits Invited Speaker, Collaborative Meeting on Defining Key HIV-1 Mutations for Determining ARV Resistance in Low and Middle Income Countries Cape Town, South Africa 2014
    Invited Speaker, Rapid inexpensive point-of-care assays Global WACh Seminar Series: 2014
    Invited Speaker, UCLA, Pediatric Departmental Grand Rounds 2014
    Invited Speaker, Conference on Cell and Gene Therapy for HIV Cure 2014, FHCRC, Seattle 2014
    Invited Speaker, Pediatric Departmental Grand Rounds Speaker Seattle Children's Hospital Seattle, WA 2014
    Invited Speaker, Pediatric Departmental Grand Rounds UCLA 2014
    Strategies Towards HIV CURE for Infected Children Washington, DC 2013
    HIV Reservoirs and Viral Eradication Transformative Science Group (Cure TSG) of the AIDS Clinical Trials Group 2013
    Invited Speaker, HIV Dynamics and Evolution Meeting Asheville, North Carolina 2012
    Invited Speaker, HIV Pathogenesis, Prevention and Treatment 2012 Lima, Peru 2012
    Invited Speaker, XII Congreso de Enfermedades Infecciosas y Tropicales Lima, Peru 2011
    Invited Speaker, XII Congreso de Enfermedades Infecciosas y Tropicales, Lima, Peru 2011
    Invited Speaker, NIH US-Japan, HIV Resistance Meeting, Singapore 2010
    Invited Speaker, 2nd Canada-Colombia Collaborative Research Wkshp HIV Cali, Colombia 2010
    Invited Speaker, 5th Annual Research Symposium Seattle Childrens Research Institute 2010
    Invited Speaker, 5th Annual Research Symposium, Seattle Children’s Research Institute 2010
    Invited Speaker, 2nd Canada-Colombia Collaborative Research Wkshp HIV, Cali, Colombia 2010
    Invited Speaker, HIV Pathogenesis, Prevention and Treatment 2010 Lima, Peru 2010
    Invited Speaker, NIH US-Japan, HIV Resistance Meeting Singapore 2010
    Invited Speaker, HIV Pathogenesis, Prevention and Treatment 2010. Lima, Peru 2010
    Invited Speaker, XVIII Curso Internacional Enfoque Global en el Cuidado de la Salud Peru 2008
    Invited Speaker, Seattle Biomedical Research Institute Seattle, WA 2008
    Invited Speaker, African International Conference on Immunity, Vic Falls, Zimbabwe 2007
    Invited Speaker, 5th Annual Western Regional International Health Conference UW 2007
    Invited Speaker, International Course: HIV, pathogenesis, prevention and treatment Peru 2007
    Invited Speaker, "Scaling Up and Optimizing HIV Treatment and Care in Asia" Thailand 2006
    Invited Speaker, Laboratory Quality Assurance and Capacity Building for HIV Research in Zimbabwe University of Zimbabwe, Harare Feb 7, 2005 - Feb 9, 2005
    Invited Speaker, 2nd Workshop on HIV Persistence St Martin 2005
    Invited Speaker. 3rd Annual Western Regional International Health Conference, February 20, Invited Speaker. 3rd Annual Western Regional International Health Conference, February 20, University of Washington, Seattle 2005
    Invited, American Association of Clinical Chemistry Annual Meeting 2004, Edutrak "The Clinical Impact of Viral Mutations" Los Angeles July 2004
    "HIV-1 Pathogenesis" and "Pediatric HIV-1 Disease and Treatment" Kenya: Fogarty IARTP Course: Principles of HIV Care and Research Jan 19, 2004 - Jan 23, 2004
    Testing for HIV-1 Drug Resistance Using Filter Paper Specimens, Manuscript Preparation, Drug-Resistance in Mother-to-Child Transmission of HIV-1 India: 4th International AIDS India Conference (3 lectures) Nov 7, 2003 - Nov 11, 2003
    2003 Invited, International Course on HIV-1 Pathogenesis, Prevention and Treatment Lima, Peru 2003
    Detection of HIV-1 Resistance to Antiretrovirals using the Oligonucleotide Ligation Assay; Centers for Disease Control and Prevention, Invited Speaker, Surveillance of Antiretroviral Drug Resistance Atlanta, GA 2003
    Invited Speaker, 8th International Congress of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Basel, Switzerland 2003
    Invited Speaker, 9th International Workshop on Virus Evolution and Molecular Epidemiology, Stanford University Palo Alto, CA 2003
    Visiting Professor, Childrens Hospital Washington DC 2003
    Invited Speaker, Challenges in Drug-resistance PACTG San Diego, CA 2002
    Invited Faculty, Course on MTCT of HIV Chennai, India 2002
    "Survivors of Childhood Disease: New Challenges for Clinicians." Visiting Professor, University of Texas in San Antonio 2002
    Invited, NIH-Caribbean Workshop on HIV/AIDS San Juan, Puerto Rico 2002
    Invited Speaker, 8th HIV Dynamics and Evolution International Discussion Paris, France 2001
    Invited Speaker, IDSA San Francisco, CA 2001
    Invited Speaker, Pediatric HIV-1 Update London, England 2000
    Invited Speaker, Thai Physicians of America Conf Chiang Mai, Thailand 2000
    Invited Speaker, IDSA New Orleans, LA 2000
    Invited Speaker, HIV-1 Symposia Bangkok, Thailand 2000
    Invited Speaker, HIV-1 Update Rio de Janeiro, Brazil 1999
    Invited Speaker, Meet-the-Experts: Perinatal HIV Transmission, ICAAC 1999
    Invited Speaker, 2nd Annual Chilean Conference on Antiretroviral Therapy 1999
    Invited Speaker, IX Peruvian Course of STD/HIV Lima, Peru 1999
    Invited Speaker, VIII Peruvian Course of STD/HIV Lima, Peru 1997
    Invited Speaker, 3rd Bi-Annual Latin American Conference on HIV/AIDS 1997
  • Research Funding
    Grant Title Grantor Amount Award Date
    "Defining HIV reservoirs that rebound following suspension of ART" - R01 AI134419 (MPI: Frenkel, Vandekerckhove) NIH $488,161 annual direct costs Aug 17, 2017 - Jul 31, 2022
    "Mechanisms controlling the persistence of infectious HIV reservoirs in children" - R01 HD094719 (PI: Frenkel) NIH $273,653 annual direct costs Aug 1, 2017 - Jun 30, 2022
    "HIV integration-mediated modulation of immune regulation in HPV-associated cancers" - R01 CA206466 (MPI: Casper, Frenkel) NIH/NCI $572,651 annual direct costs Sep 1, 2016 - Aug 31, 2021
    "Role of proviral loci in HIV latency" R01 AI125026 (PI: Mullins) NIH $112,281 subaward annual direct costs Aug 11, 2016 - Jul 31, 2020
    "Cell and Gene Therapy for HIV Cure: Therapeutic Vaccine Focus" - UM1 AI126623 (PI: Kiem) NIH $74,033 subaward annual direct costs Jul 1, 2016 - Jun 30, 2021
    "Defining Critical Events in Early HIV Infection: Effects of Alcohol and Early ART" - R01 DA040532 NIH $103,774 subaward annual direct costs Jun 1, 2016 - May 31, 2020
    "P1066" - MK-0518-022 (Brooks Jackson) Johns Hopkins University $11,447 annual direct costs Jan 1, 2015 - Dec 31, 2015
    Administrative Supplement (PEPFAR) - R01 AI100037 NIH $436,863 annual direct costs Jul 15, 2014 - May 31, 2016
    "Evaluation of mHealth strategies to optimize adherence and efficacy of PMTCT/ART" - R01 HD080460 (PI: John-Stewart) NIH $18,795 subcontract annual direct costs May 1, 2014 - Apr 30, 2019
    "A rapid point-of-treatment diagnostic assay for HIV-resistance to 1st-line ART" - R01 AI110375 NIH $250,000 annual direct costs May 1, 2014 - Apr 30, 2019
    "Mechanisms of Formation and Persistence of Active HIV Reservoirs" - R01 AI111806 (PI: Mullins) NIH $127,030 subcontract annual direct costs Apr 1, 2014 - Feb 28, 2019
    "International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group" Virology Lab - UM1 AI106716 (PI: Aldrovandi) NIH $102,272 subaward annual direct costs Jan 1, 2014 - Nov 30, 2020
    “University of Washington Center for AIDS Research” (CFAR) NIH $11,716 June 2013 - May 2019
    "Detection of HIV drug resistance mutations using highly multiplexed ligation/qPCR assays" NIH Mar 31, 2013 - Apr 1, 2014
    "International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group" NIH Sep 1, 2012 - Dec 31, 2013
    "Quantification and Dynamics of HIV-1 Drug-Resistant Mutants by Pyrosequencing" NIH Jul 1, 2009 - Jun 30, 2013
    "Effect of Lactobacillus on Genital HIV-1 RNA and DNA Shedding in Women" NIH Sep 30, 2008 - Aug 31, 2010
    "International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group" NIH Jul 1, 2006 - May 31, 2013
    "Etiology of Mastitis in HIV-1 Infected Women" NIH Aug 15, 2005 - Jul 31, 2009
    "Reservoirs of Drug-Resistant HIV-1" NIH Mar 1, 2005 - Feb 28, 2012
    "Does HIV Continue to Replicate in Lung Macrophages of Children on Effective Therapy?" The Foster Foundation Jan 1, 2005 - Dec 31, 2009
    "Reservoirs of drug-resistant HIV-1" NIAID-NIH May 1, 2004 - Apr 30, 2006
    "Pediatric HIV Clinical Trials Network" Nov 1, 2003 - Oct 31, 2008
    "Immunology and Molecular Virology of Acute HIV Infection; Core C: Specimen and Repository" NIH Sep 30, 2003 - Mar 31, 2008
    "Adaptation of an OLA for detection of drug-resistant HIV-1 mutants to non-B subtypes" NIH; Center for AIDS Research Mar 1, 2003 - Feb 29, 2004
    "HIV Pathogenesis and Shedding" NIH Sep 15, 2002 - Aug 31, 2006
    "A pilot study to evaluate a novel method to quantify mitochondrial integrity of leukocytes and red blood cells in cord and peripheral blood." Bristol Meyer Squibb Apr 1, 2002 - Dec 31, 2003
    "Immunization by HIV Exposure During Chemoprophylaxis" NIH Sep 1, 2001 - Sep 29, 2009
    "Prevention of HIV resistance to nevirapine in pregnancy." Fogarty International Center, NIH Jul 1, 2001 - Sep 30, 2008
    "Womens HIV-1 Pathogenesis Program Project" NIH Apr 1, 2001 - Mar 31, 2008
    "Viral Lymphocyte Dynamics in Children" The Foster Foundation Jan 1, 2001 - Dec 31, 2001
    "Children Affected by AIDS Foundation" Jan 1, 2001 - Dec 31, 2001
    "Pediatric AIDS Foundation Emergency Funds." Elizabeth Glaser Pediatric AIDS Foundation Jan 1, 2001 - Dec 31, 2001
    "Viral Lymphocyte Dynamics in Children " The Foster Foundation Jan 1, 2000 - Dec 31, 2000
    "Pediatric AIDS Clinical Trials Group" NIH Feb 1, 1999 - Jan 31, 2000
    "Pediatric AIDS Emergency Funds" Elizabeth Glaser Pediatric AIDS Foundation Jan 1, 1999 - Dec 31, 2000
    "Viral Lymphocyte Dynamics in Children" The Foster Foundation Dec 19, 1998 - Dec 31, 1999
    "Monitoring the emergence of HIV-1 resistance to antiretroviral drugs in Latin America." World Health Organization (WHO/UNAIDS) Oct 1, 1998 - Oct 1, 1999
    "Immunizing by Mucosal SIV Exposure during RT Inhibition" NIH Sep 30, 1998 - Sep 29, 2001
    "Ryan White Titles I and IV" Seattle-King County Department of Public Health Aug 1, 1997 - Jul 31, 2001
    "Pediatric AIDS Clinical Trials Group" NIH Mar 1, 1997
    "Pediatric AIDS Clinical Trials Group" NIH Mar 1, 1997
    "Transient HIV infection in infants." The Foster Foundation Dec 19, 1996 - Dec 18, 1998
    "Pediatric AIDS Clinical Trials Group" NIH Feb 28, 1992 - Feb 28, 1997
    “Academic Pediatric Infectious Disease” NIH $285,024 annual direct costs July 1981 - April 2023

Overview

Board Certification(s)

Pediatric Infectious Diseases
Pediatrics

Medical/Professional School

University of California Los Angeles, Los Angeles, CA
University of Kansas at Lawrence, Lawrence, KS

Residency

David Geffen School of Medicine at UCLA, Los Angeles, CA

Clinical Interests

Prevention and treatment of pediatric HIV disease, neonatal herpes simplex virus (HSV) and congenital cytomegalovirus (CMV) infections

Research Focus Area

Infectious Disease, Virology