Brain Tumor Resource Lab
The Brain Tumor Resource Lab strives to generate and distribute patient-derived xenograft models and cell lines. Our focus is on pediatric brain tumors.
The figure at right depicts the best-characterized models for comparison. Click on it for a larger version.
Please note that the tissue culture lines should not be implanted into mice and patient-derived xenograft cell lines should not be used for tissue culture.
These resources are for academic use only. Please contact us if you are interested in other uses.
Similar to ATCC, the only way to obtain these lines is to place an order through this site. This ensures that we can contact you if important information needs to be conveyed, that you understand that the lines cannot be shared, that a material transfer agreement is in place and that we can track how these lines are used to benefit science and medicine.
We gratefully acknowledge funding from the National Institutes of Health, Seattle Run of Hope, the German Cancer Consortium (DKTK), and the German Cancer Research Center (DKFZ), Heidelberg, Germany.
Resources
- BTRL Cell Line Detailed Information by Disease or Genetics (XLS)
- Models Maintained by Other Institutions (XLS)
Medulloblastoma Lines
Tumor Classification
Medulloblastoma, Group 3: 17p, 9q, PTCH1
Available As
Mouse Xenograft
Tumor Classification
Medulloblastoma, Group 3: 17p
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tissue Culture Line
Tumor Classification
Tumor Classification
Tumor Classification
Tumor Classification
Medulloblastoma, Group 3: MYC, 17p, 17q, 9p
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tissue culture line available
Tumor Classification
Tumor Classification
Medulloblastoma, Group 4: 17p, 17q, 9q
Available As
Mouse Xenograft
Tumor Classification
Medulloblastoma, SHH: TP53, MYCN, GLI2, 17p, 17q, 9q
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tumor Classification
Medulloblastoma, Group 3: MYC, 17q, 17p
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tissue culture line available
Tumor ClassificationHas not yet been characterized.
Tumor Classification
Medulloblastoma, SHH: TP53, MYCN, GLI2, 17p, 17q, 9q
Available As
Mouse Xenograft
Tumor Classification
Medulloblastoma, Group 3: KBTBD4, 17p, 17q, 9q
Available As
Mouse Xenograft
Ependymoma Lines
Tumor Classification
Ependymoma, PFA: 1q
Available As
Mouse Xenograft
Tissue Culture Line
Tumor Classification
Ependymoma
Both Tissue Culture and PDX cell lines available
Tumor Classification
Ependymoma
Available As
PDX Cell Line
Tumor Classification
Ependymoma, RELA fusion: CDKN2A/B, RELA
Available As
Mouse Xenograft
Pineoblastoma Cell Lines
Tumor ClassificationHigh Grade Glioma Lines
Tumor Classification
High Grade Glioma, K27: EGFR, H3FA/HIST1H3B
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, pedRTK1: CDK4, FGFR1-4, MDM2
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, K27: ATRX, H3FA/HIST1H3B, SETD1A, TP53
Available As
Mouse Xenograft
Tumor Classification
Tumor Classification
High Grade Glioma, MYCN: ID2, MYCN, EGFR, PIK3R1, MGMT methylation
Available As
Mouse Xenograft
Tissue Culture
Tumor Classification
High Grade Glioma, PedRTK1: CDK4, PDGFRA, TERT, TP53
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, pedRTK1: ATRX, EGFR, FGFR1-4, MGMT metylation, MSH2, hypermutator
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, pedRTK1: ATRX, EGFR, FGFR1-4, MSH2, hypermutator
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma
Available As
Mouse Xenograft
Has not been characterized, TC line only
Tumor Classification
Astrocytoma
Has not been characterized, TC line only
Tumor Classification
High Grade Glioma
Atypical Teratoid Rhabdoid Tumor Cell Lines
Tumor Classification
Atypical Teratoid Rhabdoid, SHH: SMARCB1
Available As
Mouse Xenograft
Tissue Culture Line
Tumor Classification
Atypical Teratoid Rhabdoid, SHH: SMARCB1
Available As
Mouse Xenograft
Tumor Classification
Atypical Teratoid Rhabdoid, MYC: SMARCB1
Available As
Mouse Xenograft
Terms and Conditions
In consideration for and as a condition to the receipt of cell lines from the Brain Tumor Resource Laboratory of Seattle Children’s Research Institute ("SCRI"). the undersigned investigator (“Recipient Scientist”) and institution (“Institution”) agree, represent and warrant as follows:
- Institution is a non-profit, educational or research organization.
- The Material provided to Recipient Scientist is to be used solely for research purposes at Institution and only under the direction of Recipient Scientist. The Material will not be used in human subjects or in clinical trials involving human subjects. Recipient Scientist and Institution agree not to sell, use or transfer for commercial purposes the Material or their products or to transfer the material to anyone who does not work under the direct supervision of Recipient Scientist at Institution.
- Recipient Scientist may publish the results of his or her research using the Material in scientific journals. Recipient Scientist agrees to acknowledge SCRI as the provider of the Material.
- Recipient Scientist and Institution understand and agree that Material delivered pursuant to this Agreement may have hazardous properties. Recipient Scientist and Institution agree to take appropriate safety measures concerning the use, storage, disposal of the Material. SCRI makes no representation and extends no warranties of any kind either express or implied including, without limitation any warranties or merchantability or fitness for a particular purpose or that the use of the Material will not infringe any patent, copyright, trademark or other proprietary right.
- Except to the extent prohibited by law, Recipient Scientist and Institution assume all liability for damages or loss arising from the use, storage or disposal of the Material. Except to the extent prohibited by law, Recipient Scientist and Institution agree to indemnify, defend and hold harmless SCRI and its employees, officers, trustees and agents from and against any and all loss, damage or liability arising from the use, storage or disposal of the Material by Recipient Scientist, Institution or their employees or agents.
- Recipient Scientist and Institution agree to use the Material in compliance with all applicable statutes and regulations.