Ben Towne Center for Childhood Cancer Research
Accelerating Progress Toward Cures
Dr. Julie Park is leading one of the world’s first clinical studies of immunotherapy for neuroblastoma – the deadliest childhood cancer.
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Pediatric CAR T-cell immunotherapy trial aims to improve remission rates of leukemia at Children’s National Health System (This story appeared in over 60 news outlets) – Morningstar
Children's National Health System is opening a CAR T-cell immunotherapy trial, PLAT-05, which first launched at Seattle Children’s, for pediatric patients with relapsed positive acute lymphoblastic leukemia. Children’s National and Seattle Children's are both a part of CureWorks, an international collaborative of leading academic children's hospitals determined to accelerate the development of immunotherapy treatments for childhood cancer. "Extending the reach of this clinical trial not only allows patients to be treated in their own community, but it also helps to accelerate our ability to ultimately develop a treatment that enables all kids with cancer to grow up and realize their full potential,” said Dr. Mike Jensen, executive director of CureWorks and director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's Research Institute.
BlueRock Therapeutics establishes key partnerships with leading experts in autoimmune disease (This story appeared in over 55 news outlets) – The Oklahoman
BlueRock Therapeutics, an engineered cell therapy company that aims to develop regenerative medicines for intractable diseases, announced the establishment of partnerships with Dr. Bruce Blazar of the University of Minnesota and Dr. Courtney Crane, principal investigator at the Ben Towne Center for Childhood Cancer Research at Seattle Children's.
Consolidative transplant after CAR T-cell therapy may benefit certain patients with acute lymphoblastic leukemia – 12.01.2018 – HemOnc Today
Consolidative hematopoietic stem cell transplant (HCST) after CD19-directed CAR T-cell therapy prolonged leukemia-free survival for certain pediatric and young adult patients with relapsed or refractory CD19-positive acute lymphoblastic leukemia, according to results of the PLAT-02 trial presented at ASH Annual Meeting and Exposition. However, investigators observed no significant difference in overall survival between patients who underwent consolidative HSCT and those who did not. This could be due to response to salvage therapy, according to researcher Dr. Corinne Summers, principal investigator in the Ben Towne Center for Childhood Cancer Research at Seattle Children’s Research Institute. “Longer-term follow-up is needed, and I suspect that we may see a spread from those two lines eventually,” said Summers. “I’m happy that a lot of these patients who relapse after CAR T-cell therapy are salvageable with other therapies, but these are still very high-risk patients and we just need more time and more subjects under our belt.”