Partnership Opportunities
At Seattle Children’s, we transform breakthrough research into market-ready solutions. Through the Office of Innovation and New Ventures, we manage a robust portfolio of licensable intellectual property and provide a launchpad for high-growth spin-out companies.
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Therapeutics
- ADHD
Treatments for attention deficit hyperactivity disorder (ADHD) and related problems through personalized medicine and improved diagnosis – Mark Stein - Allergy and Asthma – Mast Cell Biology and Therapeutics
Exploring novel therapeutics targeting mast cells in allergic disease – Adrian Piliponsky - Allergy and Asthma – Silencing Mast Cells
A novel platform enables new insights into mast cell function in allergic disease – Adrian Piliponsky - Asthma
Using primary cell lines from the upper and lower respiratory tracts in organotypic airway epithelial cell models of pediatric asthma – Jason Scott Debley - Autoimmune Disease – B-Cell Integrins
Identifying targets to modify B-cell activation during autoimmunity – Mridu Acharya - Bone Disorders and Malformations
Understanding bone biology through the discovery of osteogenic proteins derived from the study of craniosynostosis – Michael Cunningham - Brain Malformations
Using Next Generation Sequencing to trace the genetic basis for brain malformations linked to PI3K-AKT-MTOR dysfunction – Ghayda Mirzaa - Brain Tumors – Combination Therapies
Identifying novel targets for combination therapies that reduce toxicities of treating childhood medulloblastomas – Myron K. Evans II - Cancer, Inflammation, CNS Disorders: Small Animal Models
Custom-engineering humanized small animal models for in vivo evaluation of mechanisms and translational potential of cell, gene and biologic therapeutics – Richard James - Cancer, Inherited, and Infectious Disease – Cell Transduction
Identifying methods to enhance transduction of viral vectors or nanoparticles into hematopoietic and other stem cells – Bruce Torbett - Cancer – Costimulatory Receptors to Advance Immunotherapy
Developing dual costimulatory receptors to deliver CD40, FLT3, OX40, 4-1BB, and other function-enhancing signals to antitumor immune cells – Shannon Oda - Cancer – Drugs for Sarcomas
Identifying pathways in the development of Ewing and other sarcomas that have potential targets for existing drugs – Elizabeth Lawlor - Cancer – Epigenetic Profiling Tools
Identifying and testing chromatin-altering drugs for reduced toxicity, treatment resistance, and relapse – Jay F. Sarthy - Cancer – Macrophage Regulation
Using macrophage cytokine production and epigenetics to predict and control immune response – Heather Gustafson - Cancer – Mouse Model for CAR-T Therapy
Studying CAR T cells for solid tumors under conditions that reflect normal human immunity – Vandana Kalia and Surojit Sarkar - Cancer – Neurotoxicity
Understanding neurologic complications of CAR T-cell therapy in pediatric cancer – Juliane Gust - Cancer – Switch Receptors to Advance Immunotherapy
Switching the function of receptors for CD47, FasL, and other targets to stimulate rather than suppress T cells – Shannon Oda - Cancer – T cell conditioning
Metabolic conditioning of T cells using IL-2 – Vandana Kalia and Surojit Sarkar - Cancer – Target Validation
Rapidly measuring effects of T-cell function modulators on anti-cancer activity with gene-edited mouse models – Vandana Kalia and Surojit Sarkar - CAR-NK Cell Therapy and Adoptive Immunotherapy
Using cord blood from healthy donors to generate off-the-shelf CAR-NK cells to treat blood cancers and solid tumors – Colleen Delaney - Cell and Gene Therapies
Genome-editing B cells for in vivo delivery of antibodies and other therapeutic proteins – Richard James - Chronic Pain
Using technology to treat chronic pain in children and adolescents – Tonya Palermo - Chronic and Recurrent Pain
Clinical trial opportunities in pediatric analgesics - Gary Walco - Congenital Disorders – Genetic Testing
Developing minimally invasive genetic tests for vascular malformations and other non-neoplastic pediatric disorders – James Bennett - Congenital Disorders of Glycosylation
Discovering genes, biomarkers, and the natural history of rare, single-gene genetic diseases – Christina Lam - COVID-19 Resources – Neutralizing Nanobodies
Screening, optimizing, and producing stable, specific, recombinant nanobodies against SARS-CoV-2 – John Aitchison - Craniofacial Malformations – Clinical Data
Developing improved diagnostics, medical interventions, and coordinated care for patients with craniofacial malformations – Kelly Evans, Carrie Heike, Daniela Luquetti - Cryptosporidium and Other Parasites
Identifying and testing small molecule inhibitors of N-myristoyltransferase – Bart Staker - Developmental Disorders in Preclinical Models – Gene Discovery and Drug Screening
Applying CRISPR engineering and drug screening to zebrafish models of development and disease – Lisa Maves - Dravet – Advanced Models
Developing novel therapies for genetic refractory epilepsies of childhood using mouse and organoid models – Franck Kalume - Duchenne Muscular Dystrophy and Other Muscle Disorders – Therapies and Preclinical Models
A potential small molecule therapeutic and preclinical model for evaluating therapies and biomarkers for DMD and other muscle disorders – Lisa Maves - Epilepsy – Drug Screening
Using mouse models to screen potential drugs that could treat the most common forms of epilepsy and seizures – Kathleen J. Millen - Epilepsy – Stem Cell Models
Stem cell-based models for studying epilepsies associated with mTOR mutations – Ghayda Mirzaa and Filomena Pirozzi - Fibrosis
Acomys: A natural mammalian model of regeneration – Mark Majesky - Group B Streptococcus
Understanding GBS infection induced preterm labor – Lakshmi Rajagopal - Heart Arrhythmia
New technologies for improving catheter ablation – Stephen Seslar - Heart Metabolism and Function
Bridging clinical cardiology and research on cellular energy changes – Aaron Olson - Heart Surgery – “Ductal Paint”
Developing a method to fluorescently mark tissue for more accurate cardiac surgery – Mark Majesky - Heart Transplant – Immunoreactivity and Tolerance
Investigating why some pediatric heart transplant recipients avoid transplant rejection – Yuk Law - Hemophilia – Immunomodulation Therapy
Immunomodulation therapy to prevent or modulate inhibitory antibody responses in hemophilia patients – Carol Miao - Hemophilia – Intraosseous Lentiviral Therapy
Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets for hemophilia A treatment – Carol Miao - HIV Microbiomes
Defining the links between bacterial microbiome, virome, innate and adaptive immune responses, and the roles they play in HIV susceptibility – Heather Jaspan and Melanie Gasper - HIV – Diagnostics
Developing simple, rapid methods for determining drug resistance and viral persistence – Lisa Frenkel - HIV – CAR-T Therapies
Using a validated anti-cancer treatment to eliminate or reduce HIV-infected cells – Thor Wagner - HIV – Transmission and Progression
Studying mucosal immunology for novel approaches to vaccines and immunotherapies – Donald Sodora - HIV – Viral Reservoirs
Understanding the persistence of HIV viral reservoirs – Lisa Frenkel - Hypoplastic Left Heart Syndrome
Translational medicine for hypoplastic left heart syndrome – Vishal Nigam - Immunity and Organ Transplantation – Decoy B Cells
Regulating immunity by programming B cells as antigen-specific decoys that silence harmful immune responses – Richard James - Infantile Hemangiomas and Other Vascular Malformations
Endothelial and circulating C19MC microRNAs as biomarkers of infantile hemangioma – Jonathan Perkins - Infectious Diseases – Modeling New Therapies
Creating gene expression network models to identify new drug targets and combination therapies for tuberculosis and other diseases – Shuyi Ma - Infectious Diseases – Noninvasive Method for Vaginal Sampling of Immune Cells
Making the study of mucosal immune responses possible through noninvasive sampling – Whitney Harrington - Infectious and Neurodegenerative Diseases: Interactomes
Developing compact, high-affinity antibodies for research and clinical applications – John Aitchison - Inflammatory Bowel Disease – Dietary Modifications
Effect of dietary modifications on disease activity – David Suskind - Influenza – Vaccines
Improving flu vaccines and working toward a universal vaccine – Mridu Acharya - Kawasaki Disease
Genetic analysis for diagnosis, monitoring and predicting response to therapy in Kawasaki Disease, vasculitis and other vasculopathies – Michael Portman - Lupus – B-Cell Targets
Using novel mouse models to study the signals and pathways of systemic autoimmune diseases – Shaun Jackson - Malaria – Human Immune Response
Defining immune responses to advance development of anti malaria vaccines – Ken Stuart - Malaria – Host-Pathogen Interactions
Host-based Drug Discovery for Infectious Diseases – Alexis Kaushansky - Malaria – Molecular Mechanisms
Using in vitro models and clinical cohorts to understand vascular aspects of disease and investigate interventions to restore vascular function – Joe Smith - Malaria – Next-Generation Therapeutics
Generating highly selective inhibitors of Plasmodium N-myristoyltransferase – Alexis Kaushansky and Bart Staker - Malaria – Vaccines, Therapies and Drug Resistance
Identifying potential markers of antimalarial drug resistance and new targets for vaccines and therapies – Ashley Vaughan - Mitochondrial Diseases – Identifying Therapies
Identifying pathways, targets, and new interventions for treating childhood mitochondrial disorders and related seizures – Simon Johnson - Motor Impairments and Paralysis
Implantable sensory/stimulation devices for treatment of motor impairments – Jeffrey Ojemann - MRSA Infections
Identification of kinase inhibitors that increase the Beta-lactam sensitivity of MRSA – Lakshmi Rajagopal - Neural Development and Neurodegeneration
Applying in vivo proteomics and genetic approaches to study pathways in nervous system development and neurodegenerative disease – Brock Grill - Neurodevelopmental Disorders
Studying drivers of autism, epilepsy and rare neurogenetic conditions for preclinical drug development – Kimberly Aldinger - Nontuberculous Mycobacterial Diseases – Drug Discovery
Discovering targets and screening small molecules to treat mycobacterial infections – Tanya Parish - Obesity
Testing novel pathways for obesity drugs – Christian Roth - Opioid Sensitivity and Tolerance
Using a scalable C. elegans behavioral screening platform to identify druggable candidates for modulating μ-opioid receptor sensitivity and tolerance – Brock Grill - Optimizing CAR T Cells at the Level of Receptor Signaling
Determining responsiveness and safety using a multiplex quantitative protein-protein interaction platform – Stephen Smith - Peroxisomal Disorders
Applying a systems approach to the molecular mechanisms of rare diseases – John Aitchison - Respiratory Distress Syndrome in Neonates – Improving Lung Surfactant Therapy
Developing animal and 3D models and novel surfactant aerosols to improve respiratory therapy – Robert DiBlasi - Retinal Disorders
Using high-throughput chromatin immunoprecipitation sequencing (ChIP-Seq) to understand retinal development – Timothy Cherry - Rheumatic Diseases
Research network to study chronic recurrent multifocal osteomyelitis (CRMO) and other childhood rheumatic diseases – Yongdong (Dan) Zhao - Solid Tumors – Off-the-Shelf Immunotherapies
Engineered monocytes to target cancerous cells, secrete immune-boosting cytokines, and coordinate antitumor immune responses against solid tumors – Colleen Delaney - Stroke – Neurovascular Imaging
Using two-photon microscopy and other methods to study neurovascular structure and function, including response to injury, disease, and drugs – Andy Shih - Trypanosomal Diseases
Identifying novel drug targets for sleeping sickness, Chagas disease, and leishmaniasis – Ken Stuart - Tuberculosis
Designing vaccines and therapies with a novel mouse model – Kevin Urdahl - Tuberculosis – Drug Discovery
Identifying and optimizing candidate compounds using a high-throughput multiassay platform – Tanya Parish - Tuberculosis – Outer Membrane Proteins as New Targets
Using genetic analyses of a large family of membrane proteins to discover new resistance mechanisms and new antibiotic targets – Christoph Grundner - Tuberculosis – Phosphosignaling Pathways as New Drug Targets
Targeting phosphosignaling pathways, kinases and nonreplicating bacteria – Dr. Christoph Grundner - Tuberculosis and Nontuberculous Mycobacterial Diseases
Translating vaccine and treatment candidates from the lab to clinical trials – Rhea Coler - Vascular and Lymphatic Malformations – Genotyping and Treatment
Applying cell-free DNA testing to precision diagnosis and personalized medicine for congenital disorders – Jonathan Perkins
Diagnostics
- Autism – Characterizing Protein Interactions
Using animal models and high throughput immunoprecipitation assays to characterize disease subtypes and mechanisms of action of autism – Stephen Smith - Cancer – Macrophage Regulation
Using macrophage cytokine production and epigenetics to predict and control immune response – Heather Gustafson - Cancer – Neurotoxicity
Understanding neurologic complications of CAR T-cell therapy in pediatric cancer – Juliane Gust - COVID-19 Resources – Neutralizing Nanobodies
Screening, optimizing, and producing stable, specific, recombinant nanobodies against SARS-CoV-2 – John Aitchison - Healthcare Associated Infections
Using metagenomics Next Generation Sequencing (mNGS) to track outbreaks of healthcare associated infections – Danielle Zerr - HIV – Diagnostics
Developing simple, rapid methods for determining drug resistance and viral persistence – Lisa Frenkel - HIV – Viral Reservoirs
Understanding the persistence of HIV viral reservoirs – Lisa Frenkel - Human Herpesvirus HHV-6 – Epidemiology
Understanding primary and reactivated HHV-6 to prevent acute graft vs. host disease – Danielle Zerr - Infantile Hemangiomas and Other Vascular Malformations
Endothelial and circulating C19MC microRNAs as biomarkers of infantile hemangioma – Jonathan Perkins - Infectious Diseases – Protection via T Cells in Breast Milk
Using maternal vaccination as a tool to maximize the protection received by the infant from breastmilk – Whitney Harrington - Infectious Diseases – Vaccination and Protection Via Microchimerism
Isolating and characterizing maternal microchimeric cells to optimize childhood vaccination and immunity to infections – Whitney Harrington - Juvenile Idiopathic Arthritis
Developing a mobile phone-based thermal imaging tool for assessing JIA in primary care and family practice – Yongdong (Dan) Zhao - Kawasaki Disease
Genetic analysis for diagnosis, monitoring and predicting response to therapy in Kawasaki Disease, Vasculitis and Other Vasculopathies – Michael Portman - Lupus – B-Cell Targets
Using novel mouse models to study the signals and pathways of systemic autoimmune diseases – Shaun Jackson - Retinal Disorders
Using high-throughput chromatin immunoprecipitation sequencing (ChIP-Seq) to understand retinal development – Timothy Cherry - Sleep Apnea
Developing improved diagnostics and treatments for pediatric sleep apnea patients – Maida Chen - Tuberculosis – Phosphosignaling Pathways as New Drug Targets
Targeting phosphosignaling pathways, kinases and nonreplicating bacteria – Dr. Christoph Grundner - Tuberculosis – Outer Membrane Proteins as New Targets
Using genetic analyses of a large family of membrane proteins to discover new resistance mechanisms and new antibiotic targets – Christoph Grundner - Tuberculosis and Antimicrobial-Resistance
Adapting a single-cell growth assay for infectious disease agents – John Aitchison - Vascular and Lymphatic Malformations – Genotyping and Treatment
Applying cell-free DNA testing to precision diagnosis and personalized medicine for congenital disorders – Jonathan Perkins - Vascular Malformations and Other Birth Defects – Precision Diagnostics
Mosaicism’s contribution to disease leads to new diagnostic tools – James Bennett - Wilson Disease and Other Lysosomal Storage Diseases – Newborn Screening
A new method uses dried blood samples to detect lysosomal storage diseases, primary immunodeficiencies and Wilson disease – Sihoun Hahn
Medical Devices
- Craniofacial Malformations – Clinical Data
Developing improved diagnostics, medical interventions, and coordinated care for patients with craniofacial malformations – Kelly Evans, Carrie Heike, Daniela Luquetti - Epilepsy – Medical Device Interventions
Using advanced models to develop and test medical interventions for treatment-resistant epilepsy – Franck Kalume - Heart Arrhythmia
New technologies for improving catheter ablation – Stephen Seslar - Hemophilia – Gene Therapy
Ultrasound-mediated gene delivery for hemophilia treatment – Carol Miao - Hypoplastic Left Heart Syndrome
Translational medicine for hypoplastic left heart syndrome – Vishal Nigam - Juvenile Idiopathic Arthritis
Developing a mobile phone-based thermal imaging tool for assessing JIA in primary care and family practice – Yongdong (Dan) Zhao - Malaria – Insect Dissection Tool
Streamlining insect handling for faster workflow, higher throughput, and more uniform samples – Alexis Kaushansky - Motor Impairments and Paralysis
Implantable sensory/stimulation devices for treatment of motor impairments – Jeffrey Ojemann - Respiratory Distress Syndrome in Neonates – Improving Lung Surfactant Therapy
Developing animal and 3D models and novel surfactant aerosols to improve respiratory therapy – Robert DiBlasi - Sleep Apnea
Developing improved diagnostics and treatments for pediatric sleep apnea patients – Maida Chen
Vaccines
- Cancer, Inflammation, CNS Disorders: Small Animal Models
Custom-engineering humanized small animal models for in vivo evaluation of mechanisms and translational potential of cell, gene and biologic therapeutics – Richard James - Group B Streptococcus
Understanding GBS infection induced preterm labor – Lakshmi Rajagopal - HIV – Transmission and Progression
Studying mucosal immunology for novel approaches to vaccines and immunotherapies – Donald Sodora - Infectious Diseases – Noninvasive Method for Vaginal Sampling of Immune Cells
Making the study of mucosal immune responses possible through noninvasive sampling – Whitney Harrington - Infectious Diseases – Protection via T Cells in Breast Milk
Using maternal vaccination as a tool to maximize the protection received by the infant from breastmilk – Whitney Harrington - Infectious Diseases – Vaccination and Protection Via Microchimerism
Isolating and characterizing maternal microchimeric cells to optimize childhood vaccination and immunity to infections – Whitney Harrington - Influenza – Vaccines
Improving flu vaccines and working toward a universal vaccine – Mridu Acharya - Malaria – Human Immune Response
Defining immune responses to advance development of anti malaria vaccines – Ken Stuart - Malaria – Vaccines, Therapies and Drug Resistance
Identifying potential markers of antimalarial drug resistance and new targets for vaccines and therapies – Ashley Vaughan - Tuberculosis
Designing vaccines and therapies with a novel mouse model – Kevin Urdahl - Tuberculosis and Nontuberculous Mycobacterial Diseases
Translating vaccine and treatment candidates from the lab to clinical trials – Rhea Coler
Research Tools and Understanding Disease Pathways
- Anesthesia Risks
Understanding and reducing neurotoxicity after pediatric exposure to volatile anesthetics – Margaret Sedensky, Philip Morgan and Simon Johnson - Allergy and Asthma – Mast Cell Biology and Therapeutics
Exploring novel therapeutics targeting mast cells in allergic disease – Adrian Piliponsky - Allergy and Asthma – Silencing Mast Cells
A novel platform enables new insights into mast cell function in allergic disease – Adrian Piliponsky - Asthma
Using primary cell lines from the upper and lower respiratory tracts in organotypic airway epithelial cell models of pediatric asthma – Jason Scott Debley - Autism – Characterizing Protein Interactions
Using animal models and high throughput immunoprecipitation assays to characterize disease subtypes and mechanisms of action of autism – Stephen Smith - Autoimmune Disease – B-Cell Integrins
Identifying targets to modify B-cell activation during autoimmunity – Mridu Acharya - Bone Disorders and Malformations
Understanding bone biology through the discovery of osteogenic proteins derived from the study of craniosynostosis – Michael Cunningham - Brain Malformations
Using Next Generation Sequencing to trace the genetic basis for brain malformations linked to PI3K-AKT-MTOR dysfunction – Ghayda Mirzaa - Brain Tumors – Combination Therapies
Identifying novel targets for combination therapies that reduce toxicities of treating childhood medulloblastomas – Myron K. Evans II - Brain Tumors - Neurtotrophin Receptors
Investigating neurotrophin receptors in neural development and as gene fusions that are potential drug targets – Siobhan S. Pattwell - Breathing Dysregulation
Developing and validating animal models to characterize the neuronal control of autonomic regulation – Nino Ramirez - Cancer, Inflammation, CNS Disorders: Small Animal Models
Custom-engineering humanized small animal models for in vivo evaluation of mechanisms and translational potential of cell, gene and biologic therapeutics – Richard James - Cancer, Inherited, and Infectious Disease – Cell Transduction
Identifying methods to enhance transduction of viral vectors or nanoparticles into hematopoietic and other stem cells – Bruce Torbett - Cancer – Epigenetic Profiling Tools
Identifying and testing chromatin-altering drugs for reduced toxicity, treatment resistance, and relapse – Jay F. Sarthy - Cancer – Macrophage Regulation
Using macrophage cytokine production and epigenetics to predict and control immune response – Heather Gustafson - Cancer – Mouse Model for CAR-T Therapy
Studying CAR T cells for solid tumors under conditions that reflect normal human immunity – Michael Jensen, Vandana Kalia and Surojit Sarkar - Cancer – Neurotoxicity
Understanding neurologic complications of CAR T-cell therapy in pediatric cancer – Juliane Gust - Cancer – Target Validation
Rapidly measuring effects of T-cell function modulators on anti-cancer activity with gene-edited mouse models – Vandana Kalia and Surojit Sarkar - Cell and Gene Therapies
Genome-editing B cells for in vivo delivery of antibodies and other therapeutic proteins – Richard James - Cerebellar Development
Discovering genes that affect the cerebellum and may contribute to autism and epilepsy – Kimberly Aldinger - Congenital Disorders of Glycosylation
Discovering genes, biomarkers, and the natural history of rare, single-gene genetic diseases – Christina Lam - Cryptosporidium and Other Parasites
Identifying and testing small molecule inhibitors of N-myristoyltransferase – Bart Staker - Developmental Disorders in Preclinical Models – Gene Discovery and Drug Screening
Applying CRISPR engineering and drug screening to zebrafish models of development and disease – Lisa Maves - Dravet – Advanced Models
Developing novel therapies for genetic refractory epilepsies of childhood using mouse and organoid models – Franck Kalume - Drug Effectiveness – Mapping Variant Protein Function
Using large-scale living cell assays to reveal how genetic variants alter protein activity, signaling and drug response – Richard James - Duchenne Muscular Dystrophy and Other Muscle Disorders – Therapies and Preclinical Models
A potential small molecule therapeutic and preclinical model for evaluating therapies and biomarkers for DMD and other muscle disorders – Lisa Maves - Epilepsy – Drug Screening
Using mouse models to screen potential drugs that could treat the most common forms of epilepsy and seizures – Kathleen J. Millen - Epilepsy – Stem Cell Models
Stem cell-based models for studying epilepsies associated with mTOR mutations – Ghayda Mirzaa and Filomena Pirozzi - Fibrosis
Acomys: A natural mammalian model of regeneration – Mark Majesky - Food Insecurity and Chronic Disease Management
Understanding the role that poor nutrition caused by food insecurity has on children living with type 1 diabetes or HIV – Jason Mendoza - Healthcare Associated Infections
Using metagenomics Next Generation Sequencing (mNGS) to track outbreaks of healthcare associated infections – Danielle Zerr - Heart Metabolism and Function
Bridging clinical cardiology and research on cellular energy changes – Aaron Olson - Heart Surgery – “Ductal Paint”
Developing a method to fluorescently mark tissue for more accurate cardiac surgery – Mark Majesky - Heart Transplant – Immunoreactivity and Tolerance
Investigating why some pediatric heart transplant recipients avoid transplant rejection – Yuk Law - HIV Microbiomes
Defining the links between bacterial microbiome, virome, innate and adaptive immune responses, and the roles they play in HIV susceptibility – Heather Jaspan and Melanie Gasper - HIV – Transmission and Progression
Studying mucosal immunology for novel approaches to vaccines and immunotherapies – Donald Sodora - HIV – Viral Reservoirs
Understanding the persistence of HIV viral reservoirs – Lisa Frenkel - Human Herpesvirus HHV-6 – Epidemiology
Understanding primary and reactivated HHV-6 to prevent acute graft vs. host disease – Danielle Zerr - Hypoplastic Left Heart Syndrome
Translational medicine for hypoplastic left heart syndrome – Vishal Nigam - Infectious Diseases – Modeling New Therapies
Creating gene expression network models to identify new drug targets and combination therapies for tuberculosis and other diseases – Shuyi Ma - Infectious Diseases – Noninvasive Method for Vaginal Sampling of Immune Cells
Making the study of mucosal immune responses possible through noninvasive sampling – Whitney Harrington - Infectious Diseases – Protection via T Cells in Breast Milk
Using maternal vaccination as a tool to maximize the protection received by the infant from breastmilk – Whitney Harrington - Infectious Diseases – Vaccination and Protection Via Microchimerism
Isolating and characterizing maternal microchimeric cells to optimize childhood vaccination and immunity to infections – Whitney Harrington - Infectious and Neurodegenerative Diseases: Interactomes
Developing compact, high-affinity antibodies for research and clinical applications – John Aitchison - Influenza – Vaccines
Improving flu vaccines and working toward a universal vaccine – Mridu Acharya - Juvenile Idiopathic Arthritis
Developing a mobile phone-based thermal imaging tool for assessing JIA in primary care and family practice – Yongdong (Dan) Zhao - Lupus – B-Cell Integrins
Identifying targets to modify B cell activation during autoimmunity – Mridu Acharya - Lupus – B-Cell Targets
Using novel mouse models to study the signals and pathways of systemic autoimmune diseases – Shaun Jackson - Malaria – Host-Pathogen Interactions
Host-based drug discovery for infectious diseases – Alexis Kaushansky - Malaria – Human Immune Response
Defining immune responses to advance development of anti malaria vaccines – Ken Stuart - Malaria – Insect Dissection Tool
Streamlining insect handling for faster workflow, higher throughput, and more uniform samples – Alexis Kaushansky - Malaria – Molecular Mechanisms
Using in vitro models and clinical cohorts to understand vascular aspects of disease and investigate interventions to restore vascular function – Joe Smith -
Malaria – Vaccines, Therapies, Drug Resistance
Improving prevention and therapy with better vaccines and predictions about drug resistance – Ashley Vaughan - Mitochondrial Disease
Using Ndufs4 mouse models to understand mTOR activation in Leigh Syndrome and other mitochondrial diseases – Margaret Sedensky and Philip Morgan - Mitochondrial Diseases – Identifying Therapies
Identifying pathways, targets, and new interventions for treating childhood mitochondrial disorders and related seizures – Simon Johnson - MRSA Infections
Identification of kinase inhibitors that increase the Beta-lactam sensitivity of MRSA – Lakshmi Rajagopal - Neural Development and Neurodegeneration
Applying in vivo proteomics and genetic approaches to study pathways in nervous system development and neurodegenerative disease – Brock Grill - Nontuberculous Mycobacterial Diseases – Drug Discovery
Discovering targets and screening small molecules to treat mycobacterial infections – Tanya Parish - Obesity
Testing novel pathways for obesity drugs – Christian Roth - Opioid Sensitivity and Tolerance
Using a scalable C. elegans behavioral screening platform to identify druggable candidates for modulating μ-opioid receptor sensitivity and tolerance – Brock Grill - Optimizing CAR T Cells at the Level of Receptor Signaling
Determining responsiveness and safety using a multiplex quantitative protein-protein interaction platform – Stephen Smith - Organ Development
Using genomics, genetics, and mouse models to identify disease mechanisms and novel therapeutic targets – David Beier - Peroxisomal Disorders
Applying a systems approach to the molecular mechanisms of rare diseases – John Aitchison - Respiratory Distress Syndrome in Neonates – Improving Lung Surfactant Therapy
Developing animal and 3D models and novel surfactant aerosols to improve respiratory therapy – Robert DiBlasi - Retinal Disorders
Using high-throughput chromatin immunoprecipitation sequencing (ChIP-Seq) to understand retinal development – Timothy Cherry - Rheumatic Diseases
Research network to study chronic recurrent multifocal osteomyelitis (CRMO) and other childhood rheumatic diseases – Yongdong (Dan) Zhao - Sleep Apnea
Developing improved diagnostics and treatments for pediatric sleep apnea patients – Maida Chen - Stroke
Understanding the genetic causes and treatment options of pediatric stroke patients and developing improved prognostic biomarkers – Catherine Amlie-Lefond - Stroke – Neurovascular Imaging
Using two-photon microscopy and other methods to study neurovascular structure and function, including response to injury, disease, and drugs – Andy Shih - Trypanosomal Diseases
Identifying novel drug targets for sleeping sickness, Chagas disease, and leishmaniasis – Ken Stuart - Tuberculosis
Designing vaccines and therapies with a novel mouse model – Kevin Urdahl - Tuberculosis – Drug Discovery
Identifying and optimizing candidate compounds using a high-throughput multiassay platform – Tanya Parish - Tuberculosis and Antimicrobial-Resistance
Adapting a single-cell growth assay for infectious disease agents – John Aitchison - Vascular and Lymphatic Malformations – Genotyping and Treatment
Applying cell-free DNA testing to precision diagnosis and personalized medicine for congenital disorders – Jonathan Perkins - Vascular Malformations and Other Birth Defects – Precision Diagnostics
Mosaicism’s contribution to disease leads to new diagnostic tools – James Bennett - Viral Diseases – Improving RNA-Seq
Increasing fidelity of long-read RNA sequencing with novel template preparation chemistries – Bruce Torbett - Wilson Disease and Other Lysosomal Storage Diseases – Newborn Screening
A new method uses dried blood samples to detect lysosomal storage diseases, primary immunodeficiencies and Wilson disease – Sihoun Hahn
Educational Products and Digital Health
- Activity and Fitness
Combining wearable fitness tracking with intervention programs aimed to increase daily physical activity of children – Jason Mendoza - ADHD
Treatments for attention deficit hyperactivity disorder (ADHD) and related problems through personalized medicine and improved diagnosis – Mark Stein - Adolescent-Focused Digital Health Interventions
Developing improved electronic health assessment tools to encourage self-reported health tracking and personalized care for adolescent patients – Cari McCarty and Laura Richardson - Chronic Pain
Using technology to treat chronic pain in children and adolescents – Tonya Palermo - Inflammatory Bowel Disease
Effect of dietary modifications on disease activity – David Suskind -
Cancer – Psychosocial Biomarkers
Using biosensors and other digital health technology to link stress biomarkers with immune system changes and medical outcomes – Molly Taylor