Our Labs

Beier Lab

The Beier Lab studies organ development and repair using genetic and genomic analysis of model systems and human birth defect syndromes.

Related topics: Congenital developmental defects, genetic kidney disease

Bennett Lab

The Bennett lab at Seattle Children’s Research Institute investigates the contribution of post-zygotic mutations on human development and birth defects, with a focus on vascular malformations. We also study the impact of rapid diagnostic genomic sequencing in management of children in intensive care units.

Cherry Lab

The Cherry Lab investigates how the visual system develops, and how genetic variations contribute to blindness and other visual disorders.

Hing Studies

Dr. Anne V. Hing investigates the genetic causes of craniofacial disorders and specializes in recruiting patients for studies.

Maga Lab

The Maga lab investigates fetal alcohol syndrome and the mechanisms responsible for human malformations, specifically craniofacial disorders.

Majesky Lab

We use molecular biological and developmental genetic approaches to address fundamental questions in development and differentiation of blood vessels. Current projects use both mouse and avian models. One major research focus is on vascular stem and progenitor cells that reside in the adventitial layer of artery wall.

Maves Lab

The Maves lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new treatments for muscular dystrophy and heart disorders.

McCarthy Lab

The McCarthy Lab is focused on understanding epigenetic mechanisms regulating cell identity during development, and applying these discoveries to cell reprogramming with the goal of developing liver cell therapies for transplantation.

Nguyen Lab

In the Nguyen Lab, we investigate the genetic and epigenetic changes occurring after kidney injury.

Nigam Lab

The Nigam Lab aims to improve the care of young cardiac patients by discovering innovative solutions for hypoplastic left heart syndrome; improving outcomes for children undergoing cardiac surgery with cardiopulmonary bypass and mechanical circulatory support; and inventing new tools that make cardiac surgery safer.

Paquette Lab

Pregnancy is a transient but highly important time that shapes health throughout the lifespan. This concept is known as the Developmental Origins of Health and Disease (DOHAD) paradigm. The prenatal environment is influenced by a complex interplay of genetic, environmental and maternal factors. The placenta is a crucial mediator of the in-utero environment, and perturbations to placental function may influence fetal growth and development. Our long-term goal is to gain insight into the underlying molecular mechanisms linking the in-utero environment and birth outcomes by applying innovative network biology approaches and multi-omic data analyses within the placenta.

Shih Lab

The Shih Lab uses advanced optical imaging to study neurovascular function in the living brain. Our goal is to better understand how blood flows through the brain by watching and learning from model organisms. This can provide clues on the development and repair of key vascular functions, such as the blood-brain barrier, which may one day help protect blood vessels in the aging and diseased brain.

Yu Lab

Dr. Kai Yu’s lab studies how craniofacial malformations occur, opening the door to new ways to diagnose, prevent and treat them.