Jay F. Sarthy, MD, PhD

Jay F. Sarthy, MD, PhD

Cancer and Blood Disorders Center, Pediatric Blood and Marrow Transplant Program

On staff since December 2017

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  • Publications

    Other Publications

    • Chew GL, Bleakley M, Bradley RK, Malik HS, Henikoff S, Molaro A, Sarthy J
      Short H2A histone variants are expressed in cancer.
      33473122 Nature communications, 2021 Jan. 20 : 12(1)490 PMCID:PMC7817690
    • Chew GL, Bleakley M, Bradley RK, Malik HS, Henikoff S, Molaro A, Sarthy J
      Short H2A histone variants are expressed in cancer.
      33473122 Nature communications, 2021 Jan. 20 : 12(1)490 PMCID:PMC7817690
    • Chew GL, Bleakley M, Bradley RK, Malik HS, Henikoff S, Molaro A, Sarthy J
      Short H2A histone variants are expressed in cancer.
      33473122 Nature communications, 2021 Jan. 20 : 12(1)490 PMCID:PMC7817690
    • Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM
      Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
      33130903 Neuro-oncology, 2020 Nov. 1
    • Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM
      Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
      33130903 Neuro-oncology, 2020 Nov. 1
    • Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM
      Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
      33130903 Neuro-oncology, 2020 Nov. 1
    • Sarthy JF, Meers MP, Janssens DH, Henikoff JG, Feldman H, Paddison PJ, Lockwood CM, Vitanza NA, Olson JM, Ahmad K, Henikoff S
      Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones.
      32902381 eLife, 2020 Sept. 9 : 9 PMCID:PMC7518889
    • Sarthy JF, Meers MP, Janssens DH, Henikoff JG, Feldman H, Paddison PJ, Lockwood CM, Vitanza NA, Olson JM, Ahmad K, Henikoff S
      Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones.
      32902381 eLife, 2020 Sept. 9 : 9 PMCID:PMC7518889
    • Sarthy JF, Meers MP, Janssens DH, Henikoff JG, Feldman H, Paddison PJ, Lockwood CM, Vitanza NA, Olson JM, Ahmad K, Henikoff S
      Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones.
      32902381 eLife, 2020 Sept. 9 : 9 PMCID:PMC7518889
    • Vitanza NA, Khalatbari H, Ermoian R, Sarthy J, Lockwood CM, Cole BL, Leary SES
      Molecularly Targeted Treatments for NF1-Mutant Diffuse Intrinsic Pontine Glioma.
      32862234 The journal of applied laboratory medicine, 2020 Aug. 30
    • Vitanza NA, Khalatbari H, Ermoian R, Sarthy J, Lockwood CM, Cole BL, Leary SES
      Molecularly Targeted Treatments for NF1-Mutant Diffuse Intrinsic Pontine Glioma.
      32862234 The journal of applied laboratory medicine, 2020 Aug. 30
    • Vitanza NA, Khalatbari H, Ermoian R, Sarthy J, Lockwood CM, Cole BL, Leary SES
      Molecularly Targeted Treatments for NF1-Mutant Diffuse Intrinsic Pontine Glioma.
      32862234 The journal of applied laboratory medicine, 2020 Aug. 30
    • Woerner A, Shin DS, Chick JFB, Smith CA, Sarthy JF, Monroe EJ
      Endolymphatic exclusion for the treatment of pediatric chylous ascites secondary to neuroblastoma resection: report of two cases.
      32461775 Radiology case reports, 2020 July : 15(7)1044-1049 PMCID:PMC7240057
    • Woerner A, Shin DS, Chick JFB, Smith CA, Sarthy JF, Monroe EJ
      Endolymphatic exclusion for the treatment of pediatric chylous ascites secondary to neuroblastoma resection: report of two cases.
      32461775 Radiology case reports, 2020 July : 15(7)1044-1049 PMCID:PMC7240057
    • Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, Zhou X, Jeon J, Griffiths L, Nguyen R, Norrie J, Easton J, Mulder H, Yergeau D, Liu Y, Wu J, Van Ryn C, Naranjo A, Hogarty MD, KamiÅ„ski MM, Valentine M, Pruett-Miller SM, Pappo A, Zhang J, Clay MR, Bahrami A, Vogel P, Lee S, Shelat A, Sarthy JF, Meers MP, George RE, Mardis ER, Wilson RK, Henikoff S, Downing JR, Dyer MA
      MYCN amplification and ATRX mutations are incompatible in neuroblastoma.
      32060267 Nature communications, 2020 Feb. 14 : 11(1)913 PMCID:PMC7021759
    • Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, Zhou X, Jeon J, Griffiths L, Nguyen R, Norrie J, Easton J, Mulder H, Yergeau D, Liu Y, Wu J, Van Ryn C, Naranjo A, Hogarty MD, KamiÅ„ski MM, Valentine M, Pruett-Miller SM, Pappo A, Zhang J, Clay MR, Bahrami A, Vogel P, Lee S, Shelat A, Sarthy JF, Meers MP, George RE, Mardis ER, Wilson RK, Henikoff S, Downing JR, Dyer MA
      MYCN amplification and ATRX mutations are incompatible in neuroblastoma.
      32060267 Nature communications, 2020 Feb. 14 : 11(1)913 PMCID:PMC7021759
    • Sarthy JF, Henikoff S
      Bringing Oncohistones into the Fold.
      31575564 Cancer discovery, 2019 Oct. : 9(10)1346-1348
    • Sarthy JF, Henikoff S
      Bringing Oncohistones into the Fold.
      31575564 Cancer discovery, 2019 Oct. : 9(10)1346-1348
    • Sarthy JF, Henikoff S, Ahmad K
      Chromatin Bottlenecks in Cancer.
      30898265 Trends in cancer, 2019 March : 5(3)183-194
    • Sarthy JF, Henikoff S, Ahmad K
      Chromatin Bottlenecks in Cancer.
      30898265 Trends in cancer, 2019 March : 5(3)183-194
    • Steineck A, Krumm N, Sarthy JF, Pritchard CC, Chapman T, Stacey AW, Vitanza NA, Cole B
      Response to Pembrolizumab in a Patient With Xeroderma Pigmentosum and Advanced Squamous Cell Carcinoma.
      32923855 JCO precision oncology, 2019 : 3 PMCID:PMC7446378
    • Steineck A, Krumm N, Sarthy JF, Pritchard CC, Chapman T, Stacey AW, Vitanza NA, Cole B
      Response to Pembrolizumab in a Patient With Xeroderma Pigmentosum and Advanced Squamous Cell Carcinoma.
      32923855 JCO precision oncology, 2019 : 3 PMCID:PMC7446378
    • Steineck A, Krumm N, Sarthy JF, Pritchard CC, Chapman T, Stacey AW, Vitanza NA, Cole B
      Response to Pembrolizumab in a Patient With Xeroderma Pigmentosum and Advanced Squamous Cell Carcinoma.
      32923855 JCO precision oncology, 2019 : 3 PMCID:PMC7446378
    • Janssens DH, Wu SJ, Sarthy JF, Meers MP, Myers CH, Olson JM, Ahmad K, Henikoff S
      Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs.
      30577869 Epigenetics & chromatin, 2018 Dec. 21 : 11(1)74 PMCID:PMC6302505
    • Janssens DH, Wu SJ, Sarthy JF, Meers MP, Myers CH, Olson JM, Ahmad K, Henikoff S
      Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs.
      30577869 Epigenetics & chromatin, 2018 Dec. 21 : 11(1)74 PMCID:PMC6302505
    • Tedesco KT, Sarthy J, Pinto N, Boos MD
      Acute enlargement of a vascular plaque and gait changes in a young girl.
      30487229 BMJ (Clinical research ed.), 2018 Nov. 28 : 363k4679
    • Tedesco KT, Sarthy J, Pinto N, Boos MD
      Acute enlargement of a vascular plaque and gait changes in a young girl.
      30487229 BMJ (Clinical research ed.), 2018 Nov. 28 : 363k4679
    • Sarthy J, Zha J, Babushok D, Shenoy A, Fan JM, Wertheim G, Himebauch A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS
      Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype.
      29365320 Blood advances, 2018 Jan. 23 : 2(2)120-125 PMCID:PMC5787871
    • Sarthy J, Zha J, Babushok D, Shenoy A, Fan JM, Wertheim G, Himebauch A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS
      Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype.
      29365320 Blood advances, 2018 Jan. 23 : 2(2)120-125 PMCID:PMC5787871
    • Sarthy JF, Reddivalla N, Radhi M, Chastain K
      Pediatric 8p11 eosinophilic myeloproliferative syndrome (EMS): A case report and review of the literature.
      27808462 Pediatric blood & cancer, 2017 May : 64(5)
    • Sarthy JF, Reddivalla N, Radhi M, Chastain K
      Pediatric 8p11 eosinophilic myeloproliferative syndrome (EMS): A case report and review of the literature.
      27808462 Pediatric blood & cancer, 2017 May : 64(5)
    • Sarthy J, DiBardino D
      Pyogenic liver abscess caused by Streptococcus mitis.
      23969218 The Lancet. Infectious diseases, 2013 Sept. : 13(9)822
    • Sarthy J, DiBardino D
      Pyogenic liver abscess caused by Streptococcus mitis.
      23969218 The Lancet. Infectious diseases, 2013 Sept. : 13(9)822
    • Sarthy JF, Baumann P
      Apollo-taking the lead in telomere protection.
      20797622 Molecular cell, 2010 Aug. 27 : 39(4)489-91
    • Sarthy JF, Baumann P
      Apollo-taking the lead in telomere protection.
      20797622 Molecular cell, 2010 Aug. 27 : 39(4)489-91
    • Sarthy J, Bae NS, Scrafford J, Baumann P
      Human RAP1 inhibits non-homologous end joining at telomeres.
      19763083 The EMBO journal, 2009 Nov. 4 : 28(21)3390-9 PMCID:PMC2776107
    • Sarthy J, Bae NS, Scrafford J, Baumann P
      Human RAP1 inhibits non-homologous end joining at telomeres.
      19763083 The EMBO journal, 2009 Nov. 4 : 28(21)3390-9 PMCID:PMC2776107
    • Sarthy J, Gamblin TC
      A light scattering assay for arachidonic acid-induced tau fibrillization without interfering micellization.
      16620751 Analytical biochemistry, 2006 June 1 : 353(1)150-2
    • Sarthy J, Gamblin TC
      A light scattering assay for arachidonic acid-induced tau fibrillization without interfering micellization.
      16620751 Analytical biochemistry, 2006 June 1 : 353(1)150-2
    • Shieh CC, Trumbull JD, Sarthy JF, McKenna DG, Parihar AS, Zhang XF, Faltynek CR, Gopalakrishnan M
      Automated Parallel Oocyte Electrophysiology Test station (POETs): a screening platform for identification of ligand-gated ion channel modulators.
      15090238 Assay and drug development technologies, 2003 Oct. : 1(5)655-63

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Overview

Board Certification(s)

Pediatrics

Medical/Professional School

Northwestern University School of Medicine, Chicago
University of Kansas, Lawrence

Residency

Pediatrics, Children's Mercy Hospital, Kansas City

Fellowship

Pediatric Hematology Oncology, University of Washington School of Medicine, Seattle

Clinical Interests

Hematopoietic Stem Cell Transplantation