Current Research Studies

Sepsis – Pragmatic Pediatric Trial of Balanced vs NormaL Saline Fluid in Sepsis (PRoMPT BOLUS)

Condition or Therapy:

septic shock


Emergency Department

What is the goal of this study?

Sepsis is a severe infection that requires emergency treatment with IV fluids and antibiotics. This phase 3 study will determine which of two commonly used intravenous fluids is most effective to treat children with sepsis

Who can join the study?

This study may be a good fit for children who:

  • Are between the ages of 6 months and 18 years
  • Are suspected to have sepsis by their medical team in the Emergency Department

What will happen if my child takes part in this study?

Half of the study participants will be randomly selected to receive Normal Saline and the other half will be randomly selected to receive Balanced Fluids. All other tests and medications will be given according to normal routines in the hospital. Any fluid that a patient needs will be given as study fluid during the first one to two days in the hospital. Study team members will follow patients to see which fluid type worked the best.

Who can I contact for more information?

To learn more, call 206-987-2939 or email the study team.

Study Location(s):

Seattle Children's Main Hospital Campus

Principal Investigator:

Dr. Neil Uspal
Research Center: Center for Clinical and Translational Research