Skip to navigation menu Skip to content
High Priority Alert

We are experiencing extremely high demand in our Emergency Department. Learn more.

High Priority Alert

Masking and Visitation Changes: Due to high rates of respiratory illnesses in our community, we’ve made changes to our masking and visitation guidelines. Learn more.

CAR T Cell Trafficking Into Gliomas

An illustraion of CAR T cell trafficking into gliomasThis project develops an advanced mouse model of chimeric antigen receptor (CAR) T cell cancer immunotherapy for malignant brain tumors, which has been challenging in the clinical setting because of limited ability of the CAR T cells to travel to the tumors and survive in the hostile microenvironment.

We will use an immunocompetent transgenic mouse model to induce brain-intrinsic tumors via viral delivery of oncogenes into brain progenitor cells, and image the tumor growth and CAR T cell infiltration into the tumor using two-photon microscopy via a cranial window.

This model enables us to study of molecular mechanisms of CAR T cell targeting against brain tumors by manipulating T cell guidance cues, T cell signal recognition, and adhesion molecule activation.

By clicking “Accept All Cookies,” you agree to the storing of cookies on your device to enhance site navigation, analyze site usage and assist in marketing efforts. For more information, see Website Privacy.

Accept All Cookies