Finding factors important for differentiation of antibody-secreting cells will help us engineer a B cell therapy for protein replacement or treat antibody-mediated disease.
We are building low- and high-throughput assays to study the function of variants in B cells to help improve the diagnosis and treatment of immunological disease.
Our Methods
We use quantitative proteomics, gene editing, next generation sequencing, flow cytometry, murine modeling, and computational approaches to accomplish our experimental goals.
