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Projects

B Cell Biology and Engineering

Finding factors important for differentiation of antibody-secreting cells will help us engineer a B cell therapy for protein replacement or treat antibody-mediated disease.

Lymphoma

The goal of the lymphoma group is to identify drugs that can be combined with existing therapies to prevent or mitigate drug resistance.

Functional Interpretation of Variants in Immune Genes

We are building low- and high-throughput assays to study the function of variants in B cells to help improve the diagnosis and treatment of immunological disease.

Our Methods

We use quantitative proteomics, gene editing, next generation sequencing, flow cytometry, murine modeling, and computational approaches to accomplish our experimental goals.

Contact

Richard James

For questions or inquiries: 206-884-3290

Address

James Lab
1920 Terry Ave.
Seattle, WA 98101

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.