Jackson Lab
The Jackson Lab studies the immune mechanisms underlying the development of system autoimmune diseases, focusing in particular on the role of B cells in systemic lupus erythematosus (SLE). The lab uses various chimeric and genetic knock-in murine strains to model the biology of human autoimmune diseases.
Partnership Opportunities
Shaun W Jackson, MD, PhD
Dr. Jackson’s research aims to improve our understanding of the immune pathogenesis of human autoimmune diseases, in particular the role for B cells in Systemic Lupus Erythematosus (SLE). His research has resulted in a number of new insights into the B cell-intrinsic signals underlying lupus pathogenesis and has lent support to an emerging paradigm of humoral autoimmunity in which B cells orchestrate initial breaks in immune tolerance.
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Shari Cho
Research Scientist II
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Heidi Creed
Postdoctoral Researcher
Heidi is a postdoctoral fellow who brings a strong background in kidney physiology, lymphatics, immunology, and bioinformatics to the lab. She utilizes advanced techniques such as high-parameter flow cytometry, single-cell RNA sequencing, and spatial transcriptomics to deeply characterize renal physiology and function in the context of lupus nephritis. Heidi's research is driven by the long-term goal of intersecting the fields of big data, immunology, and kidney physiology, to identify novel mechanisms of disease and pinpoint novel therapeutic options. This work will provide the foundation for more targeted and successful treatments, significantly impacting patient care.
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Nicholas Hasle, MD, PhD
Pediatric Rheumatology Fellow