Jackson Lab
The Jackson Lab studies the immune mechanisms underlying the development of system autoimmune diseases, focusing in particular on the role of B cells in systemic lupus erythematosus (SLE). The lab uses various chimeric and genetic knock-in murine strains to model the biology of human autoimmune diseases.
Partnership Opportunities
Shaun W Jackson, MD, PhD
Dr. Jackson’s research aims to improve our understanding of the immune pathogenesis of human autoimmune diseases, in particular the role for B cells in Systemic Lupus Erythematosus (SLE). His research has resulted in a number of new insights into the B cell-intrinsic signals underlying lupus pathogenesis and has lent support to an emerging paradigm of humoral autoimmunity in which B cells orchestrate initial breaks in immune tolerance.
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Shari Cho
Research Scientist II
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Heidi Creed
Postdoctoral Researcher
Heidi is a postdoctoral fellow who brings a strong background in kidney physiology, lymphatics, immunology, and bioinformatics to the lab. She utilizes advanced techniques such as high-parameter flow cytometry, single-cell RNA sequencing, and spatial transcriptomics to deeply characterize renal physiology and function in the context of lupus nephritis. Heidi's research is driven by the long-term goal of intersecting the fields of big data, immunology, and kidney physiology, to identify novel mechanisms of disease and pinpoint novel therapeutic options. This work will provide the foundation for more targeted and successful treatments, significantly impacting patient care.
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Nicholas Hasle, MD, PhD
Pediatric Rheumatology Fellow
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Emily Mather
Research Student
Emily is a medical student at the Oakland University William Beaumont School of Medicine. Her interest in immunologic conditions stems from her previous experience in immunology research, her family's history of severe allergies, and her clinical experiences with patients affected by autoimmune and immunodeficiency disorders. Her current focus is gaining exposure to current research in immunotherapy development, with the goal of contributing to future clinical advances.
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Neelakshi Mungra, PhD
Postdoctoral Researcher
In her research, Neelakshi Mungra, PhD, focuses on the engineering of affordable cutting-edge antibody and cell-based technologies that can be used in the depletion of specific B-cell subpopulations that are involved in life-threatening autoimmune disorders such as systemic lupus erythematosus (SLE).