Shaun W. Jackson, MB ChB, PhD

Nephrology, Rheumatology

On staff since July 2012

Academic Title: Associate Professor

Research Center: Center for Immunity and Immunotherapies

"My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis."

  • Shaun Jackson, MD, PhD, is an attending physician in Pediatric Nephrology and Pediatric Rheumatology at Seattle Children's Hospital and an Associate Professor of Pediatrics of Pediatrics at the University of Washington School of Medicine. After receiving his medical degree from the University of Cape Town in South Africa, he undertook post-doctoral studies in vascular biology at Harvard Medical School and completed pediatric residency training at Boston Children's Hospital. He completed dual pediatric nephrology and rheumatology fellowship training at Seattle Children's Hospital / University of Washington.

    Dr. Jackson’s research aims to improve our understanding of the immune pathogenesis of human autoimmune diseases, in particular the role for B cells in Systemic Lupus Erythematosus (SLE). His research has resulted in a number of new insights into the B cell-intrinsic signals underlying lupus pathogenesis and has lent support to an emerging paradigm of humoral autoimmunity in which B cells orchestrate initial breaks in immune tolerance.

    • will Yakima, Wa 08.29.12

      Dr. Jackson has been instrumental in our daughter recovey and maintenance of her illness. He is personable and does a thorough job on making sure our questions are answered and we understand all the medical jargon and research. Lastly, he is a friendly and compassionate person.

  • Award Name Award Description Awarded By Award Date
    Trainee/Young Investigator Top Abstract award American Society of Nephrology (ASN) Annual Kidney Week. Nov. 2015
    Postdoctoral fellow poster prize University of Washington Immunology department annual retreat 2013
    Outstanding Presentation Award Seattle Childrens Fellow and Resident Research Day April 2012
    Distinguished Fellow Award American College of Rheumatology (ACR) 2012
    Fellow teaching award Seattle Children's Hospital June 2009
    Best oral presentation, Young Investigator Award Session Asia Pacific Association for the Study of the Liver Feb. 2004
    University Gold Medal For the most distinguished student in the graduating MBChB class University of Cape Town Dec. 2001
  • Other Publications

    • Du SW, Arkatkar T, Al Qureshah F, Jacobs HM, Thouvenel CD, Chiang K, Largent AD, Li QZ, Hou B, Rawlings DJ, Jackson SW
      Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells.
      31636237 Journal of immunology (Baltimore, Md. : 1950), 2019 Dec. 1 : 203(11)2817-2826 PMCID:PMC6864310
    • Jackson SW, Davidson A
      BAFF inhibition in SLE-Is tolerance restored?
      31562657 Immunological reviews, 2019 Nov. : 292(1)102-119 PMCID:PMC6935406
    • Du SW, Arkatkar T, Jacobs HM, Rawlings DJ, Jackson SW
      Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression.
      30353919 European journal of immunology, 2019 Jan. : 49(1)170-178 PMCID:PMC6779321
    • Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ
      The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.
      30740104 Frontiers in immunology, 2019 : 1044 PMCID:PMC6355696
    • Du SW, Jacobs HM, Arkatkar T, Rawlings DJ, Jackson SW
      Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells.
      30373855 Journal of immunology (Baltimore, Md. : 1950), 2018 Dec. 1 : 201(11)3258-3268 PMCID:PMC6779322
    • Hale M, Rawlings DJ, Jackson SW
      The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy.
      30390507 Current opinion in immunology, 2018 Dec. : 5581-88 PMCID:PMC6289281
    • Arkatkar T, Jacobs HM, Du SW, Li QZ, Hudkins KL, Alpers CE, Rawlings DJ, Jackson SW
      TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.
      29907458 Kidney international, 2018 Oct. : 94(4)728-740 PMCID:PMC6151274
    • Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, Stuart LM, Orr MT, Rawlings DJ, Jackson SW, Lacy-Hulbert A, Acharya M
      αv Integrins regulate germinal center B cell responses through noncanonical autophagy.
      29999501 The Journal of clinical investigation, 2018 Aug. 31 : 128(9)4163-4178 PMCID:PMC6118577
    • Hung KL, Meitlis I, Hale M, Chen CY, Singh S, Jackson SW, Miao CH, Khan IF, Rawlings DJ, James RG
      Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.
      29273498 Molecular therapy : the journal of the American Society of Gene Therapy, 2018 Feb. 7 : 26(2)456-467 PMCID:PMC5835153
    • Arkatkar T, Du SW, Jacobs HM, Dam EM, Hou B, Buckner JH, Rawlings DJ, Jackson SW
      B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity.
      28899868 The Journal of experimental medicine, 2017 Nov. 6 : 214(11)3207-3217 PMCID:PMC5679179
    • Singh AK, Eken A, Hagin D, Komal K, Bhise G, Shaji A, Arkatkar T, Jackson SW, Bettelli E, Torgerson TR, Oukka M
      DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling.
      28978795 JCI insight, 2017 Oct. 5 : 2(19) PMCID:PMC5841873
    • Rawlings DJ, Metzler G, Wray-Dutra M, Jackson SW
      Altered B cell signalling in autoimmunity.
      28393923 Nature reviews. Immunology, 2017 July : 17(7)421-436 PMCID:PMC5523822
    • Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ
      Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.
      28345004 Molecular therapy. Methods & clinical development, 2017 March 17 : 4192-203 PMCID:PMC5363294
    • Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ
      Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
      27837104 Journal of immunology (Baltimore, Md. : 1950), 2016 Dec. 15 : 197(12)4529-4534 PMCID:PMC5147509
    • Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ
      B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.
      27069113 The Journal of experimental medicine, 2016 May 2 : 213(5)733-50 PMCID:PMC4854732
    • Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW
      Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.
      27022196 Journal of immunology (Baltimore, Md. : 1950), 2016 May 1 : 196(9)3525-31 PMCID:PMC4868625
    • Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ, Jackson SW
      B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.
      26256668 European journal of immunology, 2015 Oct. : 45(10)2773-9 PMCID:PMC4679197
    • Jackson SW, Kolhatkar NS, Rawlings DJ
      B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production.
      25679954 Current opinion in immunology, 2015 Feb. 10 : 33C70-77
    • Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ
      Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.
      24711620 Journal of immunology (Baltimore, Md. : 1950), 2014 May 15 : 192(10)4525-32 PMCID:PMC4041708
    • Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ
      Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
      23563688 Nature immunology, 2013 May : 14(5)514-22 PMCID:PMC3631452
    • Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ
      A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
      23619366 The Journal of clinical investigation, 2013 May : 123(5)2024-36 PMCID:PMC3638909
    • Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A
      Integration of B cell responses through Toll-like receptors and antigen receptors.
      22421786 Nature reviews. Immunology, 2012 March 16 : 12(4)282-94 PMCID:PMC3437941
    • Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A
      Integration of B cell responses through Toll-like receptors and antigen receptors.
      22421786 Nature reviews. Immunology, 2012 March 16 : 12(4)282-94
    • Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL
      Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
      22291190 Journal of immunology (Baltimore, Md. : 1950), 2012 March 1 : 188(5)2065-9 PMCID:PMC3288200
    • Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
      WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
      21875954 The Journal of experimental medicine, 2011 Sept. 26 : 208(10)2033-42 PMCID:PMC3182055
    • Jackson SW
      Hypernatremia, Hyponatremia, Hyperkalemia, Hypokalemia, Renal Tubular Acidosis
      POCKET PEDIATRICS, 2nd edition, 2009
    • Jackson SW, Hoshi T, Wu Y, Sun X, Enjyoji K, Cszimadia E, Sundberg C, Robson SC
      Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice.
      17823293 The American journal of pathology, 2007 Oct. : 171(4)1395-404 PMCID:PMC1988887
    • Kittel A, Csapo ZS, Csizmadia E, Jackson SW, Robson SC.
      Co-localization of P2Y1 Receptor and NTPDase1/CD39 within Caveolae in Human Placenta.
      Eur J Histochem

  • Presentations Title Event Location Date
    B Cell-Intrinsic Interferon Gamma Signals Promote the Development of Systemic Lupus Erythematosus By Enhancing the Formation of Spontaneous Autoimmune Germinal Centers American College of Rheumatology (ACR) annual meeting San Francisco, CA Nov. 2015
    B Cell-Intrinsic Interferon Gamma (IFN-) Signals Promote B Cell Activation and the Development of Lupus Nephritis American Society of Nephrology (ASN) Kidney Week San Diego, CA Nov. 2015
    The B Cell Survival Cytokine BAFF Promotes Systemic Lupus Erythematosus Via Activation of TACI, Not BAFF Receptor American College of Rheumatology (ACR) annual meeting San Francisco, CA Nov. 2015
    The B Cell Survival Cytokine BAFF Promotes Murine Lupus Nephritis via Activation of TACI, Not BAFF Receptor. American Society of Nephrology (ASN) Kidney Week San Diego, CA Nov. 2015
    B Cell-Intrinsic Deletion of the Type 1 Interferon Receptor Does Not Impact the Development of Murine Lupus. American College of Rheumatology (ACR) annual meeting Boston, MA Nov. 2014
    Opposing impact of B cell intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. Pediatric Academic Societies (PAS) Vancouver, BC, CA May 2014
    Trypanosoma cruzi trans-sialidase initiates an ROR-t independent program leading to high-level IL-17 production by activated B cells. Keystone Symposium, "B Cell Development and Function". Keystone, CO Feb. 2013
    Marginal zone defects in Wiskott-Aldrich syndrome are dependent on B cell intrinsic TLR signals. Federation of Clinical Immunology Societies meeting (FOCIS 2012) Vancouver, BC June 2012
    Renal transplantation from a donor with undiagnosed Class V lupus nephritis demonstrates prolonged histopathologic features of lupus nephritis despite absence of SLE in recipients. Pediatric Rheumatology Symposium (PRSyM) Miami, FL June 2011
    Decreased activity of endothelial V3 integrin in the Cd39-null mouse is associated with defective tumor angiogenesis. 4th International Symposium of Nucleosides and Nucleotides.Purines 2004 Chapel Hill, NC 2004
    Disordered Liver Regeneration and Defective Angiogenesis in NTPDase1/Cd39-Null Mice. Young Investigator Award Session. Asia Pacific Association for the Study of the Liver Delhi, India 2004
  • Grant Title Grantor Amount Award Date
    B cell costimulatory signals in the pathogenesis of SLE NIH/NIAMS $325,838/year Aug. 1, 2019 - June 30, 2024
    B cell-intrinsic roles for STAT1 gain-of-function mutations in humoral autoimmunity NIH/NIAID $50,000/year June 13, 2018 - May 31, 2020
    Mechanisms underlying TACI-dependent activation of immature transitional B cells in BAFF-driven humoral autoimmunity NIH/NIAID $125,000/year Aug. 1, 2017 - July 31, 2020
    Co-Stimulatory Signals in Spontaneous Autoimmune Germinal Centers in SLE Bristol Myers Squibb $200,000 July 18, 2017 - July 17, 2022
    B cell-intrinsic cytokine regulation of spontaneous germinal center formation in SLE Lupus Research Alliance, Novel Research Grant $100,000 March 1, 2017 - Feb. 28, 2020
    Cytokine regulation of autoreactive B cell activation in SLE American College of Rheumatology (ACR), Rheumatology Research Foundation: Award: K Suppliment Career Development Bridge Funding $50,000/year Sept. 15, 2016 - Sept. 14, 2019
    Contribution of transitional B cells to the pathogenesis of systemic lupus erythematosus Arthritis National Research Foundation (ANRF) Grant $100,000 June 1, 2016 - May 31, 2018
    Contribution of transitional B cells to the pathogenesis of systemic lupus erythematosus Arthritis National Research Foundation (ANRF) Grant $100,000 June 1, 2016 - May 31, 2018
    Pediatric Early Research Career (PERC) award Seattle Children's Research Institute $150,000 July 1, 2015 - Sept. 30, 2016
    B cell-intrinsic cytokine regulation and B cell-targeted therapies in murine lupus NIH/NIAID 189,324 July 1, 2014 - June 30, 2019
    Mentored Clinical Scientist Research Career Development Award (K08) NIH/NIAID $177,250/year July 1, 2014 - June 30, 2019
    Protective and pathogenic B cell functions in murine atherosclerosis University of Washington Child Health Research Center $85,000 July 1, 2012 - June 30, 2013
    B cell mediated atherosclerosis in autoimmune disease American College of Rheumatology (ACR), Rheumatology Research Foundation: Scientist Development Award $50,000 - $75,000/year July 1, 2012 - June 30, 2014
    University of Washington, Department of Rheumatology, Institutional training grant NIH/NIAMS July 1, 2010 - June 30, 2012

Overview

Board Certification(s)

Pediatric Rheumatology
Pediatric Nephrology

Medical/Professional School

University of Cape Town, Rodebosch, Cape Town

Residency

Pediatrics, Boston Children's Hospital, Boston

Fellowship

Nephrology, University of Washington, Seattle
Rheumatology, University of Washington, Seattle

Clinical Interests

My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis.

Research Description

My research interests in the laboratory relate to basic cellular mechanisms that underlie B cell mediated autoimmunity. In particular, we study the why B cells break tolerance and develop reactivity to self in systemic autoimmune disease, for example in systemic lupus erythematosus (SLE). In addition, as accelerated cardiovascular disease is a major cause of morbidity in patients with autoimmune diseases, including SLE and rheumatoid arthritis, we are studying the B cells mechanisms responsible for accelerated atherosclerosis in autoimmune settings.