Smith Lab

Selected Publications

Listed below is a selection of recent publications from the Smith Lab.

See full list on PubMed

Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral MalariaKessler A, Dankwa S, Bernabeu M, Harawa V, Danziger SA, Duffy F, Kampondeni SD, Potchen MJ, Dambrauskas N, Vigdorovich V, Oliver BG, Hochman SE, Mowrey WB, MacCormick IJC, Mandala WL, Rogerson SJ, Sather DN, Aitchison JD, Taylor TE, Seydel KB, Smith JD, Kim K. Cell Host Microbe. 2017 Nov 8;22(5):601-614.e5.

EPCR and malaria severity: the center of a perfect stormBernabeu M, Smith JD. Trends Parasitol. 2017 Apr;33(4):295-308. 

Pathogenicity determinants of the human malaria parasite Plasmodium falciparum have ancient originsBrazier AJ, Avril M, Bernabeu M, Benjamin M, Smith JD. mSphere. 2017 Jan 11;2(1). pii: e00348-16. 

Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern IndiaChery L, Maki JN, Mascarenhas A … Bernabeu M, …Smith JD, et al. Demographic and clinical profiles of Malar J. 2016 Nov 25;15(1):569. 

Thrombin cleavage of Plasmodium falciparum erythrocyte membrane protein 1 inhibits cytoadherenceGillrie MR, Renaux B, Russell-Goldman E, Avril M, …, Smith JD, Ho M. MBio. 2016 Sep 13;7(5). pii: e01120-16

Interaction between endothelial protein C receptor and Intercellular adhesion molecule 1 to mediate binding of Plasmodium falciparum-infected erythrocytes to endothelial cellsAvril M, Bernabeu M, Benjamin M, Brazier AJ, Smith JD. MBio. 2016 Jul 12;7(4). pii: e00615-16.  

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomassBernabeu M, Danziger SA, Avril M, Vaz M, Babar PH, Brazier AJ, Herricks T, Maki JN, Pereira L, Mascarenhas A, Gomes E, Chery L, Aitchison JD, Rathod PK, Smith JDProc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3270-9.

Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: potential implications for malarial pathogenesisGillrie MR, Avril M, Brazier AJ, Davis SP, Stins MF, Smith JD, Ho M. Cell Microbiol. 2015 Dec;17(12):1883-99.

Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor. Sampath S, Brazier AJ, Avril M, Bernabeu M, Vigdorovic V, Mascarenhas A, Gomes E., Sather DN, Esmon CT, and Smith JD. Cell Microbiol. 2015 Dec;17:1868-82.

Severe malaria is associated with parasite binding to endothelial protein C receptorLouise Turner, Thomas Lavstsen, Sanne S. Berger,... Marion Avril,Joseph D. Smith, et al. Nature. 2013 Jun 27; 498(7455): 502–505.