Selected Publications
Listed below is a selection of recent publications from the Smith Lab.
Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria. Kessler A, Dankwa S, Bernabeu M, Harawa V, Danziger SA, Duffy F, Kampondeni SD, Potchen MJ, Dambrauskas N, Vigdorovich V, Oliver BG, Hochman SE, Mowrey WB, MacCormick IJC, Mandala WL, Rogerson SJ, Sather DN, Aitchison JD, Taylor TE, Seydel KB, Smith JD, Kim K. Cell Host Microbe. 2017 Nov 8;22(5):601-614.e5.
EPCR and malaria severity: the center of a perfect storm. Bernabeu M, Smith JD. Trends Parasitol. 2017 Apr;33(4):295-308.
Pathogenicity determinants of the human malaria parasite Plasmodium falciparum have ancient origins. Brazier AJ, Avril M, Bernabeu M, Benjamin M, Smith JD. mSphere. 2017 Jan 11;2(1). pii: e00348-16.
Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Chery L, Maki JN, Mascarenhas A … Bernabeu M, …Smith JD, et al. Demographic and clinical profiles of Malar J. 2016 Nov 25;15(1):569.
Thrombin cleavage of Plasmodium falciparum erythrocyte membrane protein 1 inhibits cytoadherence. Gillrie MR, Renaux B, Russell-Goldman E, Avril M, …, Smith JD, Ho M. MBio. 2016 Sep 13;7(5). pii: e01120-16
Interaction between endothelial protein C receptor and Intercellular adhesion molecule 1 to mediate binding of Plasmodium falciparum-infected erythrocytes to endothelial cells. Avril M, Bernabeu M, Benjamin M, Brazier AJ, Smith JD. MBio. 2016 Jul 12;7(4). pii: e00615-16.
Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass. Bernabeu M, Danziger SA, Avril M, Vaz M, Babar PH, Brazier AJ, Herricks T, Maki JN, Pereira L, Mascarenhas A, Gomes E, Chery L, Aitchison JD, Rathod PK, Smith JD. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3270-9.
Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: potential implications for malarial pathogenesis. Gillrie MR, Avril M, Brazier AJ, Davis SP, Stins MF, Smith JD, Ho M. Cell Microbiol. 2015 Dec;17(12):1883-99.
Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor. Sampath S, Brazier AJ, Avril M, Bernabeu M, Vigdorovic V, Mascarenhas A, Gomes E., Sather DN, Esmon CT, and Smith JD. Cell Microbiol. 2015 Dec;17:1868-82.
Severe malaria is associated with parasite binding to endothelial protein C receptor. Louise Turner, Thomas Lavstsen, Sanne S. Berger,... Marion Avril, … Joseph D. Smith, et al. Nature. 2013 Jun 27; 498(7455): 502–505.