Michael A Portman, MD

Michael A Portman, MD

Cardiology, Kawasaki Disease Clinic

On staff since October 1992

Academic Title: Professor, Pediatrics

Research Title: Director, Pediatric Cardiovascular Research

Research Center: Center for Integrative Brain Research

"Unlocking the secrets of heart disease in children both at the bench and at the bedside, and then developing new diagnostic and treatment approaches is most rewarding. In that way, my work extends not only to the children I personally treat but also to those cared for by other physicians."

  • Biography

    Michael A. Portman, MD, is director of research in the Division of Cardiology at Seattle Children’s Hospital and professor in the Department of Pediatrics at the University of Washington School of Medicine. He is attending physician at Seattle Children’s Heart Center and the Cardiology Clinic at Providence Everett Medical Center.

    Portman’s research activities include pharmacological clinical trials, basic science research projects focused on cardiac metabolism in animal models and mentoring future clinical researchers. He is an editorial board member of the American Journal of Physiology — Heart and Circulatory Physiology and co-investigator for a grant on cardiovascular research training.

    • Related Pages

    • Portman Research Group

      The Portman Research Group discovers ways to protect children’s hearts from damage related to surgery, and leads major research on Kawasaki disease.

  • Patient Testimonials

  • Publications

    Other Publications

    • Kajimoto M, O'Kelly Priddy CM, Ledee DR, Xu C, Isern N, Olson AK, Portman MA
      Extracorporeal membrane oxygenation promotes long chain fatty acid oxidation in the immature swine heart in vivo.
      23727393 Journal of molecular and cellular cardiology, 2013 Sept. : 62144-52
    • Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, Isern N, Portman MA
      C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.
      22828478 Journal of molecular and cellular cardiology, 2013 Feb. : 55156-64 PMCID:PMC3524362
    • Priddy CM, Kajimoto M, Ledee DR, Bouchard B, Isern N, Olson AK, Des Rosiers C, Portman MA
      Myocardial oxidative metabolism and protein synthesis during mechanical circulatory support by extracorporeal membrane oxygenation.
      23203964 American journal of physiology. Heart and circulatory physiology, 2013 Feb 1 : 304(3)H406-14
    • Portman MA
      Kawasaki disease and soy: potential role for isoflavone interaction with Fc receptors.
      23168576 Pediatric research, 2013 Feb. : 73(2)130-4
    • Priest JR, Slee A, Olson AK, Ledee D, Morrish F, Portman MA
      Triiodothyronine supplementation and cytokines during cardiopulmonary bypass in infants and children.
      22743177 The Journal of thoracic and cardiovascular surgery, 2012 Oct. : 144(4)938-943.e2
    • Priest JR, Girirajan S, Vu TH, Olson A, Eichler EE, Portman MA
      Rare copy number variants in isolated sporadic and syndromic atrioventricular septal defects.
      22529060 American journal of medical genetics. Part A, 2012 June : 158A(6)1279-84 PMCID:PMC3564951
    • Shrestha S, Wiener H, Shendre A, Kaslow RA, Wu J, Olson A, Bowles NE, Patel H, Edberg JC, Portman MA
      Role of activating FcR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.
      22565545 Circulation. Cardiovascular genetics, 2012 June : 5(3)309-16 PMCID:PMC3444514
    • Olson AK, Bouchard B, Ning XH, Isern N, Rosiers CD, Portman MA
      Triiodothyronine increases myocardial function and pyruvate entry into the citric acid cycle after reperfusion in a model of infant cardiopulmonary bypass.
      22180654 American journal of physiology. Heart and circulatory physiology, 2012 Mar 1 : 302(5)H1086-93 PMCID:PMC3311455
    • Buroker NE, Huang JY, Barboza J, Ledee DR, Eastman RJ Jr, Reinecke H, Ning XH, Bassuk JA, Portman MA
      The adaptor-related protein complex 2, alpha 2 subunit (AP22) gene is a peroxisome proliferator-activated receptor cardiac target gene.
      22160327 The protein journal, 2012 Jan. : 31(1)75-83 PMCID:PMC3699174
    • Shrestha S, Wiener HW, Olson AK, Edberg JC, Bowles NE, Patel H, Portman MA
      Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease.
      21601260 The Journal of allergy and clinical immunology, 2011 Sept. : 128(3)677-80 PMCID:PMC3444515
    • Choueiter NF, Olson AK, Shen DD, Portman MA
      Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease.
      20667551 The Journal of pediatrics, 2010 Dec. : 157(6)960-966.e1 PMCID:PMC2970727
    • Buroker NE, Ning XH, Zhou ZN, Li K, Cen WJ, Wu XF, Ge M, Fan LP, Zhu WZ, Portman MA, Chen SH
      Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau.
      20570668 Clinica chimica acta; international journal of clinical chemistry, 2010 Oct 9 : 1466-73
    • Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM
      Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
      20859243 Pharmacogenetics and genomics, 2010 Sep 18
    • Portman MA, Slee A, Olson AK, Cohen G, Karl T, Tong E, Hastings L, Patel H, Reinhartz O, Mott AR, Mainwaring R, Linam J, Danzi S
      Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
      20837917 Circulation, 2010 Sep 14 : S224-33
    • Hyyti OM, Ledee D, Ning XH, Ge M, Portman MA
      Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
      20601465 American journal of physiology. Heart and circulatory physiology, 2010 Sept. : H868-75
    • Choueiter NF, Olson AK, Shen DD, Portman MA
      Prospective Open-Label Trial of Etanercept as Adjunctive Therapy for Kawasaki Disease.
      20667551 The Journal of pediatrics, 2010 Jul 26
    • Portman MA
      Thyroid hormone regulation of perinatal cardiovascular function.
      19007680 Seminars in perinatology, 2008 Dec. : 419-22
    • Olson AK, Hyyti OM, Cohen GA, Ning XH, Sadilek M, Isern N, Portman MA
      Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion.
      18849332 American journal of physiology. Heart and circulatory physiology, 2008 Dec. : H2315-20
    • Hyyti OM, Olson AK, Ge M, Ning XH, Buroker NE, Chung Y, Jue T, Portman MA
      Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency.
      18523124 American journal of physiology. Endocrinology and metabolism, 2008 Aug. : E420-7
    • Ning XH, Hyyti O, Ge M, Anderson DL, Portman MA
      Rapid progressive central cooling to 29 degrees C by extracorporeal circuit preserves cardiac function and hemodynamics in immature swine.
      17976893 Resuscitation, 2008 March : 443-8
    • Portman MA
      Thyroid hormone regulation of heart metabolism.
      18279022 Thyroid : official journal of the American Thyroid Association, 2008 Feb. : 217-25
    • Ning XH, Chi EY, Buroker NE, Chen SH, Xu CS, Tien YT, Hyyti OM, Ge M, Portman MA
      Moderate hypothermia (30 degrees C) maintains myocardial integrity and modifies response of cell survival proteins after reperfusion.
      17660400 American journal of physiology. Heart and circulatory physiology, 2007 Oct. : H2119-28
    • Buroker NE, Young ME, Wei C, Serikawa K, Ge M, Ning XH, Portman MA
      The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.
      16985257 American journal of physiology. Endocrinology and metabolism, 2007 Feb. : E453-60
    • Ning XH, Chen SH, Buroker NE, Xu CS, Li FR, Li SP, Song DS, Ge M, Hyyti OM, Zhang M, Portman MA
      Short-cycle hypoxia in the intact heart: hypoxia-inducible factor 1alpha signaling and the relationship to injury threshold.
      16951052 American journal of physiology. Heart and circulatory physiology, 2007 Jan. : H333-41
    • Hyyti OM, Portman MA
      Molecular mechanisms of cross-talk between thyroid hormone and peroxisome proliferator activated receptors: focus on the heart.
      17171294 Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 2006 Dec. : 463-9
    • Morrish F, Buroker NE, Ge M, Ning XH, Lopez-Guisa J, Hockenbery D, Portman MA
      Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA.
      16730242 Mitochondrion, 2006 June : 143-8
    • Hyyti OM, Ning XH, Buroker NE, Ge M, Portman MA
      Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms.
      16204338 American journal of physiology. Endocrinology and metabolism, 2006 Feb. : E372-9
    • McClure TD, Young ME, Taegtmeyer H, Ning XH, Buroker NE, López-Guisa J, Portman MA
      Thyroid hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart.
      16024569 American journal of physiology. Heart and circulatory physiology, 2005 Nov. : H2258-64
    • Portman MA, Qian K, Krueger J, Ning XH
      Direct action of T3 on phosphorylation potential in the sheep heart in vivo.
      15637117 American journal of physiology. Heart and circulatory physiology, 2005 May : H2484-90
    • Danzi S, Klein I, Portman MA
      Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect.
      15757614 The American journal of cardiology, 2005 Mar 15 : 787-9
    • Portman MA, Fearneyhough C, Karl TR, Tong E, Seidel K, Mott A, Cohen G, Tacy T, Lewin M, Permut L, Schlater M, Azakie A
      The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale.
      15389224 American heart journal, 2004 Sept. : 393-8
    • Ning XH, Chen SH, Xu CS, Hyyti OM, Qian K, Krueger JJ, Portman MA
      Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia.
      12637348 American journal of physiology. Heart and circulatory physiology, 2003 July : H212-9
    • Ning XH, Chen SH, Xu CS, Li L, Yao LY, Qian K, Krueger JJ, Hyyti OM, Portman MA
      Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis.
      11960975 Journal of applied physiology (Bethesda, Md. : 1985), 2002 May : 2200-7
    • Portman MA
      The adenine nucleotide translocator: regulation and function during myocardial development and hypertrophy.
      11985546 Clinical and experimental pharmacology & physiology, 2002 April : 334-8
  • Presentations

    Presentation Title Event Location Date
    Etanercept for Kawasaki Disease Annual Meeting of the Western Society of Pediatric Cardiology Yosemite CA Jan 1, 2009
    Cardiology Grand Rounds University of Illinois Chicago, IL Jan 1, 2009
  • Research Funding

    Grant Title Grantor Amount Award Date
    Thyroid Control of Myocardial Metabolism in Aging NIH/NIA $439,000.00 Apr 1, 2010
    Metabolism During Mechanical Circulatory Support in the Developing Heart NIH/NHLBI $1,559,000.00 Jul 1, 2009
    Triostat in Children during Cardiopulmonary Bypass: Orphan Products Development Grant FDA Apr 1, 2009
    Etanercept for Acute Kawasaki Disease FDA $1,600,000.00 Feb 15, 2009
    Role of Fc-gamma Receptor Polymorphisms in Determining IVIG Response in Kawasaki Disease Thrasher Foundation $388,000.00 Jan 1, 2008
    Fcr Mutations in Kawasaki Disease NIH/NHLBI $439,000.00 Jun 1, 2007
    Cell Metabolism & Myc Induced Growth, Death, & Neoplasia NIH/NCI Apr 1, 2005
    UW Stipends for Training Aspiring Researchers NIH/NHLBI Apr 1, 2004

Overview

Board Certification(s)

Pediatrics
Pediatric Cardiology

Medical/Professional School

University of Cincinnati College of Medicine, Cincinnati, OH

Fellowship

Case Western Reserve University, Cleveland, OH

Clinical Interests

Cell metabolism, biomedicine, MRI

Research Description

We also perform research in Kawasaki Disease, which is an inflammatory syndrome attacking coronary arteries in children. Our work includes drug studies in animal models, and pharmacogenomic studies in patients. We are also performing clincial trials in patients.

We study cardiac metabolism and the impact of changing substrate utilization on the heart during development and during pathological states such as heart failure and cardiopulmonary bypass. Thyroid regulation of metabolism is a primary interest. Work is translational and progresses from basic benchtop studies to mice to large animals to the bedside.

Research Focus Area

Cardiac Metabolism, Cardiology, Congenital Cardiac Surgery Outcomes, Kawasaki Disease, Pulmonary