Erin E Crotty, MD

Erin E Crotty, MD

Cancer and Blood Disorders Center, Brain Tumor Program, Immunotherapy Program

On staff since July 2020

Children's Title: Attending Physician, Pediatric Hematology, Oncology, Bone Marrow Transplant, and Cellular Therapy

Academic Title: Assistant Professor, Department of Pediatrics, University of Washington School of Medicine

Research Center: Ben Towne Center for Childhood Cancer Research

"“Caring for young patients with challenging diagnoses is a privilege and I’m committed to treating not only the tumor but supporting the whole child or young adult and the community of family and friends routing for them. I’m lucky to work with a multidisciplinary team of clinical scientists and research leaders who work to bring innovative therapies from the lab directly to the patient.”"

  • Biography

    Erin Crotty, M.D. is an attending physician and pediatric oncologist in the Brain Tumor Program at Seattle Children's Hospital and Assistant Professor at the University of Washington School of Medicine. She cares for children and young adults with brain and spinal cord tumors, and is the clinical oncology lead for the Retinoblastoma Program. She is involved locally and internationally in early phase clinical trials for children with brain tumors and serves as site Principal Investigator for the Pacific Pediatric Neuro-oncology Consortium (PNOC). Her clinical research focus is dedicated to bringing new therapies, including immunotherapies, and precision medicine approaches, to young patients with difficult-to-treat central nervous system tumors. She is a member of the Collaborative Network for Neuro-oncology Clinical Trials (CONNECT) Immunotherapy Working Group and the Consortium for Pediatric Cellular Immunotherapy (CPCI) Pediatric CNS Working Group.

     

    Dr. Crotty completed her pediatric residency training at Children's National Medical Center in Washington, D.C. and returned home to the west coast for her hematology/oncology fellowship at Seattle Children's Hospital/University of Washington, where she completed additional translational research training in the laboratory of James Olson, M.D.,Ph.D. at the Fred Hutchinson Cancer Research Center, studying novel protein therapeutics.

    Dr. Crotty moderates Seattle Children’s weekly Brain Tumor Board, a platform for multidisciplinary review of patient cases offering tailored advice to providers and families on personalized treatment options and innovative clinical trials.

    • Related Pages

    • The Olson Lab

      The Olson lab identifies, prioritizes, and advances therapeutics into clinical trials for children with brain cancer, with increasing focus on types of brain tumors that are uncommon and have the greatest need for translational research.

    • Retinoblastoma Program

      Learn about treatment options for retinoblastoma, cancer in the lining of the eye. At Seattle Children’s, your child will get care from a team of specialists experienced in treating retinoblastoma. We provide the most advanced treatments in our region, including intra-arterial chemotherapy.

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    2022 Emerging Scientist Award Project: Clinical testing for residual disease biomarkers in pediatric brain tumors; Role: Principal investigator Children's Cancer Research Fund Oct. 2022 - Oct. 2023
    Clinical Scholars Research Program Project: A Phase I/II trial of immunomodulation with decitabine and nivolumab in children with recurrent/refractory brain tumors and newly diagnosed high-grade glioma and DIPG; Role: principal Investigator Seattle Children's Research Institute, Center for Clinical and Translational Research (CCTR) Oct. 2021 - Oct. 2023
    NIH Loan Repayment Award, Pediatric Extramural Project: Immunomodulation of relapsed/refractory pediatric brain tumors and newly diagnosed DIPG; Role: principal Investigator National Institutes of Health 2021 - 2023
    The Childhood Brain Tumor Foundation (CBTF) Research Award Project: Immune Priming Pediatric Brain Tumors, Olson Lab, Fred Hutchinson Cancer Research Center; Role: Principal investigator 2020
    Resident Teaching Award Children's National Medial Center 2015 - 2017
    Gill Fellowship Research Award George Washington University 2011

  • Publications

    Other Publications

    • Crotty E, Gust J
      Pediatric ependymoma: New perspectives on older trials.
      35325202 Neuro-oncology, 2022 Jun 1 : 24(6)949-950 PMCID:PMC9159413
    • Ohlsen TJD, Scanlon S, Perez FA, Ermoian RP, Paulson VA, Hauptman JS, Crotty EE, Ting MA
      Synchronous rare tumors in a pediatric patient with a de novo cancer predisposition syndrome.
      35484874 Pediatric blood & cancer, 2022 Apr 28 : e29746
    • Mustafi D, Waligorski N, Paulson V, Cole B, Crotty EE, Stacey AW
      Pineoblastoma Without Retinal Tumors in a Patient With a Mosaic Retinoblastoma Pathogenic Variant.
      35297960 JAMA ophthalmology, 2022 Apr 1 : 140(4)437-439
    • Scherpelz KP, Crotty EE, Paulson VA, Lockwood CM, Leary SES, Ellenbogen RG, Lee A, Ermoian RP, Vitanza NA, Cole BL
      Two cases of pineal anlage tumor with molecular analysis.
      35129878 Pediatric blood & cancer, 2022 April : 69(4)e29596
    • Crotty EE, Smith SMC, Brasel K, Pakiam F, Girard EJ, Connor YD, Zindy F, Mhyre AJ, Roussel MF, Olson JM
      Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.
      33963961 Journal of neuro-oncology, 2021 June : 153(2)225-237 PMCID:PMC8248272
    • Crotty E, Downey K, Ferrerosa L, Flores C, Hegde B, Raskin S, Hwang E, Vitanza N, Okada H
      Considerations when treating high-grade pediatric glioma patients with immunotherapy.
      33225764 Expert review of neurotherapeutics, 2021 Feb. : 21(2)205-219 PMCID:PMC7880880
    • Crotty EE, Leary SES, Geyer JR, Olson JM, Millard NE, Sato AA, Ermoian RP, Cole BL, Lockwood CM, Paulson VA, Browd SR, Ellenbogen RG, Hauptman JS, Lee A, Ojemann JG, Vitanza NA
      Children with DIPG and high-grade glioma treated with temozolomide, irinotecan, and bevacizumab: the Seattle Children's Hospital experience.
      32556862 Journal of neuro-oncology, 2020 July : 148(3)607-617
    • Crumm CE, Crotty EE, Albert CM, Blair AB, Otjen JP, Feldman KW
      Atraumatic Spinal Epidural Hematoma as Initial Presentation of Hemophilia A in an Infant.
      30870339 Pediatric emergency care, 2019 Mar 12
    • Crotty EE, Meier ER, Wells EM, Hwang EI, Packer RJ
      Anaplastic Ependymoma in a Child With Sickle Cell Anemia: A Case Report Highlighting Treatment Challenges for Young Children With Central Nervous System Tumors and Underlying Vasculopathy.
      26488903 Pediatric blood & cancer, 2016 March : 63(3)547-50

  • Research Funding

    Grant Title Grantor Amount Award Date
    2022 Emerging Scientist Award Children's Cancer Research Fund $100,000 2022 - 2023
    Clinical Research Scholars Program (CRSP) Award Center for Clinical and Translational Research Oct. 2021 - Oct. 2023
    NIH Loan Repayment Award, Pediatric Extramural NIH $100,000 2021 - 2023
    The Childhood Brain Tumor Foundation Research Grant The Childhood Brain Tumor Foundation $60,000 July 2020 - July 2022
    NIH 5T32CA009351 Ruth L. Kirschstein Research Service Award NIH Fellowship Support July 2018 - July 2020

Overview

Board Certification(s)

Pediatric Hematology-Oncology
Pediatrics

Medical/Professional School

George Washington University School of Medicine & Health Sciences, Washington, DC

Residency

Children's National Medical Center, Washington, DC

Fellowship

University of Washington School of Medicine, Seattle, WA

Clinical Interests

Brain and spinal cord tumors of childhood; high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG); diffuse midline glioma (DMG); medulloblastoma, ependymoma, atypical teratoid rhabdoid tumor (ATRT); CAR T cell immunotherapy; early phase clinical trials; retinoblastoma

Research Description

Dr. Crotty's research interests include immuno-oncology and precision medicine approaches for children with brain and spinal cord tumors. Dr. Crotty is particularly interested in the translation of promising therapies from the lab bench into innovative clinical trials for patients. She collaborates with international cancer consortium members in the design and implementation of clinical trials. 

Dr. Crotty's prior work in the Olson Laboratory at the Fred Hutchinson Cancer Center (now located at Seattle Children's Research Institute) studying immunotherapy approaches for medulloblastoma provided the preclinical foundation for an upcoming international CONNECT Phase I clinical trial, which she will lead as co-Principal Investigator.

In 2022, she was awarded the Children's Cancer Research Fund Emerging Scientist Award to study a liquid biopsy platform using cell-free DNA from children with brain tumors. This new test is designed to detect disease left over after treatment in the cerebrospinal fluid (CSF). For children with central nervous system tumors, this platform has the potential to transform clinical care by improving outcomes and reducing toxicity. 

Research Focus Area

Cancer biology, Immunotherapy, CAR-T cells, cell-free DNA, liquid biopsy, CSF biomarkers, DIPG, DMG, ATRT, CAR T cell therapy, epigenetics, early phase clinical trials