Christian L Roth, MD

Christian L Roth, MD

Endocrinology and Diabetes, Neuro-Oncology, Brain Tumor Program, Congenital Adrenal Hyperplasia Program

On staff since October 2006

Academic Title: Professor

Research Center: Center for Clinical and Translational Research, Center for Integrative Brain Research

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Henning-Andersen Award of the European Society for Paediatric Endocrinology (ESPE) Oral presentation, best Basic Science Abstract. Study: Gene expression profiling of the nonhuman primate hypothalamus at the time of female puberty reveals activation of tumor suppressor gene expression. European Society for Paediatric Endocrinology (ESPE) 2004
    Jrgen-Bierich Award Study: Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. German Society for Pediatric Endocrinology 2002
    First Prize Study: Comparative analysis of different puberty inhibiting mechanisms of two GnRH agonists and the GnRH antagonist cetrorelix using a female rat model. German Society for Pediatric and Adolescent Gynecology Award 2000 2001
    1997 First Prize, Poster APE Steps Award Study: Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite. German Society for Pediatric Endocrinology 1997

  • Publications

    Manuscripts in Refereed Journals

    • Perez FA, Werny D, Roth CL, Wright JN.
      Neuroimaging review of pediatric endocrinopathies.
      Neurographics, 2020 : 10(1)33-58
      https://doi.org/10.3174/ng.1900019

    Other Publications

    • Roth CL, Perez FA, Whitlock KB, Elfers C, Yanovski JA, Shoemaker AH, Abuzzahab MJ
      A phase 3 randomized clinical trial using a once-weekly glucagon-like peptide-1 receptor agonist in adolescents and young adults with hypothalamic obesity.
      33026160 Diabetes, obesity & metabolism, 2021 Feb. : 23(2)363-373 PMCID:PMC7821019
    • Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, Hayes MR, De Jonghe BC, Holz GG, Roth CL, Doyle RP
      Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.
      33449689 Journal of medicinal chemistry, 2021 Jan 28 : 64(2)1127-1138
    • Sewaybricker LE, Melhorn SJ, Papantoni A, Webb MF, Hua J, Roth CL, Carnell S, Schur EA
      Pilot multi-site and reproducibility study of hypothalamic gliosis in children.
      33084253 Pediatric obesity, 2020 Oct 20 : e12732
    • Schur EA, Melhorn SJ, Scholz K, De Leon MRB, Elfers CT, Rowland MG, Saelens BE, Roth CL
      Child neurobiology impacts success in family-based behavioral treatment for children with obesity.
      32713944 International journal of obesity (2005), 2020 Oct. : 44(10)2011-2022 PMCID:PMC7530004
    • Huang A, Reinehr T, Roth CL
      Connections Between Obesity and Puberty: Invited by Manuel Tena-Sempere, Cordoba.
      33043167 Current opinion in endocrine and metabolic research, 2020 Oct. : 14160-168 PMCID:PMC7543977
    • Roth CL, Melhorn SJ, Elfers CT, Scholz K, De Leon MRB, Rowland M, Kearns S, Aylward E, Grabowski TJ, Saelens BE, Schur EA
      Central Nervous System and Peripheral Hormone Responses to a Meal in Children.
      30418574 The Journal of clinical endocrinology and metabolism, 2019 May 1 : 104(5)1471-1483 PMCID:PMC6435098
    • Kuzma JN, Hagman DK, Cromer G, Breymeyer KL, Roth CL, Foster-Schubert KE, Holte SE, Weigle DS, Kratz M
      Intraindividual Variation in Markers of Intestinal Permeability and Adipose Tissue Inflammation in Healthy Normal-Weight to Obese Adults.
      30573517 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 March : 28(3)610-615 PMCID:PMC6401228
    • Kuzma JN, Cromer G, Hagman DK, Breymeyer KL, Roth CL, Foster-Schubert KE, Holte SE, Weigle DS, Kratz M
      Consuming glucose-sweetened, not fructose-sweetened, beverages increases fasting insulin in healthy humans.
      30166639 European journal of clinical nutrition, 2019 March : 73(3)487-490 PMCID:PMC6395516
    • Reinehr T, Roth CL
      Is there a causal relationship between obesity and puberty?
      30446301 The Lancet. Child & adolescent health, 2019 Jan. : 3(1)44-54
    • Abuzzahab MJ, Roth CL, Shoemaker AH
      Hypothalamic Obesity: Prologue and Promise.
      30884480 Hormone research in paediatrics, 2019 : 91(2)128-136
    • Reinehr T, Roth CL
      Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population.
      30338401 Current diabetes reports, 2018 Oct 18 : 18(12)131
    • Roth CL, Jain V
      Rising Obesity in Children: A Serious Public Health Concern.
      29455329 Indian journal of pediatrics, 2018 June : 85(6)461-462
    • Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG
      Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
      29654321 Scientific reports, 2018 Apr 13 : 8(1)6192 PMCID:PMC5899092
    • Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG
      Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
      29491394 Scientific reports, 2018 Feb 28 : 8(1)3749 PMCID:PMC5830615
    • Roth CL, von Schnurbein J, Elfers C, Moss A, Wabitsch M
      Changes in Satiety Hormones in Response to Leptin Treatment in a Patient with Leptin Deficiency.
      29996141 Hormone research in paediatrics, 2018 : 90(6)424-430
    • Kuzma JN, Cromer G, Hagman DK, Breymeyer KL, Roth CL, Foster-Schubert KE, Holte SE, Callahan HS, Weigle DS, Kratz M
      No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial.
      26537945 The American journal of clinical nutrition, 2015 Dec. : 102(6)1373-80 PMCID:PMC4658464
    • Henry KE, Elfers CT, Burke RM, Chepurny OG, Holz GG, Blevins JE, Roth CL, Doyle RP
      Vitamin B12 conjugation of Peptide-YY3-36 decreases food intake compared to native Peptide-YY3-36 upon subcutaneous administration in male rats.
      In Press, 2015
    • Melhorn SJ, Tyagi V, Smeraglio A, Roth CL, Schur EA
      Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans.
      25049134 Appetite, 2014 Nov. : 8285-90 PMCID:PMC4171349
    • Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR
      Hyperphagia: Current concepts and future directions proceedings of the 2nd international conference on hyperphagia.
      24574081 Obesity (Silver Spring, Md.), 2014 Feb. : 22 Suppl 1S1-S17
    • Reinehr T, Roth CL
      The gut sensor as regulator of body weight
      In Press, 2014
    • Weedon MN, Cebola I, Patch AM, Flanagan SE, De Franco E, Caswell R, Rodríguez-Seguí SA, Shaw-Smith C, Cho CH, Lango Allen H, Houghton JA, Roth CL, Chen R, Hussain K, Marsh P, Vallier L, Murray A, International Pancreatic Agenesis Consortium, Ellard S, Ferrer J, Hattersley AT
      Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
      24212882 Nature genetics, 2014 Jan. : 46(1)61-4
    • Reinehr T, Wolters B, Roth CL, Hinney A
      FTO gene: association to weight regain after lifestyle intervention in overweight children.
      24819256 Hormone research in paediatrics, 2014 : 81(6)391-6
    • Roth CL, Hinney A, Schur EA, Elfers CT, Reinehr T
      Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention.
      24283216 BMC pediatrics, 2013 Nov 27 : 13197 PMCID:PMC4219494
    • Roth CL, Hinney A, Schur EA, Elfers CT, Reinehr T
      Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention.
      24283216 BMC pediatrics, 2013 Nov 27 : 13197
    • Chow EJ, Pihoker C, Friedman DL, Lee SJ, McCune JS, Wharton C, Roth CL, Baker KS
      Glucocorticoids and insulin resistance in children with acute lymphoblastic leukemia.
      23042765 Pediatric blood & cancer, 2013 April : 60(4)621-6 PMCID:PMC3568436
    • Roth CL, Elfers C, Gebhardt U, Müller HL, Reinehr T
      Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss.
      23040414 Metabolism: clinical and experimental, 2013 Feb. : 62(2)226-34
    • Roth CL, Elfers C, Gebhardt U, Müller HL, Reinehr T
      Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss.
      23040414 Metabolism: clinical and experimental, 2013 Feb. : 62(2)226-34
    • Reinehr T, Woelfle J, Wunsch R, Roth CL
      Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis.
      22438225 The Journal of clinical endocrinology and metabolism, 2012 June : 97(6)2143-50
    • Roth CL, Sathyanarayana S
      Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: potential implications in the child born small for gestational age (SGA).
      22415297 Reviews in endocrine & metabolic disorders, 2012 June : 13(2)129-40
    • Roth CL, Aylward E, Liang O, Kleinhans NM, Pauley G, Schur EA
      Functional Neuroimaging in Craniopharyngioma: A Useful Tool to Better Understand Hypothalamic Obesity?
      22647305 Obesity facts, 2012 Apr 20 : 5(2)243-253
    • Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE, Kowdley KV
      Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation.
      21994008 Hepatology (Baltimore, Md.), 2012 April : 55(4)1103-11
    • Krone N, Reisch N, Idkowiak J, Dhir V, Ivison HE, Hughes BA, Rose IT, O'Neil DM, Vijzelaar R, Smith MJ, MacDonald F, Cole TR, Adolphs N, Barton JS, Blair EM, Braddock SR, Collins F, Cragun DL, Dattani MT, Day R, Dougan S, Feist M, Gottschalk ME, Gregory JW, Haim M, Harrison R, Olney AH, Hauffa BP, Hindmarsh PC, Hopkin RJ, Jira PE, Kempers M, Kerstens MN, Khalifa MM, Köhler B, Maiter D, Nielsen S, O'Riordan SM, Roth CL, Shane KP, Silink M, Stikkelbroeck NM, Sweeney E, Szarras-Czapnik M, Waterson JR, Williamson L, Hartmann MF, Taylor NF, Wudy SA, Malunowicz EM, Shackleton CH, Arlt W
      Genotype-phenotype analysis in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.
      22162478 The Journal of clinical endocrinology and metabolism, 2012 Feb. : 97(2)E257-67 PMCID:PMC3380101
    • Elfers CT, Simmons JH, Roth CL
      Glucagon-like peptide-1 agonist exendin-4 leads to reduction of weight and caloric intake in a rat model of hypothalamic obesity.
      22831885 Hormone research in paediatrics, 2012 : 78(1)47-53
    • Simmons JH, Shoemaker AH, Roth CL
      Treatment with glucagon-like Peptide-1 agonist exendin-4 in a patient with hypothalamic obesity secondary to intracranial tumor.
      22831918 Hormone research in paediatrics, 2012 : 78(1)54-8
    • Woelfle J, Roth CL, Wunsch R, Reinehr T
      Pregnancy-associated plasma protein A in obese children: relationship to markers and risk factors of atherosclerosis and members of the IGF system.
      21753069 European journal of endocrinology / European Federation of Endocrine Societies, 2011 Oct. : 165(4)613-22
    • Reinehr T, Woelfle J, Roth CL
      Lack of association between apelin, insulin resistance, cardiovascular risk factors, and obesity in children: a longitudinal analysis.
      21489579 Metabolism: clinical and experimental, 2011 Sept. : 60(9)1349-54
    • Reinehr T, Kleber M, Toschke AM, Woelfle J, Roth CL
      Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss.
      21198359 International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2011 Aug. : 6(3-4)236-43
    • Reinehr T, Scherag A, Wang HJ, Roth CL, Kleber M, Scherag S, Boes T, Vogel C, Hebebrand J, Hinney A
      Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.
      21366812 Pediatric diabetes, 2011 June : 12(4 Pt 2)435-41
    • Roth CL, Blevins JE, Ralston M, Elfers C, Ogimoto K, Kaiyala KJ, Morton GJ
      A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients.
      21372758 Pediatric research, 2011 March : 69(3)230-6 PMCID:PMC3673774
    • Vogel CI, Boes T, Reinehr T, Roth CL, Scherag S, Scherag A, Hebebrand J, Hinney A
      Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention.
      21372613 Obesity facts, 2011 : 4(1)67-75
    • Elfers C, Ralston M, Roth CL
      Studies of different female rat models of hypothalamic obesity.
      21648279 Journal of pediatric endocrinology & metabolism : JPEM, 2011 : 24(3-4)131-7
    • Elfers CT, Roth CL
      Effects of methylphenidate on weight gain and food intake in hypothalamic obesity.
      22649386 Frontiers in endocrinology, 2011 : 278 PMCID:PMC3355874
    • Roth CL
      Hypothalamic obesity in patients with craniopharyngioma: profound changes of several weight regulatory circuits.
      22654811 Frontiers in endocrinology, 2011 : 249 PMCID:PMC3356147
    • Roth CL, Elfers C, Kratz M, Hoofnagle AN
      Vitamin d deficiency in obese children and its relationship to insulin resistance and adipokines.
      22254134 Journal of obesity, 2011 : 2011495101 PMCID:PMC3255292
    • Roth CL, Bongiovanni KD, Gohlke B, Woelfle J
      Changes in dynamic insulin and gastrointestinal hormone secretion in obese children.
      21714464 Journal of pediatric endocrinology & metabolism : JPEM, 2010 Dec. : 23(12)1299-309
    • Chow EJ, Simmons JH, Roth CL, Baker KS, Hoffmeister PA, Sanders JE, Friedman DL
      Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation.
      20685399 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 May 31
    • Roth CL, Kratz M, Ralston MM, Reinehr T
      Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children.
      20494373 Metabolism: clinical and experimental, 2010 May 20
    • Reinehr T, Roth CL
      A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss.
      20065970 International journal of obesity (2005), 2010 May : 34(5)852-8
    • Roth CL, Gebhardt U, Müller HL
      Appetite-Regulating Hormone Changes in Patients With Craniopharyngioma.
      20379145 Obesity (Silver Spring, Md.), 2010 Apr 8
    • Roth CL, Enriori PJ, Gebhardt U, Hinney A, Müller HL, Hebebrand J, Reinehr T, Cowley MA
      Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity.
      19766264 Metabolism: clinical and experimental, 2010 Feb. : 186-94
    • Roth CL, Reinehr T
      Roles of gastrointestinal and adipose tissue peptides in childhood obesity and changes after weight loss due to lifestyle intervention.
      20124141 Archives of pediatrics & adolescent medicine, 2010 Feb. : 131-8
    • Reinehr T, Roth CL, Enriori PJ, Masur K
      Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin sensitivity.
      20432813 Journal of pediatric endocrinology & metabolism : JPEM, 2010 Jan. : 101-8
    • Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A, Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H, Erdmann J
      Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
      19660754 Atherosclerosis, 2010 Jan. : 208(1)183-9
    • Figlewicz DP, Ioannou G, Bennett Jay J, Kittleson S, Savard C, Roth CL
      Effect of moderate intake of sweeteners on metabolic health in the rat.
      19815021 Physiology & behavior, 2009 Dec 7 : 98(5)618-24 PMCID:PMC3258097
    • Roth CL, Ludwig M, Woelfle J, Fan ZC, Brumm H, Biebermann H, Tao YX
      A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity.
      19214805 Endocrine, 2009 Aug. : 52-9
    • Roth CL, Reinehr T, Schernthaner GH, Kopp HP, Kriwanek S, Schernthaner G
      Ghrelin and obestatin levels in severely obese women before and after weight loss after Roux-en-Y gastric bypass surgery.
      18521699 Obesity surgery, 2009 Jan. : 29-35
    • Reinehr T, Roth CL
      Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss.
      18728159 The Journal of clinical endocrinology and metabolism, 2008 Nov. : 4479-85
    • Roth CL, Hinney A, Reinehr T, Schreiner F, Nguyen TT, Müller T, Scholl C, Woelfle J, Karpushova A, Schäfer H, Nöthen MM, Hebebrand J
      TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.
      18546086 Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008 Oct. : 40(10)713-7
    • Müller TD, Hinney A, Scherag A, Nguyen TT, Schreiner F, Schäfer H, Hebebrand J, Roth CL, Reinehr T
      'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.
      18799002 BMC medical genetics, 2008 Sep 17 : 985 PMCID:PMC2553771
    • Linsel-Nitschke P, Götz A, Erdmann J, Braenne I, Braund P, Hengstenberg C, Stark K, Fischer M, Schreiber S, El Mokhtari NE, Schaefer A, Schrezenmeir J, Rubin D, Hinney A, Reinehr T, Roth C, Ortlepp J, Hanrath P, Hall AS, Mangino M, Lieb W, Lamina C, Heid IM, Doering A, Gieger C, Peters A, Meitinger T, Wichmann HE, König IR, Ziegler A, Kronenberg F, Samani NJ, Schunkert H, Wellcome Trust Case Control Consortium (WTCCC), Cardiogenics Consortium
      Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
      18714375 PloS one, 2008 Aug 20 : 3(8)e2986 PMCID:PMC2500189
    • Reinehr T, Stoffel-Wagner B, Roth CL
      Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss.
      18397979 The Journal of clinical endocrinology and metabolism, 2008 June : 2287-93
    • Reinehr T, de Sousa G, Roth CL
      Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight.
      17854392 Clinical endocrinology, 2008 Feb. : 304-10
    • Gohlke BC, Bartmann P, Fimmers R, Huber A, Hecher K, Roth CL
      Fetal adiponectin and resistin in correlation with birth weight difference in monozygotic twins with discordant growth.
      18059079 Hormone research, 2008 : 37-44
    • Reinehr T, Schober E, Roth CL, Wiegand S, Holl R
      Type 2 diabetes in children and adolescents in a 2-year follow-up: insufficient adherence to diabetes centers.
      18059091 Hormone research, 2008 : 107-13
    • Reinehr T, Stoffel-Wagner B, Roth CL
      Adipocyte fatty acid-binding protein in obese children before and after weight loss.
      17998029 Metabolism: clinical and experimental, 2007 Dec. : 1735-41
    • Reinehr T, Roth CL, Schernthaner GH, Kopp HP, Kriwanek S, Schernthaner G
      Peptide YY and glucagon-like peptide-1 in morbidly obese patients before and after surgically induced weight loss.
      18046613 Obesity surgery, 2007 Dec. : 1571-7
    • Roth CL, Mastronardi C, Lomniczi A, Wright H, Cabrera R, Mungenast AE, Heger S, Jung H, Dubay C, Ojeda SR
      Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty.
      17615149 Endocrinology, 2007 Nov. : 5147-61
    • Reinehr T, de Sousa G, Niklowitz P, Roth CL
      Amylin and its relation to insulin and lipids in obese children before and after weight loss.
      17712118 Obesity (Silver Spring, Md.), 2007 Aug. : 2006-11
    • Heger S, Mastronardi C, Dissen GA, Lomniczi A, Cabrera R, Roth CL, Jung H, Galimi F, Sippell W, Ojeda SR
      Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis.
      17627301 The Journal of clinical investigation, 2007 Aug. : 2145-54
    • Reinehr T, de Sousa G, Roth CL
      Fasting glucagon-like peptide-1 and its relation to insulin in obese children before and after weight loss.
      17460495 Journal of pediatric gastroenterology and nutrition, 2007 May : 608-12
    • Roth CL, Hunneman DH, Gebhardt U, Stoffel-Wagner B, Reinehr T, Müller HL
      Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma.
      17515878 Pediatric research, 2007 April : 496-501
    • Woelfle JF, Harz K, Roth C
      Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children.
      17286229 Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2007 Jan. : 115(1)17-23
    • Dost A, Herbst A, Kintzel K, Haberland H, Roth CL, Gortner L, Holl RW
      Shorter remission period in young versus older children with diabetes mellitus type 1.
      17286232 Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2007 Jan. : 115(1)33-7
    • Reinehr T, Enriori PJ, Harz K, Cowley MA, Roth CL
      Pancreatic polypeptide in obese children before and after weight loss.
      16702998 International journal of obesity (2005), 2006 Oct. : 30(10)1476-81
    • Roth CL, McCormack AL, Lomniczi A, Mungenast AE, Ojeda SR
      Quantitative proteomics identifies a change in glial glutamate metabolism at the time of female puberty.
      16753258 Molecular and cellular endocrinology, 2006 Jul 25 : 51-9
    • Ojeda SR, Lomniczi A, Mastronardi C, Heger S, Roth C, Parent AS, Matagne V, Mungenast AE
      Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach?
      16373420 Endocrinology, 2006 March : 147(3)1166-74
    • Ojeda SR, Roth C, Mungenast A, Heger S, Mastronardi C, Parent AS, Lomniczi A, Jung H
      Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts.
      16466547 International journal of andrology, 2006 Feb. : 29(1)256-63; discussion 286-90
    • Reinehr T, Roth CL, Menke T, Andler W
      Resistin concentrations before and after weight loss in obese children.
      16189500 International journal of obesity (2005), 2006 Feb. : 30(2)297-301
    • Gohlke BC, Huber A, Bartmann P, Fimmers R, Hecher K, Bouret SG, Roth CL
      Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins.
      16509522 Journal of pediatric endocrinology & metabolism : JPEM, 2006 Jan. : 3-9
    • Roth CL, Ojeda SR
      Genes involved in the neuroendocrine control of normal puberty and abnormal puberty of central origin.
      16361980 Pediatric endocrinology reviews : PER, 2005 Dec. : 67-76
    • Roth CL, Enriori PJ, Harz K, Woelfle J, Cowley MA, Reinehr T
      Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss.
      16204364 The Journal of clinical endocrinology and metabolism, 2005 Dec. : 6386-91
    • Herbst A, Roth CL, Dost AG, Fimmers R, Holl RW
      Rate of hypoglycaemia and insulin dosage in children during the initial therapy of type 1 diabetes mellitus.
      16025296 European journal of pediatrics, 2005 Oct. : 633-8
    • Reinehr T, de Sousa G, Roth CL, Andler W
      Androgens before and after weight loss in obese children.
      16014405 The Journal of clinical endocrinology and metabolism, 2005 Oct. : 90(10)5588-95
    • Reinehr T, Stoffel-Wagner B, Roth CL, Andler W
      High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children.
      16125526 Metabolism: clinical and experimental, 2005 Sept. : 1155-61
    • Roth CL, Neu C, Jarry H, Schoenau E
      Different effects of agonistic vs. antagonistic gnrh-analogues (triptorelin vs. cetrorelix) on bone modeling and remodeling in peripubertal female rats.
      16151979 Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2005 Sept. : 113(8)451-6
    • Reinehr T, Roth CL, Alexy U, Kersting M, Kiess W, Andler W
      Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents.
      15768041 International journal of obesity (2005), 2005 April : 29(4)362-8
    • Gohlke BC, Huber A, Hecher K, Fimmers R, Bartmann P, Roth CL
      Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth.
      15687342 The Journal of clinical endocrinology and metabolism, 2005 April : 2270-4
    • Reinehr T, Holl RW, Roth CL, Wiesel T, Stachow R, Wabitsch M, Andler W
      Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity.
      15787895 Pediatric diabetes, 2005 March : 5-12
    • Roth CL, Brendel L, Rückert C, Hartmann K
      Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine.
      15995342 Hormone research, 2005 : 63(5)257-62
    • Reinehr T, Roth C, Menke T, Andler W
      Adiponectin before and after weight loss in obese children.
      15292306 The Journal of clinical endocrinology and metabolism, 2004 Aug. : 89(8)3790-4
    • Roth C, Hegemann F, Hildebrandt J, Balzer I, Witt A, Wuttke W, Jarry H
      Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models.
      14605254 Pediatric research, 2004 Jan. : 55(1)126-33
    • Harz KJ, Müller HL, Waldeck E, Pudel V, Roth C
      Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity.
      14602754 The Journal of clinical endocrinology and metabolism, 2003 Nov. : 88(11)5227-31
    • Borck G, Roth C, Martiné U, Wildhardt G, Pohlenz J
      Mutations in the PDS gene in German families with Pendred's syndrome: V138F is a founder mutation.
      12788906 The Journal of clinical endocrinology and metabolism, 2003 June : 88(6)2916-21
    • Herting E, Schiffmann H, Roth C, Johansson J
      Surfactant lavage demonstrates protein fibrils in a neonate with congenital surfactant protein b deficiency.
      12403703 American journal of respiratory and critical care medicine, 2002 Nov 1 : 166(9)1292-4
    • Roth C
      Therapeutic potential of GnRH antagonists in the treatment of precocious puberty.
      12225246 Expert opinion on investigational drugs, 2002 Sept. : 11(9)1253-9
    • Woelfle J, Hoepffner W, Sippell WG, Brämswig JH, Heidemann P, Deiss D, Bökenkamp A, Roth C, Irle U, Wollmann HA, Zachmann M, Kubini K, Albers N
      Complete virilization in congenital adrenal hyperplasia: clinical course, medical management and disease-related complications.
      11874415 Clinical endocrinology, 2002 Feb. : 56(2)231-8

Overview

Board Certification(s)

Pediatrics
Neonatal-Perinatal Medicine
Pediatric Endocrinology

Medical/Professional School

Ruprecht-Karls-Universitaet Heidelberg, D-6900 Heidelberg

Clinical Interests

Clinical Interests: Children with endocrine disorders and diabetes mellitus

Research Interests: Obesity studies, including appetite-regulating peptides, factors of the metabolic syndrome, hypothalamic obesity and genetic and environmental factors involved in the onset of puberty

Research Description

My clinical work is based at Seattle Children’s Hospital as an attending of the Endocrine Division. This work involves the care of children with early onset of morbid obesity, children with brain tumors and complex endocrine disturbances such as hypothalamic obesity, as well as children with other endocrine disorders.

Most of my research to date has focused on clinical obesity studies and translational studies regarding metabolic changes associated with obesity. I have extensive experience in evaluating metabolic risk factors before and after weight loss due to lifestyle intervention. I also have experience in drug intervention studies and in connecting clinical studies with lab-based research. In my lab, which is located at Seattle Children's Research Institute, we analyze different peptides involved in the regulation of food intake and energy homeostasis as well as inflammatory markers. We also do functional neuroimaging studies in lean and obese children to better understand reward circuits and the driving forces of excessive eating and weight gain. I am a principal investigator and currently lead two NIH-funded clinical obesity intervention studies in children.

Research Focus Area

Biochemistry, Diabetes, Endocrinology / Metabolism