Alpana Amalkant Waghmare, MD

Infectious Disease

On staff since July 2014

Research Center: Center for Clinical and Translational Research

  • My research is in the field of translational infectious diseases, with a particular focus on respiratory viral infections. My interest in viral infections in immunocompromised hosts stems from my experiences as a clinician, where I witnessed the impact of respiratory viral infections in vulnerable populations. I am currently focused on an often overlooked respiratory pathogen, human rhinovirus (HRV). Our data show that HRV is also now the most common cause of lower respiratory tract infection (LRTI) and leads to mortality rates similar to those seen with known pulmonary pathogens including respiratory syncytial virus (RSV), influenza virus and parainfluenza virus. I propose that viral and host factors may serve as biomarkers for disease severity and can provide needed risk stratification and management tools. Data generated in this research will provide the critical basis to develop rational prevention and treatment strategies for immunocompromised patients. Additionally, I am also involved in clinical trials for drug development to treat infections in this patient population.

  • Award Name Award Description Awarded By Award Date
    NIH Early Career Reviewer Proram participant NIH 2019
    Insitutional nominee, Damon Runyon Clinical Investigator Award Jan. 2018 - 2018
    Top paper in transplant ID IDweek 2015
    Macrae Foundation Young Investigator Award 2015
    Faculty Abstract Award Seattle Childrens Research Institute CCTR Science Day 2015
    Joel Meyers Endowment Scholarship Award 2014
    Seattle Childrens Research Institute Clinical Research Scholar Intensive Path 2014
    IDWeek Trainee Travel Grant from Infectious Disease Society of America 2013
    National Institutes of Health Loan Repayment Program Recipient 2013
    IDWeek Trainee Travel Grant from Infectious Disease Society of America 2012
    Phi Beta Kappa Society Member 2003
  • Manuscripts in Refereed Journals

    • Vora SB, Waghmare A, Englund JA, Qu P, Gardner RA, Hill JA
      Infectious Complications Following CD19 Chimeric Antigen Receptor T-cell Therapy for Children, Adolescents, and Young Adults.
      32432149 Open forum infectious diseases, 2020 May : 7(5)ofaa121 PMCID:PMC7221263
    • Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich M, Goldman DL, Groves HE, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM
      Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2.
      32318706 Journal of the Pediatric Infectious Diseases Society, 2020 April 22 : PMCID:PMC7188128
    • Waghmare A, Krantz EM, Baral S, Vasquez E, Loeffelholz T, Chung EL, Pandey U, Kuypers J, Duke ER, Jerome KR, Greninger AL, Reeves DB, Hladik F, Cardozo-Ojeda EF, Boeckh M, Schiffer JT
      Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics.
      32511581 medRxiv : the preprint server for health sciences, 2020 April 6 : PMCID:PMC7276008
    • Chemaly RF, Dadwal SS, Bergeron A, Ljungman P, Kim YJ, Cheng GS, Pipavath SN, Limaye AP, Blanchard E, Winston DJ, Stiff PJ, Zuckerman T, Lachance S, Rahav G, Small CB, Mullane KM, Patron RL, Lee DG, Hirsch HH, Waghmare A, McKevitt M, Jordan R, Guo Y, German P, Porter DP, Gossage DL, Watkins TR, Marty FM, Chien JW, Boeckh M
      A phase 2, randomized, double-blind, placebo-controlled trial of presatovir for the treatment of respiratory syncytial virus upper respiratory tract infection in hematopoietic-cell transplant recipients.
      31793991 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Dec. 3 : PMCID:PMC7108134
    • Marty FM, Chemaly RF, Mullane KM, Lee DG, Hirsch HH, Small CB, Bergeron A, Shoham S, Ljungman P, Waghmare A, Blanchard E, Kim YJ, McKevitt M, Porter DP, Jordan R, Guo Y, German P, Boeckh M, Watkins TR, Chien JW, Dadwal SS
      A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract.
      31915807 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Dec. 3 : PMCID:PMC7108198
    • Boonyaratanakornkit J, Vivek M, Xie H, Pergam SA, Cheng GS, Mielcarek M, Hill JA, Jerome KR, Limaye AP, Leisenring W, Boeckh MJ, Waghmare A
      Predictive Value of Respiratory Viral Detection in the Upper Respiratory Tract for Infection of the Lower Respiratory Tract with Hematopoietic Stem Cell Transplantation.
      31541573 The Journal of infectious diseases, 2019 Sept. 21
    • Ogimi C, Englund JA, Bradford MC, Qin X, Boeckh M, Waghmare A
      Characteristics and Outcomes of Coronavirus Infection in Children: The Role of Viral Factors and an Immunocompromised State.
      29447395 Journal of the Pediatric Infectious Diseases Society, 2019 March 28 : 8(1)21-28 PMCID:PMC6437838
    • Waghmare A, Xie H, Kuypers J, Sorror ML, Jerome KR, Englund JA, Boeckh M, Leisenring WM
      Human Rhinovirus Infections in Hematopoietic Cell Transplant Recipients: Risk Score for Progression to Lower Respiratory Tract Infection.
      30537551 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018 Dec. 8
    • Ogimi C, Krantz EM, Golob JL, Waghmare A, Liu C, Leisenring WM, Woodard CR, Marquis S, Kuypers JM, Jerome KR, Pergam SA, Fredricks DN, Sorror ML, Englund JA, Boeckh M
      Antibiotic Exposure Prior to Respiratory Viral Infection Is Associated with Progression to Lower Respiratory Tract Disease in Allogeneic Hematopoietic Cell Transplant Recipients.
      29777867 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018 Nov. : 24(11)2293-2301 PMCID:PMC6286157
    • Ogimi C, Xie H, Leisenring WM, Kuypers JM, Jerome KR, Campbell AP, Englund JA, Boeckh M, Waghmare A
      Initial High Viral Load Is Associated with Prolonged Shedding of Human Rhinovirus in Allogeneic Hematopoietic Cell Transplant Recipients.
      30009982 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018 Oct. : 24(10)2160-2163 PMCID:PMC6239940
    • Savage TJ, Kuypers J, Chu HY, Bradford MC, Buccat AM, Qin X, Klein EJ, Jerome KR, Englund JA, Waghmare A
      Enterovirus D-68 in Children Presenting for Acute Care in the Hospital Setting.
      29498483 Influenza and other respiratory viruses, 2018 March 2
    • Vora SB, Brothers AW, Waghmare A, Englund JA
      Antiviral combination therapy for cytomegalovirus infection in high-risk infants.
      29790481 Antiviral therapy, 2018 : 23(6)505-511
    • Waghmare A, Xie H, Kimball L, Yi J, Özkök S, Leisenring W, Cheng GS, Englund JA, Watkins TR, Chien JW, Boeckh M
      Supplemental Oxygen-Free Days in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus.
      28961971 The Journal of infectious diseases, 2017 Dec. 5 : 216(10)1235-1244
    • Waghmare A, Englund JA, Boeckh M
      Parainfluenza Virus 3-Specific T Cells: Opportunity for Intervention?
      28472318 The Journal of infectious diseases, 2017 July 15 : 216(2)147-149
    • Ogimi C, Greninger AL, Waghmare AA, Kuypers JM, Shean RC, Xie H, Leisenring WM, Stevens-Ayers TL, Jerome KR, Englund JA, Boeckh M
      Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution.
      28838146 The Journal of infectious diseases, 2017 July 15 : 216(2)203-209
    • Ogimi C, Waghmare AA, Kuypers JM, Xie H, Yeung CC, Leisenring WM, Seo S, Choi SM, Jerome KR, Englund JA, Boeckh M
      Clinical Significance of Human Coronavirus in Bronchoalveolar Lavage Samples From Hematopoietic Cell Transplant Recipients and Patients With Hematologic Malignancies.
      28329354 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017 June 1 : 64(11)1532-1539 PMCID:PMC5434339
    • Greninger AL, Waghmare A, Adler A, Qin X, Crowley JL, Englund JA, Kuypers JM, Jerome KR, Zerr DM
      Rule-Out Outbreak: 24-Hour Metagenomic Next-Generation Sequencing for Characterizing Respiratory Virus Source for Infection Prevention.
      28379561 Journal of the Pediatric Infectious Diseases Society, 2017 June 1 : 6(2)168-172
    • Seo S, Waghmare A, Scott EM, Xie H, Kuypers JM, Hackman RC, Campbell AP, Choi SM, Leisenring WM, Jerome KR, Englund JA, Boeckh M
      Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality.
      28183847 Haematologica, 2017 June : 102(6)1120-1130 PMCID:PMC5451345
    • Waghmare A, Englund JA, Boeckh M
      How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation.
      26968533 Blood, 2016 June 2 : 127(22)2682-92 PMCID:PMC4891952
    • Waghmare A, Pergam SA, Jerome KR, Englund JA, Boeckh M, Kuypers J
      Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients.
      25593338 Blood, 2015 March 12 : 125(11)1724-9 PMCID:PMC4357580
    • Waghmare A, Wagner T, Andrews R, Smith S, Kuypers J, Moss R, Englund JA
      Successful treatment of parainfluenza virus respiratory tract infection with DAS181 in four immunocompromised children
      J Pediatr Inf Dis Soc, 2014
    • Kim YJ, Guthrie KA, Waghmare A, Walsh E, Falsey A, Kuypers J, Cent A, Englund JA, Boeckh M
      Respiratory syncytial virus in hematopoietic transplant recipients: factors determining progression from upper to lower respiratory tract disease
      24368837 J Infect Dis, 2014 : 209(8)1195-204
    • Waghmare A, Campbell AP, Xie H, Seo S, Kuypers J, Leisenring W, Jerome KR, Englund JA, Boeckh M
      Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes.
      24065324 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013 Dec. : 57(12)1731-41 PMCID:PMC3840404
    • Eden A, Gaudet F, Waghmare A, Jaenisch R
      Chromosomal instability and tumors promoted by DNA hypomethylation
      12702868 Science, 2013 : 300(5618)455
    • Waghmare A, Xie H, Seo S, Kuypers J, Leisenring W, Englund JA, Boeckh M, Campbell AP
      Respiratory syncytial virus (RSV) in hematopoietic cell transplant (HCT) recipients: effect of RNA detection in blood and antiviral treatment on mortality
      ID Week, 2012 Oct. 17 - 2012 Oct. 21
    • Jordan N, Waghmare A, Abi-Ghanem AS, Moon A, Salvatore CM
      Systemic Mycobacterium avium complex infection during anti-tumor necrosis factor- therapy in a pediatric patient with Crohn's disease
      21694635 J Pediatr Gastroenterol Nutr, 2011
    • Robles DT, Leonard JL, Compton N, Waghmare A, McDonough KA, George E, Wolgamot G, Fleckman P
      Severe drug hypersensitivity reaction in a young woman treated with doxycycline.
      18332631 Dermatology (Basel, Switzerland), 2008 : 217(1)23-6

    Book Chapters

    • Waghmare A, Englund JA, Boeckh M
      How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation
      How I Treat: a Compendium for the Practicing Hematologist. 3rd ed, 2017
    • Waghmare A and Boeckh M
      Rhinovirus, Coronavirus, Enterovirus and Bocavirus after HCT or SOT
      Transplant Infections, 4th edition, 2015
    • Vora S, Waghmare A, Zerr DM, Melvin AJ
      Life-threatening viral diseases and their treatment.
      Fuhrman and Zimmerman's Pediatric Critical Care, 5th edition, 2015
    • Waghmare A and Englund JA
      Respiratory Viruses
      Pediatric Transplant and Oncology Infectious Diseases

  • Presentations Title Event Location Date
    Treatment options of COVID-19 patients with focus on stem cell transplantation and CAR T Cells European Society for Blood and Marrow Transplantation/ American Society of Transplantation and Cellular Therapy Online Webinar 2020
    Assessing the clinical utility of new diagnostics in infection surveillance and diagnosis 8th Annual Pediatric Blood and Marrow Transplant Consortium Meeting at the American Society for Pediatric Hematology/Oncology Annual Meeting Fort Worth, TX 2020
    Beyond the Sniffles: Unravelling Rhinovirus Disease Severity Fred Hutchinson Cancer Center Vaccine and Infectious Disease Division Scientific Seminar Seattle, WA 2018
    Viral Infections After Hematopoieic Cell Transplant National Institutes of Health Collaborative Workshop Bethesda, MD 2018
    Rhinovirus in Hematopoietic Cell Transplant Recipients Seattle Children’s Research Institute Respiratory Virus Symposium Seattle, WA 2017
    Rhinovirus in Hematopoietic Cell Transplant Recipients 2nd Symposium on Infectious Diseases in the Immunocompromised Host Seattle, WA 2017
    Respiratory Viral Infections in Children University of Washington WAMI Visiting Professor Program Port Angeles, WA 2016
    Aspergillosis after respiratory viral infections Interscience Conference of Antimicrobial Agents and Chemotherapy/American Society of Microbiology Meeting Boston, MA June 20, 2016
    Update on respiratory viral infections in hematopoietic cell transplantation 7th Annual International Conference on Infections in Hematology and Stem Cell Transplantation Kazimierz Dolny, Poland May 7, 2015
    Antiviral therapy for respiratory viral infections in pediatric immunocompromised hosts Pediatric Academic Societies Annual Meeting San Diego, CA April 25, 2015
    Pediatric RSV, COVID-19 & Community-acquired Pneumonia 36th Annual Infectious Disease Conference Seattle, WA
    “Determinants of disease severity in rhinovirus: importance of the host Fred Hutchinson Cancer Center Vaccine and Infectious Disease Division Scientific Seminar Seattle, WA
    Respiratory viral infections in hematopoietic cell transplant recipients 3rd Symposium on Infectious Diseases in the Immunocompromised Host Seattle, WA
    COVID-19 in Pediatric Oncology Seattle Children’s Hospital Cancer Care Unit Nursing Staff Meeting Seattle, WA
    Beyond the sniffles: unraveling the common cold Seattle Children’s Hospital/Department of Pediatrics Grand Rounds Seattle, WA
    COVID-19: The Seattle Children’s Experience Seattle Children’s Hospital/Department of Pediatrics Grand Rounds Seattle, WA
    Pre-transplant respiratory viral infections/detection impacts post-transplant outcomes IDWeek 2019 Washington, D.C.
    Panel on SARS-CoV-2 Pandemic – Current Situation and Moving Forward Fred Hutch Symposium on Coronaviruses: Past and Present Seattle, Wa
  • Grant Title Grantor Amount Award Date
    P-106-001 Treatment of High-Risk Patients with Respiratory Viral Infections after HCT Allovir 2020 - 2021
    R01 AI121129-05S1 NIH/NIAID $9,360 2020 - 2021
    R01AI153087–01 NIH/NIAID $2,309,368 direct costs 2020 - 2024
    Fred Hutch COVID-19 Pilot Award Fred Hutch $75,191 total costs 2020 - 2020
    R01 AI141707-02S1 NIH/NIAID $100,000 direct costs 2020 - 2022
    Broad Agency Announcement (BAA) 75D301-20-R-67897 CDC $499,500 direct costs 2020 - 2021
    FH/UW Cancer Center Support Grant NCI/NIH $128,031 total costs 2020 - 2021
    CovidWatch CovidWatch $1,039,621 direct costs 2020 - 2020
    FH/UW Cancer Center Support Grant NCI/NIH $128,031 total costs 2020 - 2021
    FREESIA Janssen Research and Development 2020 - 2021
    Catalytic Collaborations Grant Brotman Baty Institute $134,418 total costs 2020 - 2021
    Seattle Flu Study (Year 2) Brotman Baty Institute $350,317 direct costs 2020 - 2020
    HRV Study (Year 2) $88,950 (salary support) 2020 - 2020
    Viral and Host Biomarkers of Human Rhinovirus Disease Severity in Transplantation National Institutes of Health, National Institute of Allergy and Infectious Diseases $162,988 Dec. 11, 2014 - Nov. 30, 2019
    105548 Gates Foundation 2014 - 2014
    Clinical Research Scholar’s Program – Intensive Path Seattle Children’s Research Institute $44,773 direct costs 2014 - 2016
    5T32HD007233-32 NIH 2011 - 2014
    Viral Load Measurement Using Droplet Digital PCR: Association with Disease Severity in Healthy Childrens with Human Rhinovirus Center for Clinical and Translational research $20,000

Overview

Board Certification(s)

Pediatrics
Pediatric Infectious Diseases

Medical/Professional School

University of Washington, Seattle

Residency

Pediatrics, NY Presbyterian / Weill Cornell Medical Center, New York

Fellowship

Pediatric Infectious Disease, Seattle Children's Hospital, Seattle