Current Research Studies

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Abdominal Pain – Sleep Pain And Cardiac Evaluation-XL (SPACE-XL)

Researchers at Seattle Children’s Research Institute want to learn more about the relationship between sleep and stress, and how they affect pain.

Craniofacial Microsomia – Accelerating Research and Education (CARE) Study

Our CARE team is doing this research study to understand the healthcare needs of children, adolescents, and young adults with craniofacial microsomia.

Cancer – AALL1731: A Study to Investigate Blinatumomab in Combination with Chemotherapy in Patients with Newly Diagnosed B-Lymphoblastic Leukemia

The overall goal of Part I of this study is to collect information about leukemia and patient response to the first phase of treatment, called Induction. The...

Cancer – AALL1732: A Phase 2 Randomized Trial of Inotuzumab Ozogamicin for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy

The goal of this study is to determine, in a randomized manner, if the addition of 2 blocks of inotuzumab ozogamicin to modified Berlin-Frankfurt-Münster...

Cancer – AALL1521: Phase 2 Study of Ruxolitinib with Chemotherapy in Children with Acute Lymphoblastic Leukemia

Researchers want to test the safety of taking ruxolitinib in combination with chemotherapy.

Cancer – ADVL1414: Phase 1 Study of Selinexor, a Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors

This phase 1 trial studies the side effects and best dose of selinexor in treating younger patients with solid tumors or high-grade gliomas that have come back...

Cancer – ADVL1712: Feasibility Trial of MLN4924 Given in Combination with Azacitidine, Fludarabine and Cytarabine, in Children, Adolescents and Young Adults with Relapsed or Refractory Acute Myeloid Leukemia or Relapsed Myelodysplastic Syndrome

Researchers want to evaluate how the combination of pevonedistat, azacytidine, fludarabine phosphate and cytarabine works in patients.

Cancer – ADVL1416: Phase 2 Study of Ramucirumab, a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor 2 Receptor in Children with Refractory Solid Tumors, Including CNS Tumors

Researchers at Seattle Children's want to learn how patients with solid tumors react to ramucirumab.

Cancer – AHOD1221: Phase 1/2 Trial of Brentuximab Vedotin in Combination with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma

This phase 1/2 trial studies the side effects and best dose of brentuximab vedotin when given together with gemcitabine hydrochloride to see how well they work...

Cancer – ALTE16C1: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult Survivors of Osteosarcoma

This research trial studies saliva, semen and blood samples to determine effects of chemotherapy on fertility in osteosarcoma survivors.