Current Research Studies

Phase 1 Study of Intra-Tumoral Injections of Ex Vivo Expanded Natural Killer Cells in Children and Young Adults with Recurrent or Progressive Supratentorial Malignant Brain Tumors

PNOC028

Condition(s): Brain and Nervous System
Phase: I
Clinicaltrials.gov ID: NCT05887882

What is the goal of the study?

The purpose of this study is to see if it is safe and feasible to treat brain tumors with donor natural killer (NK) cells. The cells will be administered directly into the tumor or the resection area using a device called an Ommaya reservoir. We want to find out what effects, good or bad, this has on patients and their tumors.

Who can participate in the study?

Progressive or recurrent malignant brain tumor.

Study Team:

PI (Study Doctor): Erin Crotty
Study Team Member: HemOnc CRAs, HemOncCRAs@seattlechildrens.org

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.