Current Research Studies

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (MEASURE)

MEASURE_PBRN

  • Condition(s): Other
  • Phase: N/A

What is the goal of the study?

This is a study designed to answer the following research question: which children with acute otitis media (AOM) or acute sinusitis (AS) can be safely observed, which benefit from treatment with amoxicillin, and which, if any, benefit from treatment with amoxicillin-clavulanate? Despite the commonness of these conditions, available evidence of how to treat them remains sparse and contradictory: no trials have directly compared the effectiveness of amoxicillin and amoxicillin-clavulanate?the two most frequently used agents. Moreover, since the introduction of universal pneumococcal vaccination 25 years ago, no trials have compared amoxicillin to placebo. We will use a randomized trial design across multiple practice-based research networks (Seattle Children?s PBRN being one of 5 sites) to answer this question. Without a study like this, a large proportion of children with these conditions will likely receive inappropriate treatment. Elimination of the use of ineffective antibiotics will lead to better outcomes for individual children and lower rates of antibiotic resistant organisms in the community.

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team: