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Current Research Studies

Brain systems and behaviors underlying response to obesity treatment in children-(BASIC2)

Basic 2

Condition: Endocrinology

What is the goal of the study?

This is a drug study that will examine how the combination of family-based behavioral treatment (FBT) and a glucagon-like peptide-1 receptor agonist (GLP-1RA) drug intervention affects health outcomes in obese children from 10-12 years old. Participation includes a double-blinded 24 week period where participants receive either placebo or active drug and a 1-year follow-up period. Health outcomes will be evaluated by measuring changes to (a) BMI z-score, (b) neural activation by food cues & (c) mediobasal hypothalamus gliosis (via fMRI & sMRI).

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team:

PI (Study Doctor): Christian Roth
Study Team Member: Kathya Figueroa, Kathy.Figueroa@seattlechildrens.org

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.