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Current Research Studies

APEC14B1, The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

APEC14B1

  • Condition(s): Brain Tumor, Retinoblastoma, Ependymoma, Liver Tumors, Lymphoblastic Lymphoma (LBL), High-Grade Glioma, Renal Tumors, Burkitt's Lymphoma, Soft Tissue Sarcomas, Non-rhabdomyosarcoma Soft Tissue Sarcomas, Anaplastic Large Cell Lymphoma (ALCL), Atypical Teratoid/Rhabdoid Tumor, Rhabdoid Tumor of the Kidney, Histiocytic Tumors, Low-Grade Glioma, Juvenile Xanthogranuloma (JXG), Adrenocortical Carcinoma, Leukemia & Lymphoma, Medulloblastoma, Pilocytic Astrocytoma, Hodgkin Lymphoma, Other, Malignant Bone Tumors, Clear Cell Sarcoma of the Kidney, Biology, Non-Hodgkin Lymphoma (NHL), CNS Sarcoma, Hepatoblastoma, Osteosarcoma, Neuroblastoma, Renal Cell Carcinoma, Chronic Myelogenous Leukemia (CML), Adrenal Tumors, Acute Myeloid Leukemia (AML), Diffuse Large B-cell Lymphoma (DLBCL), Thyroid Cancer, Craniopharyngioma, Acute Lymphoblastic Leukemia (ALL), Recurrent and/or Refractory, Diffuse Intrinsic Pontine Glioma (DIPG), Rhabdomyosarcoma, Germ Cell Tumors, Hepatocellular Carcinoma, Infant Leukemia, Glioneuronal and Neuronal Tumors, Newly diagnosed, CNS Germ Cell Tumors, Solid Tumor, Diffuse Midline Glioma (DMG), Langerhans Cell Histiocytosis (LCH), CNS Embryonal Tumors, Registry, Ewing Sarcoma, Choroid Plexus Tumors, Pheochromocytoma, Wilms Tumor
  • Phase: N/A
  • Clinicaltrials.gov ID: NCT02402244

What is the goal of the study?

The next generation of therapy for childhood cancers will be based upon in-depth molecular phenotyping that may facilitate the development of rational risk-adapted and target-based therapies. In order to support current and future molecularly-guided therapeutic trials and the basic science discovery efforts that will lead to more effective therapies, prevention, early detection and a reduction in early and late-onset toxicities, it is critical to implement universal, high-quality collection of annotated biospecimens from children with cancer. This protocol provides for the collection of biospecimens and accompanying demographic, epidemiologic, therapeutic, and outcome data from all children diagnosed with cancer at participating COG institutions, independent of the patient’s enrollment on a therapeutic clinical trial. Through this approach, the correlation of phenotypic and genotypic or other –omic data with the relevant outcomes at the individual, disease, and protocol levels will be ensured. Biospecimen requirements and handling may be disease specific and thus a detailed manual of procedures will provide disease specific information regarding sample collection and processing based on the clinical diagnosis.

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team: