Current Research Studies
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- Asthma – Airway Epithelial Cell Cytokine Profiles of Children With and Without Asthma Study
- Asthma: Role of the Airway Epithelium in Children with Asthma
- Autism Spectrum Disorder: Washington Study of Outcomes, Neural Development, and Early Risk (WONDER)
- Autism – SPARK: Simons Foundation Powering Autism Research for Knowledge Study
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- Cancer - A031102: Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors
- Cancer - AALL0932: Treatment of Patients with Newly Diagnosed Standard Risk B-precursor Acute Lymphoblastic Leukemia (ALL)
- Cancer - AALL1131: Phase 2 Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia including a Stratum Evaluating Dasatinib in Patients with Ph-like Tyrosine Kinase Inhibitor Sensitive Mutations
- Cancer - AALL1231: Phase 3 Randomized Trail Investigating Bortexomib on a Modified Augmented BFM Backbone in Newly Diagnosed T-Lymphoblastic Leukemia and T-Lymphoblastic Lympphoma
- Cancer - AALL1521: Phase 2 Study of Ruxolitinib with Chemotherapy in Children with Acute Lymphoblastic Leukemia
- Cancer - AALL15P1: A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine to Chemotherapy in Infants with Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement
- Cancer - AALL1631: International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones
- Cancer - AALL1731: A Study to Investigate Blinatumomab in Combination with Chemotherapy in Patients with Newly Diagnosed B-Lymphoblastic Leukemia
- Cancer - AALL1732: A Phase 2 Randomized Trial of Inotuzumab Ozogamicin for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
- Cancer - AAML1421: Phase 1/2 Study of CPX-351 Alone Followed By Fludarabine, Cytarabine and G-CSF for Children with Relapsed Acute Myeloid Leukemia
- Cancer - AAML1531: Risk-Stratified Therapy for Acute Myeloid Leukemia in Down Syndrome
- Cancer - ACCL1033: A Comprehensive Approach to Improve Medication Adherence in Pediatric ALL
- Cancer - ACCL10P1: Computerized Cognitive Training for Pediatric Brain Tumor Patients: A Pilot Study
- Cancer - ACNS02B3: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimen
- Cancer - ACNS1022: Phase 2 Randomized Trial of Lenalidomide in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
- Cancer - ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors
- Cancer - ACNS1422: Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
- Cancer - ACNS1721: Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma Without H3 K27M or BRAFV600E Mutations
- Cancer - ACNS1723: Dabrafenib Combined with Trametinib After Radiation Therapy in Treating Patients with Newly Diagnosed High-Grade Glioma
- Cancer - ADVL1217: Phase 1 Study of MK-1775 Concurrent with Local Radiation Therapy for the Treatment of Newly Diagnosed Children with Diffuse Intrinsic Pontine Gliomas
- Cancer - ADVL1312: Phase 1/2 Study of AZD1775 in Combination with Oral Irinotecan in Children, Adolescents and Young Adults with Relapsed or Refractory Solid Tumors
- Cancer - ADVL1412: Phase 1/2 Study of Nivolumab in Children, Adolescents and Young Adults with Recurrent or Refractory Solid Tumors as a Single Agent and in Combination with Ipilimumab
- Cancer - ADVL1414: Phase 1 Study of Selinexor, a Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors
- Cancer - ADVL1416: Phase 2 Study of Ramucirumab, a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor 2 Receptor in Children with Refractory Solid Tumors, Including CNS Tumors
- Cancer - ADVL1513: Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
- Cancer - ADVL1514: Phase 1 Study of ABI-009 in Pediatric Patients with Recurrent or Refractory Solid Tumors
- Cancer - ADVL1515: Phase 1 Study of LY2606368, a CHK1/2 Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, Including CNS Tumors
- Cancer - ADVL1521: Phase 2 Study of the MEK Inhibitor Trametinib in Children with Relapsed or Refractory Juvenile Myelomonocytic Leukemia
- Cancer - ADVL1614: Phase 1/2 Study of VX26/3604 in Children, Adolescents or Young Adults with Recurrent or Relapsed Solid Tumors
- Cancer - ADVL1615: Phase 1 Study of Pevonedistat, a NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors
- Cancer - ADVL1622: Phase 2 Trial of XL154 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor and Other Rare Tumors
- Cancer - ADVL1712: Feasibility Trial of MLN4924 Given in Combination with Azacitidine, Fludarabine and Cytarabine, in Children, Adolescents and Young Adults with Relapsed or Refractory Acute Myeloid Leukemia or Relapsed Myelodysplastic Syndrome
- Cancer - AEWS1031: Phase 3 Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma
- Cancer - AGCT1532: Phase 3 Accelerated BEP Trial: A Ramdomized Phase 3 Trial of Accelerated vs. Standard BEP Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumors
- Cancer - AHEP0731: Treatment of Children with All Stages of Hepatoblastoma
- Cancer - AHEP1531: A Phase 2/3 Study, Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT)
- Cancer - AHOD1221: Phase 1/2 Trial of Brentuximab Vedotin in Combination with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma
- Cancer - AHOD1331: Randomized Phase 3 Study of Brentuximab Vedotin for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma in Children and Young Adults
- Cancer - AHODO831: A Non-Randomized Phase III Study of Response Adapted Therapy for the Treatment of Children with Newly Diagnosed High Risk Hodgkin Lymphoma
- Cancer - AINV18P1: Phase 1 Study of Palbociclib, A CDK 4/6 Inhibitor, in Combination with Chemotherapy in Children with Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
- Cancer - ALTE05N1: Umbrella Long-Term Follow Up Protocol
- Cancer - ALTE07C1: Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer
- Cancer - ALTE11C2: Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
- Cancer - ALTE15N2: Late Effects After High-Risk Neuroblastoma Study
- Cancer - ALTE1621: Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure: a Phase 2b Randomized Placebo-Controlled Trial
- Cancer - ALTE1631: Randomized Web-based Physical Activity Intervention Among Children and Adolescents with Acute Lymphoblastic Leukemia
- Cancer - ALTE16C1: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult Survivors of Osteosarcoma
- Cancer - ANBL00B1: Neuroblastoma Biology Studies
- Cancer - ANBL1232: Utilizing Response - and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma - a Groupwide Historically Controlled Phase 3 Study
- Cancer - ANBL1531: Phase 3 Study of I-Metaiodobenzylguanidine (I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
- Cancer - ANBL1821: Phase 2 Randomized Study of Irinotecan/Temozoloide/Dinutuximab with or without Eflornithine in Children with Relapsed, Refractory or Progressive Neuroblastoma
- Cancer - ANHL04B1: Rare and Cutaneous Non-Hodgkin Lymphoma Registry
- Cancer - AOST1321: Phase 2 Study of Denosumab, a RANK Ligand Antibody, for Recurrent or Refractory Osteosarcoma
- Cancer - AOST1421: Phase 2 Study of Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 in Combination with Sargramostim in Patients with Recurrent Osteosarcoma
- Cancer - APEC14B1: The Project: Everychild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
- Cancer - AREN0534: Treatment for Patients with Bilateral, Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor
- Cancer - AREN1721: Randomized Phase 2 Trial of Axitinib/Nivolumab Combination Therapy vs. Single Agent Axitinib or Nivolumab for the Treatment of TFE/Translocation Renal Cell Carcinoma Across All Age Groups
- Cancer - BrainChild-03: Phase 1 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
- Cancer - CONNECT 1701: Phase 1 Study of Ribociclib and Everolimus Following Radiation Therapy in Children with Newly Diagnosed Non-Biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)
- Cancer - NANT 2011-01: Study of Single-Agent 131I-MIBG with Vincristine and Irinotecan, or 131I-MIBG with Vorinostat for Resistant/Relapsed Neuroblastoma
- Cancer - NANT 2015-01: Neuroblastoma Precision Trial
- Cancer - NANT 2015-02: Phase I Study of Lorlatinib (PF-06463922), and Oral Small Molecule Inhibitor of ALK/ROS1, for Patients with Alk-Driven Relapsed or Refractory Neuroblastoma
- Cancer - NANT 2017-01: Phase I Study of 131I-MIBG with Dinutuximab for Relapsed/Refractory Neuroblastoma
- Cancer - NANT-2013-01: Immunotherapy of relapsed refractory neuroblastoma with Expanded NK Cells, Dinutuximab and Lenalidomide
- Cancer - NIH R01 Umbrella Study: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescents and Young Adults (AYA) Survivors of Osteosarcoma
- Cancer - PLAT-01: A Phase I Feasibility and Safety Study of Cellular Immunotherapy for Relapsed/Refractory Pediatric CD19+ Acute Lymphoblastic Leukemia Using Autologous T-cells Lentivirally Transduced to Express a CD19-Specific Chimeric Antigen Receptor
- Cancer - PNOC 005: A Phase 1 Study of Modified Measles Virus (Mv-NIS) for the Treatment of Children and Young Adults with Recurrent Medulloblastoma or Recurrent Atypical Teratoid Rhabdoid Tumors (ATRT)
- Cancer - PNOC 008: A Pilot Trial Testing the Clinical Benefit of Using Molecular Profiling to Determine and Individualized Treatment Plan in Children and Young Adults with High Grade Glioma (Excluding Diffuse Intrinsic Pontine Glioma)
- Cancer - PNOC 014: A Phase I/II and Target Validation Study of TAK-580 (MLN2480) for Children with Low-Grade Gliomas and Other RAS/RAF/MEK/ERK Pathway Activated Tumor
- Cancer - PNOC 016: A Target Validation Study of Fimepinostat in Children and Young Adults with Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG), Recurrent Medulloblastoma, or Recurrent High-Grade Glioma (HGG)
- Cancer - REGN2810 in Pediatric Patients with Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination with Radiotherapy in Pediatric Patients with Newly Diagnosed or Recurrent Glioma
- Cancer – A Phase 2 Study Evaluating Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD
- Cancer – ACNS0831: Phase 3 Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 Years
- Cancer – ACNS1422: Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
- Cancer – AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
- Cancer – BrainChild-01: CAR T-Cell Therapy for Brain and Central Nervous System Tumors Clinical Trial
- Cancer – BrainChild-02: Phase 1 Study of EGFR806-Specific CAR T-Cell Locoregional Immunotherapy for EGFR-Positive Recurrent or Refractory Pediatric Central Nervous System Tumors
- Cancer – ENCIT-01: Engineered Neuroblastoma Cellular Immunotherapy
- Cancer – HA-1 TCR T-Cell Immunotherapy for Treating Patients with Relapsed or Refractory Acute Leukemia after Donor Stem Cell Transplant Clinical Trial
- Cancer – PBTC-042: Phase I Study of CDK 4-6 Inhibitor PD-0332991 In Children With Recurrent, Progressive or Refractory Central Nervous System Tumors
- Cancer – PLAT-02: A Phase 1/2 Feasibility and Safety Study of CD19-CAR T-Cell Immunotherapy for CD19+ Leukemia
- Cancer – PLAT-03: A Pilot Feasibility and Safety Study of CD19t T-APC Vaccination Following CAR T-Cell Immunotherapy for CD19+ Leukemia
- Cancer – PLAT-04: A Phase 1 Feasibility and Safety Study of CD22 CAR T-Cell Immunotherapy for CD22+ Leukemia
- Cancer – PLAT-05: A Phase 1 Feasibility and Safety Study of Dual Specificity CD19 and CD22-CAR T-Cell Immunotherapy for CD19+CD22+ Leukemia and Lymphoma
- Cancer – PNOC012: A Randomized, Blinded Study of Fluorescence Detection of Pediatric Primary Central Nervous System Tumors in Subjects Receiving Tozuleristide and Imaged With the Canvas System
- Cancer – SC-4016: Phase 1 and 2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers
- Cancer – SC-9010: Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (SJATRT)
- Cancer – SC-9012: Phase I-II Study of MEK 162 for Children with Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors
- Cancer – STRIvE-01: Phase I Study of EGFR806 CAR T Cell Immunotherapy for Relapsed or Refractory Solid Tumors in Children and Young Adults
- CDG – Clinical and Basic Investigations into Phosphomannomutase Deficiency (PMM2-CDG1a)
- Cerebral Palsy - Short Burst Locomotor Treadmill Training Study
- Cerebral Palsy – Biomechanics and Walking in Cerebral Palsy: Ankle Foot Orthoses Footwear Combinations Study
- Cerebral Palsy – Power Training Combined with Interval Treadmill Training to Improve Walking Activity in Cerebral Palsy (PT3)
- Child Health and Development - Seattle Water and Environment Early Life Longitudinal Study (SWELL)
- Cleft Lip and Palate – A Retrospective Study of Breast Milk Feeding Children with Oral Clefts
- Cleft Lip and Palate – Clinical Effectiveness of Late Maxillary Protraction in Cleft Lip and Palate Study
- Cleft Lip and Palate – Infants with Orofacial Clefts: Development and Validation of an Observer-Reported Outcomes Instrument (ICOO)
- Concussion – Collaborative Care Model for Treatment of Persistent Symptoms After Concussion Among Youth (Collaborative Care Study)
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- Orthopedics – Muscle Strength and Functional Performance After Medial Patellofemoral Ligament Reconstruction
- Orthopedics – Non-Operative Treatment Compared With Internal Fixation for Displaced Medial Humeral Epicondyle Fractures: A Multicenter Prospective Evaluation
- Orthopedics – Registries for Children with Congenital Upper Limb Differences
- Orthopedics – Registry of Children With Acquired and Congenital Limb Deficiencies
- Orthopedics – Skeletal Dysplasia Clinical Registry
- Orthopedics – Spine and Chest Wall Deformity Registries
- Orthopedics, ACL – Clinical Outcomes and Physical Therapy Functional Assessments in Pediatric and Adolescent Patients After ACL Reconstruction Study
- Orthopedics, ACL – Quadriceps Tendon Autograft Anterior Cruciate Ligament Reconstruction With Suture Tape Reinforcement: A Randomized Controlled Trial
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