Current Research Studies
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- Acidemia – Mapping the Patient Journey in Methylmalonic and Propionic Acidemia (The MaP Study)
- ADHD – The Effects of ADHD Medicine (TEAM) Study
- Asthma – Airway Epithelial Cell Cytokine Profiles of Children With and Without Asthma Study
- Autism Spectrum Disorder: Washington Study of Outcomes, Neural Development, and Early Risk (WONDER)
- Autism – SPARK: Simons Foundation Powering Autism Research for Knowledge Study
- Autism – The Autism Biomarkers Consortium Clinical Trials
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- Cancer - A031102: Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors
- Cancer - AALL0932: Treatment of Patients with Newly Diagnosed Standard Risk B-precursor Acute Lymphoblastic Leukemia (ALL)
- Cancer - AALL1131: Phase 2 Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia including a Stratum Evaluating Dasatinib in Patients with Ph-like Tyrosine Kinase Inhibitor Sensitive Mutations
- Cancer - AALL1231: Phase 3 Randomized Trail Investigating Bortexomib on a Modified Augmented BFM Backbone in Newly Diagnosed T-Lymphoblastic Leukemia and T-Lymphoblastic Lympphoma
- Cancer - AALL1521: Phase 2 Study of Ruxolitinib with Chemotherapy in Children with Acute Lymphoblastic Leukemia
- Cancer - AALL15P1: A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine to Chemotherapy in Infants with Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement
- Cancer - AALL1631: International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones
- Cancer - AAML1421: Phase 1/2 Study of CPX-351 Alone Followed By Fludarabine, Cytarabine and G-CSF for Children with Relapsed Acute Myeloid Leukemia
- Cancer - AAML1531: Risk-Stratified Therapy for Acute Myeloid Leukemia in Down Syndrome
- Cancer - ACCL1033: A Comprehensive Approach to Improve Medication Adherence in Pediatric ALL
- Cancer - ACCL10P1: Computerized Cognitive Training for Pediatric Brain Tumor Patients: A Pilot Study
- Cancer - ACNS02B3: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimen
- Cancer - ACNS1022: Phase 2 Randomized Trial of Lenalidomide in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
- Cancer - ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors
- Cancer - ACNS1422: Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
- Cancer - ACNS1721: Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma Without H3 K27M or BRAFV600E Mutations
- Cancer - ADVL1217: Phase 1 Study of MK-1775 Concurrent with Local Radiation Therapy for the Treatment of Newly Diagnosed Children with Diffuse Intrinsic Pontine Gliomas
- Cancer - ADVL1312: Phase 1/2 Study of AZD1775 in Combination with Oral Irinotecan in Children, Adolescents and Young Adults with Relapsed or Refractory Solid Tumors
- Cancer - ADVL1412: Phase 1/2 Study of Nivolumab in Children, Adolescents and Young Adults with Recurrent or Refractory Solid Tumors as a Single Agent and in Combination with Ipilimumab
- Cancer - ADVL1414: Phase 1 Study of Selinexor, a Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors
- Cancer - ADVL1416: Phase 2 Study of Ramucirumab, a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor 2 Receptor in Children with Refractory Solid Tumors, Including CNS Tumors
- Cancer - ADVL1513: Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
- Cancer - ADVL1514: Phase 1 Study of ABI-009 in Pediatric Patients with Recurrent or Refractory Solid Tumors
- Cancer - ADVL1515: Phase 1 Study of LY2606368, a CHK1/2 Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, Including CNS Tumors
- Cancer - ADVL1521: Phase 2 Study of the MEK Inhibitor Trametinib in Children with Relapsed or Refractory Juvenile Myelomonocytic Leukemia
- Cancer - ADVL1614: Phase 1/2 Study of VX26/3604 in Children, Adolescents or Young Adults with Recurrent or Relapsed Solid Tumors
- Cancer - ADVL1615: Phase 1 Study of Pevonedistat, a NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors
- Cancer - ADVL1622: Phase 2 Trial of XL154 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor and Other Rare Tumors
- Cancer - ADVL1712: Feasibility Trial of MLN4924 Given in Combination with Azacitidine, Fludarabine and Cytarabine, in Children, Adolescents and Young Adults with Relapsed or Refractory Acute Myeloid Leukemia or Relapsed Myelodysplastic Syndrome
- Cancer - AEWS1031: Phase 3 Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma
- Cancer - AHEP0731: Treatment of Children with All Stages of Hepatoblastoma
- Cancer - AHEP1531: A Phase 2/3 Study, Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT)
- Cancer - AHOD1221: Phase 1/2 Trial of Brentuximab Vedotin in Combination with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma
- Cancer - AHOD1331: Randomized Phase 3 Study of Brentuximab Vedotin for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma in Children and Young Adults
- Cancer - AHODO831: A Non-Randomized Phase III Study of Response Adapted Therapy for the Treatment of Children with Newly Diagnosed High Risk Hodgkin Lymphoma
- Cancer - AINV18P1: Phase 1 Study of Palbociclib, A CDK 4/6 Inhibitor, in Combination with Chemotherapy in Children with Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
- Cancer - ALTE05N1: Umbrella Long-Term Follow Up Protocol
- Cancer - ALTE07C1: Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer
- Cancer - ALTE11C2: Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
- Cancer - ALTE15N2: Late Effects After High-Risk Neuroblastoma Study
- Cancer - ALTE1621: Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure: a Phase 2b Randomized Placebo-Controlled Trial
- Cancer - ALTE1631: Randomized Web-based Physical Activity Intervention Among Children and Adolescents with Acute Lymphoblastic Leukemia
- Cancer - ALTE16C1: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult Survivors of Osteosarcoma
- Cancer - ANBL00B1: Neuroblastoma Biology Studies
- Cancer - ANBL1232: Utilizing Response - and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma - a Groupwide Historically Controlled Phase 3 Study
- Cancer - ANBL1531: Phase 3 Study of I-Metaiodobenzylguanidine (I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
- Cancer - ANBL1821: Phase 2 Randomized Study of Irinotecan/Temozoloide/Dinutuximab with or without Eflornithine in Children with Relapsed, Refractory or Progressive Neuroblastoma
- Cancer - ANHL04B1: Rare and Cutaneous Non-Hodgkin Lymphoma Registry
- Cancer - AOST1321: Phase 2 Study of Denosumab, a RANK Ligand Antibody, for Recurrent or Refractory Osteosarcoma
- Cancer - AOST1421: Phase 2 Study of Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 in Combination with Sargramostim in Patients with Recurrent Osteosarcoma
- Cancer - APEC14B1: The Project: Everychild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
- Cancer - AREN0534: Treatment for Patients with Bilateral, Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor
- Cancer - AREN1721: Randomized Phase 2 Trial of Axitinib/Nivolumab Combination Therapy vs. Single Agent Axitinib or Nivolumab for the Treatment of TFE/Translocation Renal Cell Carcinoma Across All Age Groups
- Cancer - BrainChild-03: Phase 1 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
- Cancer - CONNECT 1701: Phase 1 Study of Ribociclib and Everolimus Following Radiation Therapy in Children with Newly Diagnosed Non-Biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)
- Cancer - NIH R01 Umbrella Study: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescents and Young Adults (AYA) Survivors of Osteosarcoma
- Cancer – A Phase 2 Study Evaluating Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD
- Cancer – ACNS0831: Phase 3 Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 Years
- Cancer – ACNS1422: Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
- Cancer – BrainChild-01: CAR T-Cell Therapy for Brain and Central Nervous System Tumors Clinical Trial
- Cancer – BrainChild-02: Phase 1 Study of EGFR806-Specific CAR T-Cell Locoregional Immunotherapy for EGFR-Positive Recurrent or Refractory Pediatric Central Nervous System Tumors
- Cancer – ENCIT-01: Engineered Neuroblastoma Cellular Immunotherapy
- Cancer – HA-1 TCR T-Cell Immunotherapy for Treating Patients with Relapsed or Refractory Acute Leukemia after Donor Stem Cell Transplant Clinical Trial
- Cancer – PBTC-042: Phase I Study of CDK 4-6 Inhibitor PD-0332991 In Children With Recurrent, Progressive or Refractory Central Nervous System Tumors
- Cancer – PLAT-02: A Phase 1/2 Feasibility and Safety Study of CD19-CAR T-Cell Immunotherapy for CD19+ Leukemia
- Cancer – PLAT-03: A Pilot Feasibility and Safety Study of CD19t T-APC Vaccination Following CAR T-Cell Immunotherapy for CD19+ Leukemia
- Cancer – PLAT-04: A Phase 1 Feasibility and Safety Study of CD22 CAR T-Cell Immunotherapy for CD22+ Leukemia
- Cancer – PLAT-05: A Phase 1 Feasibility and Safety Study of Dual Specificity CD19 and CD22-CAR T-Cell Immunotherapy for CD19+CD22+ Leukemia and Lymphoma
- Cancer – PLAT-06: A Phase 1/2 Study of CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma
- Cancer – PNOC012: A Randomized, Blinded Study of Fluorescence Detection of Pediatric Primary Central Nervous System Tumors in Subjects Receiving Tozuleristide and Imaged With the Canvas System
- Cancer – SC-4016: Phase 1 and 2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers
- Cancer – SC-9010: Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (SJATRT)
- Cancer – SC-9012: Phase I-II Study of MEK 162 for Children with Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors
- Cancer – STRIvE-01: Phase I Study of EGFR806 CAR T Cell Immunotherapy for Relapsed or Refractory Solid Tumors in Children and Young Adults
- CDG – Clinical and Basic Investigations into Phosphomannomutase Deficiency (PMM2-CDG1a)
- Cerebral Palsy - Short Burst Locomotor Treadmill Training Study
- Cerebral Palsy – Biomechanics and Walking in Cerebral Palsy: Ankle Foot Orthoses Footwear Combinations Study
- Cerebral Palsy – Power Training Combined with Interval Treadmill Training to Improve Walking Activity in Cerebral Palsy (PT3)
- Cleft Lip and Palate – A Retrospective Study of Breast Milk Feeding Children with Oral Clefts
- Cleft Lip and Palate – Clinical Effectiveness of Late Maxillary Protraction in Cleft Lip and Palate Study
- Cleft Lip and Palate – Infants with Orofacial Clefts: Development and Validation of an Observer-Reported Outcomes Instrument (ICOO)
- Concussion – Collaborative Care Model for Treatment of Persistent Symptoms After Concussion Among Youth (Collaborative Care Study)
- Cystic Fibrosis – STOP-PEDS Feasibility: Standardizing Treatment of Pulmonary Exacerbations in Pediatrics Pilot Feasibility Study
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- Orthopedics – Lung Function in Children With Early Onset Scoliosis: Effect of Body Position Study
- Orthopedics – Muscle Strength and Functional Performance After Medial Patellofemoral Ligament Reconstruction
- Orthopedics – Non-Operative Treatment Compared With Internal Fixation for Displaced Medial Humeral Epicondyle Fractures: A Multicenter Prospective Evaluation
- Orthopedics – Registries for Children with Congenital Upper Limb Differences
- Orthopedics – Registry of Children With Acquired and Congenital Limb Deficiencies
- Orthopedics – Skeletal Dysplasia Clinical Registry
- Orthopedics – Spine and Chest Wall Deformity Registries
- Orthopedics, ACL – Clinical Outcomes and Physical Therapy Functional Assessments in Pediatric and Adolescent Patients After ACL Reconstruction Study
- Orthopedics, ACL – Quadriceps Tendon Autograft Anterior Cruciate Ligament Reconstruction With Suture Tape Reinforcement: A Randomized Controlled Trial
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