Current Research Studies

A back to top

• ADHD – Treating Parents with ADHD and Their Children (TPAC)
• Abdominal Pain – Sleep Pain And Cardiac Evaluation-XL (SPACE-XL)
• Asthma – Airway Epithelial Cell Cytokine Profiles of Children With and Without Asthma Study
• Asthma – Role of the Airway Epithelium in Children with Asthma
• Autism - CHART Study - Congenital Cytomegalovirus, Hearing Loss, and Autism Retrospective Study
• Autism - RUBIES in Educational Settings
• Autism – Generating Effectiveness Mechanisms in RUBI (GEMs in RUBI)
• Autism – SPARK: Simons Foundation Powering Autism Research for Knowledge Study

C back to top

• COVID-19 - Pfizer Bivalent Vaccine Study
• Cancer - AAML18P1: Stopping Tyrosine Kinase Inhibitors (TKI) to Assess Treatment-Free Remission (TFR) in Pediatric Chronic Myeloid Leukemia - Chronic Phase (CML-CP)
• Cancer - ANHL1931: A Randomized Phase 3 trial of Nivolumab in Combination with Chemo-immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-cell Lymphoma
• Cancer - APAL2020SC: Pediatric Acute Leukemia (PedAL) Screening Trial – Developing New Therapies for Relapsed Leukemias
• Cancer - APEC1621A: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of LOXO-101 (Larotrectinib) in Patients with Tumors Harboring Actionable NTRK Fusions
• Cancer - APEC1621F: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Ensartinib in Patients with Tumors Harboring ALK or ROS1 Genomic Alterations
• Cancer - E4412: Brentuximab Vedotin and Nivolumab with or without Ipilimumab in Treating Patients with Relapsed or Refractory Hodgkin Lymphoma
• Cancer - SC-N145, Targeted Therapy to Increase RAI Uptake in Metastatic DTC
• Cancer – A Phase 2 Study Evaluating Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD
• Cancer – AALL1731: A Study to Investigate Blinatumomab in Combination with Chemotherapy in Patients with Newly Diagnosed B-Lymphoblastic Leukemia
• Cancer – AALL1732: A Phase 2 Randomized Trial of Inotuzumab Ozogamicin for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
• Cancer – AALL1931: An Open-Label, Multicenter Study of RC-P in Patients with Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) Following Hypersensitivity to E. coli-derived Asparaginases
• Cancer – ADVL1823: Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia
• Cancer – AGCT1532: Phase 3 Accelerated BEP Trial: A Ramdomized Phase 3 Trial of Accelerated vs. Standard BEP Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumors
• Cancer – ANBL1232: Utilizing Response - and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma - a Groupwide Historically Controlled Phase 3 Study
• Cancer – APEC1621SC: The Pediatric MATCH Screening Trial
• Cancer – ARST1431: Combination Chemotherapy With or Without Temsirolimus in Treating Patients with Intermediate Risk Rhabdomyosarcoma
• Cancer – BrainChild-03: Phase 1 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
• Cancer – BrainChild-04: Phase 1 Study Of B7-H3, EGFR806, HER2, AND IL13-zetakine (QUAD) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors
• Cancer – ENLIGHTen-01: A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma
• Cancer – HA-1 TCR: T-Cell Immunotherapy for Treating Patients with Relapsed or Refractory Acute Leukemia after Donor Stem Cell Transplant Clinical Trial
• Cancer – NCT03971799: Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia
• Cancer – PEPN1812: A Phase 1 Trial of the CD123 X CD3 Dual Affinity Re-Targeting Antibody Flotetuzumab in Children, Adolescents, and Young Adults with Relapsed or Refractory Acute Myeloid Leukemia
• Cancer – PLAT-08: A Phase 1 Study of SC-DARIC33 in Children and Young Adults with Relapsed or Refractory CD33+ AML
• Cancer – PNOC-013: REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma
• Cancer – SC-4016: Phase 1 and 2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers
• Cancer – SC-9012: Phase I-II Study of MEK 162 for Children with Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors
• Cancer – SC-9015: ONC201 in Newly Diagnosed Diffuse Intrinsic Pontine Glioma and Recurrent/Refractory Pediatric H3K27M Gliomas
• Cancer – STRIvE-01: Phase I Study of EGFR806 CAR T Cell Immunotherapy for Relapsed or Refractory Solid Tumors in Children and Young Adults
• Cancer – STUDY00002718: A Study to Evaluate the Safety and Efficacy of JCAR017 in Pediatric Subjects With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia and B-cell Non-Hodgkin Lymphoma
• Cancer – T2016-002:A Phase I/II Study of Nivolumab in Combination with 5-azacytidine in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia
• Cerebral Palsy – Power Training Combined with Interval Treadmill Training to Improve Walking Activity in Cerebral Palsy (PT3)
• Cerebral Palsy – Short Burst Locomotor Treadmill Training Study
• Child Health and Development - Developing a Remote Assessment Approach to Measure Cognitive Stimulation
• Cleft Lip and Palate – A Retrospective Study of Breast Milk Feeding Children with Oral Clefts
• Cleft Lip and Palate – Clinical Effectiveness of Late Maxillary Protraction in Cleft Lip and Palate Study
• Cleft Lip and Palate – Infants with Orofacial Clefts: Development and Validation of an Observer-Reported Outcomes Instrument (ICOO)
• Concussion - Concussion Health Improvement Program (CHIP Study)
• Concussion - Four Corners Youth Concussion Registry
• Concussion – Mobile Sub-threshold Exercise Program for Concussion (M-STEP)
• Conmoción cerebral – Programa de ejercicio móvil subumbral para la conmoción cerebral
• Craniofacial Microsomia – Accelerating Research and Education (CARE) Study

D back to top

• Diabetes - Neuro T1D, Neuroimaging Eating Behaviors in Type 1 Diabetes
• Diabetes: TrialNet T1D Risk Screening Pathway to Prevention

E back to top

• Epilepsy - Seattle Children’s and Allen Brain Institute Brain Tissue Collaboration Study
• Epilepsy – Molecular Genetic Studies on Developmental Disorders

G back to top

• Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants (LVXSCID-ND)

H back to top

• Headache and Migraine – A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Adolescent Patients 12 to 17 Years of Age with Chronic Migraine – the REBUILD-2 Study
• Headache and Migraine – A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Patients 6 to 17 Years of Age with Episodic Migraine – the REBUILD-1 Study
• Headache and Migraine – Pediatric Options for Migraine Relief: A Randomized, Double-Blind, Placebo-Controlled Study of Lasmiditan for Acute Treatment of Migraine: PIONEER-PEDS1
• Hearing – The Development of Sensitivity to Electrical Stimulation with Cochlear Implants Study
• Hydrocephalus - Endoscopic versus Shunt Treatment of Hydrocephalus in Infants (ESTHI)

I back to top

• Immunology – Immunology Biorepository Study

K back to top

• Kidney Disease – Nephrotic Syndrome Study Network, 2nd cohort (cNEPTUNE)

L back to top

• Lysosomal Storage Disease Registries – Fabry, Pompe, Gaucher and MPS1

M back to top

• Mucopolysaccharidosis Type IVA – Morquio A Registry Study (MARS)

O back to top

• Orthopedics - Pediatric Tibial Spine Fractures Prospective Cohort
• Orthopedics – Does a Pre-Operative Carbohydrate Drink Decrease Time For Gastrointestinal Function To Return After Spinal Fusion Surgery?

P back to top

• Preschoolers Learning and Active in Play (PLAY) Study
• Psychiatry and Behavioral Medicine – The INCLUDE Developmental Delay Study

R back to top

• Rheumatic Diseases: Observational Study of Pediatric Rheumatic Diseases - The CARRA Registry

S back to top

• Seizure – Pediatric Dose Optimization for Seizures in Emergency Medical Services
• Sepsis – Pragmatic Pediatric Trial of Balanced vs NormaL Saline Fluid in Sepsis (PRoMPT BOLUS)

T back to top

• Tourette Disorder - Collaborative Genomic Studies of Tourette Disorder

U back to top

• Undiagnosed Diseases Network – Pacific Northwest
• Urology - Multicenter Pilot and Exploration Study of Enhanced Recovery After Surgery in Patients Undergoing Urologic Reconstructive Surgery (ERAS- PURSUE)

V back to top

• Vaccines: New Vaccine Surveillance Network (NVSN) - Healthy Control
• Vascular Anomalies – Lymphatic Malformation Quality of Life Study

W back to top

• Weight Management - Brain Activation and Satiety in Children 2 (BASIC2)
• Weight Management – Success in Health, Impacting Families Together (SHIFT) Study