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Publications

Crawley O, Opperman KJ, Desbois M, Adrados I, Borgen MA, Giles AC, Duckett DR, Grill B (2019) Autophagy is inhibited by ubiquitin ligase activity in the nervous system. Nat Commun Nov 1;10(1):5017. doi: 10.1038/s41467-019-12804-3.

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B*, Martemyanov KA*. (2019) Genetic behavioral screen identifies an orphan anti-opioid system. Science. pii: eaau2078. doi: 10.1126/science.aau2078. (abstract) * co-corresponding authors

Giles AC, Desbois M, Opperman KJ, Tavora R, Maroni MJ, Grill B. (2019) A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1regulates GABA neuron function. J Biol Chem. 294, 6843-6856. (abstract)

Borgen MA, Giles AC, Wang D and Grill B. (2019) Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub. eLife 8, pii: e44040. doi: 10.7554/eLife.44040. (abstract)

Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B. (2018) PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. J Biol Chem. 293, 13897-13909. (abstract)

Crawley O, Giles AC, Desbois M, Kashyap S, Birnbaum RL and Grill B. (2017) A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. PLoS Genetics 13(12):e1007095. (abstract)

Borgen MA, Wang D, Grill B. (2017) RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability. Development 144, 4658-4672.  (abstract)

Opperman KJ, Mulcahy B, Giles AC, Risley MG, Birnbaum RL, Tulgren ED, Dawson-Scully K, Zhen M and Grill B. (2017) The HECT family ubiquitin ligase EEL-1 regulates neuronal function and development.  Cell Reports 19:822-835. (abstract)

Baker ST and Grill B. (2017) Defining minimal binding regions in regulator of presynaptic morphology 1 (RPM-1) using C. elegans neurons reveals differential signaling complexes. Journal of Biological Chemistry 292:2519-2530. (abstract)

Grill B, Murphey RK, Borgen MA. (2016) The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration. Neural Development 11:8 doi: 10.1186/s13064-016-0063-0. (abstract)

Giles AC, Opperman KJ, Rankin CH and Grill B. (2015) Developmental function of the PHR protein RPM-1 is required for learning in C. elegans. G3 (Bethesda) 5:2745-2757. (abstract)

Baker S, Turgeon S, Tulgren E, Wigant J, Rahimi O, Opperman K and Grill B. (2015) Neuronal development in Caenorhabditis elegans Is regulated by inhibition of an MLK MAP kinase pathway. Genetics 199:151-156. (abstract)

Sharma J, Baker S, Turgeon S, Gurney A, Opperman K, and Grill B. (2014) Identification of a peptide inhibitor of the RPM-1/FSN-1 ubiquitin ligase complex. Journal of Biological Chemistry 289: 34654-34666. (abstract)

Tulgren E, Turgeon S, Opperman K, and Grill B. (2014) The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a signaling pathway with RPM-1 and beta-Catenin. PLoS Genetics e1004481. doi: 10.1371/journal.pgen.1004481. (abstract)

Opperman KJ, and Grill B (2014). RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons. Neural Development doi: 10.1186/1749-8104-9-10 (abstract)

Baker ST, Opperman KJ, Tulgren ED, Turgeon SM, Bienvenut W, Grill B (2014). RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development. PLoS Genetics e1004297. doi:10.1371/journal.pgen.1004297. (abstract)

Grill B,* Chen L, Tulgren ED, Baker ST, Bienvenut W, Anderson M, Quadroni M, Jin Y, and Garner CC (2012). RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in C. elegans. Journal of Neuroscience 32:2628-2636. (abstract) * corresponding author

Tulgren ED, Baker ST, Rapp L, Gurney AM, Grill B (2011). PPM-1, a PP2C alpha/beta phosphatase, regulates axon termination and synapse formation in Caenohabditis elegans. Genetics 189:1297-1307. (abstract)

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