News from the Carbone Lab
June 24, 2025
Investigating the Spatial Organization of the Immune Response in Tumors: Insights from the STAMP Model (Labroots)
Understanding the spatial organization of the immune response within tumors is crucial for developing effective cancer immunotherapies. In this seminar, we delve into the interactions between the tumor microenvironment and immune cells, focusing on how these interactions influence tumor progression and rejection. We introduce the Skin Tumor Array by Microporation (STAMP) model as a novel preclinical tool for studying tumor immunotypes and dynamics in real time. Through a series of experiments, we explore the cellular and molecular determinants of different immunotypes and demonstrate their dynamic nature over time. By studying the complexities of the tumor-immune microenvironment, our research aims to contribute to the development of more effective cancer treatments and improve patient outcomes.
April 30, 2025
Immuno-Oncology Virtual Event Series 2025 (Labroots)
Exploring the intricacies of immuno-oncology, the speakers and tracks in this virtual event series elucidate the remarkable strategies and therapies that promise to reshape the cancer treatment landscape.
December 19, 2024
How to find your place in science through an industry postdoc (Nature)
Nature spoke to three postdocs who work at large pharmaceutical and life-science companies: Genentech, Merck and AstraZeneca. Although the transition from academia to industry isn’t always easy, and the next step isn’t always apparent, all agree that these positions provided invaluable experience.
July 5, 2023
Recently, a team of Genentech scientists – including Christine Moussion, Lupe Ortiz-Muñoz, Markus Brown, Kate Carbone and Ximo Pechuan-Jorge – and international collaborators developed a new preclinical technique, skin tumor array by microporation, or “STAMP,” for studying different tumor microenvironments. Using STAMP, the team yielded unexpected discoveries into why seemingly identical tumors can elicit markedly different immune responses.
April 28, 2021
Composition, Communication and Function of the Tumor Microenvironment (YouTube)
The tumor microenvironment (TME) is an excellent topic for a 4D Cellular Physiology workshop, as tumors consist of a complex, heterogeneous ecosystem of cells, the collective behavior of which influences tumor progression, spread, and response to therapeutic intervention. This meeting will focus on the most pressing questions, outstanding problems and innovative approaches to understanding the mechanisms of communication, adaptations in biochemistry, and biophysical properties of the many cell types and extracellular components that comprise the TME.
December 8, 2020
Publishing in a Pandemic: The Preprint Revolution (iBiology)
As the COVID-19 pandemic escalated in the beginning of 2020, there was a need for the rapid dissemination of scientific information to understand everything from how the virus spreads, to how it affects the human body, to how the disease can be treated and prevented.