What's Happening in the Lab?

Identical genetic changes within a family can lead to surprisingly different health outcomes. Over 30 years, we studied a family of affected siblings with hypomorphic RAG2 deficiency (one of the leading causes of severe combined immunodeficiency), finding self-reactive B cells are not only selected for in this disease, but also can variably expand and create a spectrum of disease phenotypes.

Lab adventure to the Mariners game! Photo by Eric Allenspach.

Lab collaboration helps link human lupus-like features to mutation in the UNC93B1 gene.

At the Seattle Children's Research Institute holiday party. Photo by Puget Sound Photo Booth Co.

Congratulations to Patricia and Stacey for publishing a fascinating example of somatic genetic rescue.

Seattle Children’s researchers and colleagues have identified a new driver of autoimmunity that may be relevant to many diseases, including lupus.

Undergraduates Jessica Li and Josh Vo join the lab at student-researchers. Welcome!

Jake joins the Allenspach Lab. Welcome to the team!

Our paper describing an Artic variant in the IFNAR2 gene leading to life-threatening viral disease was accepted in JEM.