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Learn about progress on health equity and anti-racism efforts in Seattle Children’s fourth quarterly report.

Selected Publications

Check out a selection of publications from the Sodora Lab, listed below:


Fisher BS, Dambrauskas N, Trakhimets O, Andrade DV, Smedley J, Sodora DL, Sather DN.
Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates.
PLoS One, 2020 May 29 : 15(5)e0233577 PMCID:PMC7259690
https://pmlegacy.ncbi.nlm.nih.gov/pubmed/32470041

Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL.
Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.
J Infect Dis., 2019 Oct. 12 : jiz382
https://pubmed.ncbi.nlm.nih.gov/31605528/

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.
Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
30655382 J Virol., 2019 Jan. 17 : 93(3) PMCID:PMC6340051
https://www.ncbi.nlm.nih.gov/pubmed/30655382

Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB.
Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.
29659737 Clin Infect Dis., 2018 Sept. 28 : 67(8)1237-1246 PMCID:PMC6455922
https://www.ncbi.nlm.nih.gov/pubmed/29659737

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.
Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.
29997216 J Virol., 2018 Aug. 29 : 92(18) PMCID:PMC6146711
https://www.ncbi.nlm.nih.gov/pubmed/29997216

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL.
Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.
PLoS Pathog, 2018 Feb. 21 : 14(2)e1006871 PMCID:PMC5837102
https://www.ncbi.nlm.nih.gov/pubmed/29466439

Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB Jr., Patel NB, Sodora DL, Dawoud RA, Harris RA, Liu Y, Raveendran M, Han Y, English A, Thomas GWC, Hahn MW, Pipes L, Mason CE, Muzny DM, Gibbs RA, Sauter D, Worley K, Rogers J, Silvestri G.
Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.
Nature., 2018 Jan. 3 : 553(7686)77-81 PMCID:PMC5843367
https://www.ncbi.nlm.nih.gov/pubmed/29300007

Wood LF, Wood M, Fisher B, Jaspan HB, Sodora DL.
T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin-A Exposure.
Front Immunol., 2017 Dec. 22 : 81857 PMCID:PMC5743911
https://www.ncbi.nlm.nih.gov/pubmed/29312338

Steele AK, Carrasco-Medina L, Sodora DL, Crawley AM.
Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques.
PLoS One, 2017 Dec. 19 : 12(12)e0188427 PMCID:PMC5736176
https://www.ncbi.nlm.nih.gov/pubmed/29261677

Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, and Jaspan, HB.
BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.
JCI Insight, 2017 April 6 : 2(7)e91963 PMCID:PMC5374072
https://www.ncbi.nlm.nih.gov/pubmed/28405623

Gasper MA, Biswas SP, Fisher BS, Ehnert SC, Sherman DR, Sodora DL.
Non-pathogenic SIV and pathogenic HIV infections associate with disparate innate cytokine signatures in response to Mycobacteria bovis BCG.
PLoS One, 2016 Aug. 9 : 11(8)e0158149 PMCID:PMC4978473
https://www.ncbi.nlm.nih.gov/pubmed/27505158

Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SM, Silvestri G.
Reduced SIV replication in macrophages of sooty mangabeys is associated with increased expression of host restriction factors.
J Virol, 2015 Oct. : 89(20)10136-44 PMCID:PMC4580171
https://www.ncbi.nlm.nih.gov/pubmed/26202248

Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JS, Sodora DL, Gray CM, Jaspan HB.
Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants.
Vaccine, 2015 Sept. 11 : 33(38)4782-9 PMCID:PMC4562895
https://www.ncbi.nlm.nih.gov/pubmed/26259542

Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA.
Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.
J Virol, 2015 Aug. : 89(16)8130-51 PMCID:PMC4524250
https://www.ncbi.nlm.nih.gov/pubmed/26018167

Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB.
Delaying BCG vaccination until 8 weeks of age results in robust BCG-Specific T-cell Responses in HIV-exposed infants.
J Infect Dis, 2015 Feb. 1 : 211(3)338-46 PMCID:PMC4318913
https://www.ncbi.nlm.nih.gov/pubmed/25108027

Kilgore KM, Murphy MK, Wetzel KS, Smith SA, Burton SL, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Collman RG, Amara RR, Derdeyn CA.
DNA/MVA and protein-based SIV vaccine regimens delivered to Rhesus macaques with novel adjuvants fail to elicit neutralizing antibodies with breadth.
AIDS Res Hum Retrov., 2014 Oct. : 30 Suppl 1A84

Sundaravaradan V, Gasper MA, Mir KD, and Sodora DL.
Lack of chronic immune activation during natural host SIV infection.
Natural Hosts of SIV. , 2014 July 25 : 217-233. Ed. Ansari A and Silvestri G.

Kidzeru EB, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB.
In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.
AIDS, 2014 June 19 : 28(10)1421-30 PMCID:PMC4333196
https://www.ncbi.nlm.nih.gov/pubmed/24785950

Gasper MA, Kunwar P, Itaya G, Lejarcegui N, Bosire R, Maleche-Obimbo E, Wamalwa D, Slyker J, Overbaugh J, Horton H, Sodora DL, John-Stewart G, Lohman-Payne B.
Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.
AIDS, 2014 May 15 : 28(8)1115-24 PMCID:PMC4365995
https://www.ncbi.nlm.nih.gov/pubmed/24752082

Schmökel J, Li H, Shabir A, Yu H, Geyer M, Silvestri G, Sodora DL, Hahn BH, Kirchhoff F.
Link between primate lentiviral coreceptor usage and Nef function.
Cell Rep, 2013 Nov. 27 : 5(4)997-1009 PMCID:PMC4133736
https://www.ncbi.nlm.nih.gov/pubmed/24268781

Milush JM, Chen HL, Atteberry G, Sodora DL.
Early detection of simian immunodeficiency virus in the central nervous system following oral administration to rhesus macaques.
Front Immunol, 2013 Aug. 14 : 4236 PMCID:PMC3743037
https://www.ncbi.nlm.nih.gov/pubmed/23966995

Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL.
Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.
PLoS Pathog, 2013 Aug. : 9(6)e1003441 PMCID:PMC3694849
https://www.ncbi.nlm.nih.gov/pubmed/23825945

Wood LF, Chahroudi A, Chen HL, Jaspan HB, Sodora DL.
The oral mucosa immune environment and oral transmission of HIV/SIV.
Immunol Rev, 2013 July : 254(1)34-53. Review. PMCID:PMC3821196
https://www.ncbi.nlm.nih.gov/pubmed/23772613

Giavedoni LD, Chen HL, Hodara VL, Chu L, Parodi LM, Smith LM, Sexton V, Cappelli D, Sodora DL.
Impact of mucosal inflammation on oral simian immunodeficiency virus transmission.
J Virol, 2013 Feb. : 87(3)1750-8 PMCID:PMC3554177
https://www.ncbi.nlm.nih.gov/pubmed/23175379

Mir KD, Bosinger SE, Gasper M, Ho O, Else JG, Brenchley JM, Kelvin DJ, Silvestri G, Hu SL, Sodora DL.
Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.
J Virol, 2012 July : 86(14)7605-15 PMCID:PMC3416282
https://www.ncbi.nlm.nih.gov/pubmed/22553338

Sundaravaradan V, Mir KD, Sodora DL.
Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.
Curr Opin HIV AIDS, 2012 March : 7(2)164-71. Review. PMCID:PMC3639317
https://www.ncbi.nlm.nih.gov/pubmed/22241163

Elliott ST, Riddick NE, Francella N, Paiardini M, Vanderford TH, Li B, Apetrei C, Sodora DL, Derdeyn CA, Silvestri G, Collman RG.
Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5.
J Virol, 2012 Jan. : 86(2)898-908 PMCID:PMC3255830
https://www.ncbi.nlm.nih.gov/pubmed/22090107

Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA.
Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.
21940422 The Journal of infectious diseases, 2011 Nov. 15 : 204(10)1550-6 PMCID:PMC3192190
https://www.ncbi.nlm.nih.gov/pubmed/21940422

Bosinger SE, Sodora DL, Silvestri G.
Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.
Curr Opin HIV AIDS, 2011 Sept. : 6(5)411-8. Review. PMCID:PMC3261611
https://www.ncbi.nlm.nih.gov/pubmed/21743324

Durudas A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W, Giavedoni LD, Sodora DL.
Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.
Curr HIV Res, 2011 July : 9(5)276-88 PMCID:PMC3337698
https://www.ncbi.nlm.nih.gov/pubmed/21861823

Milush JM, Mir KD, Sundaravaradan V, Gordon SN, Engram J, Cano CA, Reeves JD, Anton E, O'Neill E, Butler E, Hancock K, Cole KS, Brenchley JM, Else JG, Silvestri G, Sodora DL.
Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.
J Clin Invest, 2011 March : 121(3)1102-10 PMCID:PMC3049370
https://www.ncbi.nlm.nih.gov/pubmed/21317533

Kuhrt D, Faith S, Hattemer A, Leone A, Sodora D, Picker L, Borghesi L, Cole KS.
Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation.
J Immunol Methods, 2011 Jan. 5 : 363(2)166-76 PMCID:PMC3357916
https://www.ncbi.nlm.nih.gov/pubmed/20875419

Mir KD, Gasper MA, Sundaravaradan V, Sodora DL.
SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.
Microbes Infect, 2011 Jan. : 13(1)14-24. Review. PMCID:PMC3022004
https://www.ncbi.nlm.nih.gov/pubmed/20951225

Riddick NE, Hermann EA, Loftin LM, Elliott ST, Wey WC, Cervasi B, Taaffe J, Engram JC, Li B, Else JG, Li Y, Hahn BH, Derdeyn CA, Sodora DL, Apetrei C, Paiardini M, Silvestri G, Collman RG.
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.
PLoS Pathog, 2010 Aug. 26 : 6(8)e1001064 PMCID:PMC2928783
https://www.ncbi.nlm.nih.gov/pubmed/20865163

Engram JC, Cervasi B, Borghans JA, Klatt NR, Gordon SN, Chahroudi A, Else JG, Mittler RS, Sodora DL, de Boer RJ, Brenchley JM, Silvestri G, Paiardini M.
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
Blood, 2010 Aug. 5 : 116(5)748-58 PMCID:PMC2918331
https://www.ncbi.nlm.nih.gov/pubmed/20484087

Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL.
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
J Immunol, 2010 : 185(3)1650-9 PMCID:PMC3050806
https://www.ncbi.nlm.nih.gov/pubmed/20622118

Harris LD, Tabb B, Sodora DL, Paiardini M, Klatt NR, Douek DC, Silvestri G, Müller-Trutwin M, Vasile-Pandrea I, Apetrei C, Hirsch V, Lifson J, Brenchley JM, Estes JD.
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.
J Virol, 2010 Aug. : 84(15)7886-91 PMCID:PMC2897601
https://www.ncbi.nlm.nih.gov/pubmed/20484518

Li B, Stefano-Cole K, Kuhrt DM, Gordon SN, Else JG, Mulenga J, Allen S, Sodora DL, Silvestri G, Derdeyn CA.
Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies.
J Virol, 2010 June : 84(12)6248-53 PMCID:PMC2876631
https://www.ncbi.nlm.nih.gov/pubmed/20375163

Sodora DL, Silvestri G.
HIV, mucosal tissues, and T helper 17 cells: where we come from, where we are, and where we go from here.
Curr Opin HIV AIDS, 2010 March : 5(2)111-3
https://www.ncbi.nlm.nih.gov/pubmed/20543586

Kuhrt D, Faith SA, Leone A, Rohankedkar M, Sodora DL, Picker LJ, Cole KS.
Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population.
J Virol, 2010 March : 84(5)2466-76 PMCID:PMC2820932
https://www.ncbi.nlm.nih.gov/pubmed/20032183

Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL.
Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.
J Virol, 2009 Dec. : 83(23)12229-40 PMCID:PMC2786739
https://www.ncbi.nlm.nih.gov/pubmed/19759147

Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.
Nat Med, 2009 Aug. : 15(8)861-5. Review. PMCID:PMC2782707
https://www.ncbi.nlm.nih.gov/pubmed/19661993

Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ.
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.
J Exp Med, 2009 July 6 : 206(7)1575-88 PMCID:PMC2715089
https://www.ncbi.nlm.nih.gov/pubmed/19546246

Paiardini M, Cervasi B, Engram JC, Gordon SN, Klatt NR, Muthukumar A, Else J, Mittler RS, Staprans SI, Sodora DL, Silvestri G.
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.
Blood, 2009 Jan. 15 : 113(3)612-21 PMCID:PMC2628369
https://www.ncbi.nlm.nih.gov/pubmed/18832134

Sodora DL, Ross TM.
Simian immunodeficiency virus pathogenesis.
Curr HIV Res, 2009 Jan. : 7(1)1. Commentary.
https://www.ncbi.nlm.nih.gov/pubmed/19149548

Leone A, Picker LJ, Sodora DL.
IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment.
Curr HIV Res, 2009 Jan. : 7(1)83-90. Review.
https://www.ncbi.nlm.nih.gov/pubmed/19149557

Kosub DA, Durudas A, Lehrman G, Milush JM, Cano CA, Jain MK, Sodora DL.
Gamma/Delta T cell mRNA levels decrease at mucosal sites and increase at lymphoid sites following an oral SIV infection of macaques.
Curr HIV Res, 2008 Nov. : 6(6)520-30 PMCID:PMC2777980
https://www.ncbi.nlm.nih.gov/pubmed/18991617

Pandrea I, Sodora DL, Silvestri G, Apetrei C.
Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts.
Trends Immunol, 2008 Sept. : 29(9)419-28. Review. PMCID:PMC2840226
https://www.ncbi.nlm.nih.gov/pubmed/18676179

Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F.
Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.
PLoS Pathog, 2008 July 18 : 4(7)e1000107 PMCID:PMC2444047
https://www.ncbi.nlm.nih.gov/pubmed/18636106

Klatt NR, Villinger F, Bostik P, Gordon SN, Pereira L, Engram JC, Mayne A, Dunham RM, Lawson B, Ratcliffe SJ, Sodora DL, Else J, Reimann K, Staprans SI, Haase AT, Estes JD, Silvestri G, Ansari AA.
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
J Clin Invest, 2008 June : 118(6)2039-49 PMCID:PMC2391063
https://www.ncbi.nlm.nih.gov/pubmed/18497876

Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G.
CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.
J Immunol, 2008 April 15 : 180(8)5582-92 PMCID:PMC2683429
https://www.ncbi.nlm.nih.gov/pubmed/18390743

Gordon SN, Dunham RM, Engram JC, Estes J, Wang Z, Klatt NR, Paiardini M, Pandrea IV, Apetrei C, Sodora DL, Lee HY, Haase AT, Miller MD, Kaur A, Staprans SI, Perelson AS, Feinberg MB, Silvestri G.
Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis.
J Virol, 2008 April : 82(7)3725-35 PMCID:PMC2268472
https://www.ncbi.nlm.nih.gov/pubmed/18216113

Sodora DL, Silvestri G.
Immune activation and AIDS pathogenesis.
AIDS, 2008 Feb. 19 : 22(4)439-46. Review.
https://www.ncbi.nlm.nih.gov/pubmed/18301056

Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL.
Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.
J Virol, 2008 Feb. : 82(3)1155-65 PMCID:PMC2224435
https://www.ncbi.nlm.nih.gov/pubmed/18045946

Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL.
Understanding the benign nature of SIV infection in natural hosts.
J Clin Invest, 2007 Nov. : 117(11)3148-54. Review. PMCID:PMC2045617
https://www.ncbi.nlm.nih.gov/pubmed/17975656

Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
J Exp Med, 2007 Sept. 3 : 204(9)2171-85 PMCID:PMC2118701
https://www.ncbi.nlm.nih.gov/pubmed/17724130

Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G.
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.
J Immunol, 2007 Sept. 1 : 179(5)3026-34 PMCID:PMC2365740
https://www.ncbi.nlm.nih.gov/pubmed/17709517

Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL.
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.
J Immunol, 2007 Sept. 1 : 179(5)3047-56
https://www.ncbi.nlm.nih.gov/pubmed/17709519

Apetrei C, Gautam R, Sumpter B, Carter AC, Gaufin T, Staprans SI, Else J, Barnes M, Cao R Jr, Garg S, Milush JM, Sodora DL, Pandrea I, Silvestri G.
Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys.
J Virol, 2007 Aug. : 81(15)7913-23 PMCID:PMC1951324
https://www.ncbi.nlm.nih.gov/pubmed/17507488

Milush JM, Stefano-Cole K, Schmidt K, Durudas A, Pandrea I, Sodora DL.
Mucosal innate immune response associated with a timely humoral immune response and slower disease progression after oral transmission of simian immunodeficiency virus to rhesus macaques.
J Virol, 2007 June : 81(12)6175-86 PMCID:PMC1900075
https://www.ncbi.nlm.nih.gov/pubmed/17428863

Estes JD, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C, Milush JM, Lifson JD, Sodora DL, Carlis JV, Haase AT.
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.
J Infect Dis, 2007 Feb. 15 : 195(4)551-61
https://www.ncbi.nlm.nih.gov/pubmed/17230415

Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A, Paiardini M, Cervasi B, Klatt N, McClure H, Milush JM, Staprans S, Sodora DL, Silvestri G.
Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis.
J Immunol, 2007 Feb. 1 : 178(3)1680-91
https://www.ncbi.nlm.nih.gov/pubmed/17237418

Levine B, Sodora DL.
HIV and CXCR4 in a kiss of autophagic death.
J Clin Invest, 2006 Aug. : 116(8)2078-80 PMCID:PMC1523409
https://www.ncbi.nlm.nih.gov/pubmed/16886053

Dunham R, Pagliardini P, Gordon S, Sumpter B, Engram J, Moanna A, Paiardini M, Mandl JN, Lawson B, Garg S, McClure HM, Xu YX, Ibegbu C, Easley K, Katz N, Pandrea I, Apetrei C, Sodora DL, Staprans SI, Feinberg MB, Silvestri G.
The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus.
Blood, 2006 July 1 : 108(1)209-17 PMCID:PMC1895834
https://www.ncbi.nlm.nih.gov/pubmed/16522814

Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F.
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
Cell, 2006 June 16 : 125(6)1055-67
https://www.ncbi.nlm.nih.gov/pubmed/16777597

Paiardini M, Cervasi B, Sumpter B, McClure HM, Sodora DL, Magnani M, Staprans SI, Piedimonte G, Silvestri G.
Perturbations of cell cycle control in T cells contribute to the different outcomes of simian immunodeficiency virus infection in rhesus macaques and sooty mangabeys.
J Virol, 2006 Jan. : 80(2)634-42 PMCID:PMC1346860
https://www.ncbi.nlm.nih.gov/pubmed/16378966

Muthukumar A, Zhou D, Paiardini M, Barry AP, Cole KS, McClure HM, Staprans SI, Silvestri G, Sodora DL.
Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys.
Blood, 2005 Dec. 1 : 106(12)3839-45 PMCID:PMC1895113
https://www.ncbi.nlm.nih.gov/pubmed/16105985

Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, Silvestri G.
Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.
J Immunol, 2005 March 1 : 174(5)2900-9
https://www.ncbi.nlm.nih.gov/pubmed/15728501

Milush JM, Kosub D, Marthas M, Schmidt K, Scott F, Wozniakowski A, Brown C, Westmoreland S, Sodora DL.
Rapid dissemination of SIV following oral inoculation.
AIDS, 2004 Dec. 3 : 18(18)2371-80
https://www.ncbi.nlm.nih.gov/pubmed/15622313

Ylisastigui L, Coull JJ, Rucker VC, Melander C, Bosch RJ, Brodie SJ, Corey L, Sodora DL, Dervan PB, Margolis DM.
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.
J Infect Dis, 2004 Oct. 15 : 190(8)1429-37
https://www.ncbi.nlm.nih.gov/pubmed/15378435

Smith SM, Mefford M, Sodora D, Klase Z, Singh M, Alexander N, Hess D, Marx PA.
Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect.
AIDS, 2004 Aug. 20 : 18(12)1637-43
https://www.ncbi.nlm.nih.gov/pubmed/15280774

Van Rompay KK, Singh RP, Brignolo LL, Lawson JR, Schmidt KA, Pahar B, Canfield DR, Tarara RP, Sodora DL, Bischofberger N, Marthas ML.
The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters.
J Acquir Immune Defic Syndr, 2004 Aug. 1 : 36(4)900-14
https://www.ncbi.nlm.nih.gov/pubmed/15220696

Van Rompay KK, Singh RP, Pahar B, Sodora DL, Wingfield C, Lawson JR, Marthas ML, Bischofberger N.
CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment.
J Virol, 2004 May : 78(10)5324-37 PMCID:PMC400346
https://www.ncbi.nlm.nih.gov/pubmed/15113912

Saavedra-Lozano J, Cao Y, Callison J, Sarode R, Sodora D, Edgar J, Hatfield J, Picker L, Peterson D, Ramilo O, Vitetta ES.
An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory.
Proc Natl Acad Sci USA, 2004 Feb. 24 : 101(8)2494-9 PMCID:PMC3566978
https://www.ncbi.nlm.nih.gov/pubmed/14983037

Muthukumar A, Wozniakowski A, Gauduin MC, Paiardini M, McClure HM, Johnson RP, Silvestri G, Sodora DL.
Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression.
Blood, 2004 Feb. 1 : 103(3)973-9
https://www.ncbi.nlm.nih.gov/pubmed/14525780

Wang C, Pflugheber J, Sumpter R Jr, Sodora DL, Hui D, Sen GC, Gale M Jr.
Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication.
J Virol, 2003 April : 77(7)3898-912 PMCID:PMC150642
https://www.ncbi.nlm.nih.gov/pubmed/12634350

Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, McClure HM, Staprans SI, Feinberg MB.
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.
Immunity, 2003 March : 18(3)441-52
https://www.ncbi.nlm.nih.gov/pubmed/12648460

Wei BL, Arora VK, Foster JL, Sodora DL, Garcia JV.
In vivo analysis of Nef function.
Curr HIV Res, 2003 Jan. : 1(1)41-50. Review.
https://www.ncbi.nlm.nih.gov/pubmed/15043211

Sodora DL, Milush JM, Ware F, Wozniakowski A, Montgomery L, McClure HM, Lackner AA, Marthas M, Hirsch V, Johnson RP, Douek DC, Koup RA.
Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus.
J Virol, 2002 Oct. : 76(19)9981-90 PMCID:PMC136511
https://www.ncbi.nlm.nih.gov/pubmed/12208974

Pflugheber J, Fredericksen B, Sumpter R Jr, Wang C, Ware F, Sodora DL, Gale M Jr.
Regulation of PKR and IRF-1 during hepatitis C virus RNA replication.
Proc Natl Acad Sci USA., 2002 April 2 : 99(7)4650-5 PMCID:PMC123702
https://www.ncbi.nlm.nih.gov/pubmed/11904369

Sodora DL, Douek DC, Silvestri G, Montgomery L, Rosenzweig M, Igarashi T, Bernacky B, Johnson RP, Feinberg MB, Martin MA, Koup RA.
Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys.
Eur J Immunol, 2000 April : 30(4)1145-53
https://www.ncbi.nlm.nih.gov/pubmed/10760804

Sodora DL, Sheridan KE, Marx PA, Connor RI.
Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge.
J Virol, 1999 May : 73(5)4443-6 PMCID:PMC104226
https://www.ncbi.nlm.nih.gov/pubmed/10196343

Sodora DL, Gettie A, Miller CJ, Marx PA.
Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks.
AIDS Res Hum Retroviruses., 1998 April : 14 Suppl 1S119-23
https://www.ncbi.nlm.nih.gov/pubmed/9581895

Sodora DL, Lee F, Dailey PJ, Marx PA.
A genetic and viral load analysis of the simian immunodeficiency virus during the acute phase in macaques inoculated by the vaginal route.
AIDS Res Hum Retroviruses., 1998 Jan. 20 : 14(2)171-81
https://www.ncbi.nlm.nih.gov/pubmed/9462928

Bachmann MH, Mathiason-Dubard C, Learn GH, Rodrigo AG, Sodora DL, Mazzetti P, Hoover EA, Mullins JI.
Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.
J Virol., 1997 June : 71(6)4241-53 PMCID:PMC191639
https://www.ncbi.nlm.nih.gov/pubmed/9151811

Chen Z, Luckay A, Sodora DL, Telfer P, Reed P, Gettie A, Kanu JM, Sadek RF, Yee J, Ho DD, Zhang L, Marx PA.
Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.
J Virol., 1997 May : 71(5)3953-60 PMCID:PMC191547
https://www.ncbi.nlm.nih.gov/pubmed/9094672

Sodora DL, Courcelle J, Brojatsch J, Berson A, Wang YC, Dow SW, Hoover EA, Mullins JI.
Analysis of a feline immunodeficiency virus provirus reveals patterns of gene sequence conservation distinct from human immunodeficiency virus type 1.
AIDS Res Hum Retroviruses., 1995 April : 11(4)531-3
https://www.ncbi.nlm.nih.gov/pubmed/7632468

Eisenberg RJ, Long D, Sodora DL, Chiang H-Y, Wilcox WC, Abrams WR, Muggeridge MI, and Cohen GH.
Structure and function of glycoprotein D from herpes simplex virus.
Frontiers in Virology. , 1994 : 3:43-65. Ed. Becker Y and Darai G.

Sodora DL, Shpaer EG, Kitchell BE, Dow SW, Hoover EA, Mullins JI.
Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns.
J Virol., 1994 April : 68(4)2230-8 PMCID:PMC236699
https://www.ncbi.nlm.nih.gov/pubmed/8139008

Cohen GH, Muggeridge MI, Long D, Sodora DL, Eisenberg RJ.
Structural and functional studies of herpes simplex virus glycoprotein D.
Adv Exp Med Biol., 1992 Jan. : 327217-28. Review.
https://www.ncbi.nlm.nih.gov/pubmed/1338265

Sodora DL, Cohen GH, Muggeridge MI, Eisenberg RJ.
Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein.
J Virol., 1991 Aug. : 65(8)4424-31 PMCID:PMC248882
https://www.ncbi.nlm.nih.gov/pubmed/1649338

Sodora DL, Eisenberg RJ, Cohen GH.
Characterization of a recombinant herpes simplex virus which expresses a glycoprotein D lacking asparagine-linked oligosaccharides.
J Virol., 1991 Aug. : 65(8)4432-41 PMCID:PMC248883
https://www.ncbi.nlm.nih.gov/pubmed/1649339

Sodora DL, Cohen GH, Eisenberg RJ.
Influence of asparagine-linked oligosaccharides on antigenicity, processing, and cell surface expression of herpes simplex virus type 1 glycoprotein D.
J Virol., 1989 Dec. : 63(12)5184-93 PMCID:PMC251182
https://www.ncbi.nlm.nih.gov/pubmed/2555549

Wilcox WC, Long D, Sodora DL, Eisenberg RJ, Cohen GH.
The contribution of cysteine residues to antigenicity and extent of processing of herpes simplex virus type 1 glycoprotein D.
J Virol., 1988 June : 62(6)1941-7 PMCID:PMC253277
https://www.ncbi.nlm.nih.gov/pubmed/2835498

Cohen GH, Wilcox WC, Sodora DL, Long D, Levin JZ, Eisenberg RJ.
Expression of herpes simplex virus type 1 glycoprotein D deletion mutants in mammalian cells.
J Virol., 1988 June : 62(6)1932-40 PMCID:PMC253276
https://www.ncbi.nlm.nih.gov/pubmed/2452897

For a full list of publications, please visit PubMed.

Contact Us

Don Sodora, PhD

For questions or inquiries,
email: donald.sodora@seattlechildrens.org

Physical Address

Center for Global Infectious Disease Research
307 Westlake Ave. N
Seattle, WA 98109

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