Full project summary
The goal of this project is to develop an effective vaccine against HIV/AIDS. To achieve this, the Sodora laboratory (in collaboration with the Sather laboratory) has undertaken a series of experiments to evaluate a new strategy to deliver recombinant HIV-1 Envelope (Env) protein vaccines directly to the oral mucosa by intra-epithelial (IEp) injection into the cheek (buccal) mucosa. The experiments represent a comprehensive vaccine approach, evaluating both innate and adaptive immune responses. The use of the macaque-SIV model is critical for the undertaking of these experiments that have the potential for reducing HIV transmission through mucosal vaccination.
We are undertaking these studies in collaboration with Dr. Jeremy Smedley and the Oregon National Primate Research Center.
Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates.
Fisher BS, Dambrauskas N, Trakhimets O, Andrade DV, Smedley J, Sodora DL, Sather DN.PLoS One. 2020 May 29;15(5):e0233577. doi: 10.1371/journal.pone.0233577. eCollection 2020.PMID: 32470041
Don Sodora, PhD
For questions or inquiries,
Center for Global Infectious Disease Research
307 Westlake Ave. N
Seattle, WA 98109