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Publications


Kumar A, Chettiar S, Brown BS, Early J, Ollinger J, Files M, Bailey MA, Korkegian A, Dennison D, McNeil M, Metz J, Osuma A, Curtin M, Kunzer A, Freiberg G, Bruncko M, Kempf D, Parish T
Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening.
36050506 Scientific reports, 2022 Sept. 1 : 12(1)14879 PMCID:PMC9435431

Galina L, Hopf FSM, Abbadi BL, Sperotto NDM, Czeczot AM, Duque-Villegas MA, Perello MA, Matter LB, de Souza EV, Parish T, Machado P, Basso LA, Bizarro CV
Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.
35862980 Microbiology spectrum, 2022 Aug. 31 : 10(4)e0072822 PMCID:PMC9430761

Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish T
Correction for Shelton et al., "Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis".
35876578 Antimicrobial agents and chemotherapy, 2022 Aug. 16 : 66(8)e0096222 PMCID:PMC9380578

Parish T
The driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation.
35939679 Proceedings of the National Academy of Sciences of the United States of America, 2022 Aug. 16 : 119(33)e2211130119 PMCID:PMC9388100

Njikan S, Ahmed S, Manning A, Awasthi D, Ovechkina Y, Chowdhury S, Butts A, Parish T
Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis.
35612308 Microbiology spectrum, 2022 June 29 : 10(3)e0116122 PMCID:PMC9241686

Basarab GS, Ghorpade S, Gibhard L, Mueller R, Njoroge M, Peton N, Govender P, Massoudi LM, Robertson GT, Lenaerts AJ, Boshoff HI, Joerss D, Parish T, Durand-Reville TF, Perros M, Singh V, Chibale K
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
35266826 Antimicrobial agents and chemotherapy, 2022 April 19 : 66(4)e0219221 PMCID:PMC9017349

Shelton C, McNeil M, Allen R, Flint L, Russell D, Berube B, Korkegian A, Ovechkina Y, Parish T
Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis.
35262374 Antimicrobial agents and chemotherapy, 2022 April 19 : 66(4)e0204121 PMCID:PMC9017309

Gold B, Zhang J, Quezada LL, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L, Bacqué E, Lagrange S, Filoche-Rommé B, Vieth M, Hipskind PA, Jungheim LN, Aubé J, Scarry SM, McDonald SL, Li K, Perkowski A, Nguyen Q, Dartois V, Zimmerman M, Olsen DB, Young K, Bonnett S, Joerss D, Parish T, Boshoff HI, Arora K, Barry CE 3rd, Guijarro L, Anca S, Rullas J, Rodríguez-Salguero B, Martínez-Martínez MS, Porras-De Francisco E, Cacho M, Barros-Aguirre D, Smith P, Berthel SJ, Nathan C, Bates RH
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.
35192346 ACS infectious diseases, 2022 March 11 : 8(3)557-573 PMCID:PMC8922279

Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RS
Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis.
35193957 Proceedings of the National Academy of Sciences of the United States of America, 2022 Feb. 22 : 119(8) PMCID:PMC8872721

Satish S, Chitral R, Kori A, Sharma B, Puttur J, Khan AA, Desle D, Raikuvar K, Korkegian A, Martis EAF, Iyer KR, Coutinho EC, Parish T, Nandan S
Design, synthesis and SAR of antitubercular benzylpiperazine ureas.
33385288 Molecular diversity, 2022 Feb. : 26(1)73-96

Zloh M, Gupta M, Parish T, Brucoli F
Novel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoBS522L strain and display a different binding mode at the RNAP β-subunit site compared to rifampicin.
34418786 European journal of medicinal chemistry, 2021 Dec. 5 : 225113734

Punetha A, Green KD, Garzan A, Thamban Chandrika N, Willby MJ, Pang AH, Hou C, Holbrook SYL, Krieger K, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance.
34825186 RSC medicinal chemistry, 2021 Nov. 17 : 12(11)1894-1909 PMCID:PMC8597425

Mandal S, Parish T
A Novel Benzoxaborole Is Active against Escherichia coli and Binds to FabI.
34152809 Antimicrobial agents and chemotherapy, 2021 Aug. 17 : 65(9)e0262220 PMCID:PMC8370241

Aldridge BB, Barros-Aguirre D, Barry CE 3rd, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, Lelièvre J, Lenaerts AJ, McNamara CW, Mizrahi V, Nathan C, Olsen DB, Parish T, Petrassi HM, Pym A, Rhee KY, Robertson GT, Rock JM, Rubin EJ, Russell B, Russell DG, Sacchettini JC, Schnappinger D, Schrimpf M, Upton AM, Warner P, Wyatt PG, Yuan Y
The Tuberculosis Drug Accelerator at year 10: what have we learned?
34226736 Nature medicine, 2021 Aug. : 27(8)1333-1337

Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish T
Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis.
33619059 Antimicrobial agents and chemotherapy, 2021 Feb. 22 : PMCID:PMC8092897

Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish T
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.
33521468 ACS omega, 2021 Jan. 26 : 6(3)2284-2311 PMCID:PMC7841955

Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish T
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.
33521468 ACS omega, 2021 Jan. 26 : 6(3)2284-2311 PMCID:PMC7841955

Soares de Melo C, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A, Parish T, Su Q, Myers TG, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden PD, Buchanan KI, Bayliss T, Green SR, Ray PC, Wyatt PG, Basarab GS, Eyermann CJ, Chibale K, Ghorpade SR
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
33395287 Journal of medicinal chemistry, 2021 Jan. 14 : 64(1)719-740 PMCID:PMC7816196

Thayer MB, Parish T
Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
33481781 PloS one, 2021 : 16(1)e0239353 PMCID:PMC7822546

Ahmed S, Manning A, Flint L, Awasthi D, Ovechkina Y, Parish T
Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages.
35046812 Frontiers in pharmacology, 2021 : 12790583 PMCID:PMC8762250

Parish T
Electroporation of Mycobacteria.
34235658 Methods in molecular biology (Clifton, N.J.), 2021 : 2314273-284

Hembre E, Early JV, Odingo J, Shelton C, Anoshchenko O, Guzman J, Flint L, Dennison D, McNeil MB, Korkegian A, Ovechkina Y, Ornstein P, Masquelin T, Hipskind PA, Parish T
Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis.
33996738 Frontiers in chemistry, 2021 : 9613349 PMCID:PMC8117417

Thayer MB, Parish T
Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
33481781 PloS one, 2021 : 16(1)e0239353 PMCID:PMC7822546

McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish T
Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.
33055263 mSphere, 2020 Oct. 14 : 5(5) PMCID:PMC7565900

McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish T
Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.
33055263 mSphere, 2020 Oct. 14 : 5(5) PMCID:PMC7565900

de Oliveira JAM, Williams DE, Bonnett S, Johnson J, Parish T, Andersen RJ
Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.
32404991 The Journal of antibiotics, 2020 Aug. : 73(8)568-573

de Oliveira JAM, Williams DE, Bonnett S, Johnson J, Parish T, Andersen RJ
Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.
32404991 The Journal of antibiotics, 2020 Aug. : 73(8)568-573

Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.
32421305 ACS chemical biology, 2020 June 19 : 15(6)1581-1594 PMCID:PMC7385556

Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.
32421305 ACS chemical biology, 2020 June 19 : 15(6)1581-1594 PMCID:PMC7385556

Parish T
In vitro drug discovery models for Mycobacterium tuberculosis relevant for host infection.
31899974 Expert opinion on drug discovery, 2020 March : 15(3)349-358

Parish T, Grech D
An interview with Dr Tanya Parish and her perspectives on women in drug discovery.
31992092 Expert opinion on drug discovery, 2020 March : 15(3)277-278

Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard A
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
32034201 Scientific reports, 2020 Feb. 7 : 10(1)2112 PMCID:PMC7005898

Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard A
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
32034201 Scientific reports, 2020 Feb. 7 : 10(1)2112 PMCID:PMC7005898

Flint L, Korkegian A, Parish T
InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.
33201882 PloS one, 2020 : 15(11)e0239354 PMCID:PMC7671525

Flint L, Korkegian A, Parish T
InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.
33201882 PloS one, 2020 : 15(11)e0239354 PMCID:PMC7671525

Parish T
Microbiology revamps its scope.
31674900 Microbiology (Reading, England), 2019 Dec. : 165(12)1251

Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli F
Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA.
31454170 ChemMedChem, 2019 Oct. 4 : 14(19)1735-1741 PMCID:PMC6800809

Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli F
Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA.
31454170 ChemMedChem, 2019 Oct. 4 : 14(19)1735-1741 PMCID:PMC6800809

Odingo JO, Early JV, Smith J, Johnson J, Bailey MA, Files M, Guzman J, Ollinger J, Korkegian A, Kumar A, Ovechkina Y, Parish T
8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.
30893501 Drug development research, 2019 Aug. : 80(5)566-572 PMCID:PMC6767403

Odingo JO, Early JV, Smith J, Johnson J, Bailey MA, Files M, Guzman J, Ollinger J, Korkegian A, Kumar A, Ovechkina Y, Parish T
8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.
30893501 Drug development research, 2019 Aug. : 80(5)566-572 PMCID:PMC6767403

Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
31047750 Bioorganic & medicinal chemistry letters, 2019 July 1 : 29(13)1665-1672 PMCID:PMC6531345

Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
31047750 Bioorganic & medicinal chemistry letters, 2019 July 1 : 29(13)1665-1672 PMCID:PMC6531345

Smith J, Wescott H, Early J, Mullen S, Guzman J, Odingo J, Lamar J, Parish T
Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential.
31303991 MedChemComm, 2019 June 1 : 10(6)934-945 PMCID:PMC6596218

Smith J, Wescott H, Early J, Mullen S, Guzman J, Odingo J, Lamar J, Parish T
Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential.
31303991 MedChemComm, 2019 June 1 : 10(6)934-945 PMCID:PMC6596218

Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish T
Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.
30962346 Antimicrobial agents and chemotherapy, 2019 June : 63(6) PMCID:PMC6535543

Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish T
Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.
30962346 Antimicrobial agents and chemotherapy, 2019 June : 63(6) PMCID:PMC6535543

Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
31002508 Journal of medicinal chemistry, 2019 May 9 : 62(9)4483-4499 PMCID:PMC6511943

Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
31002508 Journal of medicinal chemistry, 2019 May 9 : 62(9)4483-4499 PMCID:PMC6511943

Mandal S, Njikan S, Kumar A, Early JV, Parish T
The relevance of persisters in tuberculosis drug discovery.
30775961 Microbiology (Reading, England), 2019 May : 165(5)492-499

Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ
Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.
30745397 Antimicrobial agents and chemotherapy, 2019 April : 63(4) PMCID:PMC6496157

Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ
Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.
30745397 Antimicrobial agents and chemotherapy, 2019 April : 63(4) PMCID:PMC6496157

Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish T
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.
30501173 ACS infectious diseases, 2019 Feb. 8 : 5(2)272-280 PMCID:PMC6371205

Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish T
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.
30501173 ACS infectious diseases, 2019 Feb. 8 : 5(2)272-280 PMCID:PMC6371205

Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.
30516466 Journal of medical microbiology, 2019 Feb. : 68(2)117-118

Parish T
Steps to address anti-microbial drug resistance in today's drug discovery.
30466326 Expert opinion on drug discovery, 2019 Feb. : 14(2)91-94

Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.
30516468 Microbiology (Reading, England), 2019 Feb. : 165(2)125-126

McGuffin S, Mullen S, Early J, Parish T.
Development of a series of high-throughput screens to identify leads for nontuberculous mycobacteria drug design.
Open Forum Infectious Diseases, 2019 - 2019 : Supplement(6); S485.

Melief E, Bonnett SA, Zuniga ES, Parish T
Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase.
30323042 Antimicrobial agents and chemotherapy, 2019 Jan. : 63(1) PMCID:PMC6325208

Morbidoni HR, de la Iglesia AI, Figueroa V, Di Capua C, Ioerger TR, Parish T
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.
32974504 Access microbiology, 2019 : 1(10)e000070 PMCID:PMC7491931

Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DC
Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.
30978223 PloS one, 2019 : 14(4)e0214958 PMCID:PMC6461227

Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.
30516461 International journal of systematic and evolutionary microbiology, 2019 Jan. : 69(1)1-2

Early JV, Mullen S, Parish T
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.
31589621 PloS one, 2019 : 14(10)e0222970 PMCID:PMC6779252

Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.
30516467 The Journal of general virology, 2019 Jan. : 100(1)1-2

Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish T
A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis.
30650074 PloS one, 2019 : 14(1)e0205479 PMCID:PMC6334966

Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish T
A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis.
30650074 PloS one, 2019 : 14(1)e0205479 PMCID:PMC6334966

Morbidoni HR, de la Iglesia AI, Figueroa V, Di Capua C, Ioerger TR, Parish T
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.
32974504 Access microbiology, 2019 : 1(10)e000070 PMCID:PMC7491931

McNeil MB, Chettiar S, Awasthi D, Parish T
Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.
32974492 Access microbiology, 2019 : 1(1)e000006 PMCID:PMC7470358

Melief E, Bonnett SA, Zuniga ES, Parish T
Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase.
30323042 Antimicrobial agents and chemotherapy, 2019 Jan. : 63(1) PMCID:PMC6325208

McNeil MB, Chettiar S, Awasthi D, Parish T
Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.
32974492 Access microbiology, 2019 : 1(1)e000006 PMCID:PMC7470358

Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DC
Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.
30978223 PloS one, 2019 : 14(4)e0214958 PMCID:PMC6461227

Early JV, Mullen S, Parish T
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.
31589621 PloS one, 2019 : 14(10)e0222970 PMCID:PMC6779252

Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.
30516464 Microbial genomics, 2018 Dec. : 4(12) PMCID:PMC6412037

Carroll P, Muwanguzi-Karugaba J, Parish T
Codon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis.
30285840 BMC research notes, 2018 Oct. 1 : 11(1)685 PMCID:PMC6167837

Carroll P, Muwanguzi-Karugaba J, Parish T
Codon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis.
30285840 BMC research notes, 2018 Oct. 1 : 11(1)685 PMCID:PMC6167837

Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
29944372 Journal of medicinal chemistry, 2018 Aug. 9 : 61(15)6592-6608 PMCID:PMC6089501

Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
29944372 Journal of medicinal chemistry, 2018 Aug. 9 : 61(15)6592-6608 PMCID:PMC6089501

Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.
29954459 BMC research notes, 2018 June 28 : 11(1)416 PMCID:PMC6022709

Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.
29954459 BMC research notes, 2018 June 28 : 11(1)416 PMCID:PMC6022709

Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish T
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
29680666 Bioorganic & medicinal chemistry letters, 2018 June 1 : 28(10)1758-1764 PMCID:PMC5946847

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
30456352 Life science alliance, 2018 June : 1(3)e201800025 PMCID:PMC6238539

Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish T
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
29680666 Bioorganic & medicinal chemistry letters, 2018 June 1 : 28(10)1758-1764 PMCID:PMC5946847

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
30456352 Life science alliance, 2018 June : 1(3)e201800025 PMCID:PMC6238539

O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish T
Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.
29632008 Antimicrobial agents and chemotherapy, 2018 June : 62(6) PMCID:PMC5971599

O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish T
Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.
29632008 Antimicrobial agents and chemotherapy, 2018 June : 62(6) PMCID:PMC5971599

McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish T
Corrigendum to "Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA" [Tuberculosis 107 (December 2017) 133-136].
29429955 Tuberculosis (Edinburgh, Scotland), 2018 May : 110123

Gordon SV, Parish T
Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe.
29465344 Microbiology (Reading, England), 2018 April : 164(4)437-439

Berube BJ, Parish T
Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.
29061760 Antimicrobial agents and chemotherapy, 2018 Jan. : 62(1) PMCID:PMC5740367

Berube BJ, Castro L, Russell D, Ovechkina Y, Parish T
Novel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus.
30364170 Frontiers in microbiology, 2018 : 92417 PMCID:PMC6191478

Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T
Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.
30416491 Frontiers in microbiology, 2018 : 92542 PMCID:PMC6213970

Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T
Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.
30416491 Frontiers in microbiology, 2018 : 92542 PMCID:PMC6213970

Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.
29523334 Tuberculosis (Edinburgh, Scotland), 2018 Jan. : 10896-98 PMCID:PMC5854369

Bonnett SA, Dennison D, Files M, Bajpai A, Parish T
A class of hydrazones are active against non-replicating Mycobacterium tuberculosis.
30332412 PloS one, 2018 : 13(10)e0198059 PMCID:PMC6192558

Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish T
High content, high-throughput screening for small molecule inducers of NF-κB translocation.
29953522 PloS one, 2018 : 13(6)e0199966 PMCID:PMC6023200

Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.
29523334 Tuberculosis (Edinburgh, Scotland), 2018 Jan. : 10896-98 PMCID:PMC5854369

Berube BJ, Castro L, Russell D, Ovechkina Y, Parish T
Novel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus.
30364170 Frontiers in microbiology, 2018 : 92417 PMCID:PMC6191478

Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish T
Construction of an overexpression library for Mycobacterium tuberculosis.
30197930 Biology methods & protocols, 2018 : 3(1)bpy009 PMCID:PMC6118195

Berube BJ, Parish T
Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.
29061760 Antimicrobial agents and chemotherapy, 2018 Jan. : 62(1) PMCID:PMC5740367

Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish T
Construction of an overexpression library for Mycobacterium tuberculosis.
30197930 Biology methods & protocols, 2018 : 3(1)bpy009 PMCID:PMC6118195

Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish T
High content, high-throughput screening for small molecule inducers of NF-κB translocation.
29953522 PloS one, 2018 : 13(6)e0199966 PMCID:PMC6023200

Bonnett SA, Dennison D, Files M, Bajpai A, Parish T
A class of hydrazones are active against non-replicating Mycobacterium tuberculosis.
30332412 PloS one, 2018 : 13(10)e0198059 PMCID:PMC6192558

Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.
29035551 ACS infectious diseases, 2017 Dec. 8 : 3(12)898-916 PMCID:PMC5727484

Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.
29035551 ACS infectious diseases, 2017 Dec. 8 : 3(12)898-916 PMCID:PMC5727484

McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish T
Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.
29050761 Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 107133-136 PMCID:PMC5679704

McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish T
Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.
29050761 Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 107133-136 PMCID:PMC5679704

McNeil MB, Dennison DD, Shelton CD, Parish T
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.
28760892 Antimicrobial agents and chemotherapy, 2017 Oct. : 61(10) PMCID:PMC5610523

McNeil MB, Dennison DD, Shelton CD, Parish T
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.
28760892 Antimicrobial agents and chemotherapy, 2017 Oct. : 61(10) PMCID:PMC5610523

Odingo J, Bailey MA, Files M, Early JV, Alling T, Dennison D, Bowman J, Dalai S, Kumar N, Cramer J, Masquelin T, Hipskind PA, Parish T
In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis.
30023755 ACS omega, 2017 Sept. 30 : 2(9)5873-5890 PMCID:PMC6044914

Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
28674058 Antimicrobial agents and chemotherapy, 2017 Sept. : 61(9) PMCID:PMC5571309

Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
28674058 Antimicrobial agents and chemotherapy, 2017 Sept. : 61(9) PMCID:PMC5571309

Manning AJ, Ovechkina Y, McGillivray A, Flint L, Roberts DM, Parish T
A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis.
28366666 Methods (San Diego, Calif.), 2017 Aug. 15 : 1273-11

Manning AJ, Ovechkina Y, McGillivray A, Flint L, Roberts DM, Parish T
A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis.
28366666 Methods (San Diego, Calif.), 2017 Aug. 15 : 1273-11

Zuniga ES, Korkegian A, Mullen S, Hembre EJ, Ornstein PL, Cortez G, Biswas K, Kumar N, Cramer J, Masquelin T, Hipskind PA, Odingo J, Parish T
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.
28576632 Bioorganic & medicinal chemistry, 2017 Aug. 1 : 25(15)3922-3946 PMCID:PMC5513444

Zuniga ES, Korkegian A, Mullen S, Hembre EJ, Ornstein PL, Cortez G, Biswas K, Kumar N, Cramer J, Masquelin T, Hipskind PA, Odingo J, Parish T
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.
28576632 Bioorganic & medicinal chemistry, 2017 Aug. 1 : 25(15)3922-3946 PMCID:PMC5513444

McNeil MB, Dennison D, Parish T
Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis.
28703701 Microbiology (Reading, England), 2017 July : 163(7)1065-1070

McNeil MB, Dennison D, Parish T
Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis.
28703701 Microbiology (Reading, England), 2017 July : 163(7)1065-1070

Rodrigues L, Parish T, Balganesh M, Ainsa JA
Antituberculosis drugs: reducing efflux=increasing activity.
28089787 Drug discovery today, 2017 March : 22(3)592-599

Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish T
Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.
28180188 ACS omega, 2017 Jan. 31 : 2(1)41-51 PMCID:PMC5286457

Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish T
Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.
28180188 ACS omega, 2017 Jan. 31 : 2(1)41-51 PMCID:PMC5286457

Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish T
Nitazoxanide is active against Mycobacterium leprae.
28850614 PloS one, 2017 : 12(8)e0184107 PMCID:PMC5574600

Kokoczka R, Schuessler DL, Early JV, Parish T
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.
28061949 Tuberculosis (Edinburgh, Scotland), 2017 Jan. : 1023-7 PMCID:PMC5225668

Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish T
Nitazoxanide is active against Mycobacterium leprae.
28850614 PloS one, 2017 : 12(8)e0184107 PMCID:PMC5574600

Kumar A, Chettiar S, Parish T
Current challenges in drug discovery for tuberculosis.
27797593 Expert opinion on drug discovery, 2017 Jan. : 12(1)1-4

Kokoczka R, Schuessler DL, Early JV, Parish T
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.
28061949 Tuberculosis (Edinburgh, Scotland), 2017 Jan. : 1023-7 PMCID:PMC5225668

Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish T
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.
27642770 ACS infectious diseases, 2016 Dec. 9 : 2(12)893-902 PMCID:PMC5215716

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
27503647 Antimicrobial agents and chemotherapy, 2016 Oct. : 60(10)6271-80 PMCID:PMC5038265

Degiacomi G, Personne Y, Mondésert G, Ge X, Mandava CS, Hartkoorn RC, Boldrin F, Goel P, Peisker K, Benjak A, Barrio MB, Ventura M, Brown AC, Leblanc V, Bauer A, Sanyal S, Cole ST, Lagrange S, Parish T, Manganelli R
Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.
27553416 Tuberculosis (Edinburgh, Scotland), 2016 Sept. : 10095-101

Martínez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro A
Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.
27139471 Antimicrobial agents and chemotherapy, 2016 July : 60(7)4375-9 PMCID:PMC4914650

Early JV, Casey A, Martinez-Grau MA, Gonzalez Valcarcel IC, Vieth M, Ollinger J, Bailey MA, Alling T, Files M, Ovechkina Y, Parish T
Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.
27044545 Antimicrobial agents and chemotherapy, 2016 June : 60(6)3608-16 PMCID:PMC4879361

Kesicki EA, Bailey MA, Ovechkina Y, Early JV, Alling T, Bowman J, Zuniga ES, Dalai S, Kumar N, Masquelin T, Hipskind PA, Odingo JO, Parish T
Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents.
27171280 PloS one, 2016 : 11(5)e0155209 PMCID:PMC4865136

Chandrasekera NS, Alling T, Bailey MA, Files M, Early JV, Ollinger J, Ovechkina Y, Masquelin T, Desai PV, Cramer JW, Hipskind PA, Odingo JO, Parish T
Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity.
26295286 Journal of medicinal chemistry, 2015 Sept. 24 : 58(18)7273-85

Russo F, Gising J, Åkerbladh L, Roos AK, Naworyta A, Mowbray SL, Sokolowski A, Henderson I, Alling T, Bailey MA, Files M, Parish T, Karlén A, Larhed M
Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.
26246997 ChemistryOpen, 2015 June : 4(3)342-62 PMCID:PMC4522185

Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson S, Barranis NJ, hAinmhire E, Chen WL, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, Rathod PK, Parish T, Cho S, Franzblau SG, Murphy BT
Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.
26594660 ACS infectious diseases, 2015 April 10 : 1(4)168-174 PMCID:PMC4648258

Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ
A novel antimycobacterial compound acts as an intracellular iron chelator.
25645825 Antimicrobial agents and chemotherapy, 2015 April : 59(4)2256-64 PMCID:PMC4356758

Schreuder LJ, Carroll P, Muwanguzi-Karugaba J, Kokoczka R, Brown AC, Parish T
Mycobacterium tuberculosis H37Rv has a single nucleotide polymorphism in PhoR which affects cell wall hydrophobicity and gene expression.
25635271 Microbiology (Reading, England), 2015 April : 161(Pt 4)765-773

Moraski GC, Miller PA, Bailey MA, Ollinger J, Parish T, Boshoff HI, Cho S, Anderson JR, Mulugeta S, Franzblau SG, Miller MJ
Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and "Anagrams" Generated Potent Antituberculosis Agents.
25984566 ACS infectious diseases, 2015 Feb. 13 : 1(2)85-90 PMCID:PMC4426345

Chandrasekera NS, Alling T, Bailey M, Korkegian A, Ahn J, Ovechkina Y, Odingo J, Parish T
The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity.
25881065 Journal of negative results in biomedicine, 2015 Feb. 13 : 144 PMCID:PMC4336482

Goude R, Roberts DM, Parish T
Electroporation of mycobacteria.
25779313 Methods in molecular biology (Clifton, N.J.), 2015 : 1285117-30

Carroll P, Parish T
Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.
26197389 PloS one, 2015 : 10(7)e0133129 PMCID:PMC4510303

Brown AC, Kokoczka R, Parish T
LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically Redundant.
26309039 PloS one, 2015 : 10(8)e0135638 PMCID:PMC4550268

Korkegian A, Roberts DM, Blair R, Parish T
Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.
25352598 The Journal of biological chemistry, 2014 Dec. 19 : 289(51)35172-81 PMCID:PMC4271206

Odingo J, O'Malley T, Kesicki EA, Alling T, Bailey MA, Early J, Ollinger J, Dalai S, Kumar N, Singh RV, Hipskind PA, Cramer JW, Ioerger T, Sacchettini J, Vickers R, Parish T
Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.
25456390 Bioorganic & medicinal chemistry, 2014 Dec. 15 : 22(24)6965-79

Carroll P, Muwanguzi-Karugaba J, Melief E, Files M, Parish T
Identification of the translational start site of codon-optimized mCherry in Mycobacterium tuberculosis.
24934902 BMC research notes, 2014 June 17 : 7366 PMCID:PMC4091752

Ekins S, Casey AC, Roberts D, Parish T, Bunin BA
Bayesian models for screening and TB Mobile for target inference with Mycobacterium tuberculosis.
24440548 Tuberculosis (Edinburgh, Scotland), 2014 March : 94(2)162-9 PMCID:PMC4394018

Schreuder LJ, Parish T
Mycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia.
25211224 PloS one, 2014 : 9(9)e107283 PMCID:PMC4161423

Personne Y, Parish T
Mycobacterium tuberculosis possesses an unusual tmRNA rescue system.
24145139 Tuberculosis (Edinburgh, Scotland), 2014 Jan. : 94(1)34-42

Chandrasekera NS, Bailey MA, Files M, Alling T, Florio SK, Ollinger J, Odingo JO, Parish T
Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides.
25320680 PeerJ, 2014 : 2e612 PMCID:PMC4193402

Karkare S, Brown AC, Parish T, Maxwell A
Identification of the likely translational start of Mycobacterium tuberculosis GyrB.
23856181 BMC research notes, 2013 July 15 : 6274 PMCID:PMC3724585

Moraski GC, Markley LD, Cramer J, Hipskind PA, Boshoff H, Bailey M, Alling T, Ollinger J, Parish T, Miller MJ
Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis.
23930153 ACS medicinal chemistry letters, 2013 July 11 : 4(7)675-679 PMCID:PMC3733398

Kumar D, Raj KK, Bailey M, Alling T, Parish T, Rawat DS
Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives.
23357633 Bioorganic & medicinal chemistry letters, 2013 March 1 : 23(5)1365-9

Ollinger J, Bailey MA, Moraski GC, Casey A, Florio S, Alling T, Miller MJ, Parish T
A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis.
23593234 PloS one, 2013 : 8(4)e60531 PMCID:PMC3617142

Tan S, Sukumar N, Abramovitch RB, Parish T, Russell DG
Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell.
23592993 PLoS pathogens, 2013 : 9(4)e1003282 PMCID:PMC3616970

Personne Y, Brown AC, Schuessler DL, Parish T
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.
23560081 PloS one, 2013 : 8(4)e60228 PMCID:PMC3613350

Kumar A, Casey A, Odingo J, Kesicki EA, Abrahams G, Vieth M, Masquelin T, Mizrahi V, Hipskind PA, Sherman DR, Parish T
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.
24244263 PloS one, 2013 : 8(11)e72786 PMCID:PMC3820577

Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.
24086479 PloS one, 2013 : 8(9)e75245 PMCID:PMC3781026

James JN, Hasan ZU, Ioerger TR, Brown AC, Personne Y, Carroll P, Ikeh M, Tilston-Lunel NL, Palavecino C, Sacchettini JC, Parish T
Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.
22956756 Microbiology (Reading, England), 2012 Nov. : 158(Pt 11)2724-2731

Zelmer A, Carroll P, Andreu N, Hagens K, Mahlo J, Redinger N, Robertson BD, Wiles S, Ward TH, Parish T, Ripoll J, Bancroft GJ, Schaible UE
A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.
22635525 The Journal of antimicrobial chemotherapy, 2012 Aug. : 67(8)1948-60 PMCID:PMC3394442

Ollinger J, O'Malley T, Ahn J, Odingo J, Parish T
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.
22427625 Journal of bacteriology, 2012 May : 194(10)2614-9 PMCID:PMC3347204

Schuessler DL, Parish T
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis.
22485172 PloS one, 2012 : 7(4)e34471 PMCID:PMC3317779

Pecsi I, Hirmondo R, Brown AC, Lopata A, Parish T, Vertessy BG, Tóth J
The dUTPase enzyme is essential in Mycobacterium smegmatis.
22655049 PloS one, 2012 : 7(5)e37461 PMCID:PMC3360063

Carroll P, Waddell SJ, Butcher PD, Parish T
Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1.
21875360 Microbial drug resistance (Larchmont, N.Y.), 2011 Sept. : 17(3)351-5 PMCID:PMC3161625

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