Ikeh MA, Parish T
Rv0233 is not essential for the survival of Mycobacterium tuberculosis in stress conditions.36149732
Microbiology (Reading, England), 2022 Sept. : 168(9)
Kumar A, Chettiar S, Brown BS, Early J, Ollinger J, Files M, Bailey MA, Korkegian A, Dennison D, McNeil M, Metz J, Osuma A, Curtin M, Kunzer A, Freiberg G, Bruncko M, Kempf D, Parish T
Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening.36050506
Scientific reports, 2022 Sept. 1 : 12(1)14879
PMCID:PMC9435431
Galina L, Hopf FSM, Abbadi BL, Sperotto NDM, Czeczot AM, Duque-Villegas MA, Perello MA, Matter LB, de Souza EV, Parish T, Machado P, Basso LA, Bizarro CV
Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.35862980
Microbiology spectrum, 2022 Aug. 31 : 10(4)e0072822
PMCID:PMC9430761
Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish T
Correction for Shelton et al., "Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis".35876578
Antimicrobial agents and chemotherapy, 2022 Aug. 16 : 66(8)e0096222
PMCID:PMC9380578
Parish T
The driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation.35939679
Proceedings of the National Academy of Sciences of the United States of America, 2022 Aug. 16 : 119(33)e2211130119
PMCID:PMC9388100
Njikan S, Ahmed S, Manning A, Awasthi D, Ovechkina Y, Chowdhury S, Butts A, Parish T
Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis.35612308
Microbiology spectrum, 2022 June 29 : 10(3)e0116122
PMCID:PMC9241686
Basarab GS, Ghorpade S, Gibhard L, Mueller R, Njoroge M, Peton N, Govender P, Massoudi LM, Robertson GT, Lenaerts AJ, Boshoff HI, Joerss D, Parish T, Durand-Reville TF, Perros M, Singh V, Chibale K
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.35266826
Antimicrobial agents and chemotherapy, 2022 April 19 : 66(4)e0219221
PMCID:PMC9017349
Shelton C, McNeil M, Allen R, Flint L, Russell D, Berube B, Korkegian A, Ovechkina Y, Parish T
Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis.35262374
Antimicrobial agents and chemotherapy, 2022 April 19 : 66(4)e0204121
PMCID:PMC9017309
Gold B, Zhang J, Quezada LL, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L, Bacqué E, Lagrange S, Filoche-Rommé B, Vieth M, Hipskind PA, Jungheim LN, Aubé J, Scarry SM, McDonald SL, Li K, Perkowski A, Nguyen Q, Dartois V, Zimmerman M, Olsen DB, Young K, Bonnett S, Joerss D, Parish T, Boshoff HI, Arora K, Barry CE 3rd, Guijarro L, Anca S, Rullas J, Rodríguez-Salguero B, Martínez-Martínez MS, Porras-De Francisco E, Cacho M, Barros-Aguirre D, Smith P, Berthel SJ, Nathan C, Bates RH
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.35192346
ACS infectious diseases, 2022 March 11 : 8(3)557-573
PMCID:PMC8922279
Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RS
Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis.35193957
Proceedings of the National Academy of Sciences of the United States of America, 2022 Feb. 22 : 119(8)
PMCID:PMC8872721
Satish S, Chitral R, Kori A, Sharma B, Puttur J, Khan AA, Desle D, Raikuvar K, Korkegian A, Martis EAF, Iyer KR, Coutinho EC, Parish T, Nandan S
Design, synthesis and SAR of antitubercular benzylpiperazine ureas.33385288
Molecular diversity, 2022 Feb. : 26(1)73-96
Bhagwat A, Deshpande A, Parish T
How Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery.36159638
Frontiers in cellular and infection microbiology, 2022 : 12974101
PMCID:PMC9500310
Zloh M, Gupta M, Parish T, Brucoli F
Novel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoBS522L strain and display a different binding mode at the RNAP β-subunit site compared to rifampicin.34418786
European journal of medicinal chemistry, 2021 Dec. 5 : 225113734
Punetha A, Green KD, Garzan A, Thamban Chandrika N, Willby MJ, Pang AH, Hou C, Holbrook SYL, Krieger K, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance.34825186
RSC medicinal chemistry, 2021 Nov. 17 : 12(11)1894-1909
PMCID:PMC8597425
Mandal S, Parish T
A Novel Benzoxaborole Is Active against Escherichia coli and Binds to FabI.34152809
Antimicrobial agents and chemotherapy, 2021 Aug. 17 : 65(9)e0262220
PMCID:PMC8370241
Aldridge BB, Barros-Aguirre D, Barry CE 3rd, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, Lelièvre J, Lenaerts AJ, McNamara CW, Mizrahi V, Nathan C, Olsen DB, Parish T, Petrassi HM, Pym A, Rhee KY, Robertson GT, Rock JM, Rubin EJ, Russell B, Russell DG, Sacchettini JC, Schnappinger D, Schrimpf M, Upton AM, Warner P, Wyatt PG, Yuan Y
The Tuberculosis Drug Accelerator at year 10: what have we learned?34226736
Nature medicine, 2021 Aug. : 27(8)1333-1337
Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish T
Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis.33619059
Antimicrobial agents and chemotherapy, 2021 Feb. 22 :
PMCID:PMC8092897
Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish T
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.33521468
ACS omega, 2021 Jan. 26 : 6(3)2284-2311
PMCID:PMC7841955
Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish T
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.33521468
ACS omega, 2021 Jan. 26 : 6(3)2284-2311
PMCID:PMC7841955
Soares de Melo C, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A, Parish T, Su Q, Myers TG, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden PD, Buchanan KI, Bayliss T, Green SR, Ray PC, Wyatt PG, Basarab GS, Eyermann CJ, Chibale K, Ghorpade SR
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.33395287
Journal of medicinal chemistry, 2021 Jan. 14 : 64(1)719-740
PMCID:PMC7816196
Thayer MB, Parish T
Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.33481781
PloS one, 2021 : 16(1)e0239353
PMCID:PMC7822546
Ahmed S, Manning A, Flint L, Awasthi D, Ovechkina Y, Parish T
Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages.35046812
Frontiers in pharmacology, 2021 : 12790583
PMCID:PMC8762250
Parish T
Electroporation of Mycobacteria.34235658
Methods in molecular biology (Clifton, N.J.), 2021 : 2314273-284
Hembre E, Early JV, Odingo J, Shelton C, Anoshchenko O, Guzman J, Flint L, Dennison D, McNeil MB, Korkegian A, Ovechkina Y, Ornstein P, Masquelin T, Hipskind PA, Parish T
Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis.33996738
Frontiers in chemistry, 2021 : 9613349
PMCID:PMC8117417
Thayer MB, Parish T
Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.33481781
PloS one, 2021 : 16(1)e0239353
PMCID:PMC7822546
McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish T
Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.33055263
mSphere, 2020 Oct. 14 : 5(5)
PMCID:PMC7565900
McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish T
Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.33055263
mSphere, 2020 Oct. 14 : 5(5)
PMCID:PMC7565900
de Oliveira JAM, Williams DE, Bonnett S, Johnson J, Parish T, Andersen RJ
Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.32404991
The Journal of antibiotics, 2020 Aug. : 73(8)568-573
de Oliveira JAM, Williams DE, Bonnett S, Johnson J, Parish T, Andersen RJ
Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.32404991
The Journal of antibiotics, 2020 Aug. : 73(8)568-573
Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.32421305
ACS chemical biology, 2020 June 19 : 15(6)1581-1594
PMCID:PMC7385556
Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.32421305
ACS chemical biology, 2020 June 19 : 15(6)1581-1594
PMCID:PMC7385556
Parish T
In vitro drug discovery models for Mycobacterium tuberculosis relevant for host infection.31899974
Expert opinion on drug discovery, 2020 March : 15(3)349-358
Parish T, Grech D
An interview with Dr Tanya Parish and her perspectives on women in drug discovery.31992092
Expert opinion on drug discovery, 2020 March : 15(3)277-278
Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard A
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.32034201
Scientific reports, 2020 Feb. 7 : 10(1)2112
PMCID:PMC7005898
Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard A
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.32034201
Scientific reports, 2020 Feb. 7 : 10(1)2112
PMCID:PMC7005898
Flint L, Korkegian A, Parish T
InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.33201882
PloS one, 2020 : 15(11)e0239354
PMCID:PMC7671525
Flint L, Korkegian A, Parish T
InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.33201882
PloS one, 2020 : 15(11)e0239354
PMCID:PMC7671525
Parish T
Microbiology revamps its scope.31674900
Microbiology (Reading, England), 2019 Dec. : 165(12)1251
Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli F
Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA.31454170
ChemMedChem, 2019 Oct. 4 : 14(19)1735-1741
PMCID:PMC6800809
Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli F
Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA.31454170
ChemMedChem, 2019 Oct. 4 : 14(19)1735-1741
PMCID:PMC6800809
Odingo JO, Early JV, Smith J, Johnson J, Bailey MA, Files M, Guzman J, Ollinger J, Korkegian A, Kumar A, Ovechkina Y, Parish T
8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.30893501
Drug development research, 2019 Aug. : 80(5)566-572
PMCID:PMC6767403
Odingo JO, Early JV, Smith J, Johnson J, Bailey MA, Files M, Guzman J, Ollinger J, Korkegian A, Kumar A, Ovechkina Y, Parish T
8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.30893501
Drug development research, 2019 Aug. : 80(5)566-572
PMCID:PMC6767403
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.31047750
Bioorganic & medicinal chemistry letters, 2019 July 1 : 29(13)1665-1672
PMCID:PMC6531345
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.31047750
Bioorganic & medicinal chemistry letters, 2019 July 1 : 29(13)1665-1672
PMCID:PMC6531345
Smith J, Wescott H, Early J, Mullen S, Guzman J, Odingo J, Lamar J, Parish T
Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential.31303991
MedChemComm, 2019 June 1 : 10(6)934-945
PMCID:PMC6596218
Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish T
Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.30962346
Antimicrobial agents and chemotherapy, 2019 June : 63(6)
PMCID:PMC6535543
Smith J, Wescott H, Early J, Mullen S, Guzman J, Odingo J, Lamar J, Parish T
Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential.31303991
MedChemComm, 2019 June 1 : 10(6)934-945
PMCID:PMC6596218
Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish T
Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.30962346
Antimicrobial agents and chemotherapy, 2019 June : 63(6)
PMCID:PMC6535543
Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.31002508
Journal of medicinal chemistry, 2019 May 9 : 62(9)4483-4499
PMCID:PMC6511943
Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.31002508
Journal of medicinal chemistry, 2019 May 9 : 62(9)4483-4499
PMCID:PMC6511943
Mandal S, Njikan S, Kumar A, Early JV, Parish T
The relevance of persisters in tuberculosis drug discovery.30775961
Microbiology (Reading, England), 2019 May : 165(5)492-499
Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ
Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.30745397
Antimicrobial agents and chemotherapy, 2019 April : 63(4)
PMCID:PMC6496157
Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ
Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.30745397
Antimicrobial agents and chemotherapy, 2019 April : 63(4)
PMCID:PMC6496157
Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish T
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.30501173
ACS infectious diseases, 2019 Feb. 8 : 5(2)272-280
PMCID:PMC6371205
Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish T
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.30501173
ACS infectious diseases, 2019 Feb. 8 : 5(2)272-280
PMCID:PMC6371205
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.30516466
Journal of medical microbiology, 2019 Feb. : 68(2)117-118
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.30516468
Microbiology (Reading, England), 2019 Feb. : 165(2)125-126
Parish T
Steps to address anti-microbial drug resistance in today's drug discovery.30466326
Expert opinion on drug discovery, 2019 Feb. : 14(2)91-94
McGuffin S, Mullen S, Early J, Parish T.
Development of a series of high-throughput screens to identify leads for nontuberculous mycobacteria drug design.Open Forum Infectious Diseases, 2019 - 2019 : Supplement(6); S485.
Morbidoni HR, de la Iglesia AI, Figueroa V, Di Capua C, Ioerger TR, Parish T
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.32974504
Access microbiology, 2019 : 1(10)e000070
PMCID:PMC7491931
Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DC
Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.30978223
PloS one, 2019 : 14(4)e0214958
PMCID:PMC6461227
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.30516461
International journal of systematic and evolutionary microbiology, 2019 Jan. : 69(1)1-2
McNeil MB, Chettiar S, Awasthi D, Parish T
Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.32974492
Access microbiology, 2019 : 1(1)e000006
PMCID:PMC7470358
Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DC
Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.30978223
PloS one, 2019 : 14(4)e0214958
PMCID:PMC6461227
Early JV, Mullen S, Parish T
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.31589621
PloS one, 2019 : 14(10)e0222970
PMCID:PMC6779252
Morbidoni HR, de la Iglesia AI, Figueroa V, Di Capua C, Ioerger TR, Parish T
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.32974504
Access microbiology, 2019 : 1(10)e000070
PMCID:PMC7491931
McNeil MB, Chettiar S, Awasthi D, Parish T
Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.32974492
Access microbiology, 2019 : 1(1)e000006
PMCID:PMC7470358
Melief E, Bonnett SA, Zuniga ES, Parish T
Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase.30323042
Antimicrobial agents and chemotherapy, 2019 Jan. : 63(1)
PMCID:PMC6325208
Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish T
A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis.30650074
PloS one, 2019 : 14(1)e0205479
PMCID:PMC6334966
Melief E, Bonnett SA, Zuniga ES, Parish T
Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase.30323042
Antimicrobial agents and chemotherapy, 2019 Jan. : 63(1)
PMCID:PMC6325208
Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish T
A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis.30650074
PloS one, 2019 : 14(1)e0205479
PMCID:PMC6334966
Early JV, Mullen S, Parish T
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.31589621
PloS one, 2019 : 14(10)e0222970
PMCID:PMC6779252
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.30516467
The Journal of general virology, 2019 Jan. : 100(1)1-2
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson N
DORA Editorial.30516464
Microbial genomics, 2018 Dec. : 4(12)
PMCID:PMC6412037
Carroll P, Muwanguzi-Karugaba J, Parish T
Codon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis.30285840
BMC research notes, 2018 Oct. 1 : 11(1)685
PMCID:PMC6167837
Carroll P, Muwanguzi-Karugaba J, Parish T
Codon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis.30285840
BMC research notes, 2018 Oct. 1 : 11(1)685
PMCID:PMC6167837
Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.29944372
Journal of medicinal chemistry, 2018 Aug. 9 : 61(15)6592-6608
PMCID:PMC6089501
Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.29944372
Journal of medicinal chemistry, 2018 Aug. 9 : 61(15)6592-6608
PMCID:PMC6089501
Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.29954459
BMC research notes, 2018 June 28 : 11(1)416
PMCID:PMC6022709
Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.29954459
BMC research notes, 2018 June 28 : 11(1)416
PMCID:PMC6022709
Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish T
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.29680666
Bioorganic & medicinal chemistry letters, 2018 June 1 : 28(10)1758-1764
PMCID:PMC5946847
Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.30456352
Life science alliance, 2018 June : 1(3)e201800025
PMCID:PMC6238539
Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish T
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.29680666
Bioorganic & medicinal chemistry letters, 2018 June 1 : 28(10)1758-1764
PMCID:PMC5946847
Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.30456352
Life science alliance, 2018 June : 1(3)e201800025
PMCID:PMC6238539
O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish T
Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.29632008
Antimicrobial agents and chemotherapy, 2018 June : 62(6)
PMCID:PMC5971599
O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish T
Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.29632008
Antimicrobial agents and chemotherapy, 2018 June : 62(6)
PMCID:PMC5971599
McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish T
Corrigendum to "Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA" [Tuberculosis 107 (December 2017) 133-136].29429955
Tuberculosis (Edinburgh, Scotland), 2018 May : 110123
Gordon SV, Parish T
Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe.29465344
Microbiology (Reading, England), 2018 April : 164(4)437-439
Berube BJ, Parish T
Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.29061760
Antimicrobial agents and chemotherapy, 2018 Jan. : 62(1)
PMCID:PMC5740367
Berube BJ, Castro L, Russell D, Ovechkina Y, Parish T
Novel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus.30364170
Frontiers in microbiology, 2018 : 92417
PMCID:PMC6191478
Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.29523334
Tuberculosis (Edinburgh, Scotland), 2018 Jan. : 10896-98
PMCID:PMC5854369
Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T
Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.30416491
Frontiers in microbiology, 2018 : 92542
PMCID:PMC6213970
Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T
Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.30416491
Frontiers in microbiology, 2018 : 92542
PMCID:PMC6213970
Bonnett SA, Dennison D, Files M, Bajpai A, Parish T
A class of hydrazones are active against non-replicating Mycobacterium tuberculosis.30332412
PloS one, 2018 : 13(10)e0198059
PMCID:PMC6192558
Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish T
High content, high-throughput screening for small molecule inducers of NF-κB translocation.29953522
PloS one, 2018 : 13(6)e0199966
PMCID:PMC6023200
Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.29523334
Tuberculosis (Edinburgh, Scotland), 2018 Jan. : 10896-98
PMCID:PMC5854369
Berube BJ, Castro L, Russell D, Ovechkina Y, Parish T
Novel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus.30364170
Frontiers in microbiology, 2018 : 92417
PMCID:PMC6191478
Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish T
Construction of an overexpression library for Mycobacterium tuberculosis.30197930
Biology methods & protocols, 2018 : 3(1)bpy009
PMCID:PMC6118195
Berube BJ, Parish T
Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.29061760
Antimicrobial agents and chemotherapy, 2018 Jan. : 62(1)
PMCID:PMC5740367
Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish T
Construction of an overexpression library for Mycobacterium tuberculosis.30197930
Biology methods & protocols, 2018 : 3(1)bpy009
PMCID:PMC6118195
Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish T
High content, high-throughput screening for small molecule inducers of NF-κB translocation.29953522
PloS one, 2018 : 13(6)e0199966
PMCID:PMC6023200
Bonnett SA, Dennison D, Files M, Bajpai A, Parish T
A class of hydrazones are active against non-replicating Mycobacterium tuberculosis.30332412
PloS one, 2018 : 13(10)e0198059
PMCID:PMC6192558
Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.29035551
ACS infectious diseases, 2017 Dec. 8 : 3(12)898-916
PMCID:PMC5727484
Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.29035551
ACS infectious diseases, 2017 Dec. 8 : 3(12)898-916
PMCID:PMC5727484
McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish T
Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.29050761
Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 107133-136
PMCID:PMC5679704
McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish T
Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.29050761
Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 107133-136
PMCID:PMC5679704
McNeil MB, Dennison DD, Shelton CD, Parish T
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.28760892
Antimicrobial agents and chemotherapy, 2017 Oct. : 61(10)
PMCID:PMC5610523
McNeil MB, Dennison DD, Shelton CD, Parish T
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.28760892
Antimicrobial agents and chemotherapy, 2017 Oct. : 61(10)
PMCID:PMC5610523
Odingo J, Bailey MA, Files M, Early JV, Alling T, Dennison D, Bowman J, Dalai S, Kumar N, Cramer J, Masquelin T, Hipskind PA, Parish T
In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis.30023755
ACS omega, 2017 Sept. 30 : 2(9)5873-5890
PMCID:PMC6044914
Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.28674058
Antimicrobial agents and chemotherapy, 2017 Sept. : 61(9)
PMCID:PMC5571309
Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.28674058
Antimicrobial agents and chemotherapy, 2017 Sept. : 61(9)
PMCID:PMC5571309
Manning AJ, Ovechkina Y, McGillivray A, Flint L, Roberts DM, Parish T
A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis.28366666
Methods (San Diego, Calif.), 2017 Aug. 15 : 1273-11
Manning AJ, Ovechkina Y, McGillivray A, Flint L, Roberts DM, Parish T
A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis.28366666
Methods (San Diego, Calif.), 2017 Aug. 15 : 1273-11
Zuniga ES, Korkegian A, Mullen S, Hembre EJ, Ornstein PL, Cortez G, Biswas K, Kumar N, Cramer J, Masquelin T, Hipskind PA, Odingo J, Parish T
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.28576632
Bioorganic & medicinal chemistry, 2017 Aug. 1 : 25(15)3922-3946
PMCID:PMC5513444
Zuniga ES, Korkegian A, Mullen S, Hembre EJ, Ornstein PL, Cortez G, Biswas K, Kumar N, Cramer J, Masquelin T, Hipskind PA, Odingo J, Parish T
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.28576632
Bioorganic & medicinal chemistry, 2017 Aug. 1 : 25(15)3922-3946
PMCID:PMC5513444
McNeil MB, Dennison D, Parish T
Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis.28703701
Microbiology (Reading, England), 2017 July : 163(7)1065-1070
McNeil MB, Dennison D, Parish T
Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis.28703701
Microbiology (Reading, England), 2017 July : 163(7)1065-1070
Rodrigues L, Parish T, Balganesh M, Ainsa JA
Antituberculosis drugs: reducing efflux=increasing activity.28089787
Drug discovery today, 2017 March : 22(3)592-599
Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish T
Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.28180188
ACS omega, 2017 Jan. 31 : 2(1)41-51
PMCID:PMC5286457
Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish T
Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.28180188
ACS omega, 2017 Jan. 31 : 2(1)41-51
PMCID:PMC5286457
Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish T
Nitazoxanide is active against Mycobacterium leprae.28850614
PloS one, 2017 : 12(8)e0184107
PMCID:PMC5574600
Kokoczka R, Schuessler DL, Early JV, Parish T
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.28061949
Tuberculosis (Edinburgh, Scotland), 2017 Jan. : 1023-7
PMCID:PMC5225668
Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish T
Nitazoxanide is active against Mycobacterium leprae.28850614
PloS one, 2017 : 12(8)e0184107
PMCID:PMC5574600
Kumar A, Chettiar S, Parish T
Current challenges in drug discovery for tuberculosis.27797593
Expert opinion on drug discovery, 2017 Jan. : 12(1)1-4
Kokoczka R, Schuessler DL, Early JV, Parish T
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.28061949
Tuberculosis (Edinburgh, Scotland), 2017 Jan. : 1023-7
PMCID:PMC5225668
Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish T
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.27642770
ACS infectious diseases, 2016 Dec. 9 : 2(12)893-902
PMCID:PMC5215716
Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.27503647
Antimicrobial agents and chemotherapy, 2016 Oct. : 60(10)6271-80
PMCID:PMC5038265
Degiacomi G, Personne Y, Mondésert G, Ge X, Mandava CS, Hartkoorn RC, Boldrin F, Goel P, Peisker K, Benjak A, Barrio MB, Ventura M, Brown AC, Leblanc V, Bauer A, Sanyal S, Cole ST, Lagrange S, Parish T, Manganelli R
Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.27553416
Tuberculosis (Edinburgh, Scotland), 2016 Sept. : 10095-101
MartÃnez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro A
Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.27139471
Antimicrobial agents and chemotherapy, 2016 July : 60(7)4375-9
PMCID:PMC4914650
Early JV, Casey A, Martinez-Grau MA, Gonzalez Valcarcel IC, Vieth M, Ollinger J, Bailey MA, Alling T, Files M, Ovechkina Y, Parish T
Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.27044545
Antimicrobial agents and chemotherapy, 2016 June : 60(6)3608-16
PMCID:PMC4879361
Kesicki EA, Bailey MA, Ovechkina Y, Early JV, Alling T, Bowman J, Zuniga ES, Dalai S, Kumar N, Masquelin T, Hipskind PA, Odingo JO, Parish T
Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents.27171280
PloS one, 2016 : 11(5)e0155209
PMCID:PMC4865136
Chandrasekera NS, Alling T, Bailey MA, Files M, Early JV, Ollinger J, Ovechkina Y, Masquelin T, Desai PV, Cramer JW, Hipskind PA, Odingo JO, Parish T
Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity.26295286
Journal of medicinal chemistry, 2015 Sept. 24 : 58(18)7273-85
Russo F, Gising J, Åkerbladh L, Roos AK, Naworyta A, Mowbray SL, Sokolowski A, Henderson I, Alling T, Bailey MA, Files M, Parish T, Karlén A, Larhed M
Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.26246997
ChemistryOpen, 2015 June : 4(3)342-62
PMCID:PMC4522185
Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson S, Barranis NJ, hAinmhire E, Chen WL, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, Rathod PK, Parish T, Cho S, Franzblau SG, Murphy BT
Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.26594660
ACS infectious diseases, 2015 April 10 : 1(4)168-174
PMCID:PMC4648258
Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ
A novel antimycobacterial compound acts as an intracellular iron chelator.25645825
Antimicrobial agents and chemotherapy, 2015 April : 59(4)2256-64
PMCID:PMC4356758
Schreuder LJ, Carroll P, Muwanguzi-Karugaba J, Kokoczka R, Brown AC, Parish T
Mycobacterium tuberculosis H37Rv has a single nucleotide polymorphism in PhoR which affects cell wall hydrophobicity and gene expression.25635271
Microbiology (Reading, England), 2015 April : 161(Pt 4)765-773
Moraski GC, Miller PA, Bailey MA, Ollinger J, Parish T, Boshoff HI, Cho S, Anderson JR, Mulugeta S, Franzblau SG, Miller MJ
Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and "Anagrams" Generated Potent Antituberculosis Agents.25984566
ACS infectious diseases, 2015 Feb. 13 : 1(2)85-90
PMCID:PMC4426345
Chandrasekera NS, Alling T, Bailey M, Korkegian A, Ahn J, Ovechkina Y, Odingo J, Parish T
The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity.25881065
Journal of negative results in biomedicine, 2015 Feb. 13 : 144
PMCID:PMC4336482
Goude R, Roberts DM, Parish T
Electroporation of mycobacteria.25779313
Methods in molecular biology (Clifton, N.J.), 2015 : 1285117-30
Carroll P, Parish T
Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.26197389
PloS one, 2015 : 10(7)e0133129
PMCID:PMC4510303
Brown AC, Kokoczka R, Parish T
LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically Redundant.26309039
PloS one, 2015 : 10(8)e0135638
PMCID:PMC4550268
Korkegian A, Roberts DM, Blair R, Parish T
Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.25352598
The Journal of biological chemistry, 2014 Dec. 19 : 289(51)35172-81
PMCID:PMC4271206
Odingo J, O'Malley T, Kesicki EA, Alling T, Bailey MA, Early J, Ollinger J, Dalai S, Kumar N, Singh RV, Hipskind PA, Cramer JW, Ioerger T, Sacchettini J, Vickers R, Parish T
Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.25456390
Bioorganic & medicinal chemistry, 2014 Dec. 15 : 22(24)6965-79
Carroll P, Muwanguzi-Karugaba J, Melief E, Files M, Parish T
Identification of the translational start site of codon-optimized mCherry in Mycobacterium tuberculosis.24934902
BMC research notes, 2014 June 17 : 7366
PMCID:PMC4091752
Ekins S, Casey AC, Roberts D, Parish T, Bunin BA
Bayesian models for screening and TB Mobile for target inference with Mycobacterium tuberculosis.24440548
Tuberculosis (Edinburgh, Scotland), 2014 March : 94(2)162-9
PMCID:PMC4394018
Personne Y, Parish T
Mycobacterium tuberculosis possesses an unusual tmRNA rescue system.24145139
Tuberculosis (Edinburgh, Scotland), 2014 Jan. : 94(1)34-42
Schreuder LJ, Parish T
Mycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia.25211224
PloS one, 2014 : 9(9)e107283
PMCID:PMC4161423
Chandrasekera NS, Bailey MA, Files M, Alling T, Florio SK, Ollinger J, Odingo JO, Parish T
Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides.25320680
PeerJ, 2014 : 2e612
PMCID:PMC4193402
Karkare S, Brown AC, Parish T, Maxwell A
Identification of the likely translational start of Mycobacterium tuberculosis GyrB.23856181
BMC research notes, 2013 July 15 : 6274
PMCID:PMC3724585
Moraski GC, Markley LD, Cramer J, Hipskind PA, Boshoff H, Bailey M, Alling T, Ollinger J, Parish T, Miller MJ
Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis.23930153
ACS medicinal chemistry letters, 2013 July 11 : 4(7)675-679
PMCID:PMC3733398
Kumar D, Raj KK, Bailey M, Alling T, Parish T, Rawat DS
Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives.23357633
Bioorganic & medicinal chemistry letters, 2013 March 1 : 23(5)1365-9
Ollinger J, Bailey MA, Moraski GC, Casey A, Florio S, Alling T, Miller MJ, Parish T
A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis.23593234
PloS one, 2013 : 8(4)e60531
PMCID:PMC3617142
Tan S, Sukumar N, Abramovitch RB, Parish T, Russell DG
Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell.23592993
PLoS pathogens, 2013 : 9(4)e1003282
PMCID:PMC3616970
Personne Y, Brown AC, Schuessler DL, Parish T
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.23560081
PloS one, 2013 : 8(4)e60228
PMCID:PMC3613350
Kumar A, Casey A, Odingo J, Kesicki EA, Abrahams G, Vieth M, Masquelin T, Mizrahi V, Hipskind PA, Sherman DR, Parish T
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.24244263
PloS one, 2013 : 8(11)e72786
PMCID:PMC3820577
Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.24086479
PloS one, 2013 : 8(9)e75245
PMCID:PMC3781026
James JN, Hasan ZU, Ioerger TR, Brown AC, Personne Y, Carroll P, Ikeh M, Tilston-Lunel NL, Palavecino C, Sacchettini JC, Parish T
Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.22956756
Microbiology (Reading, England), 2012 Nov. : 158(Pt 11)2724-2731
Zelmer A, Carroll P, Andreu N, Hagens K, Mahlo J, Redinger N, Robertson BD, Wiles S, Ward TH, Parish T, Ripoll J, Bancroft GJ, Schaible UE
A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.22635525
The Journal of antimicrobial chemotherapy, 2012 Aug. : 67(8)1948-60
PMCID:PMC3394442
Ollinger J, O'Malley T, Ahn J, Odingo J, Parish T
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.22427625
Journal of bacteriology, 2012 May : 194(10)2614-9
PMCID:PMC3347204
Schuessler DL, Parish T
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis.22485172
PloS one, 2012 : 7(4)e34471
PMCID:PMC3317779