Center for Global Infectious Disease Research

The Aitchison Lab focuses on the development and application of systems biology approaches to infectious diseases.

The Coler Lab focuses on vaccine development and host-directed therapies against a variety of epidemic and pandemic diseases.

The Frenkel Lab aims to: understand the mechanisms that allow HIV to persist during antiretroviral therapy; develop practical, affordable tests to detect drug-resistant HIV; make insights into reservoirs of drug-resistant HIV and illuminate the pathogenesis of HIV-related diseases.

Studying host-pathogen interactions as they occur in tissues.

The Grundner Lab seeks to map the signaling pathways that underlie Mycobacterium tuberculosis’s (Mtb’s) adaptability and pathogenesis. Our studies provide fundamental insight into Mtb biology and identify new targets for therapeutic interference.

The Harrington Lab focuses on intergenerational immune interactions and their effect on susceptibility to infection during pregnancy and infection.

In the Hernandez Lab, we use a combination of genetics, molecular biology, cell culture models and animal models to probe the interactions between mycobacterial pathogens and host immune cells.

The Jaspan Lab seeks to identify correlates of HIV risk at mucosal surfaces, study the role of the commensal bacteria at these mucosal surfaces in modulating immunity, understand immunity of infants born to HIV-infected mothers who are uninfected yet have high morbidity and mortality, and identify vaccination strategie

The Kaushansky Lab works with the pathogens of infectious diseases like malaria that infect hundreds of millions of people every year. Research areas of focus include malaria host-parasite interaction; host-based drug discovery; cross-pathogen studies and co-infections; global health; immunology and infectious disease.

The Ma Lab at the Seattle Children’s Research Institute combines computational and experimental network biology approaches to understand the molecular interactions that determine infection and treatment fate in tuberculosis.

The McDermott Lab explores the unique molecular and developmental biology of protozoan parasites such as trypanosomes that cause global disease, human host immune responses to their vaccination and infection, and the advancement of technologies to study both pathogen development and host responses.

The primary goal of the Minkah lab is to discover and define mechanisms that dictate the generation of durable, protective liver-resident memory T cell responses.

The Myler Lab uses cutting-edge genomic, bioinformatic and molecular approaches to study gene function and protein structure in a variety of infectious disease organisms.

The focus of the Obado Lab is understanding the functional relationship between the control of gene regulation, RNA export and the nuclear pore complex (NPC), which is the sole mediator of nucleocytoplasmic transport.

The Rajagopal Lab utilizes genetic, molecular, biochemical and proteomic approaches to study infectious diseases caused by bacteria. The lab focuses on the human pathogens group B Streptococcus and Staphylococcus aureus.

The Smith Lab studies the biology of the Plasmodium malaria parasite during the blood stage. The main research interests of the lab are to characterize parasite-host binding interactions and to better understand malaria disease mechanisms. We use this knowledge to design vaccine or disease interventions.

Work in the Sodora Lab primarily focuses on two principal areas of HIV research: HIV transmission and HIV-induced disease and immune factors that impact progression to AIDS.

Research in the Stuart Lab is focused on diseases that are caused by three related parasitic protozoa (Human African trypanosomiasis [sleeping sickness], Chagas disease and Leishmaniasis) and on malaria, which is caused by another protozoan parasite.

Today, tuberculosis (TB) kills more than 1 million people every year, and an effective vaccine is urgently needed. The primary goal of the Urdahl Lab is to perform fundamental research into the immune response to TB that will help inform the rational design of a new and effective vaccine.

The mission of the Vaughan Lab is to alleviate the suffering of those affected by the disease malaria, which kills upwards of 400,000 people, mostly young children, every year.