Profile

Cate Pihoker, MD

Cate Pihoker, MD

Endocrinology, Diabetes Research, Differences in Sex Development

On staff since July 1997

Children's Title: Program Director, Endocrinology Education; Clinic Chief, Diabetes/Endocrine (interim); Division Chief, Endocrinology

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

  • Biography

    Catherine Pihoker, MD, is chief of the Division of Endocrinology and Diabetes and attending physician at Seattle Childrens Hospital and Professor in the Department of Pediatrics at the University of Washington School of Medicine. Her clinical focus is inpatient and outpatient attending for endocrinology and diabetes. Her main research interests include investigating factors that predict the clinical course of diabetes, diabetes typology and improving outcomes of children with diabetes.

    Dr. Pihoker is also interested in the impact on children of being overweight and living sedentary lifestyles, and she is involved in proposals studying the quality of life and metabolic measures in the general population as well as in cancer survivors. Other research interests include endocrine dysfunction in childhood cancer survivors and hypothalamic-pituitary function in children with tumors in the pituitary region. The studies Pihoker has been involved with include the SEARCH for Diabetes in Youth, TrialNet and the Type 1 Diabetes Genetics Consortium. Her teaching activities include serving as fellowship director, and didactic and direct teaching of resident physicians, medical students and support staff.

  • Patient Testimonials

    • Kitt Renton, WA 04.23.13

      Dr. Pihoker has been providing expert care to our daughter since she began throwing seizures at only 3 months of age! Where other doctors had struggled, Dr. P. made a quick and correct diagnosis of a very rare but treatable condition, hypoparathyroidism. My kid is now a healthy teenager and living a normal life, thanks in no small part to Dr. Pihoker and the CHMC team. The gratitude I feel for not only the knowledge and experience, but the unfailing kindness and patience with parental questions and concerns, can barely be put into words. Dr. Pihoker is the best!

    • Jeanne Milton, WA 03.31.11

      I can recommend Dr. Pihoker without reservation for any patient who needs to see an endocrine or diabetes specialist. She works with families and children in a supportive way which allows the child to gradually take on appropriate self-care, and encourages families to learn about their child's condition to help make decisions about long term treatment plans (or tweeks of plans as new needs come up). Although Dr. Pihoker doesn't waste appointment time on chit-chat, we feel she shows genuine concern and interest in our son as her patient, and has become a partner in his care. Our son has been her patient for about 12 of his 14 years of diabetes care at Children's and we are truly thankful for her guidance over the years.

    Recommend Dr. Cate Pihoker

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    SEATTLE MAGAZINE TOP DOCTOR - 2015 Seattle Magazine 2015
    SEATTLE'S TOP DOCTOR - 2015 Seattle Met Magazine 2015
    SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
    SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014
    Diabetes Care Community Ambassador Project The Washington State Office of the Attorney General 2013
    Seattle Magazine Top Doctor - 2013 Seattle Magazine 2013

  • Publications

    • Dabelea D, Lawrence JM, Pihoker C, Dolan L, D'Agostino RB Jr, Marcovina S, Mayer-Davis EJ, SEARCH for Diabetes in Youth Study
      Re: "Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among US Adolescents: Results From the Continuous NHANES, 1999-2010".
      24243743 American journal of epidemiology , 2014 Feb. 1 : 179(3)396-7
    • Badaru A, Klingensmith GJ, Dabelea D, Mayer-Davis EJ, Dolan L, Lawrence JM, Marcovina S, Beavers D, Rodriguez BL, Imperatore G, Pihoker C
      Correlates of treatment patterns among youth with type 2 diabetes.
      24026554 Diabetes care , 2014 Jan. : 37(1)64-72 PMCID: PMC3867996
    • Jaiswal M, Lauer A, Martin CL, Bell RA, Divers J, Dabelea D, Pettitt DJ, Saydah S, Pihoker C, Standiford DA, Rodriguez BL, Pop-Busui R, Feldman EL, SEARCH for Diabetes in Youth Study Group
      Peripheral neuropathy in adolescents and young adults with type 1 and type 2 diabetes from the SEARCH for Diabetes in Youth follow-up cohort: a pilot study.
      24144652 Diabetes care , 2013 Dec. : 36(12)3903-8 PMCID: PMC3836139
    • Shankar RK, Ellard S, Standiford D, Pihoker C, Gilliam LK, Hattersley A, Dolan LM
      Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes.
      23551881 Pediatric diabetes , 2013 Nov. : 14(7)535-8
    • The NS, Crandell JL, Lawrence JM, King IB, Dabelea D, Marcovina SM, D'Agostino RB Jr, Norris JM, Pihoker C, Mayer-Davis EJ
      Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study.
      23909945 Diabetic medicine : a journal of the British Diabetic Association , 2013 Nov. : 30(11)1324-32 PMCID: PMC3822440
    • Pihoker C, Gilliam LK, Ellard S, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, Hattersley AT, SEARCH for Diabetes in Youth Study Group
      Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth.
      23771925 The Journal of clinical endocrinology and metabolism , 2013 Oct. : 98(10)4055-62 PMCID: PMC3790621
    • Pihoker C, Gilliam LK, Ellard S, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, Hattersley AT, SEARCH for Diabetes in Youth Study Group
      Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth.
      23771925 The Journal of clinical endocrinology and metabolism , 2013 Oct. : 98(10)4055-62 PMCID: PMC3790621
    • Pettitt DJ, Talton J, Dabelea D, Divers J, Imperatore G, Lawrence JM, Liese AD, Linder B, Mayer-Davis EJ, Pihoker C, Saydah SH, Standiford DA, Hamman RF, for the SEARCH for Diabetes in Youth Study Group
      Prevalence of Diabetes Mellitus in U.S. Youth in 2009: The SEARCH for Diabetes in Youth Study.
      24041677 Diabetes care , 2013 Sept. 16
    • Mayer-Davis EJ, Dabelea D, Crandell JL, Crume T, D'Agostino RB Jr, Dolan L, King IB, Lawrence JM, Norris JM, Pihoker C, The N
      Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study.
      23801797 Diabetes care , 2013 July : 36(7)1842-50 PMCID: PMC3687285
    • Kanakatti Shankar R, Pihoker C, Dolan LM, Standiford D, Badaru A, Dabelea D, Rodriguez B, Black MH, Imperatore G, Hattersley A, Ellard S, Gilliam LK, SEARCH for Diabetes in Youth Study Group
      Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study.
      23050777 Pediatric diabetes , 2013 May : 14(3)174-80
    • Couch SC, Crandell JL, Shah AS, Dolan LM, Merchant AT, Liese AD, Lawrence JM, Pihoker C, Mayer-Davis EJ
      Fructose intake and cardiovascular risk factors in youth with type 1 diabetes: SEARCH for diabetes in youth study.
      23540682 Diabetes research and clinical practice , 2013 May : 100(2)265-71 PMCID: PMC3764988
    • Lotstein DS, Seid M, Klingensmith G, Case D, Lawrence JM, Pihoker C, Dabelea D, Mayer-Davis EJ, Gilliam LK, Corathers S, Imperatore G, Dolan L, Anderson A, Bell RA, Waitzfelder B, SEARCH for Diabetes in Youth Study Group
      Transition from pediatric to adult care for youth diagnosed with type 1 diabetes in adolescence.
      23530167 Pediatrics , 2013 Apr, : 131(4)e1062-70
    • Black MH, Lawrence JM, Pihoker C, Dolan LM, Anderson A, Rodriguez B, Marcovina SM, Mayer-Davis EJ, Imperatore G, Dabelea D, SEARCH for Diabetes in Youth Study Group
      HLA-associated phenotypes in youth with autoimmune diabetes.
      22913598 Pediatric diabetes , 2013 Mar. : 14(2)121-8
    • Maahs DM, Dabelea D, D'Agostino RB Jr, Andrews JS, Shah AS, Crimmins N, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Dolan LM, SEARCH for Diabetes in Youth Study
      Glucose control predicts 2-year change in lipid profile in youth with type 1 diabetes.
      22795314 The Journal of pediatrics , 2013 Jan. : 162(1)101-7.e1 PMCID: PMC3807690
    • Pihoker C, Badaru A, Anderson A, Morgan T, Dolan L, Dabelea D, Imperatore G, Linder B, Marcovina S, Mayer-Davis E, Reynolds K, Klingensmith GJ, SEARCH for Diabetes in Youth Study Group
      Insulin regimens and clinical outcomes in a type 1 diabetes cohort: the SEARCH for Diabetes in Youth study.
      22961571 Diabetes care , 2013 Jan. : 36(1)27-33 PMCID: PMC3526205
    • Jaacks LM, Oza-Frank R, D'Agostino R Jr, Dolan LM, Dabelea D, Lawrence JM, Pihoker C, O'Connor MR, Linder B, Imperatore G, Seid M, Narayan KM, Mayer-Davis EJ
      Migration status in relation to clinical characteristics and barriers to care among youth with diabetes in the US.
      22481308 Journal of immigrant and minority health / Center for Minority Public Health , 2012 Dec. : 14(6)949-58
    • Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA, T1D Exchange Clinic Network
      The T1D Exchange clinic registry.
      22996145 The Journal of clinical endocrinology and metabolism , 2012 Dec. : 97(12)4383-9
    • Dabelea D, Mayer-Davis EJ, Andrews JS, Dolan LM, Pihoker C, Hamman RF, Greenbaum C, Marcovina S, Fujimoto W, Linder B, Imperatore G, D'Agostino R Jr
      Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study.
      22990715 Diabetologia , 2012 Dec. : 55(12)3359-68
    • Mayer-Davis EJ, Davis C, Saadine J, D'Agostino RB Jr, Dabelea D, Dolan L, Garg S, Lawrence JM, Pihoker C, Rodriguez BL, Klein BE, Klein R, SEARCH for Diabetes in Youth Study Group
      Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study.
      22269205 Diabetic medicine : a journal of the British Diabetic Association , 2012 Sept. : 29(9)1148-52
    • Lawrence JM, Yi-Frazier JP, Black MH, Anderson A, Hood K, Imperatore G, Klingensmith GJ, Naughton M, Mayer-Davis EJ, Seid M, SEARCH for Diabetes in Youth Study Group
      Demographic and clinical correlates of diabetes-related quality of life among youth with type 1 diabetes.
      22361221 The Journal of pediatrics , 2012 Aug. : 161(2)201-7.e2
    • Chiu HK, Sanda S, Fechner PY, Pihoker C
      Correlation of TSH with the risk of paediatric thyroid carcinoma.
      22404106 Clinical endocrinology , 2012 Aug. : 77(2)316-22
    • Shah AS, Dolan LM, D'Agostino RB Jr, Standiford D, Davis C, Testaverde L, Pihoker C, Daniels SR, Urbina EM, SEARCH for Diabetes in Youth Study Group
      Comparison of mercury and aneroid blood pressure measurements in youth.
      22508914 Pediatrics , 2012 May : 129(5)e1205-10 PMCID: PMC3340597
    • Badaru A, Pihoker C
      Type 2 diabetes in childhood: clinical characteristics and role of -cell autoimmunity.
      22139556 Current diabetes reports , 2012 Feb. : 12(1)75-81
    • Vavilala MS, Marro KI, Richards TL, Roberts JS, Curry P, Pihoker C, Bradford H, Shaw D
      Change in mean transit time, apparent diffusion coefficient, and cerebral blood volume during pediatric diabetic ketoacidosis treatment.
      21516055 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2011 Nov. : 12(6)e344-9 PMCID: PMC3157541
    • Elding Larsson H, Vehik K, Bell R, Dabelea D, Dolan L, Pihoker C, Knip M, Veijola R, Lindblad B, Samuelsson U, Holl R, Haller MJ, TEDDY Study Group, SEARCH Study Group, Swediabkids Study Group, DPV Study Group, Finnish Diabetes Registry Study Group
      Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up.
      21972409 Diabetes care , 2011 Nov. : 34(11)2347-52 PMCID: PMC3198296
    • Black MH, Anderson A, Bell RA, Dabelea D, Pihoker C, Saydah S, Seid M, Standiford DA, Waitzfelder B, Marcovina SM, Lawrence JM
      Prevalence of asthma and its association with glycemic control among youth with diabetes.
      21949144 Pediatrics , 2011 Oct. : 128(4)e839-47 PMCID: PMC3387907
    • Waitzfelder B, Pihoker C, Klingensmith G, Case D, Anderson A, Bell RA, Lawrence JM, Mayer-Davis EJ, Imperatore G, Standiford D, Rodriguez BL, Dabelea D, Seid M, SEARCH for Diabetes in Youth Study Group
      Adherence to guidelines for youths with diabetes mellitus.
      21859914 Pediatrics , 2011 Sept. : 128(3)531-8 PMCID: PMC3164090
    • Dabelea D, Pihoker C, Talton JW, D'Agostino RB Jr, Fujimoto W, Klingensmith GJ, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Imperatore G, Dolan LM, SEARCH for Diabetes in Youth Study
      Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study.
      21636800 Diabetes care , 2011 July : 34(7)1628-33 PMCID: PMC3120176
    • Deeter KH, Roberts JS, Bradford H, Richards T, Shaw D, Marro K, Chiu H, Pihoker C, Lynn A, Vavilala MS
      Hypertension despite dehydration during severe pediatric diabetic ketoacidosis.
      21443581 Pediatric diabetes , 2011 June : 12(4 Pt 1)295-301 PMCID: PMC3103609
    • Dabelea D, Dolan LM, D'Agostino R Jr, Hernandez AM, McAteer JB, Hamman RF, Mayer-Davis EJ, Marcovina S, Lawrence JM, Pihoker C, Florez JC
      Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.
      21109996 Diabetologia , 2011 Mar. : 54(3)535-9 PMCID: PMC3766323
    • Fofanova-Gambetti OV, Hwa V, Wit JM, Domene HM, Argente J, Bang P, Högler W, Kirsch S, Pihoker C, Chiu HK, Cohen L, Jacobsen C, Jasper HG, Haeusler G, Campos-Barros A, Gallego-Gómez E, Gracia-Bouthelier R, van Duyvenvoorde HA, Pozo J, Rosenfeld RG
      Impact of heterozygosity for acid-labile subunit (IGFALS) gene mutations on stature: results from the international acid-labile subunit consortium.
      20591980 The Journal of clinical endocrinology and metabolism , 2010 Sept. : 95(9)4184-91
    • Rodriguez BL, Dabelea D, Liese AD, Fujimoto W, Waitzfelder B, Liu L, Bell R, Talton J, Snively BM, Kershnar A, Urbina E, Daniels S, Imperatore G, SEARCH Study Group
      Prevalence and correlates of elevated blood pressure in youth with diabetes mellitus: the SEARCH for diabetes in youth study.
      20394942 The Journal of pediatrics , 2010 Aug. : 157(2)245-251.e1
    • Vavilala MS, Richards TL, Roberts JS, Chiu H, Pihoker C, Bradford H, Deeter K, Marro KI, Shaw D
      Change in blood-brain barrier permeability during pediatric diabetic ketoacidosis treatment.
      19838141 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 May : 11(3)332-8 PMCID: PMC2913885
    • Liu LL, Lawrence JM, Davis C, Liese AD, Pettitt DJ, Pihoker C, Dabelea D, Hamman R, Waitzfelder B, Kahn HS, SEARCH for Diabetes in Youth Study Group
      Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study.
      19473302 Pediatric diabetes , 2010 Feb. : 11(1)4-11
    • McCarty RL, Weber WJ, Loots B, Breuner CC, Vander Stoep A, Manhart L, Pihoker C
      Complementary and alternative medicine use and quality of life in pediatric diabetes.
      20180689 Journal of alternative and complementary medicine (New York, N.Y.) , 2010 Feb. : 16(2)165-73 PMCID: PMC3110095
    • Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, Zhang ZY, Pihoker C, Sanda S, Greenbaum C, Buckner JH
      Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.
      19875613 Diabetes , 2010 Feb. : 59(2)407-15 PMCID: PMC2809970
    • Hilner JE, Perdue LH, Sides EG, Pierce JJ, Wägner AM, Aldrich A, Loth A, Albret L, Wagenknecht LE, Nierras C, Akolkar B, T1DGC
      Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).
      20603248 Clinical trials (London, England) , 2010 : 7(1 Suppl)S5-S32 PMCID: PMC2917852
    • Petitti DB, Klingensmith GJ, Bell RA, Andrews JS, Dabelea D, Imperatore G, Marcovina S, Pihoker C, Standiford D, Waitzfelder B, Mayer-Davis E, SEARCH for Diabetes in Youth Study Group
      Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth Study.
      19643434 The Journal of pediatrics , 2009 Nov. : 155(5)668-72.e1-3
    • Greenbaum CJ, Anderson AM, Dolan LM, Mayer-Davis EJ, Dabelea D, Imperatore G, Marcovina S, Pihoker C, SEARCH Study Group
      Preservation of beta-cell function in autoantibody-positive youth with diabetes.
      19587365 Diabetes care , 2009 Oct. : 32(10)1839-44 PMCID: PMC2752937
    • Pihoker C, Forsander G, Wolfsdorf J, Klingensmith GJ
      The delivery of ambulatory diabetes care to children and adolescents with diabetes.
      19754619 Pediatric diabetes , 2009 Sept. : 10 Suppl 1258-70
    • Rewers M, Pihoker C, Donaghue K, Hanas R, Swift P, Klingensmith GJ
      Assessment and monitoring of glycemic control in children and adolescents with diabetes.
      19754620 Pediatric diabetes , 2009 Sept. : 10 Suppl 1271-81
    • Paris CA, Imperatore G, Klingensmith G, Petitti D, Rodriguez B, Anderson AM, Schwartz ID, Standiford DA, Pihoker C
      Predictors of insulin regimens and impact on outcomes in youth with type 1 diabetes: the SEARCH for Diabetes in Youth study.
      19394043 The Journal of pediatrics , 2009 Aug. : 155(2)183-9.e1
    • Maahs DM, Hamman RF, D'Agostino R Jr, Dolan LM, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis EJ, Pihoker C, Dabelea D
      The association between adiponectin/leptin ratio and diabetes type: the SEARCH for Diabetes in Youth Study.
      19559298 The Journal of pediatrics , 2009 July : 155(1)133-5, 135.e1 PMCID: PMC2743881
    • Long SA, Walker MR, Rieck M, James E, Kwok WW, Sanda S, Pihoker C, Greenbaum C, Nepom GT, Buckner JH
      Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.
      19180473 European journal of immunology , 2009 Feb. : 39(2)612-20 PMCID: PMC2743096
    • Fofanova-Gambetti OV, Hwa V, Kirsch S, Pihoker C, Chiu HK, Högler W, Cohen LE, Jacobsen C, Derr MA, Rosenfeld RG
      Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins.
      19129715 Hormone research , 2009 : 71(2)100-10
    • Pihoker C, Forsander G, Wolfsdorf J, Klingensmith GJ
      The delivery of ambulatory diabetes care: structures, processes, and outcomes of ambulatory diabetes care.
      19067893 Pediatric diabetes , 2008 Dec. : 9(6)609-20
    • Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, Buckner JH
      The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.
      18981158 Journal of immunology (Baltimore, Md. : 1950) , 2008 Nov. 15 : 181(10)7350-5 PMCID: PMC2597079
    • Yang J, Danke N, Roti M, Huston L, Greenbaum C, Pihoker C, James E, Kwok WW
      CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope.
      18385016 Journal of autoimmunity , 2008 Aug. : 31(1)30-41
    • Naughton MJ, Ruggiero AM, Lawrence JM, Imperatore G, Klingensmith GJ, Waitzfelder B, McKeown RE, Standiford DA, Liese AD, Loots B, SEARCH for Diabetes in Youth Study Group
      Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus: SEARCH for Diabetes in Youth Study.
      18606936 Archives of pediatrics & adolescent medicine , 2008 July : 162(7)649-57
    • Rewers A, Klingensmith G, Davis C, Petitti DB, Pihoker C, Rodriguez B, Schwartz ID, Imperatore G, Williams D, Dolan LM, Dabelea D
      Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study.
      18450868 Pediatrics , 2008 May : 121(5)e1258-66
    • Krudys KM, Greenbaum CJ, Pihoker C, Vicini P
      Use of oral glucose minimal model-derived index of insulin sensitivity in subjects with early type 1 diabetes mellitus.
      18328342 Metabolism: clinical and experimental , 2008 Apr, : 57(4)445-7
    • Albers JJ, Marcovina SM, Imperatore G, Snively BM, Stafford J, Fujimoto WY, Mayer-Davis EJ, Petitti DB, Pihoker C, Dolan L, Dabelea DM
      Prevalence and determinants of elevated apolipoprotein B and dense low-density lipoprotein in youths with type 1 and type 2 diabetes.
      18089692 The Journal of clinical endocrinology and metabolism , 2008 Mar. : 93(3)735-42 PMCID: PMC2266957
    • Gilliam LK, Liese AD, Bloch CA, Davis C, Snively BM, Curb D, Williams DE, Pihoker C, SEARCH for Diabetes in Youth Study Group
      Family history of diabetes, autoimmunity, and risk factors for cardiovascular disease among children with diabetes in the SEARCH for Diabetes in Youth Study.
      18036060 Pediatric diabetes , 2007 Dec. : 8(6)354-61
    • Rewers M, Pihoker C, Donaghue K, Hanas R, Swift P, Klingensmith GJ, International Society for Pediatric and Adolescent Diabetes (ISBAD)
      Assessment and monitoring of glycemic control in children and adolescents with diabetes.
      18036070 Pediatric diabetes , 2007 Dec. : 8(6)408-18
    • Chow EJ, Pihoker C, Hunt K, Wilkinson K, Friedman DL
      Obesity and hypertension among children after treatment for acute lymphoblastic leukemia.
      17896787 Cancer , 2007 Nov. 15 : 110(10)2313-20
    • Parisi MA, Ramsdell LA, Burns MW, Carr MC, Grady RE, Gunther DF, Kletter GB, McCauley E, Mitchell ME, Opheim KE, Pihoker C, Richards GE, Soules MR, Pagon RA
      A Gender Assessment Team: experience with 250 patients over a period of 25 years.
      17575501 Genetics in medicine : official journal of the American College of Medical Genetics , 2007 June : 9(6)348-57
    • Tontisirin N, Muangman SL, Suz P, Pihoker C, Fisk D, Moore A, Lam AM, Vavilala MS
      Early childhood gender differences in anterior and posterior cerebral blood flow velocity and autoregulation.
      17283178 Pediatrics , 2007 Mar. : 119(3)e610-5
    • Petitti DB, Imperatore G, Palla SL, Daniels SR, Dolan LM, Kershnar AK, Marcovina S, Pettitt DJ, Pihoker C, SEARCH for Diabetes in Youth Study Group
      Serum lipids and glucose control: the SEARCH for Diabetes in Youth study.
      17283301 Archives of pediatrics & adolescent medicine , 2007 Feb. : 161(2)159-65
    • Standifer NE, Ouyang Q, Panagiotopoulos C, Verchere CB, Tan R, Greenbaum CJ, Pihoker C, Nepom GT
      Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives.
      17065343 Diabetes , 2006 Nov. : 55(11)3061-7
    • Kershnar AK, Daniels SR, Imperatore G, Palla SL, Petitti DB, Pettitt DJ, Marcovina S, Dolan LM, Hamman RF, Liese AD, Pihoker C, Rodriguez BL
      Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study.
      16939739 The Journal of pediatrics , 2006 Sept. : 149(3)314-9
    • Mayer-Davis EJ, Nichols M, Liese AD, Bell RA, Dabelea DM, Johansen JM, Pihoker C, Rodriguez BL, Thomas J, Williams D, SEARCH for Diabetes in Youth Study Group
      Dietary intake among youth with diabetes: the SEARCH for Diabetes in Youth Study.
      16647326 Journal of the American Dietetic Association , 2006 May : 106(5)689-97
    • Pihoker C
      What type of diabetes do young people have?
      16542620 Current diabetes reports , 2006 Apr, : 6(2)108-12
    • Yang J, Danke NA, Berger D, Reichstetter S, Reijonen H, Greenbaum C, Pihoker C, James EA, Kwok WW
      Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.
      16493034 Journal of immunology (Baltimore, Md. : 1950) , 2006 Mar. 1 : 176(5)2781-9
    • Gilliam LK, Jensen RA, Yang P, Weigle DS, Greenbaum CJ, Pihoker C
      Evaluation of leptin levels in subjects at risk for type 1 diabetes.
      16380228 Journal of autoimmunity , 2006 Mar. : 26(2)133-7
    • Dabelea D, D'Agostino RB Jr, Mayer-Davis EJ, Pettitt DJ, Imperatore G, Dolan LM, Pihoker C, Hillier TA, Marcovina SM, Linder B, Ruggiero AM, Hamman RF, SEARCH for Diabetes in Youth Study Group
      Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes.
      16443875 Diabetes care , 2006 Feb. : 29(2)290-4
    • Pihoker C, Gilliam LK, Hampe CS, Lernmark A
      Autoantibodies in diabetes.
      16306341 Diabetes , 2005 Dec. : 54 Suppl 2S52-61
    • Gilliam LK, Brooks-Worrell BM, Palmer JP, Greenbaum CJ, Pihoker C
      Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes.
      16243484 Journal of autoimmunity , 2005 Nov. : 25(3)244-50
    • Liu L, Hironaka K, Pihoker C
      Type 2 diabetes in youth.
      15286592 Current problems in pediatric and adolescent health care , 2004 Aug. : 34(7)254-72
    • Brooks-Worrell BM, Greenbaum CJ, Palmer JP, Pihoker C
      Autoimmunity to islet proteins in children diagnosed with new-onset diabetes.
      15126545 The Journal of clinical endocrinology and metabolism , 2004 May : 89(5)2222-7
    • Greenbaum C, Seidel K, Pihoker C
      The case for intravenous arginine stimulation in lieu of mixed-meal tolerance tests as outcome measure for intervention studies in recent-onset type 1 diabetes.
      15111546 Diabetes care , 2004 May : 27(5)1202-4
    • Christakis DA, Feudtner C, Pihoker C, Connell FA
      Continuity and quality of care for children with diabetes who are covered by medicaid.
      11888380 Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association , 2001 Mar. : 1(2)99-103
    • Williams J, Bates S, Griebel ML, Lange B, Mancias P, Pihoker CM, Dykman R
      Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes?
      9776326 Epilepsia , 1998 Oct. : 39(10)1064-9
    • Pihoker C, Kearns GL, French D, Bowers CY
      Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children.
      9543135 The Journal of clinical endocrinology and metabolism , 1998 Apr, : 83(4)1168-72
    • Pihoker C, Scott CR, Lensing SY, Cradock MM, Smith J
      Non-insulin dependent diabetes mellitus in African-American youths of Arkansas.
      9492117 Clinical pediatrics , 1998 Feb. : 37(2)97-102
    • Pihoker C, Badger TM, Reynolds GA, Bowers CY
      Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature.
      9390009 The Journal of endocrinology , 1997 Oct. : 155(1)79-86
    • Scott CR, Smith JM, Cradock MM, Pihoker C
      Characteristics of youth-onset noninsulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis.
      9200365 Pediatrics , 1997 July : 100(1)84-91
    • Frindik JP, Kemp SF, Pihoker C
      Effective use of magnetic resonance imaging in the assessment of children with possible growth hormone deficiency.
      15251557 Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists , 1996 Jan. : 2(1)8-12
    • Pihoker C, Middleton R, Reynolds GA, Bowers CY, Badger TM
      Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature.
      7559885 The Journal of clinical endocrinology and metabolism , 1995 Oct. : 80(10)2987-92
    • Pihoker C, Robertson MC, Freemark M
      Rat placental lactogen-I binds to the choroid plexus and hypothalamus of the pregnant rat.
      8308459 The Journal of endocrinology , 1993 Nov. : 139(2)235-42
    • Freemark M, Kirk K, Pihoker C, Robertson MC, Shiu RP, Driscoll P
      Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger ribonucleic acid.
      8404626 Endocrinology , 1993 Oct. : 133(4)1830-42
    • Pihoker C, Owens MJ, Kuhn CM, Schanberg SM, Nemeroff CB
      Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor.
      8265736 Psychoneuroendocrinology , 1993 : 18(7)485-93
    • Pihoker C, Cain ST, Nemeroff CB
      Postnatal development of regional binding of corticotropin-releasing factor and adenylate cyclase activity in the rat brain.
      1641499 Progress in neuro-psychopharmacology & biological psychiatry , 1992 July : 16(4)581-6
    • Pihoker C, Feeney RJ, Su JL, Handwerger S
      Lipocortin-I inhibits the synthesis and release of prolactin from human decidual cells: evidence for autocrine/paracrine regulation by lipocortin-I.
      1824932 Endocrinology , 1991 Feb. : 128(2)1123-8

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  • Research Funding

    Grant Title Grantor Amount Award Date
    Monogenic Diabetes – an Ancillary Study of SEARCH for Diabetes in Youth Juvenile Diabetes Research Foundation, Wake Forest University March 1, 2008
    Nutrition and Metabolic Status in Youth with Type 1 DM- SEARCH Ancillary Study NIH, NIDDK, University of South Carolina Feb. 1, 2008
    JDRF-BRI Center for Translational Research Juvenile Diabetes Research Foundation Jan. 1, 2008
    SEARCH for Diabetes in Youth 2- Washington Site NIH CDC Sept. 30, 2005
    Type 1 Diabetes Genetics Consortium NIDDK, Benaroya Research Institute Virginia Mason Sept. 1, 2004
    TrialNet Clinical Agreement, site 307 NIH/NIDDK Oct. 1, 2002

Overview

Board Certification(s)

Pediatric Endocrinology

Medical/Professional School

Jefferson Medical College of Thomas Jefferson University, Philadelphia

Residency

Pediatrics, Hershey Medical Center, Hershey

Fellowship

Pediatric Endocrinology, Duke University Medical Center, Durham

Clinical Interests

Diabetes

Research Focus Area

Diabetes