Stephen Ray Reeves, MD, PhD
On staff since September 2014
Academic Title: Acting Assistant Professor
Research Center: Center for Immunity and Immunotherapies
"I strive to understand the underlying causes for respiratory diseases so that we can develop innovative approaches to treat them. I hope to someday put myself out of work."
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Stephen R. Reeves, MD, PhD is an attending physician in the Division of Pulmonary and Sleep Medicine at Seattle Children's Hospital. He is a native of Kentucky and completed his MD and PhD degrees at the University of Louisville as part of the combined MD/PhD physician scientist training program. Following completion of his degrees, Steve moved to Southern California to complete his residency in General Pediatric Medicine at the University of California, San Diego Department of Pediatrics, affiliated with Rady Childrens Hospital. Steve then completed his Pediatric Pulmonary Medicine fellowship at Seattle Childrens Hospital and the University of Washington School of Medicine. He is excited to stay on as faculty at Seattle Childrens and to continue helping to provide care for the children of the WWAMI Region with chronic respiratory disease.
In addition to his clinical duties, Steve is also junior faculty at the Seattle Childrens Research Institute: Center for Immunity and Immunotherapeutics where he works with Jason Debley, MD, MPH characterizing the cellular biology of airway remodeling in asthmatic children. His current projects are aimed at understanding cell-cell interactions underlying airway remodeling and inflammation.
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Other Publications
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Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JSInterferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
29106997 The Journal of allergy and clinical immunology, 2017 Oct. 26 -
Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JSInterferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
29106997 The Journal of allergy and clinical immunology, 2017 Oct. 26 -
Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SFInterplay of extracellular matrix and leukocytes in lung inflammation.
28077237 Cellular immunology, 2017 Feb. : 3121-14 PMCID:PMC5290208 -
Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SFInterplay of extracellular matrix and leukocytes in lung inflammation.
28077237 Cellular immunology, 2017 Feb. : 3121-14 PMCID:PMC5290208 -
Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AMProteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356 -
Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AMProteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356 -
Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TNSubepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.
27126823 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2016 June : 64(6)364-80 PMCID:PMC4888411 -
Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TNSubepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.
27126823 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2016 June : 64(6)364-80 PMCID:PMC4888411 -
Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JSFibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
25849331 Respiratory research, 2015 Feb. 13 : 1621 PMCID:PMC4333174 -
Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JSFibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
25849331 Respiratory research, 2015 Feb. 13 : 1621 PMCID:PMC4333174 -
Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JSAsthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.
24875618 The Journal of allergy and clinical immunology, 2014 Sept. : 134(3)663-670.e1 PMCID:PMC4149938 -
Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JSAsthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.
24875618 The Journal of allergy and clinical immunology, 2014 Sept. : 134(3)663-670.e1 PMCID:PMC4149938 -
Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski NNetwork analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.
18826996 Physiological genomics, 2008 Dec. 12 : 36(1)24-34 PMCID:PMC2604785 -
Reeves SR, Simakajornboon N, Gozal DThe role of nitric oxide in the neural control of breathing.
18786658 Respiratory physiology and neurobiology, 2008 Dec. 10 : 164(1-2)143-50 -
Reeves SR, Gozal DProtein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats.
17675414 Experimental physiology, 2007 Nov. : 92(6)1057-66 -
Reeves SR, Gozal DRespiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing rat.
17065578 Pediatric research, 2006 Dec. : 60(6)680-6 -
Reeves SR, Gozal DRespiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing rat.
17065578 Pediatric research, 2006 Dec. : 60(6)680-6 -
Reeves SR, Guo SZ, Brittian KR, Row BW, Gozal DAnatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia.
16697524 Neuroscience letters, 2006 July 24 : 402(3)233-7 -
Reeves SR, Mitchell GS, Gozal DEarly postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
16455761 American journal of physiology. Regulatory, integrative and comparative physiology, 2006 June : 290(6)R1664-71 -
Reeves SR, Gozal DChanges in ventilatory adaptations associated with long-term intermittent hypoxia across the age spectrum in the rat.
15908284 Respiratory physiology and neurobiology, 2006 Feb. 28 : 150(2-3)135-43 -
Reeves SR, Gozal DDevelopmental plasticity of respiratory control following intermittent hypoxia.
16203218 Respiratory physiology and neurobiology, 2005 Nov. 15 : 149(1-3)301-11 -
Reeves SR, Gozal DDevelopmental plasticity of respiratory control following intermittent hypoxia.
16203218 Respiratory physiology & neurobiology, 2005 Nov. 15 : 149(1-3)301-11 -
Reeves SR, Carter ES, Guo SZ, Gozal DCalcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats.
15890791 American journal of physiology. Regulatory, integrative and comparative physiology, 2005 Sept. : 289(3)R871-6 -
Reeves SR, Gozal DPlatelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice.
15087283 American journal of physiology. Regulatory, integrative and comparative physiology, 2004 Aug. : 287(2)R369-74 -
Reeves SR, Gozal DPlatelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia.
15234672 Respiratory physiology and neurobiology, 2004 July 12 : 141(1)13-20 -
Reeves SR, Gozal E, Guo SZ, Sachleben LR Jr, Brittian KR, Lipton AJ, Gozal DEffect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat.
14555663 Journal of applied physiology (Bethesda, Md. : 1985), 2003 Nov. : 95(5)1767-74 -
Reeves SR, Gozal E, Guo SZ, Sachleben LR Jr, Brittian KR, Lipton AJ, Gozal DEffect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat.
14555663 Journal of applied physiology (Bethesda, Md. : 1985), 2003 Nov. : 95(5)1767-74 -
Gozal D, Reeves SR, Row BW, Neville JJ, Guo SZ, Lipton AJRespiratory effects of gestational intermittent hypoxia in the developing rat.
12626349 American journal of respiratory and critical care medicine, 2003 June 1 : 167(11)1540-7 -
Gozal D, Gozal E, Reeves SR, Lipton AJGasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxia.
11842051 Journal of applied physiology (Bethesda, Md. : 1985), 2002 March : 92(3)1141-4
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Presentations Title Event Location Date Asthmatic Airway Epithelium in Airway Remodeling and Pacific Northwest Epithelial Biology Group Portland, OR 2014 The NTS and Hypoxic Ventilatory Control; From Signaling to (Patho) Physiology Experimental Biology Conference New Orleans, LA 2009
Overview
- Medical/Professional School
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University of Louisville, Louisville
- Residency
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Pediatrics, University of California - San Diego, San Diego
- Fellowship
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Pediatric Pulmonology, University of Washington, Seattle
- Clinical Interests
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Asthma, transient wheezing of infancy, chronic cough, recurrent lung infections, respiratory viruses, chronic respiratory failure
- Research Description
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Asthma, airway biology, respiratory viruses and wheezing
