Stephen Ray Reeves, MD, PhD

Pulmonary and Sleep Medicine

On staff since September 2014

Academic Title: Acting Assistant Professor

Research Center: Center for Immunity and Immunotherapies

"I strive to understand the underlying causes for respiratory diseases so that we can develop innovative approaches to treat them. I hope to someday put myself out of work."

• Biography

  Stephen R. Reeves, MD, PhD is an attending physician in the Division of Pulmonary and Sleep Medicine at Seattle Children's Hospital. He is a native of Kentucky and completed his MD and PhD degrees at the University of Louisville as part of the combined MD/PhD physician scientist training program. Following completion of his degrees, Steve moved to Southern California to complete his residency in General Pediatric Medicine at the University of California, San Diego Department of Pediatrics, affiliated with Rady Childrens Hospital. Steve then completed his Pediatric Pulmonary Medicine fellowship at Seattle Childrens Hospital and the University of Washington School of Medicine. He is excited to stay on as faculty at Seattle Childrens and to continue helping to provide care for the children of the WWAMI Region with chronic respiratory disease.

  In addition to his clinical duties, Steve is also junior faculty at the Seattle Childrens Research Institute: Center for Immunity and Immunotherapeutics where he works with Jason Debley, MD, MPH characterizing the cellular biology of airway remodeling in asthmatic children. His current projects are aimed at understanding cell-cell interactions underlying airway remodeling and inflammation.

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• Publications

  Other Publications

  • Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS
    Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
    29106997 The Journal of allergy and clinical immunology, 2017 Oct. 26
  • Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS
    Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
    29106997 The Journal of allergy and clinical immunology, 2017 Oct. 26
  • Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SF
    Interplay of extracellular matrix and leukocytes in lung inflammation.
    28077237 Cellular immunology, 2017 Feb. : 3121-14 PMCID:PMC5290208
  • Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SF
    Interplay of extracellular matrix and leukocytes in lung inflammation.
    28077237 Cellular immunology, 2017 Feb. : 3121-14 PMCID:PMC5290208
  • Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM
    Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
    27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356
  • Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM
    Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
    27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356
  • Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TN
    Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.
    27126823 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2016 June : 64(6)364-80 PMCID:PMC4888411
  • Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TN
    Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.
    27126823 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2016 June : 64(6)364-80 PMCID:PMC4888411
  • Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JS
    Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
    25849331 Respiratory research, 2015 Feb. 13 : 1621 PMCID:PMC4333174
  • Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JS
    Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
    25849331 Respiratory research, 2015 Feb. 13 : 1621 PMCID:PMC4333174
  • Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS
    Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.
    24875618 The Journal of allergy and clinical immunology, 2014 Sept. : 134(3)663-670.e1 PMCID:PMC4149938
  • Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS
    Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.
    24875618 The Journal of allergy and clinical immunology, 2014 Sept. : 134(3)663-670.e1 PMCID:PMC4149938
  • Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski N
    Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.
    18826996 Physiological genomics, 2008 Dec. 12 : 36(1)24-34 PMCID:PMC2604785
  • Reeves SR, Simakajornboon N, Gozal D
    The role of nitric oxide in the neural control of breathing.
    18786658 Respiratory physiology and neurobiology, 2008 Dec. 10 : 164(1-2)143-50
  • Reeves SR, Gozal D
    Protein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats.
    17675414 Experimental physiology, 2007 Nov. : 92(6)1057-66
  • Reeves SR, Gozal D
    Respiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing rat.
    17065578 Pediatric research, 2006 Dec. : 60(6)680-6
  • Reeves SR, Gozal D
    Respiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing rat.
    17065578 Pediatric research, 2006 Dec. : 60(6)680-6
  • Reeves SR, Guo SZ, Brittian KR, Row BW, Gozal D
    Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia.
    16697524 Neuroscience letters, 2006 July 24 : 402(3)233-7
  • Reeves SR, Mitchell GS, Gozal D
    Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
    16455761 American journal of physiology. Regulatory, integrative and comparative physiology, 2006 June : 290(6)R1664-71
  • Reeves SR, Gozal D
    Changes in ventilatory adaptations associated with long-term intermittent hypoxia across the age spectrum in the rat.
    15908284 Respiratory physiology and neurobiology, 2006 Feb. 28 : 150(2-3)135-43
  • Reeves SR, Gozal D
    Developmental plasticity of respiratory control following intermittent hypoxia.
    16203218 Respiratory physiology and neurobiology, 2005 Nov. 15 : 149(1-3)301-11
  • Reeves SR, Gozal D
    Developmental plasticity of respiratory control following intermittent hypoxia.
    16203218 Respiratory physiology & neurobiology, 2005 Nov. 15 : 149(1-3)301-11
  • Reeves SR, Carter ES, Guo SZ, Gozal D
    Calcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats.
    15890791 American journal of physiology. Regulatory, integrative and comparative physiology, 2005 Sept. : 289(3)R871-6
  • Reeves SR, Gozal D
    Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice.
    15087283 American journal of physiology. Regulatory, integrative and comparative physiology, 2004 Aug. : 287(2)R369-74
  • Reeves SR, Gozal D
    Platelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia.
    15234672 Respiratory physiology and neurobiology, 2004 July 12 : 141(1)13-20
  • Reeves SR, Gozal E, Guo SZ, Sachleben LR Jr, Brittian KR, Lipton AJ, Gozal D
    Effect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat.
    14555663 Journal of applied physiology (Bethesda, Md. : 1985), 2003 Nov. : 95(5)1767-74
  • Reeves SR, Gozal E, Guo SZ, Sachleben LR Jr, Brittian KR, Lipton AJ, Gozal D
    Effect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat.
    14555663 Journal of applied physiology (Bethesda, Md. : 1985), 2003 Nov. : 95(5)1767-74
  • Gozal D, Reeves SR, Row BW, Neville JJ, Guo SZ, Lipton AJ
    Respiratory effects of gestational intermittent hypoxia in the developing rat.
    12626349 American journal of respiratory and critical care medicine, 2003 June 1 : 167(11)1540-7
  • Gozal D, Gozal E, Reeves SR, Lipton AJ
    Gasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxia.
    11842051 Journal of applied physiology (Bethesda, Md. : 1985), 2002 March : 92(3)1141-4

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• Presentations

  Presentations Title	Event	Location	Date
  Asthmatic Airway Epithelium in Airway Remodeling and	Pacific Northwest Epithelial Biology Group	Portland, OR	2014
  The NTS and Hypoxic Ventilatory Control; From Signaling to (Patho) Physiology	Experimental Biology Conference	New Orleans, LA	2009