Stephen Ray Reeves, MD, PhD

Pulmonary

On staff since September 2014

Academic Title: Acting Assistant Professor

Research Center: Center for Immunity and Immunotherapies

"I strive to understand the underlying causes for respiratory diseases so that we can develop innovative approaches to treat them. I hope to someday put myself out of work."

• Biography

  Stephen R. Reeves, MD, PhD is an attending physician in the Division of Pulmonary and Sleep Medicine at Seattle Children's Hospital. He is a native of Kentucky and completed his MD and PhD degrees at the University of Louisville as part of the combined MD/PhD physician scientist training program. Following completion of his degrees, Steve moved to Southern California to complete his residency in General Pediatric Medicine at the University of California San Diego Department of Pediatrics. He then completed his Pediatric Pulmonary Medicine fellowship at Seattle Children’s Hospital and the University of Washington School of Medicine. Steve’s clinical interests include asthma management, chronic respiratory failure, and technology dependent children, as well as general pulmonary medicine.

  In addition to his clinical duties, Steve is a principal investigator in the Center for Immunity and Immunotherapies at the Seattle Children’s Research Institute. His research interests include investigating the contribution of extracellular matrix changes during lung disease and evaluating the effects of the extracellular matrix remodeling on airway inflammation. Steve’s specific areas of research interest include lung epithelial cell – stromal cell crosstalk that promotes a pro-inflammatory microenvironment during chronic lung inflammation (ex. asthma) and acute lung inflammation (ex. viral infections).

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• Publications

  Other Publications

  • Barrow KA, Rich LM, Vanderwall ER, Reeves SR, Rathe JA, White MP, Debley JS
    Inactivation of Material from SARS-CoV-2-Infected Primary Airway Epithelial Cell Cultures.
    33430421 Methods and protocols, 2021 Jan. 7 : 4(1) PMCID:PMC7839057
  • Kellar GG, Reeves SR, Barrow KA, Debley JS, Wight TN, Ziegler SF
    Juvenile, but Not Adult, Mice Display Increased Myeloid Recruitment and Extracellular Matrix Remodeling during Respiratory Syncytial Virus Infection.
    33097575 Journal of immunology (Baltimore, Md. : 1950), 2020 Dec. 1 : 205(11)3050-3057 PMCID:PMC7747670
  • Kellar GG, Barrow KA, Rich LM, Debley JS, Wight TN, Ziegler SF, Reeves SR
    Loss of versican and production of hyaluronan in lung epithelial cells are associated with airway inflammation during RSV infection.
    33429211 The Journal of biological chemistry, 2020 Nov. 21 : 296100076
  • Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS
    Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases.
    32047499 Frontiers in immunology, 2019 : 103159 PMCID:PMC6997473
  • Reeves SR, Barrow KA, Kolstad TK, White MP, Rich LM, Wight TN, Debley JS
    Fibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history.
    30361541 Scientific reports, 2018 Oct. 25 : 8(1)15768 PMCID:PMC6202408
  • Reeves SR, Kang I, Chan CK, Barrow KA, Kolstad TK, White MP, Ziegler SF, Wight TN, Debley JS
    Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts.
    30071849 Respiratory research, 2018 Aug. 2 : 19(1)146 PMCID:PMC6090698
  • James RG, Reeves SR, Barrow KA, White MP, Glukhova VA, Haghighi C, Seyoum D, Debley JS
    Deficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-Myofibroblast Transition.
    29394092 American journal of respiratory cell and molecular biology, 2018 July : 59(1)104-113 PMCID:PMC6039878
  • Reeves SR, Barrow KA, White MP, Rich LM, Naushab M, Debley JS
    Stability of gene expression by primary bronchial epithelial cells over increasing passage number.
    29843677 BMC pulmonary medicine, 2018 May 29 : 18(1)91 PMCID:PMC5975426
  • Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS
    Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
    29106997 The Journal of allergy and clinical immunology, 2017 Oct. 26
  • Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SF
    Interplay of extracellular matrix and leukocytes in lung inflammation.
    28077237 Cellular immunology, 2017 Feb. : 3121-14 PMCID:PMC5290208
  • Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM
    Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
    27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356
  • Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TN
    Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.
    27126823 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2016 June : 64(6)364-80 PMCID:PMC4888411
  • Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JS
    Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
    25849331 Respiratory research, 2015 Feb. 13 : 1621 PMCID:PMC4333174
  • Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS
    Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.
    24875618 The Journal of allergy and clinical immunology, 2014 Sept. : 134(3)663-670.e1 PMCID:PMC4149938
  • Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski N
    Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.
    18826996 Physiological genomics, 2008 Dec. 12 : 36(1)24-34 PMCID:PMC2604785
  • Reeves SR, Simakajornboon N, Gozal D
    The role of nitric oxide in the neural control of breathing.
    18786658 Respiratory physiology and neurobiology, 2008 Dec. 10 : 164(1-2)143-50
  • Reeves SR, Gozal D
    Protein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats.
    17675414 Experimental physiology, 2007 Nov. : 92(6)1057-66
  • Reeves SR, Gozal D
    Respiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing rat.
    17065578 Pediatric research, 2006 Dec. : 60(6)680-6
  • Reeves SR, Guo SZ, Brittian KR, Row BW, Gozal D
    Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia.
    16697524 Neuroscience letters, 2006 July 24 : 402(3)233-7
  • Reeves SR, Mitchell GS, Gozal D
    Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
    16455761 American journal of physiology. Regulatory, integrative and comparative physiology, 2006 June : 290(6)R1664-71
  • Reeves SR, Gozal D
    Changes in ventilatory adaptations associated with long-term intermittent hypoxia across the age spectrum in the rat.
    15908284 Respiratory physiology and neurobiology, 2006 Feb. 28 : 150(2-3)135-43
  • Reeves SR, Gozal D
    Developmental plasticity of respiratory control following intermittent hypoxia.
    16203218 Respiratory physiology and neurobiology, 2005 Nov. 15 : 149(1-3)301-11
  • Reeves SR, Gozal D
    Developmental plasticity of respiratory control following intermittent hypoxia.
    16203218 Respiratory physiology & neurobiology, 2005 Nov. 15 : 149(1-3)301-11
  • Reeves SR, Carter ES, Guo SZ, Gozal D
    Calcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats.
    15890791 American journal of physiology. Regulatory, integrative and comparative physiology, 2005 Sept. : 289(3)R871-6
  • Reeves SR, Gozal D
    Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice.
    15087283 American journal of physiology. Regulatory, integrative and comparative physiology, 2004 Aug. : 287(2)R369-74
  • Reeves SR, Gozal D
    Platelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia.
    15234672 Respiratory physiology and neurobiology, 2004 July 12 : 141(1)13-20
  • Reeves SR, Gozal E, Guo SZ, Sachleben LR Jr, Brittian KR, Lipton AJ, Gozal D
    Effect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat.
    14555663 Journal of applied physiology (Bethesda, Md. : 1985), 2003 Nov. : 95(5)1767-74
  • Gozal D, Reeves SR, Row BW, Neville JJ, Guo SZ, Lipton AJ
    Respiratory effects of gestational intermittent hypoxia in the developing rat.
    12626349 American journal of respiratory and critical care medicine, 2003 June 1 : 167(11)1540-7
  • Gozal D, Gozal E, Reeves SR, Lipton AJ
    Gasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxia.
    11842051 Journal of applied physiology (Bethesda, Md. : 1985), 2002 March : 92(3)1141-4

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• Presentations

  Presentations Title	Event	Location	Date
  Pediatric Asthma Cases	47th Annual University of Washington Family Medicine and Primary Care Conference	Seattle, WA	2019
  Pediatric Asthma: An Overview	46th Annual University of Washington Family Medicine and Primary Care Conference	Seattle, WA	2018
  Novel multi-color assay for extracellular matrix/leukocyte interactions in the airway	Asthma and Allergic Diseases Cooperative Research Centers Steering Committee Meeting, NIAID	Rockville, MD	2018
  Regulation of leukocyte trafficking and activation by the extracellular matrix component hyaluronan during respiratory viral infections	Pacific Northwest Epithelial Biology Group Meeting	Seattle, WA	2018
  Extra-cellular matrix accumulation of hyaluronan is increased by RSV infection in airway epithelium - lung fibroblast co-cultures	Pacific Northwest Epithelial Biology Group Meeting	Seattle, WA	2017
  Pediatric Asthma Cases Workshop	45th Annual University of Washington Family Medicine and Primary Care Conference	Seattle, WA	2017
  Pediatric Asthma Cases Workshop	44th Annual University of Washington Family Medicine and Primary Care Conference	Seattle, WA	2016
  Airway epithelial regulation of extracellular matrix constituents in asthmatic airway	Pacific Northwest Epithelial Biology Group Meeting	Seattle, WA	2016
  Asthmatic Airway Epithelium in Airway Remodeling and	Pacific Northwest Epithelial Biology Group	Portland, OR	2014
  The NTS and Hypoxic Ventilatory Control; From Signaling to (Patho) Physiology	Experimental Biology Conference	New Orleans, LA	2009