Richard G James, PhD

Richard G James,  PhD

Academic Title: Associate Professor, Pediatrics and Pharmacology

Research Title: Principal Investigator, Seattle Children's Research Institute

Research Center: Center for Immunity and Immunotherapies

  • Biography

    PubMed Bibliography

    • Related Pages

    • James Lab

      The James lab investigates how genetic variation and pharmacological treatments alter cellular signaling.

  • Patient Testimonials

  • Publications

    Other Publications

    • Al Qureshah F, Sagadiev S, Thouvenel CD, Liu S, Hua Z, Hou B, Acharya M, James RG, Rawlings DJ
      Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress.
      34586341 The Journal of experimental medicine, 2021 Dec 6 : 218(12)
    • Saha SS, Samanas NB, Miralda I, Shubin NJ, Niino K, Bhise G, Acharya M, Seo AJ, Camp N, Deutsch GH, James RG, Piliponsky AM
      Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function.
      34324892 The Journal of allergy and clinical immunology, 2021 Jul 27
    • Thomas KR, Allenspach EJ, Camp ND, Wray-Dutra MN, Khim S, Zielinska-Kwiatkowska A, Timms AE, Loftus JP, Liggitt HD, Georgopoulos K, Tasian SK, James RG, Rawlings DJ
      Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.
      34193976 Leukemia, 2021 Jun 30
    • Meitlis I, Allenspach EJ, Bauman BM, Phan IQ, Dabbah G, Schmitt EG, Camp ND, Torgerson TR, Nickerson DA, Bamshad MJ, Hagin D, Luthers CR, Stinson JR, Gray J, Lundgren I, Church JA, Butte MJ, Jordan MB, Aceves SS, Schwartz DM, Milner JD, Schuval S, Skoda-Smith S, Cooper MA, Starita LM, Rawlings DJ, Snow AL, James RG
      Multiplexed Functional Assessment of Genetic Variants in CARD11.
      33202260 American journal of human genetics, 2020 Dec 3 : 107(6)1029-1043 PMCID:PMC7820631
    • Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M Jr, James RC, Stetson DB
      Human DNA-PK activates a STING-independent DNA sensing pathway.
      31980485 Science immunology, 2020 Jan 24 : 5(43) PMCID:PMC7081723
    • Gelman H, Dines JN, Berg J, Berger AH, Brnich S, Hisama FM, James RG, Rubin AF, Shendure J, Shirts B, Fowler DM, Starita LM, Brotman Baty Institute Mutational Scanning Working Group.
      Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation.
      31862013 Genome medicine, 2019 Dec 20 : 11(1)85 PMCID:PMC6925490
    • Ramírez JA, Iwata T, Park H, Tsang M, Kang J, Cui K, Kwong W, James RG, Baba M, Schmidt LS, Iritani BM
      Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3.
      31676673 Journal of immunology (Baltimore, Md. : 1950), 2019 Dec 1 : 203(11)2899-2908 PMCID:PMC6864314
    • Carpentier SJ, Ni M, Duggan JM, James RG, Cookson BT, Hamerman JA
      The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1.
      31088976 Science signaling, 2019 May 14 : 12(581) PMCID:PMC6604799
    • Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ
      Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses.
      30194267 The Journal of experimental medicine, 2018 Oct 1 : 215(10)2485-2496 PMCID:PMC6170176
    • Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ
      Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.
      30127060 The Journal of experimental medicine, 2018 Sep 3 : 215(9)2445-2461 PMCID:PMC6122963
    • Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS
      Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
      29106997 The Journal of allergy and clinical immunology, 2018 Aug. : 142(2)451-459 PMCID:PMC5951761
    • James RG, Reeves SR, Barrow KA, White MP, Glukhova VA, Haghighi C, Seyoum D, Debley JS
      Deficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-Myofibroblast Transition.
      29394092 American journal of respiratory cell and molecular biology, 2018 July : 59(1)104-113 PMCID:PMC6039878
    • Hung KL, Meitlis I, Hale M, Chen CY, Singh S, Jackson SW, Miao CH, Khan IF, Rawlings DJ, James RG
      Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.
      29273498 Molecular therapy : the journal of the American Society of Gene Therapy, 2018 Feb 7 : 26(2)456-467 PMCID:PMC5835153
    • Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ
      The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
      28553952 Nature immunology, 2017 July : 18(7)744-752 PMCID:PMC5697900
    • Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM
      Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
      27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356
    • Dam EM, Habib T, Chen J, Funk A, Glukhova V, Davis-Pickett M, Wei S, James R, Buckner JH, Cerosaletti K
      The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.
      27816669 Clinical immunology (Orlando, Fla.), 2016 Dec. : 173171-180 PMCID:PMC5148640
    • Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG
      The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
      26026062 Journal of immunology (Baltimore, Md. : 1950), 2015 Jul 1 : 195(1)246-56 PMCID:PMC4475445
    • Robin NC, Agoston Z, Biechele TL, James RG, Berndt JD, Moon RT
      Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling.
      24511465 Stem cell reports, 2014 Jan 14 : 2(1)9-17 PMCID:PMC3916759
    • James RG, Bosch KA, Kulikauskas RM, Yang PT, Robin NC, Toroni RA, Biechele TL, Berndt JD, von Haller PD, Eng JK, Wolf-Yadlin A, Chien AJ, Moon RT
      Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.
      24114839 The Journal of biological chemistry, 2013 Nov 29 : 288(48)34658-70 PMCID:PMC3843078
    • Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O
      A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.
      23583077 Molecular cell, 2013 May 9 : 50(3)444-56 PMCID:PMC3660009
    • Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ
      A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
      23619366 The Journal of clinical investigation, 2013 May : 123(5)2024-36 PMCID:PMC3638909
    • Fleming BM, Yelin R, James RG, Schultheiss TM
      A role for Vg1/Nodal signaling in specification of the intermediate mesoderm.
      23533180 Development (Cambridge, England), 2013 April : 140(8)1819-29 PMCID:PMC3621495
    • K G Silvério 1, K C Davidson, R G James, A M Adams, B L Foster, F H Nociti Jr, M J Somerman, R T Moon
      Wnt/β-catenin pathway regulates bone morphogenetic protein (BMP2)-mediated differentiation of dental follicle cells
      Comparative Study, 2012 : PMCID:PMC3865600
    • Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT
      Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
      22215675 The Journal of biological chemistry, 2012 Feb 24 : 287(9)6539-50 PMCID:PMC3307315
    • Biechele TL, Kulikauskas RM, Toroni RA, Lucero OM, Swift RD, James RG, Robin NC, Dawson DW, Moon RT, Chien AJ
      Wnt/ß-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.
      22234612 Science signaling, 2012 Jan 10 : 5(206)ra3 PMCID:PMC3297477
    • James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT
      WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
      23227175 PloS one, 2012 : 7(12)e50457 PMCID:PMC3515623
    • Kamei CN, Kempf H, Yelin R, Daoud G, James RG, Lassar AB, Tabin CJ, Schultheiss TM
      Promotion of avian endothelial cell differentiation by GATA transcription factors.
      21354132 Developmental biology, 2011 May 1 : 353(1)29-37 PMCID:PMC3165022
    • Cimetta E, Cannizzaro C, James R, Biechele T, Moon RT, Elvassore N, Vunjak-Novakovic G
      Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling.
      20936235 Lab on a chip, 2010 Dec 7 : 10(23)3277-83 PMCID:PMC4106280
    • James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
      Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
      19471023 Science signaling, 2009 May 26 : 2(72)ra25 PMCID:PMC4790753
    • James RG, Conrad WH, Moon RT
      Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors.
      19099251 Methods in molecular biology (Clifton, N.J.), 2008 : 468131-44
    • James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM
      Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells.
      16790474 Development (Cambridge, England), 2006 Aug. : 133(15)2995-3004
    • James RG, Schultheiss TM
      Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner.
      Developmental biology, 2005 Dec 1 : 288(1)113-25
    • Wilm B, James RG, Schultheiss TM, Hogan BL
      The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
      Developmental biology, 2004 Jul 1 : 271(1)176-89
    • James RG, Schultheiss TM
      Patterning of the avian intermediate mesoderm by lateral plate and axial tissues.
      Developmental biology, 2003 : 253(1)109-24