Li Li, MD, PhD

Li Li, MD, PhD


On staff since September 2019

Academic Title: Assistant Professor, Anesthesiology

Research Center: Center for Integrative Brain Research

  • Biography

    Li Li, MD, PhD is a pediatric anesthesiologist, a principal investigator at the Center for Integrative Brain Research (CIBR) at Seattle Children's Research Institute (SCRI), and a member of the University of Washington (UW) Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE). He seeks to improve medical care involving anesthetics and sedatives by better understanding the brain circuits that regulate arousal, and by developing drugs and technology that can more precisely modulate those circuits.

    Dr. Li received his MD and PhD in neurosciences with Prof. Richard Tsien at Stanford University. He then completed his anesthesiology residency at UW and his pediatric anesthesiology fellowship at Seattle Children's Hospital. He subsequently joined the UW clinical faculty while conducting postdoctoral research with Prof. Michael Bruchas. Dr. Li is passionate about mentoring and training the next generation of physician-scientists.


  • Patient Testimonials

  • Publications

    Other Publications

    • Jung S, Kayser EB, Johnson SC, Li L, Worstman HM, Sun GX, Sedensky MM, Morgan PG
      Tetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice
      Br J Anaesth, 2022 Jan. : 128(1)77-88 PMCID:PMC8787783
    • Li L, Nandate K, Hecker J, Bentov N, Gowda GAN, Raftery D, Sharma D
      A Novel Approach to Investigating Brain Waste Removal in Humans
      Journal of Neurosurgical Anesthesiology, 2021 : 33(2)185-186 PMCID:31651552
    • Johnson SC, Pan A, Sun GX, Freed A, Stokes JC, Bornstein R, Witkowski M, Li L, Ford JM, Howard CRA, Sedensky MM, Morgan PG
      Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse
      PLoS One, 2019 : 14(3)e0213543 PMCID:30897103
    • Johnson SC, Pan A, Li L, Sedensky M, Morgan P
      Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies
      Neurotoxicol Teratol, 2019 : 7122-31 PMCID:30472095
    • Li L, Johnsen JM, Doan CX, Bollag LA
      Case Report: Anesthetic management for Cesarean section in a parturient with unspecified inherited bleeding disorder
      F1000Res, 2018 : 71482 PMCID:30581553
    • Tham SW, Li L, Effraim P, Waxman S
      Between fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia
      BMJ Case Rep, 2017 : pii(bcr-2017)219486 PMCID:28751508
    • Li L, Harper MW, Chen MA
      An Unusual Case of Supraventricular Tachycardia in a 64‐Year‐Old
      J Am Geriatr Soc, 2015 : 63(3)616-8 PMCID:25800923
    • Han Z, Li L, Wang L, Degos V, Maze M, Su H
      Alpha‐7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture
      J Neurochem, 2014 : 131(4)498-508 PMCID:25040630
    • Li L, Kay AW, Hong DK
      Seizure and Meningoencephalitis in an Adolescent
      Clin Pediatr (Phila), 2013 : 52(12)1181-3 PMCID:24137030
    • Yoo AS*, Sun AX*, Li L*, Shcheglovitov A*, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR
      MicroRNA-mediated conversion of human fibroblasts to neurons
      Nature, 2011 : 476(7359)228-31 PMCID:21753754
    • Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RW
      β Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons
      Proc Natl Acad Sci USA, 2011 : 108(2)828-33 PMCID:21187407
    • Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RW
      Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity
      Proc Natl Acad Sci USA, 2010 : 107(50)21806-11 PMCID:21098665
    • Li L, Rao NN, Kornberg A
      Inorganic polyphosphate essential for lytic growth of phages P1 and fd
      Proc Natl Acad Sci USA, 2007 : 104(6)1794-9 PMCID:17261797
  • Research Funding

    Grant Title Grantor Amount Award Date
    Unraveling the Locus Coeruleus Circuitry in Opioid-induced Sleep Disturbances National Institute on Drug Abuse July 2021 - June 2026
    Deciphering the Locus Coeruleus-Thalamic Circuit in Anesthetic Emergence Foundation for Anesthesia Education and Research 2020 - 2021


Board Certification(s)

Pediatric Anesthesiology

Medical/Professional School

Stanford University School of Medicine, Stanford, CA


University of Washington, Seattle, WA


University of Washington, Seattle, WA

Clinical Interests

Precision anesthesia; Brain monitoring during anesthesia

Research Description

Understanding brain circuits involved in modulating arousal; Developing more precise drugs and technology to modulate arousal

Research Focus Area

Arousal neurobiology, neuromodulation, anesthesiology, integrative physiology