Li Li, MD, PhD
On staff since September 2019
Academic Title: Assistant Professor, Anesthesiology
Research Center: Center for Integrative Brain Research
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Li Li, MD, PhD is a pediatric anesthesiologist, a principal investigator at the Center for Integrative Brain Research (CIBR) at Seattle Children's Research Institute (SCRI), and a member of the University of Washington (UW) Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE). He seeks to improve medical care involving anesthetics and sedatives by better understanding the brain circuits that regulate arousal, and by developing drugs and technology that can more precisely modulate those circuits.
Dr. Li received his MD and PhD in neurosciences with Prof. Richard Tsien at Stanford University. He then completed his anesthesiology residency at UW and his pediatric anesthesiology fellowship at Seattle Children's Hospital. He subsequently joined the UW clinical faculty while conducting postdoctoral research with Prof. Michael Bruchas. Dr. Li is passionate about mentoring and training the next generation of physician-scientists.
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Other Publications
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Jung S, Kayser EB, Johnson SC, Li L, Worstman HM, Sun GX, Sedensky MM, Morgan PGTetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice
Br J Anaesth, 2022 Jan. : 128(1)77-88 PMCID:PMC8787783 -
Li L, Nandate K, Hecker J, Bentov N, Gowda GAN, Raftery D, Sharma DA Novel Approach to Investigating Brain Waste Removal in Humans
Journal of Neurosurgical Anesthesiology, 2021 : 33(2)185-186 PMCID:31651552 -
Johnson SC, Pan A, Sun GX, Freed A, Stokes JC, Bornstein R, Witkowski M, Li L, Ford JM, Howard CRA, Sedensky MM, Morgan PGRelevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse
PLoS One, 2019 : 14(3)e0213543 PMCID:30897103 -
Johnson SC, Pan A, Li L, Sedensky M, Morgan PNeurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies
Neurotoxicol Teratol, 2019 : 7122-31 PMCID:30472095 -
Li L, Johnsen JM, Doan CX, Bollag LACase Report: Anesthetic management for Cesarean section in a parturient with unspecified inherited bleeding disorder
F1000Res, 2018 : 71482 PMCID:30581553 -
Tham SW, Li L, Effraim P, Waxman SBetween fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia
BMJ Case Rep, 2017 : pii(bcr-2017)219486 PMCID:28751508 -
Li L, Harper MW, Chen MAAn Unusual Case of Supraventricular Tachycardia in a 64‐Year‐Old
J Am Geriatr Soc, 2015 : 63(3)616-8 PMCID:25800923 -
Han Z, Li L, Wang L, Degos V, Maze M, Su HAlpha‐7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture
J Neurochem, 2014 : 131(4)498-508 PMCID:25040630 -
Li L, Kay AW, Hong DKSeizure and Meningoencephalitis in an Adolescent
Clin Pediatr (Phila), 2013 : 52(12)1181-3 PMCID:24137030 -
Yoo AS*, Sun AX*, Li L*, Shcheglovitov A*, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GRMicroRNA-mediated conversion of human fibroblasts to neurons
Nature, 2011 : 476(7359)228-31 PMCID:21753754 -
Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RWβ Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons
Proc Natl Acad Sci USA, 2011 : 108(2)828-33 PMCID:21187407 -
Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RWPostsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity
Proc Natl Acad Sci USA, 2010 : 107(50)21806-11 PMCID:21098665 -
Li L, Rao NN, Kornberg AInorganic polyphosphate essential for lytic growth of phages P1 and fd
Proc Natl Acad Sci USA, 2007 : 104(6)1794-9 PMCID:17261797
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Grant Title Grantor Amount Award Date Unraveling the Locus Coeruleus Circuitry in Opioid-induced Sleep Disturbances National Institute on Drug Abuse July 2021 - June 2026 Deciphering the Locus Coeruleus-Thalamic Circuit in Anesthetic Emergence Foundation for Anesthesia Education and Research 2020 - 2021
Overview
- Board Certification(s)
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Anesthesiology
Pediatric Anesthesiology
- Medical/Professional School
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Stanford University School of Medicine, Stanford, CA
- Residency
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University of Washington, Seattle, WA
- Fellowship
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University of Washington, Seattle, WA
- Clinical Interests
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Precision anesthesia; Brain monitoring during anesthesia
- Research Description
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Understanding brain circuits involved in modulating arousal; Developing more precise drugs and technology to modulate arousal
- Research Focus Area
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Arousal neurobiology, neuromodulation, anesthesiology, integrative physiology