Lauri M. Burroughs, MD
On staff since November 2004
Academic Title: Associate Professor
"The patients and families are really what motivate me to keep striving to do better. I am always amazed at the inner strength these kids and their parents have. It is so rewarding to be a part of their lives and help them through a really difficult time. To see a child pull through and come out the other side and thrive is a wonderful feeling."
Lauri M. Burroughs, MD, is attending physician at Seattle Children’s Hospital, assistant professor in the Division of Pediatric Hematology/Oncology at the University of Washington School of Medicine and assistant member in the Clinical Research Division and in the Pediatric Stem Cell Transplantation Center of Fred Hutchinson Cancer Research Center (FHCRC). Her research interests include hematopoietic cell transplant for patients with primary immunodeficiencies and other nonmalignant inherited disorders, and she has focused her research efforts on reducing transplant-related complications.
She is conducting several clinical trials evaluating reduced intensity or nonmyelobaltive conditioning followed by transplant for patients with nonmalignant disorders. One of the clinical trial is evaluating whether the addition of the T cell depleting agent Campath can decrease the incidence of graft versus host disease (GVHD) and improve donor chimerism following hematopoietic cell transplantation. In addition, in order to increase the number of patients with primary immunodeficiencies and other rare nonmalignant inherited diseases who may benefit from a transplant, Dr. Burroughs developed a clinical trial for patients who do not have an HLA-matched related or unrelated donor. Patients receiving a nonmyeloablative conditioning regimen will receive cyclophosphamide before and after hematopoietic cell transplantation followed by HLA-haploidentical grafts to remove alloreactive T cells with the goal of improving engraftment and decreasing GVHD. Finally, Dr. Burroughs is exploring a reduced intensity regimen that incorporates Treosulfan a Busulfan analog into the preparative regimen which in several clinical trials has been shown to be associated with significantly reduced toxicity and as a result decreased transplant related mortality following transplant. In collaboration with the Immunology group at Seattle Children's, Dr. Burroughs is evaluating how the immune system reconstitutes following transplant.
Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AEStable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
20643476 The Journal of allergy and clinical immunology, 2010 July 17
Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AMImmunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
18952502 Clinical immunology (Orlando, Fla.), 2009 Feb. : 162-74
- Board Certification(s)
- Medical/Professional School
University of Wisconsin School of Medicine and Public Health, Madison
Indiana University School of Medicine, Indianapolis
Pediatric Hematology-Oncology, University of Washington School of Medicine, Seattle
- Clinical Interests
Bone marrow transplantation for patients with nonmalignant and malignant diseases.
- Research Description
Primary research focus is bone marrow transplantation for patients with nonmalignant diseases including primary immunodeficiency disorders, bone marrow failure syndromes, metabolic diseases, and hemoglobinopathies (sickle cell and thalassemia).