Kimberly Aldinger, PhD

"I've always been fascinated by scientific puzzles, and I'm excited to apply that fascination to genetics and neuroscience. My goal is to understand how genetic changes contribute to neurodevelopmental disorders, and to make discoveries that lead to new therapies. "
  • Biography

    Kimberly Aldinger, PhD, studies how genes influence brain development, and how those processes malfunction to cause neurodevelopmental disorders.

    She is particularly interested in understanding disorders that affect the cerebellum the part of the brain most known for fine-tuning motor movements to enable posture, balance and speech. The cerebellum also plays an important role in the network that controls intellectual and emotional skills, which can be affected when the cerebellum is disconnected from other areas of the brain.

    Through her research, Aldinger has discovered many gene mutations that drive neurodevelopmental disorders, and unraveling how previously-discovered mutations influence these disorders and normal brain development.

    Her goal is to contribute to therapies that help children overcome limitations due to genetic and acquired changes during early development.

    Research Description

    Dr. Aldinger's research investigates how the brain develops normally and how brain development can be impacted by genetic or non-genetic factors. She investigates how genes and cells cooperate to regulate brain development. Her goals are to define: (1) the molecular and cellular changes associated with neurodevelopmental conditions, (2) where, when, and how gene variants derail brain development, and (3) assays to test existing and new treatments for neurodevelopmental disorders.

    Research Focus Area

    Autism Spectrum Disorders, Genetics and Developmental Biology, Genomics, Neuroscience / Neurodevelopment, Neurovascular Development, Stem Cell Biology

  • Related Resources

    • Aldinger Lab

      The Aldinger Lab uses developmental neuroscience and computational approaches to decipher the mechanisms that cause pediatric neurogenetic disorders and pathologies associated with structural brain changes, cognitive impairment, and epilepsy.

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