Joshua Michael Friedland-Little, MD

Joshua Michael Friedland-Little, MD

Cardiology, Transplant Center, Heart Failure Program, VAD Program

On staff since July 2015

Children's Title: Medical Director, Mechanical Circulatory Support

Academic Title: Associate Professor, Pediatrics

  • Joshua Friedland-Little, MD, is an attending pediatric cardiologist at Seattle Children's Hospital and is an Associate Professor in the Department of Pediatrics at the University of Washington School of Medicine.

    Dr. Friedland-Little earned his MD at the University of Michigan Medical School in Ann Arbor and completed his pediatrics residency at the University of Chicago in Chicago, IL. He returned to the University of Michigan to complete his pediatric cardiology fellowship as well as sub-specialty training in pediatric heart failure and transplantation and cardiac critical care. Following the completion of his training, he spent two years as a heart failure/heart transplant cardiologist and cardiac intensivist at the University of Michigan before joining the Seattle Children's Heart Center in 2015.

    Dr. Friedland-Little enjoys caring for infants and children of all ages with congenital and acquired heart disease. He has specific research interests and clinical expertise in pediatric heart failure and heart transplantation as well as the management of mechanical circulatory support in the pediatric population.

    • Amanda Renton, Wa 07.12.19

      Dr. Freidland-Little is simply phenomenal! He has been incredibly thorough, patient, and helpful to us. Our son is 8 months old and has a rare collection of heart defects, and Dr. Freidland-Little has walked us through any/all steps that have been involved. We feel very confident with him, and have hope that we have not had until now. I can’t thank or appreciate him any more than I do! Amanda Meyer

  • Other Publications

    • Frandsen EL, Banker KA, Mazor RL, McMullan DM, Law YM, Kemna MS, Albers EL, Hong BJ, Friedland-Little JM
      Waitlist and posttransplant outcomes of critically ill infants awaiting heart transplantation managed without ventricular assist device support.
      35587026 Pediatric transplantation, 2022 May 19 : e14308
    • Gambetta KE, McCulloch MA, Lal AK, Knecht K, Butts RJ, Villa CR, Johnson JN, Conway J, Bock MJ, Schumacher KR, Law SP, Friedland-Little JM, Deshpande SR, West SC, Lytrivi ID, Wittlieb-Weber CA
      Diversity of Dystrophin Gene Mutations and Disease Progression in a Contemporary Cohort of Duchenne Muscular Dystrophy.
      35064276 Pediatric cardiology, 2022 April : 43(4)855-867
    • Friedland-Little JM, Joong A, Shugh SB, O'Connor MJ, Bansal N, Davies RR, Ploutz MS
      Patient and Device Selection in Pediatric MCS: A Review of Current Consensus and Unsettled Questions.
      35325280 Pediatric cardiology, 2022 Mar 24
    • Albers EL, Friedland-Little JM, Hong BJ, Kemna MS, Warner P, Law YM
      Human leukocyte antigen eplet mismatching is associated with increased risk of graft loss and rejection after pediatric heart transplant.
      34476876 Pediatric transplantation, 2022 Feb. : 26(1)e14126
    • Manning LN, Schumacher KR, Friedland-Little JM, Yu S, Lowery R, Goldstein BH, Charpie JR
      Impact of Protein-Losing Enteropathy on Inflammatory Biomarkers and Vascular Dysfunction in Fontan Circulation.
      34315570 The American journal of cardiology, 2021 Sep 15 : 155128-134
    • Lorts A, Conway J, Schweiger M, Adachi I, Amdani S, Auerbach SR, Barr C, Bleiweis MS, Blume ED, Burstein DS, Cedars A, Chen S, Cousino-Hood MK, Daly KP, Danziger-Isakov LA, Dubyk N, Eastaugh L, Friedland-Little J, Gajarski R, Hasan A, Hawkins B, Jeewa A, Kindel SJ, Kogaki S, Lantz J, Law SP, Maeda K, Mathew J, May LJ, Miera O, Murray J, Niebler RA, O'Connor MJ, Özbaran M, Peng DM, Philip J, Reardon LC, Rosenthal DN, Rossano J, Salazar L, Schumacher KR, Simpson KE, Stiller B, Sutcliffe DL, Tunuguntla H, VanderPluym C, Villa C, Wearden PD, Zafar F, Zimpfer D, Zinn MD, Morales IRD, Cowger J, Buchholz H, Amodeo A
      ISHLT consensus statement for the selection and management of pediatric and congenital heart disease patients on ventricular assist devices Endorsed by the American Heart Association.
      34193359 The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021 Aug. : 40(8)709-732
    • Berkman E, Wightman A, Friedland-Little JM, Albers EL, Diekema D, Lewis-Newby M
      An ethical analysis of obesity as a determinant of pediatric heart transplant candidacy.
      33179426 Pediatric transplantation, 2021 May : 25(3)e13913
    • Law SP, Morales DLS, Si MS, Friedland-Little JM, Joong A, Bearl DW, Bansal N, Sutcliffe DL, Philip J, Mehegan M, Simpson KE, Conway J, Peng DM, ACTION Learning Network.
      Right heart failure considerations in pediatric ventricular assist devices.
      33666316 Pediatric transplantation, 2021 May : 25(3)e13990
    • Zafar F, Conway J, Bleiweis MS, Al-Aklabi M, Ameduri R, Barnes A, Bearl DW, Buchholz H, Church S, Do NL, Duffy V, Dykes JC, Eghtesady P, Fisher L, Friedland-Little J, Fuller S, Fynn-Thompson F, George K, Gossett JG, Griffiths ER, Griselli M, Hawkins B, Honjo O, Jeewa A, Joong A, Kindel S, Kouretas P, Lorts A, Machado D, Maeda K, Maurich A, May LJ, McConnell P, Mehegan M, Mongé M, Morales DLS, Murray J, Niebler RA, O'Connor M, Peng DM, Phelps C, Philip J, Ploutz M, Profsky M, Reichhold A, Rosenthal DN, Said AS, Schumacher KR, Si MS, Simpson KE, Sparks J, Louis JS, Steiner ME, VanderPluym C, Villa C, ACTION Learning Network Investigators.
      Berlin Heart EXCOR and ACTION post-approval surveillance study report.
      33579597 The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021 April : 40(4)251-259
    • Olsen J, Tjoeng YL, Friedland-Little J, Chan T
      Racial Disparities in Hospital Mortality Among Pediatric Cardiomyopathy and Myocarditis Patients.
      33025028 Pediatric cardiology, 2021 Jan. : 42(1)59-71


Board Certification(s)

Pediatric Cardiology

Medical/Professional School

University of Michigan Medical School, Ann Arbor, MI


University of Chicago Comer Children's Hospital GM, Chicago, IL


University of Michigan Medical School, Ann Arbor, MI

Clinical Interests

Pediatric heart failure, heart transplantation, mechanical circulatory support

Research Description

I am a pediatric cardiologist whose research focuses on improving outcomes for children with advanced heart failure, particularly those who require mechanical circulatory support (VAD) or heart transplant. I am primarily engaged in retrospective clinical research utilizing large multi-center registries of pediatric VAD and heart transplant patients. A particular interest of mine is in better defining which children with advanced heart failure will benefit from receiving a VAD rather than continued medical management.