Jarrad Matthew Scarlett, MD, PhD

Jarrad Matthew Scarlett, MD, PhD

Gastroenterology and Hepatology

On staff since July 2015

Academic Title: Assistant Professor

Research Center: Center for Integrative Brain Research

  • Patient Testimonials
    • Becky La Conner 07.23.19

      Dr. Scarlett is an amazing doctor who is knowledgeable, compassionate, and invested in the whole patient. He goes above and beyond his area of care to see that his patients find answers to sometimes complicated medical issues. He is more than a caregiver and expert in his field, he is a kind and compassionate human being. Seattle Children's Hospital is lucky to have him on staff. We are grateful to be in his continuing care.

    Recommend Jarrad Matthew Scarlett, MD, PhD
  • Awards and Honors
    Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    John Brunzell Research Award University of Washington 2015
    Elected to Alpha Omega Alpha Honor Medical Society Alpha Omega Alpha Society 2008
    American Physiological Society Research Fellowship American Physiological Society 2001
    Mary Gates Scholar Research Training Grant University of Washington 2000
    Howard Hughes Undergraduate Research Training Grant University of Washington
  • Publications

    Other Publications

    • Deem JD, Muta K, Scarlett JM, Morton GJ, Schwartz MW
      How Should We Think About the Role of the Brain in Glucose Homeostasis and Diabetes?
      28603139 Diabetes, 2017 July : 66(7)1758-1765 PMCID:PMC5482090
    • Morton GJ, Muta K, Kaiyala KJ, Rojas JM, Scarlett JM, Matsen ME, Nelson JT, Acharya NK, Piccinini F, Stefanovski D, Bergman RN, Taborsky GJ Jr, Kahn SE, Schwartz MW
      Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure.
      28115396 Diabetes, 2017 April : 66(4)823-834 PMCID:PMC5360298
    • Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP
      Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
      28073831 Diabetes, 2017 April : 66(4)920-934 PMCID:PMC5360303
    • Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP
      Deletion of Protein Kinase C Lambda in POMC Neurons Predisposes to Diet-Induced Obesity.
      28073831 Diabetes, 2017 Jan 10
    • Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
      Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
      27213816 Nature medicine, 2016 July : 22(7)800-6 PMCID:PMC4938755
    • Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
      Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
      27213816 Nature medicine, 2016 July : 22(7)800-6 PMCID:PMC4938755
    • Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
      Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
      27213816 Nature medicine, 2016 July : 22(7)800-6 PMCID:PMC4938755
    • Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG Jr, Schwartz MW, Morton GJ
      Functional identification of a neurocircuit regulating blood glucose.
      27001850 Proceedings of the National Academy of Sciences of the United States of America, 2016 Apr 5 : 113(14)E2073-82 PMCID:PMC4833243
    • Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG Jr, Schwartz MW, Morton GJ
      Functional identification of a neurocircuit regulating blood glucose.
      27001850 Proceedings of the National Academy of Sciences of the United States of America, 2016 Apr 5 : 113(14)E2073-82 PMCID:PMC4833243
    • Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG Jr, Schwartz MW, Morton GJ
      Functional identification of a neurocircuit regulating blood glucose.
      27001850 Proceedings of the National Academy of Sciences of the United States of America, 2016 Apr 5 : 113(14)E2073-82 PMCID:PMC4833243
    • Scarlett JM, Schwartz MW
      Gut-brain mechanisms controlling glucose homeostasis.
      25705395 F1000prime reports, 2015 Jan 5 : 712 PMCID:PMC4311273
    • Scarlett JM, Schwartz MW
      Gut-brain mechanisms controlling glucose homeostasis.
      25705395 F1000prime reports, 2015 Jan 5 : 712 PMCID:PMC4311273
    • Scarlett JM, Schwartz MW
      Gut-brain mechanisms controlling glucose homeostasis.
      25705395 F1000prime reports, 2015 : 712 PMCID:PMC4311273
    • Scarlett JM, Murray KF
      Disorders of Amino Acid Metabolism
      Walker’s Pediatric Gastrointestinal Disease: Physiology, Diagnosis, Management, 2013 : 6th Editio
    • Grossberg AJ, Scarlett JM, Marks DL
      Hypothalamic mechanisms in cachexia.
      20346963 Physiology and behavior, 2010 Jul 14 : 100(5)478-89 PMCID:PMC2927357
    • Grossberg AJ, Scarlett JM, Marks DL
      Hypothalamic mechanisms in cachexia.
      20346963 Physiology and behavior, 2010 Jul 14 : 100(5)478-89 PMCID:PMC2927357
    • Scarlett JM, Bowe DD, Zhu X, Batra AK, Grant WF, Marks DL
      Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure.
      20371568 The Journal of endocrinology, 2010 July : 206(1)121-30 PMCID:PMC2887273
    • Scarlett JM, Bowe DD, Zhu X, Batra AK, Grant WF, Marks DL
      Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure.
      20371568 The Journal of endocrinology, 2010 July : 206(1)121-30 PMCID:PMC2887273
    • Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL
      Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.
      20016025 Endocrinology, 2010 Feb. : 151(2)606-16 PMCID:PMC2817620
    • Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL
      Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.
      20016025 Endocrinology, 2010 Feb. : 151(2)606-16 PMCID:PMC2817620
    • DeBoer MD, Scarlett JM, Levasseur PR, Grant WF, Marks DL
      Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract.
      19028534 Peptides, 2009 Feb. : 30(2)210-8 PMCID:PMC2853249
    • DeBoer MD, Scarlett JM, Levasseur PR, Grant WF, Marks DL
      Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract.
      19028534 Peptides, 2009 Feb. : 30(2)210-8 PMCID:PMC2853249
    • Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL
      Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
      18583425 Endocrinology, 2008 Oct. : 149(10)4837-45 PMCID:PMC2582916
    • Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL
      Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
      18583425 Endocrinology, 2008 Oct. : 149(10)4837-45 PMCID:PMC2582916
    • Madison LD, Scarlett JM, Levasseur P, Zhu X, Newcomb K, Batra A, Bowe D, Marks DL
      Prostacyclin signaling regulates circulating ghrelin during acute inflammation.
      18252949 The Journal of endocrinology, 2008 Feb. : 196(2)263-73
    • Madison LD, Scarlett JM, Levasseur P, Zhu X, Newcomb K, Batra A, Bowe D, Marks DL
      Prostacyclin signaling regulates circulating ghrelin during acute inflammation.
      18252949 The Journal of endocrinology, 2008 Feb. : 196(2)263-73
    • Scarlett JM, Jobst EE, Enriori PJ, Bowe DD, Batra AK, Grant WF, Cowley MA, Marks DL
      Regulation of central melanocortin signaling by interleukin-1 beta.
      17525125 Endocrinology, 2007 Sept. : 148(9)4217-25
    • Scarlett JM, Jobst EE, Enriori PJ, Bowe DD, Batra AK, Grant WF, Cowley MA, Marks DL
      Regulation of central melanocortin signaling by interleukin-1 beta.
      17525125 Endocrinology, 2007 Sept. : 148(9)4217-25
    • Pan YW, Scarlett JM, Luoh TT, Kurre P
      Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo.
      17035328 Journal of virology, 2007 Jan. : 81(2)639-49 PMCID:PMC1797443
    • Scarlett JM, Marks DL
      The use of melanocortin antagonists in cachexia of chronic disease.
      16185165 Expert opinion on investigational drugs, 2005 Oct. : 14(10)1233-9
    • Scarlett JM, Marks DL
      The use of melanocortin antagonists in cachexia of chronic disease.
      16185165 Expert opinion on investigational drugs, 2005 Oct. : 14(10)1233-9
    • Fraley GS, Scarlett JM, Shimada I, Teklemichael DN, Acohido BV, Clifton DK, Steiner RA
      Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat.
      15111492 Diabetes, 2004 May : 53(5)1237-42
    • Fraley GS, Scarlett JM, Shimada I, Teklemichael DN, Acohido BV, Clifton DK, Steiner RA
      Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat.
      15111492 Diabetes, 2004 May : 53(5)1237-42
    • Cunningham MJ, Shahab M, Grove KL, Scarlett JM, Plant TM, Cameron JL, Smith MS, Clifton DK, Steiner RA
      Galanin-like peptide as a possible link between metabolism and reproduction in the macaque.
      15070942 The Journal of clinical endocrinology and metabolism, 2004 April : 89(4)1760-6
    • Cunningham MJ, Shahab M, Grove KL, Scarlett JM, Plant TM, Cameron JL, Smith MS, Clifton DK, Steiner RA
      Galanin-like peptide as a possible link between metabolism and reproduction in the macaque.
      15070942 The Journal of clinical endocrinology and metabolism, 2004 April : 89(4)1760-6
    • Cunningham MJ, Scarlett JM, Steiner RA
      Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque.
      11861493 Endocrinology, 2002 March : 143(3)755-63
    • Cunningham MJ, Scarlett JM, Steiner RA
      Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque.
      11861493 Endocrinology, 2002 March : 143(3)755-63

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  • Presentations
    Presentations Title Event Location Date
    Targeting the Brain to Treat Diabetes Leptin and FGFs 77th Scientific Session of the American Diabetes Association San Diego, CA 2017
    Mechanisms of Central FGF1-Mediated Remission of Diabetic Hyperglyemia American Society for Nephrology Kidney Week Chicago, IL 2016
    Diabetes remission induced by the central action of fibroblast growth factor 1 76th Annual Meeting of the American Diabetes Association New Orleans, LA 2016
    Prolonged Glucose Lowering by Central Administration of Fibroblast Growth Factor 1 University of Washington Division of Gastroenterology Frontiers in Gastroenterology and Hepatology Seattle, WA 2015
    FGF1, Glucose Homeostasis and the Brain Nutrition Obesity Research Center Directors Meeting Seattle, WA 2015
    The Role of Central Fibroblast Growth Factor Signaling in the Regulation of Glucose Homeostasis Seattle Childrens Center for Integrative Brain Research Seattle, WA 2015
    The Brain-Glucose Regulatory System 74th Scientific Session of the American Diabetes Association San Francisco, CA 2014
    Regulation of Hypothalamic Melanocortin Signaling by Interleukin-1 88th Annual Meeting of the Endocrine Society Boston, MA 2006
    Direct activation of hypothalamic melanocortin system by interleukin-1 86th Annual Meeting of the Endocrine Society New Orleans, LA 2004
  • Research Funding
    Grant Title Grantor Amount Award Date
    Central and Peripheral Mechanisms of FGF1-Mediated Remission of Diabetic Hyperglycemia NIH-NIDDK K08 Mentored Clinical Scientist Research Career $163,824 2017 - 2022
    Hypothalamic mechanisms of FGF1-mediated remission of diabetic hyperglycemia University of Washington NIH Nutrition Obesity Research Center $90,000 2016 - 2018
    Regulation of glucose homeostasis by intestinal macronutrients and surgery NIH $119,944 2014 - 2016
    University of Washington GI Training Grant NIH-NIDDK 2013 - 2014
    Role of the Central Melanocortin System in Cardiac Cachexia American Heart Association 2005 - 2007

Overview

Board Certification(s)

Pediatrics
Pediatric Gastroenterology

Medical/Professional School

Oregon Health & Science University School of Medicine, Portland, OR

Residency

Oregon Health Sciences University School of Medici, Portland, OR

Fellowship

University of Washington, Seattle, WA

Clinical Interests

Hepatic and gastrointestinal manifestations of impaired glucose tolerance and diabetes