Don Sodora, PhD

Don Sodora, PhD

Infectious Disease Research

Children's Title: Principal Investigator, Supervisor, Center for Global Infectious Disease Research

Academic Title: Professor

Research Title: Principal Investigator, Center for Global Infectious Disease Research, Seattle Children’s Research Institute

Research Center: Center for Global Infectious Disease Research

  • Biography

    Don Sodora, is a professor at the Center for Global Infectious Disease Research. He joined in 2007 to advance the center’s mission in the field of HIV research. Don received his PhD in microbiology from the University of Pennsylvania. He performed postdoctoral research at Stanford University and the Aaron Diamond AIDS Research Center in New York. Sodora has collaborators in Atlanta, Philadelphia, Oregon, Northern Ireland and Cape Town, South Africa. He is dedicated to the training of undergraduate and graduate students, including serving on the Graduate Student Advisory Committee for the Pathobiology Graduate Program at the University of Washington. Outside of the lab, he enjoys spending time with his friends and family, traveling, hiking, taking photographs and camping.

    Email: donald.sodora@seattlechildrens.org

    Education

    Rutgers University BS 1985 Microbiology

    University of Pennsylvania PhD 1991 Microbiology/Virology

    Training

    09/1985-02/1990 Graduate Student, University of Pennsylvania

    01/1991-08/1994 Postdoctoral Fellow, Stanford University

    09/1994-10/1997 Postdoctoral Fellow, Aaron Diamond AIDS Center, Rockefeller

    Faculty Positions Held

    10/1997-08/2001 Instructor, University of Texas, Southwestern Medical Center

    09/2001-08/2007 Assistant Professor, University Texas, Southwestern Med. Center, Department of Internal Medicine

    10/2001-08/2007 Assistant Professor, University of Texas

    09/2007-06/2014 Associate Professor, Seattle Biomedical Research Institute

    07/2014-9/2018 Professor, CID Research (formerly Seattle Biomedical Research Institute)

    07/2017-Present.    Affiliate Professor, University of Washington, Department of Global Health

    10/2018-Present.   Professor, Seattle Children’s Research Institute

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  • Publications

    Manuscripts in Refereed Journals

    • Fisher BS, Dambrauskas N, Trakhimets O, Andrade DV, Smedley J, Sodora DL, Sather DN.
      Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates.
      PLoS One, 2020 May 29 : 15(5)e0233577 PMCID:PMC7259690
      https://pmlegacy.ncbi.nlm.nih.gov/pubmed/32470041
    • Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL.
      Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.
      J Infect Dis., 2019 Oct 12 : jiz382
      https://pubmed.ncbi.nlm.nih.gov/31605528/
    • Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.
      Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
      30655382 J Virol., 2019 Jan 17 : 93(3) PMCID:PMC6340051
      https://www.ncbi.nlm.nih.gov/pubmed/30655382
    • Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB.
      Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.
      29659737 Clin Infect Dis., 2018 Sep 28 : 67(8)1237-1246 PMCID:PMC6455922
      https://www.ncbi.nlm.nih.gov/pubmed/29659737
    • Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.
      Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.
      29997216 J Virol., 2018 Aug 29 : 92(18) PMCID:PMC6146711
      https://www.ncbi.nlm.nih.gov/pubmed/29997216
    • Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL.
      Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.
      PLoS Pathog, 2018 Feb 21 : 14(2)e1006871 PMCID:PMC5837102
      https://www.ncbi.nlm.nih.gov/pubmed/29466439
    • Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB Jr., Patel NB, Sodora DL, Dawoud RA, Harris RA, Liu Y, Raveendran M, Han Y, English A, Thomas GWC, Hahn MW, Pipes L, Mason CE, Muzny DM, Gibbs RA, Sauter D, Worley K, Rogers J, Silvestri G.
      Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.
      Nature., 2018 Jan 3 : 553(7686)77-81 PMCID:PMC5843367
      https://www.ncbi.nlm.nih.gov/pubmed/29300007
    • Wood LF, Wood M, Fisher B, Jaspan HB, Sodora DL.
      T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin-A Exposure.
      Front Immunol., 2017 Dec 22 : 81857 PMCID:PMC5743911
      https://www.ncbi.nlm.nih.gov/pubmed/29312338
    • Steele AK, Carrasco-Medina L, Sodora DL, Crawley AM.
      Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques.
      PLoS One, 2017 Dec 19 : 12(12)e0188427 PMCID:PMC5736176
      https://www.ncbi.nlm.nih.gov/pubmed/29261677
    • Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, and Jaspan, HB.
      BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.
      JCI Insight, 2017 Apr 6 : 2(7)e91963 PMCID:PMC5374072
      https://www.ncbi.nlm.nih.gov/pubmed/28405623
    • Gasper MA, Biswas SP, Fisher BS, Ehnert SC, Sherman DR, Sodora DL.
      Non-pathogenic SIV and pathogenic HIV infections associate with disparate innate cytokine signatures in response to Mycobacteria bovis BCG.
      PLoS One, 2016 Aug 9 : 11(8)e0158149 PMCID:PMC4978473
      https://www.ncbi.nlm.nih.gov/pubmed/27505158
    • Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SM, Silvestri G.
      Reduced SIV replication in macrophages of sooty mangabeys is associated with increased expression of host restriction factors.
      J Virol, 2015 Oct. : 89(20)10136-44 PMCID:PMC4580171
      https://www.ncbi.nlm.nih.gov/pubmed/26202248
    • Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JS, Sodora DL, Gray CM, Jaspan HB.
      Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants.
      Vaccine, 2015 Sep 11 : 33(38)4782-9 PMCID:PMC4562895
      https://www.ncbi.nlm.nih.gov/pubmed/26259542
    • Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA.
      Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.
      J Virol, 2015 Aug. : 89(16)8130-51 PMCID:PMC4524250
      https://www.ncbi.nlm.nih.gov/pubmed/26018167
    • Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB.
      Delaying BCG vaccination until 8 weeks of age results in robust BCG-Specific T-cell Responses in HIV-exposed infants.
      J Infect Dis, 2015 Feb 1 : 211(3)338-46 PMCID:PMC4318913
      https://www.ncbi.nlm.nih.gov/pubmed/25108027
    • Kilgore KM, Murphy MK, Wetzel KS, Smith SA, Burton SL, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Collman RG, Amara RR, Derdeyn CA.
      DNA/MVA and protein-based SIV vaccine regimens delivered to Rhesus macaques with novel adjuvants fail to elicit neutralizing antibodies with breadth.
      AIDS Res Hum Retrov., 2014 Oct. : 30 Suppl 1A84
    • Kidzeru EB, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB.
      In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.
      AIDS, 2014 Jun 19 : 28(10)1421-30 PMCID:PMC4333196
      https://www.ncbi.nlm.nih.gov/pubmed/24785950
    • Gasper MA, Kunwar P, Itaya G, Lejarcegui N, Bosire R, Maleche-Obimbo E, Wamalwa D, Slyker J, Overbaugh J, Horton H, Sodora DL, John-Stewart G, Lohman-Payne B.
      Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.
      AIDS, 2014 May 15 : 28(8)1115-24 PMCID:PMC4365995
      https://www.ncbi.nlm.nih.gov/pubmed/24752082
    • Schmökel J, Li H, Shabir A, Yu H, Geyer M, Silvestri G, Sodora DL, Hahn BH, Kirchhoff F.
      Link between primate lentiviral coreceptor usage and Nef function.
      Cell Rep, 2013 Nov 27 : 5(4)997-1009 PMCID:PMC4133736
      https://www.ncbi.nlm.nih.gov/pubmed/24268781
    • Milush JM, Chen HL, Atteberry G, Sodora DL.
      Early detection of simian immunodeficiency virus in the central nervous system following oral administration to rhesus macaques.
      Front Immunol, 2013 Aug 14 : 4236 PMCID:PMC3743037
      https://www.ncbi.nlm.nih.gov/pubmed/23966995
    • Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL.
      Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.
      PLoS Pathog, 2013 Aug. : 9(6)e1003441 PMCID:PMC3694849
      https://www.ncbi.nlm.nih.gov/pubmed/23825945
    • Giavedoni LD, Chen HL, Hodara VL, Chu L, Parodi LM, Smith LM, Sexton V, Cappelli D, Sodora DL.
      Impact of mucosal inflammation on oral simian immunodeficiency virus transmission.
      J Virol, 2013 Feb. : 87(3)1750-8 PMCID:PMC3554177
      https://www.ncbi.nlm.nih.gov/pubmed/23175379
    • Mir KD, Bosinger SE, Gasper M, Ho O, Else JG, Brenchley JM, Kelvin DJ, Silvestri G, Hu SL, Sodora DL.
      Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.
      J Virol, 2012 July : 86(14)7605-15 PMCID:PMC3416282
      https://www.ncbi.nlm.nih.gov/pubmed/22553338
    • Elliott ST, Riddick NE, Francella N, Paiardini M, Vanderford TH, Li B, Apetrei C, Sodora DL, Derdeyn CA, Silvestri G, Collman RG.
      Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5.
      J Virol, 2012 Jan. : 86(2)898-908 PMCID:PMC3255830
      https://www.ncbi.nlm.nih.gov/pubmed/22090107
    • Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA.
      Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.
      21940422 The Journal of infectious diseases, 2011 Nov 15 : 204(10)1550-6 PMCID:PMC3192190
      https://www.ncbi.nlm.nih.gov/pubmed/21940422
    • Durudas A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W, Giavedoni LD, Sodora DL.
      Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.
      Curr HIV Res, 2011 July : 9(5)276-88 PMCID:PMC3337698
      https://www.ncbi.nlm.nih.gov/pubmed/21861823
    • Milush JM, Mir KD, Sundaravaradan V, Gordon SN, Engram J, Cano CA, Reeves JD, Anton E, O'Neill E, Butler E, Hancock K, Cole KS, Brenchley JM, Else JG, Silvestri G, Sodora DL.
      Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.
      J Clin Invest, 2011 March : 121(3)1102-10 PMCID:PMC3049370
      https://www.ncbi.nlm.nih.gov/pubmed/21317533
    • Kuhrt D, Faith S, Hattemer A, Leone A, Sodora D, Picker L, Borghesi L, Cole KS.
      Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation.
      J Immunol Methods, 2011 Jan 5 : 363(2)166-76 PMCID:PMC3357916
      https://www.ncbi.nlm.nih.gov/pubmed/20875419
    • Riddick NE, Hermann EA, Loftin LM, Elliott ST, Wey WC, Cervasi B, Taaffe J, Engram JC, Li B, Else JG, Li Y, Hahn BH, Derdeyn CA, Sodora DL, Apetrei C, Paiardini M, Silvestri G, Collman RG.
      A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.
      PLoS Pathog, 2010 Aug 26 : 6(8)e1001064 PMCID:PMC2928783
      https://www.ncbi.nlm.nih.gov/pubmed/20865163
    • Engram JC, Cervasi B, Borghans JA, Klatt NR, Gordon SN, Chahroudi A, Else JG, Mittler RS, Sodora DL, de Boer RJ, Brenchley JM, Silvestri G, Paiardini M.
      Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
      Blood, 2010 Aug 5 : 116(5)748-58 PMCID:PMC2918331
      https://www.ncbi.nlm.nih.gov/pubmed/20484087
    • Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL.
      Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
      J Immunol, 2010 : 185(3)1650-9 PMCID:PMC3050806
      https://www.ncbi.nlm.nih.gov/pubmed/20622118
    • Harris LD, Tabb B, Sodora DL, Paiardini M, Klatt NR, Douek DC, Silvestri G, Müller-Trutwin M, Vasile-Pandrea I, Apetrei C, Hirsch V, Lifson J, Brenchley JM, Estes JD.
      Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.
      J Virol, 2010 Aug. : 84(15)7886-91 PMCID:PMC2897601
      https://www.ncbi.nlm.nih.gov/pubmed/20484518
    • Li B, Stefano-Cole K, Kuhrt DM, Gordon SN, Else JG, Mulenga J, Allen S, Sodora DL, Silvestri G, Derdeyn CA.
      Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies.
      J Virol, 2010 June : 84(12)6248-53 PMCID:PMC2876631
      https://www.ncbi.nlm.nih.gov/pubmed/20375163
    • Kuhrt D, Faith SA, Leone A, Rohankedkar M, Sodora DL, Picker LJ, Cole KS.
      Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population.
      J Virol, 2010 March : 84(5)2466-76 PMCID:PMC2820932
      https://www.ncbi.nlm.nih.gov/pubmed/20032183
    • Sodora DL, Silvestri G.
      HIV, mucosal tissues, and T helper 17 cells: where we come from, where we are, and where we go from here.
      Curr Opin HIV AIDS, 2010 March : 5(2)111-3
      https://www.ncbi.nlm.nih.gov/pubmed/20543586
    • Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL.
      Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.
      J Virol, 2009 Dec. : 83(23)12229-40 PMCID:PMC2786739
      https://www.ncbi.nlm.nih.gov/pubmed/19759147
    • Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ.
      Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.
      J Exp Med, 2009 Jul 6 : 206(7)1575-88 PMCID:PMC2715089
      https://www.ncbi.nlm.nih.gov/pubmed/19546246
    • Paiardini M, Cervasi B, Engram JC, Gordon SN, Klatt NR, Muthukumar A, Else J, Mittler RS, Staprans SI, Sodora DL, Silvestri G.
      Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.
      Blood, 2009 Jan 15 : 113(3)612-21 PMCID:PMC2628369
      https://www.ncbi.nlm.nih.gov/pubmed/18832134
    • Kosub DA, Durudas A, Lehrman G, Milush JM, Cano CA, Jain MK, Sodora DL.
      Gamma/Delta T cell mRNA levels decrease at mucosal sites and increase at lymphoid sites following an oral SIV infection of macaques.
      Curr HIV Res, 2008 Nov. : 6(6)520-30 PMCID:PMC2777980
      https://www.ncbi.nlm.nih.gov/pubmed/18991617
    • Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F.
      Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.
      PLoS Pathog, 2008 Jul 18 : 4(7)e1000107 PMCID:PMC2444047
      https://www.ncbi.nlm.nih.gov/pubmed/18636106
    • Klatt NR, Villinger F, Bostik P, Gordon SN, Pereira L, Engram JC, Mayne A, Dunham RM, Lawson B, Ratcliffe SJ, Sodora DL, Else J, Reimann K, Staprans SI, Haase AT, Estes JD, Silvestri G, Ansari AA.
      Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
      J Clin Invest, 2008 June : 118(6)2039-49 PMCID:PMC2391063
      https://www.ncbi.nlm.nih.gov/pubmed/18497876
    • Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G.
      CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.
      J Immunol, 2008 Apr 15 : 180(8)5582-92 PMCID:PMC2683429
      https://www.ncbi.nlm.nih.gov/pubmed/18390743
    • Gordon SN, Dunham RM, Engram JC, Estes J, Wang Z, Klatt NR, Paiardini M, Pandrea IV, Apetrei C, Sodora DL, Lee HY, Haase AT, Miller MD, Kaur A, Staprans SI, Perelson AS, Feinberg MB, Silvestri G.
      Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis.
      J Virol, 2008 April : 82(7)3725-35 PMCID:PMC2268472
      https://www.ncbi.nlm.nih.gov/pubmed/18216113
    • Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL.
      Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.
      J Virol, 2008 Feb. : 82(3)1155-65 PMCID:PMC2224435
      https://www.ncbi.nlm.nih.gov/pubmed/18045946
    • Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
      Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
      J Exp Med, 2007 Sep 3 : 204(9)2171-85 PMCID:PMC2118701
      https://www.ncbi.nlm.nih.gov/pubmed/17724130
    • Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G.
      Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.
      J Immunol, 2007 Sep 1 : 179(5)3026-34 PMCID:PMC2365740
      https://www.ncbi.nlm.nih.gov/pubmed/17709517
    • Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL.
      Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.
      J Immunol, 2007 Sep 1 : 179(5)3047-56
      https://www.ncbi.nlm.nih.gov/pubmed/17709519
    • Apetrei C, Gautam R, Sumpter B, Carter AC, Gaufin T, Staprans SI, Else J, Barnes M, Cao R Jr, Garg S, Milush JM, Sodora DL, Pandrea I, Silvestri G.
      Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys.
      J Virol, 2007 Aug. : 81(15)7913-23 PMCID:PMC1951324
      https://www.ncbi.nlm.nih.gov/pubmed/17507488
    • Milush JM, Stefano-Cole K, Schmidt K, Durudas A, Pandrea I, Sodora DL.
      Mucosal innate immune response associated with a timely humoral immune response and slower disease progression after oral transmission of simian immunodeficiency virus to rhesus macaques.
      J Virol, 2007 June : 81(12)6175-86 PMCID:PMC1900075
      https://www.ncbi.nlm.nih.gov/pubmed/17428863
    • Estes JD, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C, Milush JM, Lifson JD, Sodora DL, Carlis JV, Haase AT.
      Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.
      J Infect Dis, 2007 Feb 15 : 195(4)551-61
      https://www.ncbi.nlm.nih.gov/pubmed/17230415
    • Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A, Paiardini M, Cervasi B, Klatt N, McClure H, Milush JM, Staprans S, Sodora DL, Silvestri G.
      Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis.
      J Immunol, 2007 Feb 1 : 178(3)1680-91
      https://www.ncbi.nlm.nih.gov/pubmed/17237418
    • Levine B, Sodora DL.
      HIV and CXCR4 in a kiss of autophagic death.
      J Clin Invest, 2006 Aug. : 116(8)2078-80 PMCID:PMC1523409
      https://www.ncbi.nlm.nih.gov/pubmed/16886053
    • Dunham R, Pagliardini P, Gordon S, Sumpter B, Engram J, Moanna A, Paiardini M, Mandl JN, Lawson B, Garg S, McClure HM, Xu YX, Ibegbu C, Easley K, Katz N, Pandrea I, Apetrei C, Sodora DL, Staprans SI, Feinberg MB, Silvestri G.
      The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus.
      Blood, 2006 Jul 1 : 108(1)209-17 PMCID:PMC1895834
      https://www.ncbi.nlm.nih.gov/pubmed/16522814
    • Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F.
      Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
      Cell, 2006 Jun 16 : 125(6)1055-67
      https://www.ncbi.nlm.nih.gov/pubmed/16777597
    • Paiardini M, Cervasi B, Sumpter B, McClure HM, Sodora DL, Magnani M, Staprans SI, Piedimonte G, Silvestri G.
      Perturbations of cell cycle control in T cells contribute to the different outcomes of simian immunodeficiency virus infection in rhesus macaques and sooty mangabeys.
      J Virol, 2006 Jan. : 80(2)634-42 PMCID:PMC1346860
      https://www.ncbi.nlm.nih.gov/pubmed/16378966
    • Muthukumar A, Zhou D, Paiardini M, Barry AP, Cole KS, McClure HM, Staprans SI, Silvestri G, Sodora DL.
      Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys.
      Blood, 2005 Dec 1 : 106(12)3839-45 PMCID:PMC1895113
      https://www.ncbi.nlm.nih.gov/pubmed/16105985
    • Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, Silvestri G.
      Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.
      J Immunol, 2005 Mar 1 : 174(5)2900-9
      https://www.ncbi.nlm.nih.gov/pubmed/15728501
    • Milush JM, Kosub D, Marthas M, Schmidt K, Scott F, Wozniakowski A, Brown C, Westmoreland S, Sodora DL.
      Rapid dissemination of SIV following oral inoculation.
      AIDS, 2004 Dec 3 : 18(18)2371-80
      https://www.ncbi.nlm.nih.gov/pubmed/15622313
    • Ylisastigui L, Coull JJ, Rucker VC, Melander C, Bosch RJ, Brodie SJ, Corey L, Sodora DL, Dervan PB, Margolis DM.
      Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.
      J Infect Dis, 2004 Oct 15 : 190(8)1429-37
      https://www.ncbi.nlm.nih.gov/pubmed/15378435
    • Smith SM, Mefford M, Sodora D, Klase Z, Singh M, Alexander N, Hess D, Marx PA.
      Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect.
      AIDS, 2004 Aug 20 : 18(12)1637-43
      https://www.ncbi.nlm.nih.gov/pubmed/15280774
    • Van Rompay KK, Singh RP, Brignolo LL, Lawson JR, Schmidt KA, Pahar B, Canfield DR, Tarara RP, Sodora DL, Bischofberger N, Marthas ML.
      The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters.
      J Acquir Immune Defic Syndr, 2004 Aug 1 : 36(4)900-14
      https://www.ncbi.nlm.nih.gov/pubmed/15220696
    • Van Rompay KK, Singh RP, Pahar B, Sodora DL, Wingfield C, Lawson JR, Marthas ML, Bischofberger N.
      CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment.
      J Virol, 2004 May : 78(10)5324-37 PMCID:PMC400346
      https://www.ncbi.nlm.nih.gov/pubmed/15113912
    • Saavedra-Lozano J, Cao Y, Callison J, Sarode R, Sodora D, Edgar J, Hatfield J, Picker L, Peterson D, Ramilo O, Vitetta ES.
      An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory.
      Proc Natl Acad Sci USA, 2004 Feb 24 : 101(8)2494-9 PMCID:PMC3566978
      https://www.ncbi.nlm.nih.gov/pubmed/14983037
    • Muthukumar A, Wozniakowski A, Gauduin MC, Paiardini M, McClure HM, Johnson RP, Silvestri G, Sodora DL.
      Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression.
      Blood, 2004 Feb 1 : 103(3)973-9
      https://www.ncbi.nlm.nih.gov/pubmed/14525780
    • Wang C, Pflugheber J, Sumpter R Jr, Sodora DL, Hui D, Sen GC, Gale M Jr.
      Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication.
      J Virol, 2003 April : 77(7)3898-912 PMCID:PMC150642
      https://www.ncbi.nlm.nih.gov/pubmed/12634350
    • Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, McClure HM, Staprans SI, Feinberg MB.
      Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.
      Immunity, 2003 March : 18(3)441-52
      https://www.ncbi.nlm.nih.gov/pubmed/12648460
    • Sodora DL, Milush JM, Ware F, Wozniakowski A, Montgomery L, McClure HM, Lackner AA, Marthas M, Hirsch V, Johnson RP, Douek DC, Koup RA.
      Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus.
      J Virol, 2002 Oct. : 76(19)9981-90 PMCID:PMC136511
      https://www.ncbi.nlm.nih.gov/pubmed/12208974
    • Pflugheber J, Fredericksen B, Sumpter R Jr, Wang C, Ware F, Sodora DL, Gale M Jr.
      Regulation of PKR and IRF-1 during hepatitis C virus RNA replication.
      Proc Natl Acad Sci USA., 2002 Apr 2 : 99(7)4650-5 PMCID:PMC123702
      https://www.ncbi.nlm.nih.gov/pubmed/11904369
    • Sodora DL, Douek DC, Silvestri G, Montgomery L, Rosenzweig M, Igarashi T, Bernacky B, Johnson RP, Feinberg MB, Martin MA, Koup RA.
      Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys.
      Eur J Immunol, 2000 April : 30(4)1145-53
      https://www.ncbi.nlm.nih.gov/pubmed/10760804
    • Sodora DL, Sheridan KE, Marx PA, Connor RI.
      Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge.
      J Virol, 1999 May : 73(5)4443-6 PMCID:PMC104226
      https://www.ncbi.nlm.nih.gov/pubmed/10196343
    • Sodora DL, Gettie A, Miller CJ, Marx PA.
      Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks.
      AIDS Res Hum Retroviruses., 1998 April : 14 Suppl 1S119-23
      https://www.ncbi.nlm.nih.gov/pubmed/9581895
    • Sodora DL, Lee F, Dailey PJ, Marx PA.
      A genetic and viral load analysis of the simian immunodeficiency virus during the acute phase in macaques inoculated by the vaginal route.
      AIDS Res Hum Retroviruses., 1998 Jan 20 : 14(2)171-81
      https://www.ncbi.nlm.nih.gov/pubmed/9462928
    • Bachmann MH, Mathiason-Dubard C, Learn GH, Rodrigo AG, Sodora DL, Mazzetti P, Hoover EA, Mullins JI.
      Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.
      J Virol., 1997 June : 71(6)4241-53 PMCID:PMC191639
      https://www.ncbi.nlm.nih.gov/pubmed/9151811
    • Chen Z, Luckay A, Sodora DL, Telfer P, Reed P, Gettie A, Kanu JM, Sadek RF, Yee J, Ho DD, Zhang L, Marx PA.
      Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.
      J Virol., 1997 May : 71(5)3953-60 PMCID:PMC191547
      https://www.ncbi.nlm.nih.gov/pubmed/9094672
    • Sodora DL, Courcelle J, Brojatsch J, Berson A, Wang YC, Dow SW, Hoover EA, Mullins JI.
      Analysis of a feline immunodeficiency virus provirus reveals patterns of gene sequence conservation distinct from human immunodeficiency virus type 1.
      AIDS Res Hum Retroviruses., 1995 April : 11(4)531-3
      https://www.ncbi.nlm.nih.gov/pubmed/7632468
    • Sodora DL, Shpaer EG, Kitchell BE, Dow SW, Hoover EA, Mullins JI.
      Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns.
      J Virol., 1994 April : 68(4)2230-8 PMCID:PMC236699
      https://www.ncbi.nlm.nih.gov/pubmed/8139008
    • Sodora DL, Eisenberg RJ, Cohen GH.
      Characterization of a recombinant herpes simplex virus which expresses a glycoprotein D lacking asparagine-linked oligosaccharides.
      J Virol., 1991 Aug. : 65(8)4432-41 PMCID:PMC248883
      https://www.ncbi.nlm.nih.gov/pubmed/1649339
    • Sodora DL, Cohen GH, Muggeridge MI, Eisenberg RJ.
      Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein.
      J Virol., 1991 Aug. : 65(8)4424-31 PMCID:PMC248882
      https://www.ncbi.nlm.nih.gov/pubmed/1649338
    • Sodora DL, Cohen GH, Eisenberg RJ.
      Influence of asparagine-linked oligosaccharides on antigenicity, processing, and cell surface expression of herpes simplex virus type 1 glycoprotein D.
      J Virol., 1989 Dec. : 63(12)5184-93 PMCID:PMC251182
      https://www.ncbi.nlm.nih.gov/pubmed/2555549
    • Wilcox WC, Long D, Sodora DL, Eisenberg RJ, Cohen GH.
      The contribution of cysteine residues to antigenicity and extent of processing of herpes simplex virus type 1 glycoprotein D.
      J Virol., 1988 June : 62(6)1941-7 PMCID:PMC253277
      https://www.ncbi.nlm.nih.gov/pubmed/2835498
    • Cohen GH, Wilcox WC, Sodora DL, Long D, Levin JZ, Eisenberg RJ.
      Expression of herpes simplex virus type 1 glycoprotein D deletion mutants in mammalian cells.
      J Virol., 1988 June : 62(6)1932-40 PMCID:PMC253276
      https://www.ncbi.nlm.nih.gov/pubmed/2452897

    Book Chapters

    • Sundaravaradan V, Gasper MA, Mir KD, and Sodora DL.
      Lack of chronic immune activation during natural host SIV infection.
      Natural Hosts of SIV. , 2014 Jul 25 : 217-233. Ed. Ansari A and Silvestri G.
    • Eisenberg RJ, Long D, Sodora DL, Chiang H-Y, Wilcox WC, Abrams WR, Muggeridge MI, and Cohen GH.
      Structure and function of glycoprotein D from herpes simplex virus.
      Frontiers in Virology. , 1994 : 3:43-65. Ed. Becker Y and Darai G.

    Other Publications

    • Wood LF, Chahroudi A, Chen HL, Jaspan HB, Sodora DL.
      The oral mucosa immune environment and oral transmission of HIV/SIV.
      Immunol Rev, 2013 July : 254(1)34-53. Review. PMCID:PMC3821196
      https://www.ncbi.nlm.nih.gov/pubmed/23772613
    • Sundaravaradan V, Mir KD, Sodora DL.
      Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.
      Curr Opin HIV AIDS, 2012 March : 7(2)164-71. Review. PMCID:PMC3639317
      https://www.ncbi.nlm.nih.gov/pubmed/22241163
    • Bosinger SE, Sodora DL, Silvestri G.
      Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.
      Curr Opin HIV AIDS, 2011 Sept. : 6(5)411-8. Review. PMCID:PMC3261611
      https://www.ncbi.nlm.nih.gov/pubmed/21743324
    • Mir KD, Gasper MA, Sundaravaradan V, Sodora DL.
      SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.
      Microbes Infect, 2011 Jan. : 13(1)14-24. Review. PMCID:PMC3022004
      https://www.ncbi.nlm.nih.gov/pubmed/20951225
    • Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.
      Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.
      Nat Med, 2009 Aug. : 15(8)861-5. Review. PMCID:PMC2782707
      https://www.ncbi.nlm.nih.gov/pubmed/19661993
    • Sodora DL, Ross TM.
      Simian immunodeficiency virus pathogenesis.
      Curr HIV Res, 2009 Jan. : 7(1)1. Commentary.
      https://www.ncbi.nlm.nih.gov/pubmed/19149548
    • Leone A, Picker LJ, Sodora DL.
      IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment.
      Curr HIV Res, 2009 Jan. : 7(1)83-90. Review.
      https://www.ncbi.nlm.nih.gov/pubmed/19149557
    • Pandrea I, Sodora DL, Silvestri G, Apetrei C.
      Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts.
      Trends Immunol, 2008 Sept. : 29(9)419-28. Review. PMCID:PMC2840226
      https://www.ncbi.nlm.nih.gov/pubmed/18676179
    • Sodora DL, Silvestri G.
      Immune activation and AIDS pathogenesis.
      AIDS, 2008 Feb 19 : 22(4)439-46. Review.
      https://www.ncbi.nlm.nih.gov/pubmed/18301056
    • Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL.
      Understanding the benign nature of SIV infection in natural hosts.
      J Clin Invest, 2007 Nov. : 117(11)3148-54. Review. PMCID:PMC2045617
      https://www.ncbi.nlm.nih.gov/pubmed/17975656
    • Wei BL, Arora VK, Foster JL, Sodora DL, Garcia JV.
      In vivo analysis of Nef function.
      Curr HIV Res, 2003 Jan. : 1(1)41-50. Review.
      https://www.ncbi.nlm.nih.gov/pubmed/15043211
    • Cohen GH, Muggeridge MI, Long D, Sodora DL, Eisenberg RJ.
      Structural and functional studies of herpes simplex virus glycoprotein D.
      Adv Exp Med Biol., 1992 Jan. : 327217-28. Review.
      https://www.ncbi.nlm.nih.gov/pubmed/1338265

  • Presentations

    Presentation Title Event Location Date
    Utilizing the Infant SIV-monkey to assess earliest events after mother-to-child HIV transmission HIV Mucosal Systems Meeting Chicago, IL May 2019
    Macrophages, Mycobacteria and Liver Dysfunction during SIV infection of macaques Mycobacterial Interest Group (MIG) Seattle, WA May 1, 2017
    Macrophages and Liver Dysfunction during SIV infection of macaques Emory University, Yerkes Primate Center Atlanta, GA Dec. 2016
    DN T cells and monocytes function in sooty mangabeys to inhibit SIV and OIs Emory University, Yerkes Primate Center Atlanta, GA June 2013
    Double negative T cells take on Helper T cell function in SIV infected mangabeys Pasteur Institute Paris, France Sept. 2012
    Double negative T cells and monocytes in SIV infected monkeys University of Cape Town Cape Town, South Africa Sept. 2011
    Double negative T cells in sooty mangabeys maintain helper T cell function during SIV infection Emory University, Yerkes Primate Center Atlanta, GA Sept. 2011
    Double negative T cells in sooty mangabeys maintain helper T cell function during SIV infection International AIDS Society (IAS) meeting Rome, Italy July 2011
    SIV infection of Natural Host Monkey Species: How do they maintain high viral loads with no clinical signs of AIDS? Aaron Diamond AIDS Research Center New York, NY June 2010
    Double-negative T cells with potential CD4 T cell function during natural SIV infection of sooty mangabeys Keystone Symposium, HIV pathogenesis Santa Fe, NM Jan. 2010
    SIV infection of Natural Host Monkey Species: How do they maintain high viral loads with no clinical signs of AIDS? Rush University Chicago, IL April 2009
    SIV infection of Natural Host Monkey Species University of Pennsylvania Philadelphia, PA Feb. 2009

  • Research Funding

    Grant Title Grantor Amount Award Date
    Impact of Cigarette Smoke on RNA-cap Modifications within HIV Infected Cells- R21DA046168 (Sodora) NIH/NIAID $513,800 Total Direct Costs May 2018 - April 2020
    Mediators of Fatty Liver Disease during HIV/SIV and cART Treatment- R01AI134630 (Sodora) NIH/NIAID $3,096,500 Total Direct Costs Feb 19, 2018 - Jan. 2023
    Harnessing Oral Mucosa Vaccination to Drive Protective HIV Antibody Responses - R01DE026336 (Sodora/Sather) NIH/NIDCR $2,468,892 Total Direct Costs July 2016 - May 2021

Overview

Research Description

Work in the Sodora Lab primarily focuses on two principal areas of HIV research: HIV transmission and HIV-induced disease and immune factors that impact progression to AIDS. Collectively, these research strategies are designed to produce novel vaccine approaches and immune therapies that will decrease the spread of HIV and/or prevent disease progression in HIV-infected people.

Research Focus Area

HIV/AIDS, Immunology, Infectious Disease, Systems Biology, Tuberculosis, Virology